WO2013135240A1 - Vorrichtung zur durchführung einer anästhesie oder analgosedierung und verfahren zum betreiben einer vorrichtung zur durchführung einer anästhesie oder analgosedierung - Google Patents
Vorrichtung zur durchführung einer anästhesie oder analgosedierung und verfahren zum betreiben einer vorrichtung zur durchführung einer anästhesie oder analgosedierung Download PDFInfo
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- WO2013135240A1 WO2013135240A1 PCT/DE2013/200006 DE2013200006W WO2013135240A1 WO 2013135240 A1 WO2013135240 A1 WO 2013135240A1 DE 2013200006 W DE2013200006 W DE 2013200006W WO 2013135240 A1 WO2013135240 A1 WO 2013135240A1
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- patient
- anesthetic
- concentration
- determining
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
- A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2505/00—Evaluating, monitoring or diagnosing in the context of a particular type of medical care
- A61B2505/03—Intensive care
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2505/00—Evaluating, monitoring or diagnosing in the context of a particular type of medical care
- A61B2505/05—Surgical care
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
- A61B5/0836—Measuring rate of CO2 production
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/087—Measuring breath flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M2005/14208—Pressure infusion, e.g. using pumps with a programmable infusion control system, characterised by the infusion program
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0241—Anaesthetics; Analgesics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0468—Liquids non-physiological
- A61M2202/048—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3306—Optical measuring means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/005—Parameter used as control input for the apparatus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/04—Heartbeat characteristics, e.g. ECG, blood pressure modulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/08—Other bio-electrical signals
- A61M2230/10—Electroencephalographic signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/40—Respiratory characteristics
- A61M2230/43—Composition of exhalation
- A61M2230/432—Composition of exhalation partial CO2 pressure (P-CO2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/40—Respiratory characteristics
- A61M2230/43—Composition of exhalation
- A61M2230/437—Composition of exhalation the anaesthetic agent concentration
Definitions
- the invention relates to an apparatus for performing anesthesia or analgesic sedation and to a method for operating an apparatus for performing anesthesia or analgesic sedation.
- anesthesia or anesthesia certain body functions are switched off for the purpose of tolerance of diagnostic or surgical procedures on or in the body.
- the goal of adequate anesthesia is to realize a combined effect of hypnotic, analgesic, and muscle relaxant effects, so as to ensure that the patient is in a state of unconsciousness during the procedure and does not perceive the procedure accordingly and that he It is also insensitive to pain-sensitive stimuli during the procedure.
- a graded form of anesthesia depth is sought which, without the action of muscle relaxants, is a combination of hypnotic and analgesic effects.
- the anesthetist usually administers a combination of anesthetic drugs having different effects on the brain, spinal cord, autonomic nervous system, and / or neuromuscular junctions.
- anesthetic drugs having different effects on the brain, spinal cord, autonomic nervous system, and / or neuromuscular junctions.
- narcotics / sedatives are commonly used for unconsciousness, sedation or sedation combined with analgesics for pain suppression.
- a commonly used drug from the group of narcotics is propofol (active ingredient: 2,6-diisopropylphenol), while as analgesics typically opioids, such as remifentanil, fentanyl or morphine, are used.
- opioids such as remifentanil, fentanyl or morphine
- propofol can be dosed by computer-assisted syringes (Target Controlled Infusion, TCI) that infuse the drug based on pharmacokinetic data.
- TCI Target Controlled Infusion
- the relationship between the propofol concentration in the patient's blood and the administered dose is calculated exclusively on the basis of demographic data of the patient, such as size, weight, age, gender.
- the pharmacological models stored in TCI syringe pumps as found today in everyday clinical practice, have an accuracy of approximately 20% in healthy patients. Patients with organ dysfunction have an even greater deviation. Further restrictions exist, for example obese patients and children. Accordingly, anesthesia control based on these models is inevitably inaccurate.
