WO2013117332A1 - Dispositif d'injection - Google Patents

Dispositif d'injection Download PDF

Info

Publication number
WO2013117332A1
WO2013117332A1 PCT/EP2013/000359 EP2013000359W WO2013117332A1 WO 2013117332 A1 WO2013117332 A1 WO 2013117332A1 EP 2013000359 W EP2013000359 W EP 2013000359W WO 2013117332 A1 WO2013117332 A1 WO 2013117332A1
Authority
WO
WIPO (PCT)
Prior art keywords
injection
injection device
locking
control button
control knob
Prior art date
Application number
PCT/EP2013/000359
Other languages
German (de)
English (en)
Inventor
Herbert Bechtold
Original Assignee
Haselmeier Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Haselmeier Gmbh filed Critical Haselmeier Gmbh
Priority to BR112014014902-0A priority Critical patent/BR112014014902B1/pt
Priority to MX2014009123A priority patent/MX344115B/es
Priority to RU2014134275A priority patent/RU2615122C2/ru
Priority to CN201380008645.3A priority patent/CN104220117B/zh
Publication of WO2013117332A1 publication Critical patent/WO2013117332A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button

Definitions

  • the invention relates to an injection device of the type specified in the preamble of claim 1.
  • an injection device in which a knob is rotated to set the amount of liquid to be injected.
  • the control knob moves with an injection sleeve in the distal direction of the injection device.
  • the control knob has a locking device, which ensures that the control knob can only be placed in structurally predetermined positions. An adjustment of intermediate positions is not possible due to the sprung arms of the locking device.
  • the control knob is moved in the proximal direction.
  • the control knob automatically and safely jumps from an intermediate position in a detent position
  • the detent must be sufficiently strong, and the radial detent positions must be sufficiently close to each other.
  • the strength of the detent influences the torque that the user must use to turn the control knob and adjust the dose.
  • the constructive possible distance of the locking positions is largely predetermined and can be adapted only within narrow limits to the application.
  • an injection device for administering a medicament is known.
  • the injection device has a rotary knob, which is rotated to adjust the amount of liquid to be injected.
  • the control knob can only up to one maximum adjustable dose to be rotated. However, it is possible to adjust and inject less than the maximum dose.
  • the invention has for its object to provide an injection device of the generic type, in which only predetermined amounts of injection liquid can be pressed out of the container and allows a good adaptation to the desired application.
  • a locking device that ensures that the control knob stops only in injection positions and are not placed in blocking positions can, can be omitted.
  • a locking device for the control knob can be adapted to the needs of the operator and be designed, for example, with very noticeable detents or with little noticeable detents, which also allow intermediate positions of the control knob. This achieves a high degree of operating comfort and at the same time it can be ensured that no impermissible quantities of injection liquid can be squeezed out of the container.
  • the "proximal direction” designates the injection direction, that is to say in the direction of a receptacle for the injection needle or the direction in which the injection liquid is pressed out of the container.
  • the “distal direction” refers to the opposite direction, ie away from the injection needle.
  • the distal end of the injection device is the end facing away from the injection needle.
  • Proximal refers to the side of the injection device that faces the puncture site during an injection and “distal” to the side away from the puncture site.
  • the injection device has a first latching device which defines the at least one injection position.
  • the locking device is designed so that even blocking positions, which are assigned to impermissible amounts of injection liquid, are adjustable.
  • the first latching device advantageously has at least one latching element which cooperates with a latching contour. In injection position, the latching element is advantageously engaged in a latching recess of the latching contour. In the locked position, the latching element is deflected by the latching contour. It is intended that the
  • Injection device has a locking contour, which cooperates with the deflected locking element and locks in the blocking position of the control knob displacement of the control knob relative to the housing in the proximal direction.
  • the locking contour is formed on the control knob.
  • the locking element is advantageously arranged within the control knob.
  • the control knob is adjustable in particular with respect to the latching element between a first, distal position and a second proximal position. In the first position of the control knob, the locking element is arranged in a first axial portion of the control knob, which allows a deflection of the locking element. In the second position of the control knob, the latching element is advantageously arranged in a second axial section, which blocks a deflection of the latching element.
  • the locking element is advantageous relative to the longitudinal central axis deflected outwards, ie away from the longitudinal center axis.
  • the control knob advantageously has in the first section a first inner diameter that is larger than a second inner diameter in the second section. As a result, a blocking contour can be realized in a simple manner.
  • the control knob is advantageously sprung in the direction of its first, distal position.
  • the injection device advantageously has an injection sleeve which is non-rotatably and axially displaceably connected to the housing.
  • the injection sleeve is connected via a first threaded connection with a metering member which is rotatably and axially immovably mounted relative to the housing. A rotation of the metering causes thus over the first threaded connection an axial displacement of the injection sleeve.
  • the injection device advantageously has a first clutch, which produces a rotationally fixed connection between the control knob and the metering in the first position of the control knob. A rotation of the control knob thereby rotates the metering, whereby the injection sleeve is moved in the axial direction over the first threaded connection.
