WO2013100331A1 - Procédé de fabrication d'un implant dentaire ayant une surface hydrophile pour une ossification améliorée - Google Patents

Procédé de fabrication d'un implant dentaire ayant une surface hydrophile pour une ossification améliorée Download PDF

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Publication number
WO2013100331A1
WO2013100331A1 PCT/KR2012/008018 KR2012008018W WO2013100331A1 WO 2013100331 A1 WO2013100331 A1 WO 2013100331A1 KR 2012008018 W KR2012008018 W KR 2012008018W WO 2013100331 A1 WO2013100331 A1 WO 2013100331A1
Authority
WO
WIPO (PCT)
Prior art keywords
implant
dental implant
wavelength
dental
titanium
Prior art date
Application number
PCT/KR2012/008018
Other languages
English (en)
Korean (ko)
Inventor
김수경
강은정
송주동
엄태관
최규옥
Original Assignee
오스템임플란트 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 오스템임플란트 주식회사 filed Critical 오스템임플란트 주식회사
Publication of WO2013100331A1 publication Critical patent/WO2013100331A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/10—Ultra-violet radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/06—Titanium or titanium alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses

Definitions

  • the present invention relates to a method for manufacturing a dental implant having a hydrophilic surface having an effect of promoting bone formation, and to irradiate the surface of the hydrophobized implant with ultraviolet rays to hydrophilize the surface and improve body fluid and blood affinity.
  • the present invention relates to a method for producing a dental implant that can improve the bone formation effect and shorten the bone fusion period after the implant procedure.
  • the purpose of the present invention is to solve problems of surface treatment methods such as RBM and SLA, to hydrophilize the hydrophobized surface and to improve the fluid and blood affinity of the implant. It is to provide a method for producing a dental implant having a hydrophilic surface that can improve the formation and shorten the period of bone fusion.
  • the present invention for achieving the above object is a step of forming a roughness on the dental implant surface of titanium or titanium alloy material, and irradiated with ultraviolet rays of 10 ⁇ 400nm wavelength on the surface of the implant is formed rough surface contamination source It provides a method for producing a dental implant having a hydrophilic surface comprising the step of oxidizing.
  • ultraviolet rays irradiated onto the surface of the implant to oxidize the surface contamination source It is preferable to have a wavelength of 100 to 200 nm to generate the reactive oxygen species, and it is preferable to irradiate ultraviolet rays of 320 to 400 nm having a photocatalytic effect. , .
  • the hydrophobized surface of the implant may be hydrophilized and the body fluid and blood affinity of the implant may be improved without finally undergoing a complicated process, thereby improving bone formation and shortening the bone fusion period after the implant procedure.
  • 1 is a schematic view showing the hydrophilization process according to the present invention of the hydrophobized titanium implant surface.
  • 2 and 3 are graph and photographic results showing surface contact angle changes with UV-ozone treatment time of SA disks.
  • Figure 4 is the result of measuring the blood affinity of the dental implant treated with ultraviolet rays.
  • the nature of the implant surface is an important factor in the bone adhesion process in which new bone tissue is fused to the implant surface, and the implant surface is changed to improve implant fixation and hardening of the implant to hard tissue. It can accelerate the healing process by strengthening the bone adhesion of the implant.
  • Osteoadhesion of such implants can be improved by creating micro-grained roughness on the implant surface, and the micro-grained roughness can be improved by particle spraying, absorbent spray media, acid etching, alkali etching, and titanium plasma. It can be formed by a variety of methods, such as spray method, particle treatment after acid treatment method, anodization method, laser surface processing method. Implants formed with micro roughness have the advantage of increasing the surface area and improving bone adhesion. However, as the surface area is large during storage before implantation, contamination caused by various pollutants in the air increases. There are disadvantages. In particular, the carbon pollutant present in the air is irreversibly adsorbed on the surface of the implant to hydrophobic the surface of the implant.