- the present invention is therefore based on the object, a device for performing anesthesia or Analgosedtechnik and a method for operating a device for performing anesthesia or Analgosed réelle such and further, that anesthesia control with improved accuracy is possible. According to the invention the above object is solved by the features of claim 1.
- the device in question for performing anesthesia or analgesic sedation comprises a metering device for intravenous administration of an adjustable dose of at least one anesthetic agent to a patient, a measuring device for determining the concentration of the at least one anesthetic in the patient's exhalation air, means for determining the effect of at least one Anesthesia means on the patient, preferably in the form of an anesthetic or Analgosed iststiefe, and a data processing device which communicates via interfaces with the metering device, the measuring device and the means for determining the effect, based on the determined values of the parameters dose, concentration and effect of the at least one Anesthetized with a patient-individualized pharmacological model, and based on the individualized pharmacological model calculated on the patient optimized dosage of at least one anesthetic agent.
- the method for operating an apparatus for performing anesthesia comprises the steps:
- Anesthetic agent to a patient
- a measuring device for determining the concentration of an anesthetic in the exhaled air of the patient means for determining the effect (anesthetic or analgosedation depth) of the administered anesthetic and a dosing device for the intravenous administration of an anesthetic via a data processing device.
- the measured concentration values flow into an individualized pharmacological model tailored to each patient.
- the pharmacological model is a complete PK / PD model that takes into account both pharmacokinetic and pharmacodynamic aspects.
- An individual patient-specific anesthesia or analgesic sedation control can be realized by the calculation of such a pharmacological model individualized for the respective patient in parallel with the intervention on the patient.
- the metering device comprises a computer-controlled syringe pump.
- This allows the anesthesiologist according to the identified need for a simple and accurate replenishment of the anesthetic during the procedure.
- the syringe pump records the dosage of the patient administered during the procedure respective AnITAhesiestoffs continuously and transmits the data via a corresponding interface to the data processing device.
- the measuring device for determining the concentration of the at least one Anxhesiestoffs works continuously, wherein the discontinuous respiratory gas flow is transferred into a continuous sample gas flow and this is fed to a sensor system of the measuring device.
- the measurements can also be carried out timed with short measuring intervals of less than 60 s, ideally of less than 30 s, and preferably in a range of 15-25 s, so that approx Every 3-5 breaths of the patient, a current concentration value, which can be incorporated into the PK / PD model, is available.
- the measuring device is advantageously designed as an ion mobility spectrometer with upstream gas-chromatographic separation column, preferably a multi-capillary column.
- upstream gas-chromatographic separation column preferably a multi-capillary column.
- an advance separation of the individual components contained in the respiratory gas can be carried out so that the individual components enter the drift tube of the ion mobility spectrometer at different times and / or have different drift times / mobilities. Accordingly, it is possible to determine the concentration of several different anesthetic agents independently of each other and almost in parallel with each other.
- concentration measurements carried out in the exhaled air of a patient the defined withdrawal of respiratory gas samples, both with regard to the respective volumes and with regard to the respective respiratory phases, is of crucial importance.
- the ion mobility spectrometer is coupled to a volume flow sensor (flow sensor) and / or to a CO 2 sensor.
- a volume flow sensor flow sensor
- CO 2 sensor a CO 2 sensor
- the means for determining the effect of the at least one anesthetic agent on the patient comprises a device for deriving an EEG, referred to below as an EEG module.
- demographic data of the patient are integrated into the individualized PK / PD model in addition to the values of the parameters dosage, concentration and effect with a view to a more extensive individualization.
- the demographic data of the patient in particular age, weight, height, gender and BMI (body mass index), can either be entered manually into the data processing device with the aid of appropriate input means or read directly from a patient database into the data processing device.
- the at least one anesthetic for which an individualized patient-specific PK / PD model is created taking into account measured concentration values in the exhaled air of the patient, it may be, for example, a narcotic, in particular propofol. Additionally or alternatively, the at least one anesthetic agent may comprise an analgesic, in particular an opiod.