  • the non-rotatable connection between the control knob and dosing is made via a driver which is rotatably connected to the metering and axially fixed and rotatably connected to the injection sleeve.
  • the driver thereby moves together with the injection sleeve in the axial direction when the control knob is rotated.
  • the control knob In its second position, the control knob is advantageously rotatably connected via a second coupling with the injection sleeve.
  • the latching element of the first latching device is advantageously a part of the second clutch, and the latching contour is formed on the injection sleeve. This results in a simple structure.
  • the locking element blocks an axial displacement of the control knob and the second clutch can not be closed.
  • the injection device advantageously has a metering piston which is non-rotatably connected to the control knob and a second threaded connection with the metering.
  • a rotation of the metering causes via the second threaded connection a movement of the metering piston, which serves for the extrusion of injection liquid.
  • a small size of the injection device can be achieved when the metering piston is rotatably connected to the control knob via a telescopic part, wherein the telescopic part against one of the parts of metering and control knob is axially displaceable.
  • the telescopic part can be axially displaceable relative to the metering and be held on the control knob axially immovable or held against the metering axially non-displaceable and axially displaceable on the control knob.
  • the telescopic part is displaceable axially relative to one of the parts of metering piston and control knob, ie in the direction of the longitudinal central axis of the injection device, the metering piston and control knob can be made shorter. This reduces the overall length of the injection device.
  • a simple structure results when the metering piston has a guide portion, and when the telescopic part has two guide webs which rest on opposite sides of guide surfaces of the guide portion.
  • a compact construction results, although the control knob has two guide webs which protrude through at least one receptacle of the telescopic part, wherein the guide webs abut the guide portion of the metering piston in the circumferential direction between the guide webs of the telescopic part with the control knob fully depressed.
  • the fact that the guide webs of telescopic part and control knob are adjacent to each other in the circumferential direction, resulting in a small outer diameter of the injection device.
  • a second locking device may be provided, which acts between metering and housing.
  • the first latching device is only active when setting the amount of injection liquid to be pressed out, while the second latching device is active both when setting the quantity to be pressed out
  • the second locking device can be designed very smoothly, so that the force to be applied by the operator during the injection process for squeezing the liquid is only slightly increased by the second locking device. Because both locking devices are active when setting the amount of injection liquid to be squeezed out, the locking positions can be made well palpable and / or audible to the operator.
  • 1 is a side view of an injection device
  • FIG. 3 shows a side view of the injection device from FIG. 1 after setting the amount of injection liquid to be squeezed out
  • FIG. 9 is a perspective view of a locking part of the injection device
  • FIG. 12 is a section along the line XII-XII in Fig. 11, 13 is a side view of an injection sleeve of the injection device,
  • 16 is a perspective view of a driver of the injection device
  • FIG. 17 is a side view of the driver of FIG. 16,
  • 21 is a side view of a metering of the injection device
  • FIG. 23 shows a section along the line XXIII-XXIII in FIG. 21, FIG.
  • FIG. 24 is a perspective view of a telescopic part of the injection device
  • 26 is a side view in the direction of arrow XXVI in Fig. 25,
  • FIG. 27 is a section along the line XXVÜ-XXVII in Fig. 25, 28 is a side view of a metering piston
  • FIG. 29 shows a section along the line XXLX-XXLX in FIG. 28, FIG.
  • 31 is a side view of a housing part of the injection device
  • Fig. 32 is a side view of the housing part in the direction of arrow XXXII in
  • FIG. 34 shows a section along the line XXXTV-XXXIV in FIG. 32, FIG.
  • FIG. 36 shows a section along the line XXXVI-XXXVI in FIG. 33, FIG.
  • Fig. 38 is a section along the line XXXVIII-XXXVIII in Fig. 1 in
  • 39 is a section along the line XXXVIII-XXXVIII in Fig. 1 in the locked position of the control knob
  • 40 is a side view of the injection device after adjusting the amount of injection liquid to be squeezed and after pressing the control knob in its second, proximal position
  • Fig. 42 is a section along the line XXXVIII-XXXVIII in Fig. 1 at a
  • Fig. 43 is a section along the line XXXVIII-XXXVIII by another
  • Fig. 1 shows an injection device 1, which has a housing 2.
  • the housing 2 comprises a distal housing part 3 and a holder 4 fixed to the proximal side of the distal housing part.
  • the holder 4 may be firmly fixed to the distal housing part 3, for example by welding to it.
  • the holder 4 can also be removably held on the housing part 3, for example, screwed to the housing part to allow replacement of the container 4 arranged in the holder 4, shown in Fig. 2.
  • the container 5 contains injection liquid.
  • the holder 4 forms a receptacle for the container 5.
  • the holder 4 has a connecting element to which an injection needle can be attached.
  • the connecting element is a standardized external thread 11, onto which an injection needle with a corresponding internal thread can be screwed.
  • another connection element may also be provided at the proximal end of the holder 4.
  • the connecting element is adapted to the intended type of injection needle.
  • the injection device 1 has a longitudinal central axis 6. At the distal end of the injection device 1, a control knob 8 is arranged.
  • the distal housing part 3 has a viewing window 7, which is made for example of transparent plastic.
  • the viewing window 7 can be produced as a separate component or can be produced in one piece in a two-component injection molding process with the distal housing part 3. It can also be provided that the
  • Housing part 3 with the viewing window 7 is completely made of a transparent plastic, which can be roughened except in the region of the viewing window 7, painted or otherwise masked, so that only the area of the viewing window 7 is transparent.
