WO2014015841A3 - 一种利用微藻高效生产虾青素的方法 - Google Patents

一种利用微藻高效生产虾青素的方法 Download PDF

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Publication number
WO2014015841A3
WO2014015841A3 PCT/CN2013/084262 CN2013084262W WO2014015841A3 WO 2014015841 A3 WO2014015841 A3 WO 2014015841A3 CN 2013084262 W CN2013084262 W CN 2013084262W WO 2014015841 A3 WO2014015841 A3 WO 2014015841A3
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WO
WIPO (PCT)
Prior art keywords
algae
astaxanthin
micro
efficiency production
culture
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PCT/CN2013/084262
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English (en)
French (fr)
Other versions
WO2014015841A2 (zh
Inventor
李元广
章真
范建华
万民熙
侯冬梅
张京奎
黄建科
梁松涛
王俊
陈杰
王伟良
王军
李淑兰
沈国敏
Original Assignee
华东理工大学
嘉兴泽元生物制品有限责任公司
上海泽元海洋生物技术有限公司
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Application filed by 华东理工大学, 嘉兴泽元生物制品有限责任公司, 上海泽元海洋生物技术有限公司 filed Critical 华东理工大学
Priority to EP13823422.4A priority Critical patent/EP2878676A4/en
Priority to IN1606DEN2015 priority patent/IN2015DN01606A/en
Priority to US14/417,166 priority patent/US20150252391A1/en
Priority to BR112015001637A priority patent/BR112015001637A2/pt
Priority to AU2013295436A priority patent/AU2013295436A1/en
Priority to CN201380039500.XA priority patent/CN104662162A/zh
Publication of WO2014015841A2 publication Critical patent/WO2014015841A2/zh
Publication of WO2014015841A3 publication Critical patent/WO2014015841A3/zh

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

本发明公开一种培养微藻生产虾青素的方法。方法包括微藻异氧培养、稀释、光诱导培养、藻细胞采集和虾青素提取步骤。
PCT/CN2013/084262 2012-07-27 2013-09-26 一种利用微藻高效生产虾青素的新方法 WO2014015841A2 (zh)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP13823422.4A EP2878676A4 (en) 2012-07-27 2013-09-26 PROCESS WITH MICROALGEN FOR THE HIGHLY EFFICIENT MANUFACTURE OF ASTAXANTHINE
IN1606DEN2015 IN2015DN01606A (zh) 2012-07-27 2013-09-26
US14/417,166 US20150252391A1 (en) 2012-07-27 2013-09-26 Method using microalgae for high-efficiency production of astaxanthin
BR112015001637A BR112015001637A2 (pt) 2012-07-27 2013-09-26 método usando microalgas para produção com eficiência elevada de astaxantina
AU2013295436A AU2013295436A1 (en) 2012-07-27 2013-09-26 Method using micro-algae for high-efficiency production of astaxanthin
CN201380039500.XA CN104662162A (zh) 2013-09-26 2013-09-26 一种利用微藻高效生产虾青素的新方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201210264946.XA CN103571906B (zh) 2012-07-27 2012-07-27 一种利用微藻高效生产虾青素的新方法
CN201210264946.X 2012-07-27

Publications (2)

Publication Number Publication Date
WO2014015841A2 WO2014015841A2 (zh) 2014-01-30
WO2014015841A3 true WO2014015841A3 (zh) 2014-03-20

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PCT/CN2013/084262 WO2014015841A2 (zh) 2012-07-27 2013-09-26 一种利用微藻高效生产虾青素的新方法

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US (1) US20150252391A1 (zh)
EP (1) EP2878676A4 (zh)
CN (1) CN103571906B (zh)
AU (1) AU2013295436A1 (zh)
BR (1) BR112015001637A2 (zh)
IN (1) IN2015DN01606A (zh)
WO (1) WO2014015841A2 (zh)