- an analgesic in particular an opiod.
- interaction models between, for example, propofol and an opiod can be generated. This is of particular advantage since in the vast majority of surgical interventions propofol is used as a hypnotic opiode as an analgesic.
- the time intervals for determining the concentration values of the narcotics and the opiod need not necessarily be identical, but may well differ from one another.
- the at least one anesthetic for which an individualized patient-specific PK / PD model is created taking into account measured concentration values in the exhaled air of the patient, comprises a muscle relaxant.
- the device is designed in the sense of an "open loop" system
- a display device can be provided, on which the calculated, optimized for the patient dosage of the administered or anesthetic (s) The anesthetist may then decide whether to follow the recommendation and to adjust the dosage accordingly, taking into account the overall anesthetic situation.
- the device may be designed in the sense of a "closed loop" system
- the patient-specific optimized dosage of the anesthetic agent calculated on the basis of the created individualized PK / PD model is used to generate corresponding control signals which are sent to the metering device automatic adjustment of the dosage to be transmitted.
- the data processing device is set up to carry out a correlation analysis between EEG index values determined by means of the EEG module and the measured concentration of the at least one anesthetic in the exhaled air of the patient.
- FIG. 1 is a schematic representation of an embodiment of an inventive device for performing anesthesia
- FIG. 2 is a schematic representation of a method for creating an individual patient-specific PK / PD model according to an exemplary embodiment of the invention.
- Fig. 1 shows a schematic representation of a preferred embodiment of a device according to the invention for performing anesthesia, which could be transferred directly to the implementation of a Analgosed ist. Shown are the patient 1 and the essential components of the device. Specifically, the illustrated device comprises a measuring device 2 for determining the concentration of an anesthetic in the exhaled air of the patient 1 in the form of an ion mobility spectrometer (IMS) 3 with multi-capillary column (MCC), an EEG module 8, a metering device 5 for intravenous Administration of an adjustable dose of anesthetic to a patient in the form of a TCI syringe pump 6 and a data processing device 7.
- IMS ion mobility spectrometer
- MCC multi-capillary column
- the IMS 2 measures continuously or at regular intervals the current propofol concentration in the exhaled air of the patient 1. In the case of temporally These measurements are carried out with a maximum time interval of approx. 30 s. These short measurement intervals ensure that the measurements virtually represent real-time measurements. The measured values are therefore immediately available online during the procedure.
- an unillustrated respiratory gas sensor is provided in addition to the IMS 2, which is embodied in particular as a CC sensor or as a flow sensor and measures the CO 2 concentration in the exhalation phase.
- the respiratory gas sensor is used to control the sample gas removal from the respiratory gas flow. As soon as the respiratory gas sensor detects a CO2 concentration in the expiration phase which exceeds a first predetermined value, the sample gas withdrawal is started. As soon as the CO 2 concentration falls below a second predetermined value, the sample gas withdrawal is ended. In this way, reproducible samples are generated, which always result from the same defined respiratory phase. The samples thus generated are then fed to the IMS 2 to determine the exact propofol concentration.
- an EEG of the patient 1 is derived by means of the EEG module 4.
- the EEG is displayed to the anesthesiologist at a corresponding EEG monitor.
- index values for example so-called BIS values (Bispectral Index Monitoring) are transmitted from the EEG monitor and also displayed.
- BIS values Breast Imaging Monitoring
- the EEG values, the measured propofol concentrations and the dose of propofol administered to the patient 1 are transmitted via corresponding interfaces to a data processing device 7.
- a pharmacological model individualized for the patient 1-PK / PD model- is created on the basis of these values.
- an individual propofol dosage optimized for the respective patient 1 is then calculated.
- the optimized propofol dosage can then the anaesthesiologist via appropriate Ausgabet. Display means are provided in the sense of a recommendation.
- a control loop can be realized, in which case the optimized propofol dosage is transmitted directly to the syringe pump 6 as a corresponding control signal.
