WO2013089105A1 - Corps cylindrique de seringue préremplie, instrument de perforation pour seringue préremplie, appareil d'injection pour seringue préremplie, et seringue préremplie - Google Patents

Corps cylindrique de seringue préremplie, instrument de perforation pour seringue préremplie, appareil d'injection pour seringue préremplie, et seringue préremplie Download PDF

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Publication number
WO2013089105A1
WO2013089105A1 PCT/JP2012/082075 JP2012082075W WO2013089105A1 WO 2013089105 A1 WO2013089105 A1 WO 2013089105A1 JP 2012082075 W JP2012082075 W JP 2012082075W WO 2013089105 A1 WO2013089105 A1 WO 2013089105A1
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WO
WIPO (PCT)
Prior art keywords
puncture member
puncture
outer cylinder
prefilled syringe
cylindrical body
Prior art date
Application number
PCT/JP2012/082075
Other languages
English (en)
Japanese (ja)
Inventor
等 沖原
伸吾 小山
Original Assignee
テルモ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by テルモ株式会社 filed Critical テルモ株式会社
Publication of WO2013089105A1 publication Critical patent/WO2013089105A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A61M5/2466—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/344—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub using additional parts, e.g. clamping rings or collets
    • A61M5/345—Adaptors positioned between needle hub and syringe nozzle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A61M5/2466—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase
    • A61M2005/2474—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase with movable piercing means, e.g. ampoule remains fixed or steady

Definitions

  • the present invention relates to a cylindrical body for a prefilled syringe, a puncture device for a prefilled syringe, an injector for a prefilled syringe, and a prefilled syringe.
  • the prefilled syringe is provided in a state where it is filled with a medical liquid such as a drug solution or a drug solution.
  • a medical liquid such as a drug solution or a drug solution.
  • a prefilled syringe for example, there is a prefilled syringe whose tip is sealed with a cap to which a double-ended needle can be attached.
  • a puncture member having a double-ended needle is attached at the time of use.
  • Patent Document 1 Japanese Patent Publication No. 2010-540122, WO2009-043000, US2012-0209171.
  • the present invention provides a cylindrical body for a prefilled syringe, a puncture tool for a prefilled syringe, a syringe for a prefilled syringe, and a prefilled syringe, in which the sealing member of the prefilled syringe is prevented from being loosened.
  • a cylindrical body for a prefilled syringe to which a puncture member comprising a puncture member main body having a joint portion can be mounted, wherein the puncture member mounting portion is screwed with the puncture member side threaded portion After the threaded portion, the
  • a puncture device for a prefilled syringe that is attachable to and detachable from the puncture member mounting portion of the cylindrical body for a prefilled syringe, wherein the puncture device is mounted with the hollow needle having the needle portions at both ends, and the hollow needle.
  • the puncture member including the puncture member main body having the puncture member side screwing portion and the puncture member side engaging portion, which is detachable from the puncture member mounting portion, and detachably stores the puncture member.
  • a storage member, and the storage member and the puncture member further include a rotational force transmitting portion that transmits a rotational force applied to the storage member to the puncture member, and the storage member includes the puncture member.
  • a puncture device for a prefilled syringe which is detached from the puncture member by pulling in a distal direction after the member is mounted on the puncture member mounting portion.
  • Syringe comprising a prefilled syringe outer cylinder which is a cylindrical body for the prefilled syringe, a slidable gasket housed in the outer cylinder, and a plunger attached to or attached to the rear end of the gasket
  • a syringe for a prefilled syringe comprising a main body, the puncture member that can be attached to and detached from the puncture member mounting portion of the prefilled syringe outer cylinder, and a puncture device that detachably accommodates the puncture member.
  • the puncture member mounting portion includes the cylindrical body side screwing portion and the cylindrical body side engaging portion, and the puncture member is screwed to the cylindrical body side screwing portion.
  • the engaging portion, the tubular body side threaded portion and the puncture member side threaded portion are engaged with each other, and then engaged with the tubular body side engaging portion, and the puncture member side engagement for restricting retraction of the threaded engagement.
  • the storage member and the puncture member have a rotational force transmitting portion that transmits the rotational force applied to the storage member to the puncture member, and the storage member is attached to the puncture member mounting portion by the puncture member After being done, the prefilled syringe injector that is detached from the puncture member by pulling in the distal direction.