  • Fig. 2 shows the structure of the injection device 1 in detail.
  • a plug 21 is arranged, against which a metering piston 103 of the injection device.
  • the metering piston 103 has a piston disk 20, which bears against the plug 21, and a piston rod 19 rotatably connected to the piston disk 20.
  • the piston rod 19 is non-rotatably connected via a telescopic part 18 to a guide 17 of the control knob 8.
  • the control knob 8 is shown in Fig. 2 in its first, distal position 95.
  • a compression spring 13 is arranged, which loads the control knob 8 in the direction of its first position 95.
  • the compression spring 13 is supported with a first end on an end face 105 of the control knob 8 and with a second end on a driver 16.
  • the driver 16 is rotatably in the first position 95 of the control knob 8 shown in Fig. 2 via a first clutch 23 connected to the control knob 8.
  • the driver 16 is arranged on the outer circumference of the guide 17 of the control knob 8.
  • a sleeve-shaped metering member 15 which is also referred to as a scale tube and rotatably and axially slidably connected to the driver 16 extends.
  • the metering member 15 is surrounded by an injection sleeve 14 which projects as well as the driver 16 with its distal end in the control knob 8.
  • the metering 15 is connected to the injection sleeve 14 via a first threaded connection 33.
  • the metering member 15 is rotatably and axially non-displaceably held on the housing part 3 at its proximal end on a bearing 32.
  • the injection sleeve 14 is in the housing part 3 axially, so slidably held in the direction of the longitudinal central axis 6 but rotatably.
  • a locking member 12 is arranged, which is rotatably mounted in the control knob 8 and which cooperates with the injection sleeve 14 and forms with this a first latching device 29.
  • a second latching device 30 acts between the housing part 3 and the outer periphery of the metering member 15 adjacent to the proximal end of the metering member 15.
  • the latching devices 29 and 30 do not extend in the sectional plane shown in Fig. 2, so that the associated reference numerals indicate only where the Catches 29 and 30 are arranged without showing their construction in detail.
  • the locking part 12 is part of a second clutch 24 which is open in the first position 95 of the control knob 8.
  • the second clutch 24 rotatably connects the control knob 8 in its second position 96 (FIG. 40) with the injection sleeve 14.
  • FIG. 2 shows the injection device 1 after the injection of injection liquid and before the setting of the quantity of injection liquid to be expelled from the container 5 during the next injection.
  • This position of the injection sleeve 14 is defined by a first stop 26 which is formed between the injection sleeve 14 and the housing part 3.
  • the operation knob 8 is rotated.
  • the control knob 8 is rotatably connected in its first position 95 with the driver 16 and the metering member 15 and with the metering piston 103.
  • the first threaded connection 33 causes a relative axial movement between injection sleeve 14 and metering member 15.
  • the injection sleeve 14 is thereby displaced in the distal direction, ie in the direction of the arrow 25, when the control knob 8 is rotated in the direction corresponding to an increase in the set dose , Due to the bearing 32 of the metering member 15 in the housing part 3, which prevents axial movement of the metering member 15, the injection sleeve 14 pushes axially from the housing part 3 and takes the driver 16 and the control knob 8 with.
  • both the first latching device 29 and the second latching device 30 are active, since both the control knob 8 rotates with respect to the injection sleeve 14 and the metering member 15 with respect to the housing part 3.
  • FIGS. 3 and 4 show the injection device 1 after the amount of injection liquid to be squeezed out has been set.
  • the maximum amount of injection liquid to be squeezed is set here. This position is defined by a second stop 27, which is also between the injection sleeve 14 and the
  • Housing part 3 is formed.
  • the control knob 8 For expressing the set amount of injection liquid, the control knob 8 is pressed in the direction of arrow 28 in Fig. 4. Thereby, the first clutch 23 is opened and the second clutch 24 is closed. This will be described in more detail below.
  • the compression spring 13 is designed so that initially the control knob 8 relative to the injection sleeve 14 moves in the proximal direction, before the injection sleeve 14 is displaced in the axial direction.
  • the second clutch 24 is closed, the control knob 8 is non-rotatably connected to the injection sleeve 14.
  • the metering member 15 By the movement of the injection sleeve 14 in the direction of the arrow 28 in the proximal direction, the metering member 15 is rotated.
  • a second threaded connection 34 is formed between the metering member 15 and the piston rod 19, a second threaded connection 34 is formed. Since the piston rod 19 is rotatably connected via the telescopic part 18 with the control knob 8, the piston rod 19 can not rotate relative to the injection sleeve 14. The rotation of the metering member 15 relative to the injection sleeve 14 thereby causes a movement of the piston rod 19 in the proximal direction, which moves the plug 21 in the container 5 and leads to the ejection of injection liquid from the container 5. Since the metering member 15 rotates relative to the housing part 3, the second latching device 30 is also active when expressing injection liquid and also shows the operator acoustically, the squeezing of injection liquid. Since the first clutch 23 is released, the driver 16 can rotate relative to the control knob 8 together with the metering member 15.
  • the components of the injection device 1 are explained in detail.
  • the components represent functional groups, which are drawn in one piece for the sake of simplicity. In order to simplify the manufacture of the parts, however, it may be advantageous to manufacture the elements from several individual parts.
  • Figures 5 to 8 show the structure of the control knob 8 in detail.
  • the guide 17 of the control knob 8 is formed by two guide webs 36, which are aligned in the direction of the longitudinal central axis 6 of the injection device 1.
  • guide surfaces 37 are formed.
  • the control knob 8 has a first portion 38 in which the control knob 8 has an inner diameter a.