  • the present invention is to form a roughness on the surface of the dental implant made of titanium or titanium alloy, in order to hydrophilize the titanium surface in which the various contaminants including hydrocarbons described above, 10 ⁇ 10 on the surface of the implant formed Ultraviolet rays having a wavelength of 400 nm may be irradiated and removed by oxidizing surface contamination sources.
  • the present invention as shown in Figure 1 by oxidizing and volatilizing the surface contamination source through the ultraviolet irradiation on the titanium surface in which various pollutants including hydrocarbons exist, by removing the contamination source causing surface hydrophobicity of the titanium surface
  • the hydrophilicity of the surface improves body fluid and blood affinity, which ultimately improves bone formation and shortens bone fusion after implantation.
  • the ultraviolet rays irradiated onto the implant surface for the oxidation of the surface contaminants are preferably ultraviolet rays having a wavelength of 100 to 200 nm to generate reactive oxygen species, wherein the ultraviolet rays having 320 to 400 nm wavelength have a photocatalytic effect. Can be investigated together to promote oxidation of the pollutant.
  • the step may be additionally performed by irradiating 180-190 nm wavelength ultraviolet rays to the dental implant surface of which the surface contaminant is oxidized.
  • the hydrophilized implant according to the present invention is preferably implanted during a period in which the contaminant is not resorbed on the hydrophilized surface.
  • the machined titanium implant or disk is blasted for 1 to 60 seconds at a blasting pressure of 1 to 10 atm using A1203 powder having a particle size of 1 ⁇ or less, and then the acid treatment method using a mixed acid aqueous solution is used. Macro & micro morphology was applied to the implant or disc surface.
  • the acid-treated dental titanium implant or disc was ultrasonically cleaned with ethane for 30 minutes and with distilled water for 30 minutes and then dried.
  • distilled water 5 was dropped in the center of the disk and photographed with a digital camera from the side. The contact angle of was measured. In addition, the contact angle was measured for each UV irradiation time in order to confirm the effect of improving the wettability of the titanium disk according to the UV irradiation time. At this time, as a negative control was used a disk without removing the source.
  • the implant was loaded with about 1 5 in 53 ⁇ 4 BSA (bovine serum albumin) solution or FBS (Fetal Bovine Serum) Afterwards, BSA or plasma proteins adhered to the surface were confirmed by BCA assay. At this time, the negative control group was used as the implant was not removed.
  • BSA bovine serum albumin
  • FBS Fetal Bovine Serum
  • the adhesion of blood proteins on the surface of the UV-treated implants was increased by about 70% in 53 ⁇ 4 FBS and about 40% in BSA.
  • Example 1 the osteoblast cell line MG63 in order to measure the cell adhesion function of the produced disc seeding with 1X10 S eel ls / disk and then in one hour the cultured adhering to the disc surface with crystal violet assay Cells Quantification. At this time, the negative control group was used as an implant was not removed. ⁇
  • the implant is placed in a micropig tibia and the removal torque after 16 days of bone formation period (removal torque) The measurement was made. At this time, the negative control group was used as the implant was not removed.
  • the torsional removal force was improved by about 50% in the experimental group irradiated with ultraviolet rays compared to the negative control group SA, resulting in a strong implant-bone interface binding force. It was confirmed to disappear.
  • the present invention is not limited to the above specific embodiments and descriptions, and various modifications can be made by those skilled in the art without departing from the spirit of the invention as claimed in the claims. It is possible for such modifications to fall within the protection scope of the present invention.

Abstract

La présente invention concerne un procédé de fabrication d'un implant dentaire ayant une surface hydrophile pour une ossification améliorée, la surface d'un implant rendu hydrophobe étant hydrophilisée et son affinité pour les fluides biologiques et le sang étant améliorée par irradiation de celle-ci avec une lumière ultraviolette, améliorant ainsi finalement l'ossification après une procédure de mise en place d'implant, et permettant de raccourcir la période de fusion osseuse.
PCT/KR2012/008018 2011-12-27 2012-10-04 Procédé de fabrication d'un implant dentaire ayant une surface hydrophile pour une ossification améliorée WO2013100331A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2011-0143048 2011-12-27
KR1020110143048A KR101196171B1 (ko) 2011-12-27 2011-12-27 골형성 증진 효과가 있는 친수성 표면을 가진 치과용 임플란트의 제조방법