  • the prefilled syringe which consists of said syringe for prefilled syringes, and the chemical
  • FIG. 1 is an external view of a prefilled syringe and a prefilled syringe syringe of the present invention.
  • FIG. 2 is an enlarged longitudinal sectional view of a syringe body used for the prefilled syringe of the present invention.
  • FIG. 3 is an enlarged longitudinal sectional view of the prefilled syringe puncture device of the present invention.
  • FIG. 4 is a front view of an outer cylinder used in the prefilled syringe cylinder, the prefilled syringe, and the prefilled syringe injector of the present invention.
  • 5 is a right side view of the outer cylinder shown in FIG. 6 is an enlarged plan view of the outer cylinder shown in FIG.
  • FIG. 7 is a perspective view of the outer cylinder shown in FIG.
  • FIG. 8 is an enlarged front view of an outer cylinder sealing member used in the tubular body for prefilled syringe, the prefilled syringe, and the syringe for prefilled syringe of the present invention.
  • FIG. 9 is a right side view of the outer cylinder sealing member shown in FIG.
  • FIG. 10 is a longitudinal sectional view of the outer cylinder sealing member shown in FIG.
  • FIG. 11 is a perspective view of the outer cylinder sealing member shown in FIG. 8 as viewed from above.
  • 12 is a perspective view of the outer cylinder sealing member shown in FIG. 8 as viewed from below.
  • FIG. 9 is a right side view of the outer cylinder sealing member shown in FIG.
  • FIG. 10 is a longitudinal sectional view of the outer cylinder sealing member shown in FIG.
  • FIG. 11 is a perspective view of the outer cylinder sealing member shown in FIG. 8 as viewed from above.
  • 12
  • FIG. 13 is an enlarged front view of a puncture member used in the prefilled syringe puncture device of the present invention.
  • FIG. 14 is a left side view of the puncture member shown in FIG. 15 is a longitudinal sectional view of the puncture member shown in FIG. 16 is a longitudinal sectional view of the puncture member shown in FIG. 17 is a perspective view of the puncture member shown in FIG.
  • FIG. 18 is an enlarged front view of a storage member used for the prefilled syringe puncture device of the present invention.
  • 19 is a vertical cross-sectional view of the storage member shown in FIG.
  • FIG. 20 is an enlarged front view of a plunger used in the prefilled syringe and the prefilled syringe syringe of the present invention.
  • FIG. 21 is a longitudinal sectional view of a gasket used in the prefilled syringe and the prefilled syringe syringe of the present invention.
  • FIG. 22 is an explanatory diagram for explaining constituent members used in the prefilled syringe and the prefilled syringe syringe of the present invention.
  • FIG. 23 is an explanatory diagram for explaining the operation of the prefilled syringe and the prefilled syringe syringe of the present invention.
  • FIG. 24 is an explanatory diagram for explaining the operation of the prefilled syringe and the prefilled syringe syringe of the present invention.
  • FIG. 22 is an explanatory diagram for explaining constituent members used in the prefilled syringe and the prefilled syringe syringe of the present invention.
  • FIG. 23 is an explanatory diagram for explaining the operation of the prefilled syringe and the prefilled syringe sy
  • FIG. 25 is an explanatory diagram for explaining the operation of the prefilled syringe and the prefilled syringe syringe of the present invention.
  • FIG. 26 is an explanatory diagram for explaining the operation of the prefilled syringe and the prefilled syringe syringe of the present invention.
  • FIG. 27 is an explanatory diagram for explaining the operation of the prefilled syringe and the prefilled syringe syringe of the present invention.
  • FIG. 28 is an enlarged external view of an outer cylinder sealing member of another example used for the prefilled syringe and the prefilled syringe syringe of the present invention.
  • FIG. 29 is an enlarged external view of an outer cylinder sealing member of another example used in the prefilled syringe and the prefilled syringe injector of the present invention.
  • FIG. 30 is an enlarged external view of another example of the outer cylinder sealing member used in the prefilled syringe and the prefilled syringe injector of the present invention.
  • FIG. 31 is an enlarged external view of the distal end side portion of the outer cylinder of another example used in the prefilled syringe and the prefilled syringe syringe of the present invention.
  • FIG. 32 is a longitudinal sectional view of the outer cylinder shown in FIG.