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CN103966103A (zh) * 2014-05-26 2014-08-06 临沂大学 利用啤酒厂废水培养雨生红球藻的培养基及培养方法
CN104263649A (zh) * 2014-09-15 2015-01-07 李健 一种大规模微藻培养的方法
WO2016146803A1 (de) * 2015-03-19 2016-09-22 Basf Se Astaxanthinzusammensetzungen (iii)
JP2018510634A (ja) * 2015-03-19 2018-04-19 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ アスタキサンチン組成物（ｉ）
CN105420332A (zh) * 2015-12-10 2016-03-23 天津科技大学 一种雨生红球藻高产虾青素的方法
CN105462844B (zh) * 2015-12-16 2019-05-03 中国科学院青岛生物能源与过程研究所 一种雨生红球藻细胞周期同步化的调控方法及其应用
CN107189946B (zh) * 2016-03-15 2022-07-01 嘉兴泽元生物制品有限责任公司 一种避免微藻光抑制以提高虾青素产量的方法
CA3028227A1 (en) 2016-06-30 2018-01-04 Kuehnle Agrosystems, Inc. Improved heterotrophic production methods for microbial biomass and bioproducts
CN106316847B (zh) * 2016-08-16 2019-01-15 集美大学 一种虾青素亚油酸单酯的制备方法
WO2018056160A1 (ja) * 2016-09-21 2018-03-29 日本水産株式会社 アスタキサンチンの生産方法
CN106434817B (zh) * 2016-09-29 2020-03-10 山东金晶生物技术有限公司 一种利用碱预处理技术提升雨生红球藻生产虾青素的方法
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US10793547B2 (en) 2016-12-09 2020-10-06 Vertex Pharmaceuticals Incorporated Modulator of the cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
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CN107384907A (zh) * 2017-07-13 2017-11-24 荆楚理工学院 一种富硒虾青素小球藻粉的制备方法
CA3069226A1 (en) 2017-07-17 2019-01-24 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
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CA3078893A1 (en) 2017-10-19 2019-04-25 Vertex Pharmaceuticals Incorporated Crystalline forms and compositions of cftr modulators
WO2019113089A1 (en) 2017-12-04 2019-06-13 Vertex Pharmaceuticals Incorporated Compositions for treating cystic fibrosis
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
PT3752510T (pt) 2018-02-15 2023-03-15 Vertex Pharma Macrociclos como moduladores do regulador de condutância de transmembrana da fibrose cística, suas composições farmacêuticas, seu uso no tratamento da fibrose cística e processos para produzi-los
WO2019195739A1 (en) 2018-04-05 2019-10-10 Alexander Russell Abela Modulators of cystic fibrosis transmembrane conductance regulator
US11414439B2 (en) 2018-04-13 2022-08-16 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
CN108504619B (zh) * 2018-06-06 2021-06-01 中国科学院海洋研究所 一种缓解雨生红球藻光抑制的方法
IT201800006555A1 (it) * 2018-06-21 2019-12-21 Procedimento per la coltivazione di alghe, preferibilmente di microalghe
CN109566393A (zh) * 2018-12-14 2019-04-05 浙江海洋大学 用于提取多糖的海藻的培养方法
JP7535103B2 (ja) * 2019-09-23 2024-08-15 バイオアルゴ（ダブリュエフ）カンパニー，リミテッド ヘマトコッカス・プルビアリス（Ｈａｅｍａｔｏｃｏｃｃｕｓ ｐｌｕｖｉａｌｉｓ）を培養して、アスタキサンチンを産生する方法
CN114729297B (zh) * 2019-09-23 2024-04-12 山东拜昂生物技术有限公司 一种异养培养雨生红球藻生产虾青素的方法
WO2022194399A1 (en) 2020-07-13 2022-09-22 Idorsia Pharmaceuticals Ltd Macrocycles as cftr modulators
CN111979097A (zh) * 2020-09-04 2020-11-24 清华大学 一种微藻培养用光生物反应器
CN112239727B (zh) * 2020-10-15 2022-04-01 大连理工大学 一种基于人工智能微藻混合系统培养微藻的方法
KR102535358B1 (ko) * 2021-03-30 2023-05-26 고려대학교 산학협력단 초음파 자극의 도입을 통한 미세조류 유래 고부가 가치 물질 생합성 증대법
CN113717917A (zh) * 2021-06-30 2021-11-30 中国海洋大学 一种雨生红球藻纯种培养的联合抗生素施用方法
CN113817793A (zh) * 2021-09-14 2021-12-21 国青(浙江)科学研究有限公司 一种叶黄素提高雨生红球藻中虾青素含量的生产工艺
CN114214386A (zh) * 2021-12-13 2022-03-22 广东百睿盈科生物科技有限公司 一种异养培养小球藻生产虾青素的方法
CN114214202B (zh) * 2021-12-27 2024-02-13 广西源藻生物科技有限公司 异养-光诱导串联培养微藻联产叶黄素和蛋白质的方法
WO2024056791A1 (en) 2022-09-15 2024-03-21 Idorsia Pharmaceuticals Ltd Combination of macrocyclic cftr modulators with cftr correctors and / or cftr potentiators
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Also Published As

Publication number Publication date
CN103571906A (zh) 2014-02-12
BR112015001637A2 (pt) 2017-07-04
IN2015DN01606A (zh) 2015-07-03
CN103571906B (zh) 2018-12-11
AU2013295436A1 (en) 2015-03-19
EP2878676A4 (en) 2016-05-25
EP2878676A2 (en) 2015-06-03
WO2014015841A2 (zh) 2014-01-30
US20150252391A1 (en) 2015-09-10

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