  • a second section 39 whose inner diameter b is smaller than the inner diameter a in the first section 38, adjoins the first section 38 in the distal direction. Between the two sections 38 and 39, a step is formed which forms a blocking contour 102 which will be described in more detail below.
  • the first portion 38 is bounded by holding portions 43 which project radially inward, as shown in FIG. 8. The holding portions 43 engage on the edge 49 of the injection sleeve 14 shown in FIG. 13 and fix the injection sleeve 14 in the direction of the longitudinal central axis 6 on the control knob 8.
  • the control knob 8 has in its interior a protruding from the end face 105 in the proximal direction stub 40, at the end of an outer toothing 41 is arranged.
  • the outer teeth 41 are made of individual outwardly projecting teeth arranged side by side in groups of three teeth each are, wherein between the individual groups of teeth in each case a distance is formed.
  • the external teeth 41 may also extend over the entire outer circumference of the nozzle 40.
  • the external toothing 41 is arranged in the first section 38.
  • the control knob 8 has longitudinally extending guide grooves 42 which extend over the first section 38 and the second section 39. In the exemplary embodiment, two oppositely arranged guide grooves 42 are provided.
  • the guide grooves 42 serve to receive guide webs 44 of the locking part 12, which are shown in Fig. 9.
  • the locking part 12 has a ring 107. On its opposite sides two radially outwardly projecting guide webs 44 are arranged.
  • the guide webs 44 each carry two latching arms 45, which extend in the circumferential direction in both directions of the guide webs 44 and which are arranged at the proximal side of the ring 107 at a small distance from the ring 107.
  • At the free ends of the latching arms 45 inwardly projecting detents 46 are formed. This also show the figures 7 to 12.
  • the locking arms 45 with the detents 46 form locking elements. As shown in FIG.
  • the latching arms 45 and the detents 46 viewed in the direction of the longitudinal center axis 6, overlap with the ring 107, ie they do not project beyond the ring 107.
  • the detents 46 cooperate with a detent contour 47 formed on the injection sleeve 14, which is shown in FIG. 13.
  • the locking contour 47 is bounded at its distal end by a first edge 48 and at its proximal end by the second edge 49, which engages behind the holding portions 43.
  • the first, distal edge 48 protrudes between the ring 107 of the latching part 12 and the latching arms 45, as shown in FIGS. 2 and 4, and thereby fixes the latching part 12 in the direction of the longitudinal central axis 6 on the injection sleeve 14.
  • the injection sleeve 14 has a shoulder 97, on which the outer diameter of the injection sleeve 14 increases in the proximal direction. As shown in FIG. 2, a distance c is formed between the proximal end of the control knob 8 and the shoulder 97. When pressing the control knob 8 in the proximal direction of the paragraph 97 forms a stop for the control knob 8.
  • the injection sleeve 14 has a Window 31, in the middle of a marker arrow 54 protrudes indicating the set dose.
  • the injection sleeve 14 has a cover 56 arranged proximally to the window 31.
  • the cover 56 serves to cover the metering element, so that only the marking of the metering element 15 arranged in the window 31 is visible through the viewing window 7.
  • the cover 56 extends in the position of the injection device 1 shown in Figures 1 and 2 into the region of the holder 4.
  • a tongue 9 is arranged on the distal housing part 3, which protrudes over the holder 4 and the cover 56 covers.
  • the injection sleeve 14 has approximately at the height of the shoulder 97 inwardly projecting locking projections 53. In the embodiment, four evenly distributed over the circumference locking projections 53 are provided.
  • the latching projections 53 latch on the driver 16, specifically on the groove 59 of the driver 16 shown in FIGS. 16 and 17, and form a bearing 35, shown in FIG. 4, for the driver 16. Via the latching projections 53 protruding into the groove 59 the driver 16 on the injection sleeve 14 axially immovable but rotatably mounted.
  • the injection sleeve 14 has an internal thread 55, which is formed adjacent to the proximal end of the injection sleeve 14. In the region of the latching projections 53, the internal thread 55 is interrupted, so that the injection sleeve 14 can be produced in an injection molding process.
  • the internal thread 55 forms the first threaded connection 33 with the external thread 62 of the metering element 15 shown in FIGS. 21 and 22.
  • the injection sleeve 14 has a longitudinal groove 50 on its side facing away from the window 31.
  • the longitudinal groove 50 is formed in the region of a thickening 89 of the injection sleeve 14.
  • the projection 90 has a proximal edge 91, which with the proximal end 52 of the longitudinal groove 50 that shown in Fig. 4 second stop 27 forms.
  • the projection 90 also has a distal edge 92 which forms the first stop 26 (Fig. 2) with the distal end 51 of the longitudinal groove 50.
  • the projection 90 is disposed in a longitudinal groove 88.
  • the longitudinal groove 88 is formed so that the thickening 89 of the injection sleeve 14 is in place.
  • FIGS. 16 to 20 show the driver 16 in detail.
  • the driver 16 has at its distal end an internal toothing 57 which cooperates with the external teeth 41 on the neck 40 of the control knob 8 (FIG. 8).
  • Adjacent to the internal teeth 57 recesses 58 are arranged on the proximal side of the internal teeth 57. If the control knob 8 is displaced in the proximal direction with respect to the driver 16, then the external teeth 41 of the control knob 8 from the region of the internal teeth 57 of the driver 16 in the region of the recesses 58, whereby the rotationally fixed connection between the control knob 8 and driver 16 is released.
  • the configurations of the internal teeth 57 and the recesses 58 are also shown in detail in FIGS. 18 and 19.
  • the driver 16 has an edge 106 which limits the groove 59 on the proximal side.
  • the edge 106 limits the insertion depth of the driver 16 in the metering member 15, as shown in FIG. 2.
  • At its adjoining the edge 106 portion of the driver 16 is sleeve-shaped and has on its outer circumference four evenly distributed on the outer circumference longitudinal grooves 60, which, as Fig. 20 shows, have a trapezoidal cross-section.