  • FIG. 33 is an explanatory diagram for explaining a prefilled syringe holder which is a tubular body for a prefilled syringe according to the present invention.
  • the cylindrical body for prefilled syringes, the prefilled syringe, and the syringe for prefilled syringes of the present invention will be described based on examples shown in the drawings.
  • the cylindrical body for prefilled syringes of the present invention (for example, the prefilled syringe outer cylinders 4 and 4a and the prefilled syringe holder 100) has puncture member mounting portions 50, 40a and 102 as shown in FIGS.
  • a hollow needle 61 having needle portions 61a and 61b at both ends and a hollow needle 61 is attached to the puncture member mounting portions 50, 40a and 102, and is detachable from the puncture member side screwing portion 85 and puncture.
  • the puncture member 6 provided with the puncture member main body 60 which has the member side engaging part 86 can be mounted
  • the cylindrical body for prefilled syringes of the present invention is applied to, for example, an outer cylinder for prefilled syringes and a holder for prefilled syringes.
  • the prefilled syringe outer cylinder to which the prefilled syringe tubular body of the present invention is applied has an outer puncture member mounting portion 50 in which the opening 48 of the distal end portion 41 is sealed by a seal member.
  • a hollow needle 61 that is a cylinder and has a needle part at both ends (specifically, a needle part 61a for puncture at one end and a needle part 61b for a seal member at the other end) at both ends;
  • the puncture member 6 equipped with the needle 61 and detachable from the puncture member mounting portion 50 and having the puncture member main body 60 having the puncture member side screwing portion 85 and the puncture member side engaging portion 86 can be attached.
  • the puncture member mounting portion 50 is formed after the cylindrical body side screwing portion 52 that can be screwed with the puncture member side screwing portion 85, and the cylindrical body side screwing portion 52 and the puncture member side screwing portion 85 are screwed together.
  • a tubular body side engaging portion 53 that engages with the puncture member side engaging portion 86 and restricts the backward movement of the screwing.
  • the puncture member is attached to the prefilled syringe outer cylinder by screwing and engagement, the puncture member is loosened at the time of administration operation of the prefilled syringe. There is no leakage due to looseness.
  • prefilled syringe 1 injector for prefilled syringe
  • the prefilled syringe outer cylinder uses the above-mentioned prefilled syringe outer cylinder.
  • the prefilled syringe 1 (injector for prefilled syringe) of the present invention includes a prefilled syringe outer cylinder, a slidable gasket 8 housed in the outer cylinder, and a plunger attached to or attachable to the rear end of the gasket 8. 9, a hollow needle 61 having a puncture needle portion 61 a at one end and a seal needle piercing needle portion 61 b at the other end, a hollow needle 61 attached, and the outer cylinder sealing member 5
  • the puncture member 3 includes a puncture member 6 having a detachable puncture member body 60 and a storage member 7 that detachably accommodates the puncture member 6.
  • the puncture member mounting portion 50 includes a cylindrical body side screwing portion 52 and a cylindrical body side engaging portion 53, and the puncture member 6 is piercing member side screw that can be screwed with the cylindrical body side screwing portion 52. After the mating portion 85 and the two screwing portions 52 and 85 are screwed together, the mating portion 85 is engaged with the tubular body side engaging portion 53 and includes a puncture member side engaging portion 86 that regulates the progress and retreat of the screwing. . And in the prefilled syringe 1 of this invention, the chemical
  • FIG. The difference between the prefilled syringe and the syringe for the prefilled syringe is whether or not the medicine is filled.
  • the prefilled syringe outer cylinder 4 of the illustrated embodiment is constituted by an outer cylinder main body 40 and an outer cylinder sealing member 5 attached to the tip portion thereof.
  • the puncture member mounting portion 50 is configured by the outer cylinder sealing member 5.
  • the outer cylinder sealing member 5 includes the puncture member mounting portion 50.
  • the distal end portion 41 and the outer cylinder sealing member 5 of the outer cylinder main body 40 are detached and rotated from the outer cylinder sealing member 5 attached to the distal end portion 41.
  • the outer cylinder sealing member 5 includes a cylindrical body side screwing part (in other words, a sealing member side screwing part) 52 and a cylindrical body side engaging part.