- FIG. 2 schematically illustrates the creation of an individualized PK / PD model according to an embodiment of the invention.
- the illustrated embodiment is based on a conventional three-compartment model. This type of model has so far best proven in practice for describing and interpreting pharmacokinetic processes occurring within the body.
- the organism is divided into a central (V zen trai) and two parallel peripheral (V2 and V3) compartments.
- the central compartment V ze ntrai corresponds to the blood volume and the organs with a high proportion of the cardiac output, in particular the brain, heart and lungs.
- One of the peripheral compartments (V2) corresponds to the musculature and the other organs, while the other of the peripheral compartments (V3) describes the fatty and connective tissue.
- an individual patient-specific PK / PD model is calculated during the anesthesia, taking into account not only the demographic data of the patient but additionally concentration values of the administered anesthetic agent measured in real time or virtually in real time and additionally measured EEG Index values integrated into the model calculation become.
- concentration values of the administered anesthetic agent measured in real time or virtually in real time and additionally measured EEG Index values integrated into the model calculation become.
- the size of the central compartment V ze ntrai is not simply determined on the basis of the demographic data of the patient, but is calculated individually from the concentrations of the administered anesthetic agent actually measured by means of the IMS. This result, together with the dosage administered, is used in the calculation of the exchange process with the peripheral compartments V2 and V3 as well as the elimination process.
- the effect of the administered anesthetic agent is modeled on the basis of the determined size of the central compartment V ze ntrai in combination with the recorded EEG index values.
- the conventional three-compartment model is extended by additional compartments to calculate the individual patient-specific PK / PD model.
- an anesthesia monitor is implemented which enables anesthesiologists who are anesthetized on the basis of a pharmacological model optimized for the individual patient to have optimized anesthesia or analgesic administration.
- the anesthesiologist can make all relevant information available to the anesthesiologist.
- the dose-response curve of the patient can be calculated.
- a prediction of the further course can be made.
- a comparison with pharmacological averages can be made.
- ⁇ Metabolism rate of Propofol To further optimize and improve the predictive value of PK / PD models based on concentrations actually measured in patient exhaled air, different correlation analyzes may be performed. For example, a correlation analysis between a subsequently measured propofol blood concentration in the laboratory and the end-tidal propofol concentration measured during the procedure could help to incorporate more accurate information regarding the actual propofol blood concentration into the models. Correlation analysis between clinical endpoints (eg, loss of consciousness) and measured end-tidal propofol concentrations, as well as correlation analyzes between EEG index values and the measured end-tidal propofol concentration, could also contribute to further improvement.
- clinical endpoints eg, loss of consciousness
- measured end-tidal propofol concentrations as well as correlation analyzes between EEG index values and the measured end-tidal propofol concentration
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Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/384,320 US20150038940A1 (en) | 2012-03-13 | 2013-03-13 | Appliance for performing anaesthesia or analgosedation, and method for operating an appliance for performing anaesthesia or analgosedation |