  • the metering element 15 has corresponding, radially inwardly projecting longitudinal webs 68. The longitudinal webs 68 protrude into the longitudinal grooves 60 and thereby connect the driver 16 in a rotationally fixed manner to the metering device 15.
  • Figures 21 to 23 show the design of the metering member 15 in detail.
  • the metering member 15 is formed sleeve-shaped and has on its outer circumference the external thread 62, which cooperates with the internal thread 55 of the injection sleeve 14.
  • a scale 61 is printed, the values of which increase from the proximal end of the metering member 15 to the distal end.
  • the scale 61 is shown schematically in Fig. 21, with only even numbers shown. The odd numbers can advantageously be indicated by dashes between the numbers. These bars are not shown in the illustration in FIG. 21.
  • setting positions per revolution of the metering 15 are provided.
  • the cover 56 covers the values of the scale 61 which are not arranged within the window 31, so that it is avoided that a plurality of values of the scale 61 are displayed in the viewing window 7 of the housing 2.
  • the metering member 15 has a latching contour 63, which is part of the second latching device 30 (FIG. 2).
  • the metering member 15 has at its proximal end also four radially outwardly projecting latching hooks 64, which are part of the bearing 32 and engage behind a latching edge 85 of the housing part 3 shown in Fig. 35.
  • the metering member 15 is secured in the axial direction on the housing part 3.
  • the metering member 15 also has an inner, cylindrical neck 65, which has an internal thread 66. The internal thread
  • the metering device 15 interacts with an external thread 76 of the metering piston 103 shown in FIG. 28 and forms with it the second threaded connection 34.
  • the metering device 15 has inwardly protruding latching hooks 67 which are used for the axial fixation of the coupling shown in FIG shown telescopic part 18 serve. To do this, the locking hooks snap
  • the telescopic part 18 is shown in detail in FIGS. 24 to 27.
  • the telescope part 18 has a proximal pin 70, which has a square opening 71.
  • the telescopic part 18 has a ring 72.
  • Between the pin 70 and the ring 72 extend two guide webs 73, whose mutually facing surfaces are formed as guide surfaces 74.
  • a respective extending in the longitudinal direction stiffening web 75 is attached.
  • the guide webs 73 are chamfered at their outer edges.
  • a receptacle 104 is formed in the ring 72.
  • FIGS. 28 to 30 show the design of the metering piston 103 in detail.
  • the metering piston 103 has at its distal end of the piston disc 20, a guide portion 77.
  • the guide portion 77 has a rectangular, in particular square cross-section.
  • two opposing first guide surfaces 78 are formed, on which the guide surfaces 37 of the guide webs 36 of the control knob 8 can rest.
  • the two other opposing guide surfaces 79 abut against the guide surfaces 74 of the telescopic part 18.
  • the receptacle 104 in the telescope part 18 is designed so that the guide portion 77 and arranged on the guide surfaces 78 guide webs 37 of the control knob 8 can be inserted therethrough.
  • the injection sleeve 14 is arranged in its proximal position.
  • the guide 17 of the control knob 8 projects through the receptacle 104.
  • the guide 17 has a distance to the piston rod 19. This distance is bridged by the telescopic part 18, which is rotatably connected both with the guide portion 77 and with the guide 17.
  • the guide 17 on the control knob 8 are formed comparatively short, so that a small length of the injection device 1 in the state shown in Figures 1 and 2, ie after a successful injection results.
  • Figures 31 to 37 show the design of the housing part 3 in detail. As shown in FIGS.
  • the housing part 3 has a wall 83 which is perpendicular to the longitudinal central axis 6 and which has an opening 87.
  • the opening 87 is bounded by an inner sleeve 86, which is integrally formed on the wall 83 and projecting in the distal direction.
  • a sleeve portion 84 is arranged, which carries a locking rim 85 protruding in the distal direction, to which the latching hooks 64 of the metering member 15 hook.
  • two locking arms 80 Adjacent to the wall 83, on the distal side of the wall 83, two locking arms 80 are integrally formed on the housing part 3, which are shown in Fig. 34.
  • the latching arms 80 are held by a holding web 82 on the housing part 3 and carry at their free ends detents 81.
  • the detents 81 are arranged approximately opposite each other in the embodiment and engage in the detent contour 63 on the metering 15 a.
  • the detents 81 form with the detent contour 63 the second detent device 30.
  • FIG. 38 and FIG. 39 show sections through the control knob 8.
  • the control knob 8 is shown in the injection position 100 and in the blocking position 101 in FIG. 39.
  • an admissible dose of injection liquid is set, whereas the injection fluid shown in FIG 39 set amount of injection fluid is not allowed.
  • the allowable amount of injection liquid is a constructively predetermined amount that corresponds to a desired dose of the drug to be administered with the injection device. Several quantities may be permissible, for example multiple doses of a single dose.
  • Impermissible quantities of injection fluid are amounts that should not be administered, for example, because the effectiveness of the drug is demonstrated only for permissible levels of injection fluid or because self-adjustment of the dose by the patient and administration of an unspecified amount of drug is avoided should.
  • the detent contour 47 on the injection sleeve 14 has elevations 93 and detent recesses 94.
  • the detents 46 of the detent part 12 are each arranged in a detent recess 94.
  • the detents 46 are pivoted radially inward.
  • Fig. 38 also shows the arrangement of the external teeth 41 of the control knob 8 in the internal teeth 57 of the driver 16. External teeth 41 and internal teeth 57 are shown in FIG. 38 the same height, but arranged below the cutting plane. About the external teeth 41 and the internal teeth 57, a rotationally fixed connection between the driver 16 and the control knob 8 is made.
  • the control knob 8 can be pressed in the direction of the arrow 28 shown in FIG. 4 in the proximal direction into the second proximal position 96 shown in FIGS. 40 and 41.
  • the latching part 12 with the detents 46 reaches the second section 39 shown in FIGS. 6 and 41, which has a smaller diameter b than the section 38 shown in FIG. 38.