  • the puncture member 6 includes a puncture member side screwing portion 85 that can be screwed with the cylindrical body side screwing portion 52, and two screwing portions screwed together. Then, the storage member 7 and the puncture member 6 are attached to the storage member 7. The storage member 7 and the puncture member 6 are provided to the storage member 7. Rotation force transmitting portions 65 and 74 that transmit the rotational force to the puncture member 6 are provided. After being, by pulling in the distal direction, which is assumed to from piercing member 6, disengaged.
  • the prefilled syringe 1 and the syringe for prefilled syringe of the present invention are composed of a syringe body 2 and a puncture tool 3, both of which are not mounted, and a mounting operation is performed during use. Further, a cap (not shown) may be attached to the syringe body 2 at the distal end portion of the outer cylinder (specifically, the outer cylinder sealing member 5 attached to the distal end portion of the outer cylinder main body 40). . This cap is removed before the puncture tool 3 is mounted.
  • the syringe body 2 includes a prefilled syringe outer cylinder 4 including an outer cylinder main body 40 and an outer cylinder sealing member 5 that seals a distal end portion 41 of the outer cylinder main body 40, and a gasket accommodated in the outer cylinder main body 40. 8, a drug 11 stored (filled) in an outer cylinder main body 40 sealed by the outer cylinder sealing member 5 and the gasket 8, and a plunger 9 attached to the gasket 8.
  • the plunger 9 may be attached to the gasket 8 at the time of use without being attached to the gasket in advance.
  • the outer cylinder main body 40 includes a main body portion 45, a distal end portion 41, and a flange 46.
  • the main body 45 has a substantially cylindrical shape and has a liquid storage space inside.
  • the tip portion 41 protrudes from the shoulder portion of the main body portion 45 in the tip direction.
  • the distal end portion 41 includes a distal end opening 48 for discharging a chemical solution or the like in the outer cylinder and cannot be connected to a medical device having a connection portion to a nozzle portion conforming to the ISO standard. That is, it is not a luer taper shape that the tip of a normal syringe has.
  • the distal end portion 41 includes a large diameter portion 44 formed at a boundary portion with the main body portion 45, and a concave portion 47 (specifically, Two concavities facing each other) and near the tip of the intermediate portion 42 of the tip 41 (a portion having a smaller diameter than the enlarged diameter portion 44 and a diameter larger than the most distal portion) (in other words, near the central portion in the axial direction of the tip 41).
  • the protruding portion 43 (specifically, two protruding portions facing each other) is provided.
  • tip part 41 is equipped with the small diameter part at the front-end
  • the protrusion part 43 is extended predetermined length in the circumferential direction.
  • the two recesses 47 extend a predetermined length in the axial direction.
  • the two protrusions 43 and the two recesses 47 are provided so as not to overlap in the axial direction.
  • each recessed portion 47 and each protruding portion 43 are shifted from each other by approximately 90 degrees with respect to the central axis of the distal end portion 41.
  • tip part 41 of the outer cylinder main body 40 comprises the engaging part for outer cylinder sealing member detachment
  • a restricting engaging portion is formed.
  • the flange 46 is an elliptical donut-shaped disk portion formed so as to protrude in the vertical direction from the entire rear end circumference of the outer cylinder main body 40.
  • the flange 46 includes two gripping portions facing each other as shown in FIGS.
  • the outer cylinder main body 40 is a cylindrical body made of a transparent or translucent material, if necessary, made of a material having low oxygen permeability and water vapor permeability. Examples of a material for forming the outer cylinder main body 40 include polypropylene, polyethylene, polystyrene, polyamide, polycarbonate, polyvinyl chloride, poly- (4-methylpentene-1), acrylic resin, acrylonitrile-butadiene-styrene copolymer, polyethylene.
  • polyesters such as terephthalate and cyclic polyolefins
  • resins such as polypropylene and cyclic polyolefins are preferred because they are easy to mold and have heat resistance.
  • tip part 41 of the outer cylinder main body 40 is sealed by the outer cylinder sealing member 5 mentioned later.
  • the gasket 8 includes a main body portion 81 whose front end is closed and extends with substantially the same outer diameter, and a plurality of annular ribs 82 and 83 provided on the main body portion.
  • the rib is in liquid-tight contact with the inner surface of the main body 45 of the outer cylinder main body 40.