JP2014561288A JP2015512698A (ja) | 2012-03-13 | 2013-03-13 | 麻酔または鎮痛鎮静を実行するための装置および麻酔または鎮痛鎮静を実行するための装置の操作方法 |
KR1020147028463A KR20140135818A (ko) | 2012-03-13 | 2013-03-13 | 마취 또는 통증-진정을 수행하는 장치, 및 마취 또는 통증-진정을 수행하는 장치를 동작시키는 방법 |
EP13719010.4A EP2825238A1 (de) | 2012-03-13 | 2013-03-13 | Vorrichtung zur durchführung einer anästhesie oder analgosedierung und verfahren zum betreiben einer vorrichtung zur durchführung einer anästhesie oder analgosedierung |
CA2867067A CA2867067A1 (en) | 2012-03-13 | 2013-03-13 | Apparatus for the performance of anesthesia or analgo-sedation and method for operating an apparatus for performance of anesthesia or analgo-sedation |
CN201380024448.0A CN104302342A (zh) | 2012-03-13 | 2013-03-13 | 用于进行麻醉或镇痛镇静的设备以及操作用于进行麻醉或镇痛镇静的设备的方法 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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DE102012203897.3 | 2012-03-13 | ||
DE102012203897.3A DE102012203897B4 (de) | 2012-03-13 | 2012-03-13 | Vorrichtung zur Durchführung einer Anästhesie oder Analgosedierung und Verfahren zum Betreiben einer Vorrichtung zur Durchführung einer Anästhesie oder Analgosedierung |
Publications (1)
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WO2013135240A1 true WO2013135240A1 (de) | 2013-09-19 |
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PCT/DE2013/200006 WO2013135240A1 (de) | 2012-03-13 | 2013-03-13 | Vorrichtung zur durchführung einer anästhesie oder analgosedierung und verfahren zum betreiben einer vorrichtung zur durchführung einer anästhesie oder analgosedierung |
Country Status (8)
Country | Link |
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US (1) | US20150038940A1 (de) |
EP (1) | EP2825238A1 (de) |
JP (1) | JP2015512698A (de) |
KR (1) | KR20140135818A (de) |
CN (1) | CN104302342A (de) |
CA (1) | CA2867067A1 (de) |
DE (1) | DE102012203897B4 (de) |
WO (1) | WO2013135240A1 (de) |
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US11167084B2 (en) | 2016-05-02 | 2021-11-09 | Fresenius Vial Sas | Control device for controlling the administration of propofol to a patient |
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US10388405B2 (en) | 2013-03-22 | 2019-08-20 | Massachusetts Institute Of Technology | Systems and methods for predicting adverse events and assessing level of sedation during medical procedures |
WO2014173558A1 (en) | 2013-04-24 | 2014-10-30 | Fresenius Kabi Deutschland Gmbh | Method of operating a control device for controlling an infusion device |
US10391243B2 (en) * | 2013-07-02 | 2019-08-27 | Eyetracking Llc | Detecting depth of anesthesia via pupil metrics |
DE102014015897A1 (de) | 2014-10-28 | 2016-04-28 | Drägerwerk AG & Co. KGaA | Verfahren und System zum Kontrollieren einer Medikamentendosiereinrichtung |
CN107847172B (zh) * | 2015-07-17 | 2021-04-30 | 昆腾医疗公司 | 用于评估觉醒、镇静和全身麻醉期间的意识、疼痛和伤害感受的水平的设备和方法 |
WO2017027855A1 (en) * | 2015-08-12 | 2017-02-16 | Massachusetts Institute Of Technology | Systems and methods for predicting adverse events and assessing level of sedation during medical procedures |
JP6944183B2 (ja) * | 2017-07-18 | 2021-10-06 | 国立大学法人福井大学 | 麻酔補助プログラム、麻酔補助装置、麻酔補助システム及び麻酔補助方法 |
KR102271175B1 (ko) * | 2019-07-31 | 2021-07-01 | 주식회사 바이오넷 | 목표 농도 주입의 복구 조절 방법 |
DE102021110371A1 (de) | 2021-04-22 | 2022-10-27 | Medicad Hectec Gmbh | Verfahren zur Planung der Dosierung eines Anästhetikums zur Herbeiführung eines Zustands der Anästhesie |
CN117503106B (zh) * | 2023-11-27 | 2024-06-11 | 苏州邦伊医疗科技有限公司 | 呼出气中丙泊酚浓度与血药浓度的动态相关系数检测系统 |
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Also Published As
Publication number | Publication date |
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DE102012203897B4 (de) | 2014-11-27 |
JP2015512698A (ja) | 2015-04-30 |
CA2867067A1 (en) | 2013-09-19 |
CN104302342A (zh) | 2015-01-21 |
EP2825238A1 (de) | 2015-01-21 |
DE102012203897A1 (de) | 2013-09-19 |
US20150038940A1 (en) | 2015-02-05 |
KR20140135818A (ko) | 2014-11-26 |
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