  • the outer diameter of the latching part 12 in the region of the latching arms 45 is sufficiently small when arranged in the locking recesses 94 notches 46 so that the control knob 8 can be moved in the proximal direction and an injection can be triggered.
  • the latching arms can no longer be deflected radially outwards, since the cylindrical outer wall of the first section 38 prevents this movement.
  • the control knob 8 is rotatably connected via the locking part 12 with the injection sleeve.
  • the second clutch 24, which is formed by the locking part 12, is closed.
  • the outer teeth 41 moves on the control knob 8 in the proximal direction and passes from the region of the internal teeth 57 in the region of the recesses 38.
  • the first clutch 2 is opened and the driver is opposite to
  • Fig. 39 shows the control knob 8 in blocking position 101.
  • the detents 46 are in the region of the elevations 93 of the locking contour 47.
  • the latching arms 45 are deflected radially outwards.
  • the inner diameter in the second portion 39 is shown in Fig. 39 in dashed line.
  • the dashed line intersects the latching arms 45.
  • the blocking contour 102 shown in FIG. 6 bears against the latching arms 45 and thus prevents a displacement of the control knob 8 in the proximal direction.
  • the triggering of an injection or the pressing out of injection liquid from the container 5 in a blocking position 101 of the control knob 8 is not possible.
  • the locking arms 45 are designed very narrow.
  • the force exerted by the latching arms 45 in the radial direction inwardly is therefore very small.
  • the force exerted by the latching arms 45 on the latching contour 47 is too low to turn the control knob 8 into an injection position 100.
  • a blocking position 101 of the control knob can be adjusted.
  • the blocking contour 102 prevents injection liquid from being pressed out of the container 5 in a blocking position 101 of the operating button 8.
  • Figures 42 and 43 show sections corresponding to Fig. 38 by embodiments.
  • a locking contour 98 is provided on the injection sleeve 14, the locking recesses 94 has, between which elevations 108 are formed.
  • the elevations 108 extend in the exemplary embodiment in each case over a circumferential angle of about 18 °.
  • Injection sleeve 14 constant.
  • the latching arms 45 can not spring inwards. Of the locking arms 45, no force can be exerted in the circumferential direction on the locking contour 98 in this area.
  • a position of the control knob 8 is in a plurality of blocking positions 101 possible.
  • a total of ten detent positions are possible, while in the exemplary embodiment according to FIGS. 38 to 41 a total of 20 positions are provided on the outer circumference.
  • a locking contour 99 is shown in which only two injection positions are provided. In each case, an angle of 180 °, ie half a turn of the control knob 8, is located between the injection positions.
  • an angle of 180 °, ie half a turn of the control knob 8 is located between the injection positions.
  • six detent recesses 94 are arranged next to each other, between which elevations 110 extend.
  • the ridges 110 extend over different circumferential angles. However, it can also be provided that the elevations 110 extend over the same circumferential angle.
  • the arrangement of the elevations 110 and the latching recesses 94 is selected so that only in two positions of the control knob 8, namely in the position shown and rotated by 180 °, all the detents 46 are arranged in latching recesses 94.
  • At least one detent 46 is deflected radially outward by an elevation 110, so that a displacement of the operating button 8 in the proximal direction into the second position 96 shown in FIG. 40 is not possible.
  • the detent recesses 94 are also arranged so that at each rotation of the control knob 8 by 18 ° at least one detent 46 engages in a detent recess 94, so that there are 20 noticeable detent positions.
  • the control knob 8 can be displaced in the axial direction with respect to the driver 16 and the injection sleeve 14, from the first, distal position 95 shown in FIG. 1 to that shown in FIG , Second, proximal position 96.
  • the holding portion 43 abuts the shoulder 97 of the injection sleeve 14.
  • the arrangement of the locking recesses and elevations can be arbitrarily adapted to the particular application. It can also be provided that between the injection positions 100 no locking positions are given and the only noticeable Latching results due to the second locking device 30 between metering member 15 and housing part 3.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Dispositif d'injection (1) comprenant un corps (2) dans lequel est réalisé un logement pour un contenant (5) rempli de liquide pour injection. Le dispositif d'injection (1) comprend un bouton de réglage (8) servant à régler une quantité de liquide pour injection destinée à être expulsée du contenant (5). A cet effet, le bouton de réglage (8) est rotatif. Lors de sa rotation, le bouton de réglage (8) se déplace dans le sens d'un axe central longitudinal (6) du dispositif d'injection (1) dans la direction distale vis-à-vis du corps (2). Pour l'expulsion du liquide pour injection contenu dans le contenant (5), le bouton de réglage (8) est déplacé dans le sens de l'axe central longitudinal (6) dans la direction proximale du dispositif d'injection (1). Lors du réglage de la quantité de liquide pour injection à expulser, le bouton de réglage (8) peut être amené dans au moins une position d'injection (100), dans laquelle une quantité admissible de liquide pour injection est réglée, et dans au moins une position de blocage (101), dans laquelle une quantité inadmissible de liquide pour injection est réglée. Dans la position d'injection (100), le bouton de réglage (8) peut être déplacé dans le sens de l'axe central longitudinal (6) dans la direction proximale. Le but de l'invention est d'éviter l'injection d'une quantité inadmissible de liquide pour injection. A cet effet, en position de blocage (101), le déplacement du bouton de réglage (8) dans le sens de l'axe central longitudinal (6) dans la direction proximale est bloqué.
PCT/EP2013/000359 2012-02-10 2013-02-06 Dispositif d'injection WO2013117332A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
BR112014014902-0A BR112014014902B1 (pt) 2012-02-10 2013-02-06 aparelho injetor
MX2014009123A MX344115B (es) 2012-02-10 2013-02-06 Dispositivo de inyección.
RU2014134275A RU2615122C2 (ru) 2012-02-10 2013-02-06 Инъекционный аппарат
CN201380008645.3A CN104220117B (zh) 2012-02-10 2013-02-06 注射器