  • the gasket 8 As a material for forming the gasket 8, elastic rubber (for example, butyl rubber, latex rubber, silicone rubber, styrene-butadiene rubber, isoprene rubber, etc.), thermoplastic elastomer (for example, SBS elastomer, SEBS elastomer, SEPS elastomer, styrene, etc.) It is preferable to use olefin-based elastomers such as olefin-based elastomers and ethylene- ⁇ -olefin copolymer elastomers).
  • the gasket 8 is provided with a recess extending inward from the rear end thereof, and this recess serves as a plunger mounting portion 84.
  • the plunger mounting portion 84 has a female screw shape, and can be screwed with a male screw portion 93 formed on the outer surface of the gasket mounting portion 92 formed at the distal end portion of the plunger 9.
  • the plunger 9 is attached to the gasket 8 by screwing them together.
  • the plunger 9 includes a gasket mounting portion 92 provided at the distal end portion, a main body portion 91 extending in the axial direction having a cross-shaped cross section, a flat plate portion 95 provided at the distal end of the main body portion, and a main body.
  • a pressing portion 94 provided at the rear end portion of the portion 91 and reinforcing ribs 96 and 98 provided in the middle of the main body portion 91 are provided.
  • a male screw portion 93 that is screwed with the plunger mounting portion 84 is formed on the outer surface of the gasket mounting portion 92.
  • the plunger 9 is connected to the gasket 8 when the plunger mounting portion 84 and the male threaded portion 93 of the gasket mounting portion 92 are screwed together.
  • vitamin agents total vitamin agents
  • various amino acids such as heparin, insulin, antibiotics, antitumor agents, analgesics, cardiotonics, intravenous anesthesia Agents, anti-Parkinson agents, ulcer treatment agents, corticosteroid agents, arrhythmia agents, hormone preparations, interferon preparations, human immunoglobulin preparations, blood coagulation factor preparations, vaccine preparations, and other protein preparations.
  • the outer cylinder sealing member 5 includes a main body 51 having a puncture member mounting portion 50 and a seal member 10 housed in the main body 51.
  • the seal member 10 is for sealing the opening at the tip of the outer cylinder main body.
  • the main body 51 having the puncture member mounting portion 50 is a cylindrical body, and has a small-diameter opening 57 provided at the distal end, a flange 55 provided at the proximal end, and a window 53 provided at the side.
  • a cylindrical body-side threaded portion 52 provided on the outer surface on the distal end side from the window portion 53, a distal end side from the flange portion 55 and a proximal end side from the window portion 53.
  • the formed ribs 59 (a plurality of circumferential ribs), the excessive rotation restricting ribs 88 (specifically, two ribs facing each other) provided on the side of the opening 57, and the base end of the main body 51
  • a protrusion 58 (specifically, two protrusions facing each other) extending in the axial direction is provided on the inner surface of the head.
  • the window 53 is for accommodating and engaging the protrusion 43 of the outer cylinder main body 40, and extends a predetermined length in the circumferential direction. .
  • the protrusion 43 of the outer cylinder main body 40 enters and engages the window 53 of the outer cylinder sealing member 5, thereby preventing the outer cylinder sealing member from being detached from the outer cylinder main body 40, and turning. It also regulates. Therefore, in the prefilled syringe 3 of this embodiment, the outer cylinder sealing member 5 is mounted so as not to be detached from the outer cylinder main body 40.
  • the protruding portion 58 provided on the inner surface of the proximal end portion of the outer cylinder sealing member 5 enters the concave portion 47 of the outer cylinder main body 40. And are engaged. For this reason, the outer cylinder sealing member 5 cannot rotate with respect to the outer cylinder main body 40. Therefore, by rotating the outer cylinder main body 40, the outer cylinder sealing member 5 follows and rotates. Therefore, the window portion 53 of the outer cylinder sealing member 5 constitutes an outer cylinder sealing member detachment restricting engagement portion on the cylindrical body side, and the projecting portion 58 is an outer cylinder sealing member rotation restriction on the cylindrical body side.
  • the engagement part is constituted.
  • a cylindrical body side screwing portion 52 is provided on the outer surface of the distal end side portion of the main body 51 having the puncture member mounting portion 50.
  • the cylindrical body side screwing portion 52 is formed by two spiral ribs. Further, a bulging portion 52a is formed at the central portion of the spiral rib, and a bulging portion 52b is also formed at the terminal portion of the spiral rib.