Publications (1)

Publication Number Publication Date
WO2013100331A1 true WO2013100331A1 (fr) 2013-07-04

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Country Status (2)

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KR (1) KR101196171B1 (fr)
WO (1) WO2013100331A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104083801A (zh) * 2014-07-25 2014-10-08 林野 一种使牙种植体粗化表面具有亲水性的方法
CN105125304A (zh) * 2015-08-19 2015-12-09 周正 种植体亲水活化仪以及活化方法
CN110403720A (zh) * 2019-09-03 2019-11-05 恒泰医疗科技(天津)有限公司 种植体智能活化仪
CN113413247A (zh) * 2021-06-21 2021-09-21 尹川 一种针对钛合金内植物表面改性的多方向光功能化仪器及其使用方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102563889B1 (ko) * 2020-05-06 2023-08-09 한국전기연구원 레이저 표면처리 방법 및 그 장치
KR102569320B1 (ko) 2021-03-08 2023-08-25 주식회사 코렌텍 플라즈마를 통한 포장된 임플란트 표면개질 방법 및 포장된 임플란트 표면개질 시스템
KR102569325B1 (ko) 2021-03-08 2023-08-25 주식회사 코렌텍 임플란트 표면처리 포장방법 및 그 시스템
KR102569322B1 (ko) 2021-03-08 2023-08-25 주식회사 코렌텍 플라즈마를 통한 포장된 임플란트 표면개질 방법 및 포장된 임플란트 표면개질 시스템

Citations (5)

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KR20040046248A (ko) * 2002-11-26 2004-06-05 설영택 마그네슘 티타네이트 산화막 임플란트 및 그 제조방법
US20040210309A1 (en) * 2001-10-11 2004-10-21 Denzer Alain J Osteophilic implants
KR100814355B1 (ko) * 2007-02-27 2008-03-18 (주)메디사이텍 티타네이트 산화막 임플란트의 제조 방법 및 그 방법에의해 제조되는 티타네이트 산화막 임플란트
US20100159118A1 (en) * 2007-05-18 2010-06-24 National University Corporation Okayama University Method for production of biocompatible implant
KR20110131551A (ko) * 2010-05-31 2011-12-07 주식회사 메가젠임플란트 골유착 증진을 위한 자외선 광조사기 및 이를 이용한 치과용 임플란트 표면 개질방법

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040210309A1 (en) * 2001-10-11 2004-10-21 Denzer Alain J Osteophilic implants
KR20040046248A (ko) * 2002-11-26 2004-06-05 설영택 마그네슘 티타네이트 산화막 임플란트 및 그 제조방법
KR100814355B1 (ko) * 2007-02-27 2008-03-18 (주)메디사이텍 티타네이트 산화막 임플란트의 제조 방법 및 그 방법에의해 제조되는 티타네이트 산화막 임플란트
US20100159118A1 (en) * 2007-05-18 2010-06-24 National University Corporation Okayama University Method for production of biocompatible implant
KR20110131551A (ko) * 2010-05-31 2011-12-07 주식회사 메가젠임플란트 골유착 증진을 위한 자외선 광조사기 및 이를 이용한 치과용 임플란트 표면 개질방법

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104083801A (zh) * 2014-07-25 2014-10-08 林野 一种使牙种植体粗化表面具有亲水性的方法
CN105125304A (zh) * 2015-08-19 2015-12-09 周正 种植体亲水活化仪以及活化方法
CN110403720A (zh) * 2019-09-03 2019-11-05 恒泰医疗科技(天津)有限公司 种植体智能活化仪
CN113413247A (zh) * 2021-06-21 2021-09-21 尹川 一种针对钛合金内植物表面改性的多方向光功能化仪器及其使用方法

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Publication number Publication date
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