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE202012001411.0 2012-02-10
DE202012001411U DE202012001411U1 (de) 2012-02-10 2012-02-10 Injektionsgerät

Publications (1)

Publication Number Publication Date
WO2013117332A1 true WO2013117332A1 (fr) 2013-08-15

Family

ID=47683689

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2013/000359 WO2013117332A1 (fr) 2012-02-10 2013-02-06 Dispositif d'injection

Country Status (6)

Country Link
CN (1) CN105126203B (fr)
BR (1) BR112014014902B1 (fr)
DE (1) DE202012001411U1 (fr)
MX (1) MX344115B (fr)
RU (1) RU2615122C2 (fr)
WO (1) WO2013117332A1 (fr)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE202014001134U1 (de) 2014-02-05 2015-05-06 Haselmeier Gmbh Injektionsgerät
WO2015117741A1 (fr) * 2014-02-05 2015-08-13 Haselmeier Gmbh Appareil d'injection
WO2015117747A1 (fr) * 2014-02-05 2015-08-13 Haselmeier Gmbh Appareil d'injection
DE202015006845U1 (de) 2015-09-30 2016-01-15 Haselmeier Ag Injektionsgerät
DE202015007351U1 (de) 2015-10-22 2017-01-27 Haselmeier Ag Injektionsgerät
CN109310824A (zh) * 2016-06-23 2019-02-05 艾斯曲尔医疗公司 药剂输送装置
US10639426B2 (en) 2015-09-30 2020-05-05 Haselmeier Ag Injection device
US10646658B2 (en) 2015-09-30 2020-05-12 Haselmeier Ag Injection device
WO2021099415A1 (fr) 2019-11-18 2021-05-27 Haselmeier Ag Dispositif d'administration de médicament
US11969584B2 (en) 2017-07-13 2024-04-30 Medmix Switzerland Ag Injection device with flexible dose selection
US11969583B2 (en) 2018-07-17 2024-04-30 Medmix Switzerland Ag Injection device with dose interruption fail safe

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202100012020A1 (it) 2021-05-11 2022-11-11 Stevanato Group Spa Dispositivo di iniezione di un farmaco
IT202100032357A1 (it) 2021-12-23 2023-06-23 Stevanato Group Spa Dispositivo di iniezione di un farmaco

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1326664B1 (fr) 2000-10-09 2006-08-09 Eli Lilly And Company Dispositif du type stylo pour l'administration d'hormone parathyroide
DE102007026083A1 (de) 2007-05-25 2008-11-27 Haselmeier S.A.R.L. Injektionsgerät

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3645245C2 (de) * 1986-11-14 1994-01-27 Haselmeier Wilhelm Fa Injektionsgerät
DK0525525T3 (da) * 1991-07-24 1995-10-02 Medico Dev Investment Co Injektor
DE10248061A1 (de) * 2002-10-15 2004-05-06 Disetronic Licensing Ag Injektionsvorrichtung mit Leerhub
GB0306642D0 (en) * 2003-03-22 2003-04-30 Dca Design Int Ltd Improvements in and relating to an injector for a medical product
DE102005063311A1 (de) * 2005-02-23 2006-08-24 Tecpharma Licensing Ag Verabreichungsvorrichtung mit Anzeigetrommel
DK2288400T3 (da) * 2008-05-20 2013-01-14 Tecpharma Licensing Ag Apparat til indgivelse af et injicerbart produkt med restmængdevisning

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1326664B1 (fr) 2000-10-09 2006-08-09 Eli Lilly And Company Dispositif du type stylo pour l'administration d'hormone parathyroide
DE102007026083A1 (de) 2007-05-25 2008-11-27 Haselmeier S.A.R.L. Injektionsgerät