  • An excessive rotation restricting rib 88 (specifically, two ribs facing each other) is provided on the distal end surface of the outer cylinder sealing member 5.
  • the cylindrical body side screwing portion 52 is screwed with a puncture member side screwing portion 85 described later.
  • outer cylinder sealing member 5 of this embodiment two flat portions 54 facing each other are provided on the side of the base end portion side, so that the outer cylinder sealing member 5 can be easily held.
  • the material for forming the outer cylinder sealing member include polypropylene, polyethylene, polystyrene, polyamide, polycarbonate, polyvinyl chloride, poly- (4-methylpentene-1), acrylic resin, acrylonitrile-butadiene-styrene copolymer, Various resins such as polyesters such as polyethylene terephthalate and cyclic polyolefins can be mentioned. Among them, resins such as polypropylene and cyclic polyolefins are preferred because they are easy to mold and have heat resistance.
  • the seal member 10 is accommodated in the distal end portion of the main body 51 having the puncture member mounting portion 50, seals the opening 57, and the outer cylinder sealing member 5 is attached to the outer cylinder main body 40 as shown in FIG. In a state where the front end portion 41 is mounted, the front end opening 48 of the outer cylinder main body 40 is sealed in a liquid-tight manner.
  • the seal member 10 is formed of an elastic member that can seal the tip opening of the tip portion 41 of the outer cylinder main body 40 in a liquid-tight manner and that can be pierced with a seal member piercing needle portion 61b of the puncture member 6 described later. Further, the seal member 10 may include a protruding portion that enters the outer cylinder main body 40.
  • tip part of the outer cylinder main body 40 can be reduced.
  • a material for forming the sealing member it is preferable to use, for example, natural rubber, isoprene rubber, butadiene rubber, fluororubber, silicone rubber or other synthetic rubber, or thermoplastic elastomer such as olefin elastomer or styrene elastomer.
  • the prefilled syringe puncture device 3 of the present invention can be attached to and detached from the puncture member mounting portions 50, 40a, 102 of the above-mentioned prefilled syringe cylindrical body, and further has needle portions at both ends (specifically, puncture at one end).
  • the puncture member 6 includes a puncture member main body 60 having a puncture member side engagement portion 86 and a storage member 7 that detachably accommodates the puncture member 6. Furthermore, the storage member 7 and the puncture member 6 are provided with rotational force transmitting portions 65 and 74 that transmit the rotational force applied to the storage member 7 to the puncture member 6, and the storage member 7 includes the outer tube. After being attached to the sealing member 5, it is detached from the puncture member 6 by pulling in the distal direction.
  • the puncture device 3 includes a storage member 7 and a puncture member 6 stored in the storage member 7.
  • the storage member 7 has a cap shape with one end closed as shown in FIGS. 3, 18 and 19.
  • the storage member 7 includes a cylindrical main body portion 71, a closing portion 75 formed at the front end portion thereof, a small diameter portion 73 formed at the front end side portion of the main body portion 71, and a flange 72 formed at the rear end portion. I have.
  • a plurality of bulging portions 74 are provided on the inner surface of the central portion of the main body in the axial direction.
  • the storage member 7 stores the entire puncture member 6. In particular, the storage member stores the puncture member so that the blade surface of the hollow needle of the puncture member is not exposed.
  • the puncture member 6 includes a puncture member main body 60 and a hollow needle 61 fixed to the puncture member main body 60 as shown in FIGS. 3 and 13 to 17.
  • the puncture member main body 60 is a cylindrical body having a hollow needle fixing portion having a small diameter at the distal end portion and an outer cylinder sealing member accommodating portion at the proximal end side portion.
  • the outer cylinder sealing member housing portion includes an outer cylinder sealing member mounting portion to which the outer cylinder sealing member 5 of the syringe body 2 can be mounted.
  • the outer tube sealing member mounting portion includes a puncture device side screwing portion 85 that is screwed with a cylindrical body side screwing portion 52 provided on the outer surface of the outer tube sealing member 5.
  • the puncture member 6 includes an opening 64 (specifically, two openings facing each other), and protrudes obliquely (short spiral) protruding inward from the bottom of the opening 64.
  • the rib 85 forms a puncture device side threaded portion.