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017506099A (ja) * 2014-02-05 2017-03-02 ハーゼルマイアー アーゲー 噴射器
US11376368B2 (en) 2014-02-05 2022-07-05 Medmix Switzerland Ag Injection device
CN106163592B (zh) * 2014-02-05 2020-02-21 海斯迈股份公司 注射器
US10898654B2 (en) 2014-02-05 2021-01-26 Haselmeier Ag Injection device
JP2017507696A (ja) * 2014-02-05 2017-03-23 ハーゼルマイアー アーゲー 噴射器
CN106132459A (zh) * 2014-02-05 2016-11-16 海斯迈股份公司 注射设备
CN106163592A (zh) * 2014-02-05 2016-11-23 海斯迈股份公司 注射器
CN106163591A (zh) * 2014-02-05 2016-11-23 海斯迈股份公司 注射设备
US11364348B2 (en) 2014-02-05 2022-06-21 Medmix Switzerland Ag Injection device
JP2017505177A (ja) * 2014-02-05 2017-02-16 ハーゼルマイアー アーゲー 噴射器
WO2015117746A1 (fr) * 2014-02-05 2015-08-13 Haselmeier Gmbh Appareil d'injection
WO2015117741A1 (fr) * 2014-02-05 2015-08-13 Haselmeier Gmbh Appareil d'injection
WO2015117747A1 (fr) * 2014-02-05 2015-08-13 Haselmeier Gmbh Appareil d'injection
DE202014001134U1 (de) 2014-02-05 2015-05-06 Haselmeier Gmbh Injektionsgerät
RU2661755C1 (ru) * 2014-02-05 2018-07-19 Хазельмайер Аг Инъекционный аппарат
RU2672523C1 (ru) * 2014-02-05 2018-11-15 Хазельмайер Аг Инъекционный аппарат
RU2672682C1 (ru) * 2014-02-05 2018-11-19 Хазельмайер Аг Инъекционный аппарат
US10583259B2 (en) 2014-02-05 2020-03-10 Haselmeier Ag Injection device
US10413674B2 (en) 2014-02-05 2019-09-17 Haselmeier Ag Injection device
US10493211B2 (en) 2014-02-05 2019-12-03 Haselmeier Ag Injection device
CN106163591B (zh) * 2014-02-05 2020-02-07 海斯迈股份公司 注射设备
US10646658B2 (en) 2015-09-30 2020-05-12 Haselmeier Ag Injection device
US10639426B2 (en) 2015-09-30 2020-05-05 Haselmeier Ag Injection device
US10751475B2 (en) 2015-09-30 2020-08-25 Haselmeier Ag Injection device
WO2017054914A1 (fr) * 2015-09-30 2017-04-06 Haselmeier Ag Auto-injecteur comprenant un doseur
DE202015006845U1 (de) 2015-09-30 2016-01-15 Haselmeier Ag Injektionsgerät
WO2017067646A1 (fr) 2015-10-22 2017-04-27 Haselmeier Ag Dispositif d'injection
US11033685B2 (en) 2015-10-22 2021-06-15 Haselmeier Ag Injection device
DE202015007351U1 (de) 2015-10-22 2017-01-27 Haselmeier Ag Injektionsgerät
CN109310824A (zh) * 2016-06-23 2019-02-05 艾斯曲尔医疗公司 药剂输送装置
US11969584B2 (en) 2017-07-13 2024-04-30 Medmix Switzerland Ag Injection device with flexible dose selection
US11969583B2 (en) 2018-07-17 2024-04-30 Medmix Switzerland Ag Injection device with dose interruption fail safe
WO2021099415A1 (fr) 2019-11-18 2021-05-27 Haselmeier Ag Dispositif d'administration de médicament

Also Published As

Publication number Publication date
CN105126203B (zh) 2019-01-04
MX344115B (es) 2016-12-06
MX2014009123A (es) 2014-08-27
BR112014014902A2 (pt) 2017-06-13
CN105126203A (zh) 2015-12-09
CN104220117A (zh) 2014-12-17
DE202012001411U1 (de) 2013-05-13
BR112014014902B1 (pt) 2021-02-23
RU2014134275A (ru) 2016-03-27
RU2615122C2 (ru) 2017-04-03

Similar Documents

Publication Publication Date Title
WO2013117332A1 (fr) Dispositif d'injection
EP3284498B1 (fr) Appareil d'injection
EP0581788B1 (fr) Dispositif d'injection
EP1926514B1 (fr) Dispositif d'injection à accouplement à glissement à deux voies
EP3102254B1 (fr) Dispositif d'injection
EP2678054B1 (fr) Tete de seringue d'injection, dispositif d'injection et seringue d'injection
WO1997036626A1 (fr) Dispositif d'injection
EP3102256B1 (fr) Dispositif d'injection
WO2005002652A2 (fr) Dispositif d'administration d'un produit liquide
WO2005102421A1 (fr) Appareil d'injection comportant un dispositif de dosage pouvant etre bloque plusieurs fois en rotation
WO2007071080A1 (fr) Dispositif d'injection doté d'un organe de dosage ou d'affichage a superposition axiale
EP3355965B1 (fr) Auto-injecteur comprenant un doseur
EP3102257B1 (fr) Dispositif d'injection
WO2002064198A1 (fr) Auxiliaire de lecture destine a un dispositif d'administration d'une dose reglable d'un produit injectable
EP3355967B1 (fr) Dispositif d'injection
EP2692376B1 (fr) Dispositif d'injection avec échelle de dosage en forme d'hélice ou de spirale
EP2812054B1 (fr) Dispositif d'injection
WO2004006997A1 (fr) Dispositif d'administration presentant une tige de piston a retour bloque
EP2168533A2 (fr) Seringue, notamment pour applications médicales vétérinaires
EP3355963A1 (fr) Dispositif d'injection
EP3365048B1 (fr) Dispositif d'injection

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13703530

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: MX/A/2014/009123

Country of ref document: MX

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112014014902

Country of ref document: BR

WWE Wipo information: entry into national phase

Ref document number: 2014134275

Country of ref document: RU

122 Ep: pct application non-entry in european phase

Ref document number: 13703530

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 112014014902

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20140618