  • the puncture member 6 includes a protrusion 86 (specifically, two protrusions facing each other) provided on the inner surface in the vicinity of the central portion in the axial direction (slightly from the base end). The protrusion 86 extends a predetermined length in the circumferential direction. Then, when the puncture member 6 is attached to the outer cylinder sealing member 5, the protrusion 86 enters and engages in the window 53 of the outer cylinder sealing member 5, as shown in FIG.
  • the mounting state of the puncture member 6 to the outer cylinder main body 40 becomes stable, the rotation of the puncture member in the direction in which the screwing is retracted is regulated, the careless loosening of the puncture member, and the separation from the outer cylinder. To prevent.
  • the puncture member 6 of this embodiment includes an annular recess 87 provided on the inner surface near the base end.
  • the ribs 59 a plurality of circumferential ribs
  • the outer cylinder sealing member 5 of this embodiment is located closer to the proximal end side of the outer cylinder sealing member 5 than the first cylindrical body side engaging portion 53 and the first cylindrical body side engaging portion 53.
  • the puncture member 6 is provided with a second tubular body side engaging portion (arc-shaped rib) 59, and the puncture member 6 includes a first puncture member side engaging portion 86 that engages with the first tubular body side engaging portion 53, and A second puncture member side engagement portion (annular recess) 87 that is positioned on the proximal end side of the puncture member 6 with respect to the first puncture member side engagement portion 86 and engages with the second cylindrical body side engagement portion 59. It has. Further, a concave portion 67 (specifically, two concave portions facing each other) is provided on the outer surface of the central portion of the main body 60 in the axial direction.
  • the distal end portion of the main body 60 has a small diameter portion 62, and a bulging portion 65 (specifically, faces the outer surface of the small diameter portion 62 that extends in the axial direction. 2 bulges).
  • the bulging portion 65 enters and engages between the plurality of bulging portions 74 formed on the inner surface of the central portion in the axial direction of the storage member 7 described above. As a result, the puncture member 6 is prevented from idling in the state of being stored in the storage member 7, and rotates by following the rotation of the storage member 7.
  • the bulging portion 65 of the puncture member 6 and the plurality of bulging portions 74 formed on the inner surface of the central portion in the axial direction of the storage member 7 constitute a rotational force transmitting portion.
  • the puncture member 6 includes a protruding portion 89 (specifically, two bulging portions facing each other) provided on the inner surface of the distal end of the small diameter portion 62.
  • the protruding portion 89 comes into contact with the excessive rotation regulating rib 88 provided on the distal end surface of the outer cylinder sealing member 5 after the cylindrical body side screwing portion 52 and the puncture member side screwing portion 85 are screwed together. And preventing excessive rotation of the puncture member.
  • the hollow needle 61 is fixed to the hollow needle fixing portion 63 of the puncture member main body 60 with an adhesive 68, and has needle portions at both ends. Specifically, one end side of the hollow needle 61 protrudes from the fixed portion 63 to the distal end side, and a puncture needle portion 61 a for living body is provided at the distal end, and the other end side of the hollow needle 61 is punctured from the fixed portion 73. 6 is protruded inward, and a sealing member piercing needle portion 61b capable of piercing the sealing member of the outer cylinder sealing member 5 is provided at an end thereof.
  • the hollow needle 61 extends substantially parallel to the central axis of the puncture member body 60.
  • the storage member 7 can be attached to the puncture member 6 again after being detached from the puncture member 6, and the storage member 7 attached to the puncture member 6 again. Is rotated in the direction in which the screwing of the cylindrical body side screwing portion 52 and the puncture member side screwing portion 85 is retracted, the engagement between the cylindrical body side engaging portion and the puncture member side engaging portion is released.
  • the puncture device 3 can be detached from the syringe body 2 with the puncture member 9 stored in the storage member 7.
  • the cylindrical body side screwing portion 52 and the puncture member side screwing portion 85 are formed after the seal member piercing needle portion 61b of the hollow needle 61 pierces the seal member 10, It arrange
  • the protrusion part 76 may comprise by the protrusion part 76 provided in the outer surface of the small diameter part of the sealing member main body 51.
  • the inner surface of the screwing portion 85 of the puncture member 6 is provided with a recess (not shown) that receives the protrusion 76.
  • the projecting portion 76 is formed between the spiral ribs.
  • an outer cylinder sealing member 5b shown in FIG. You may comprise by the small protrusion 77 provided in the front end surface and the position close
  • an outer cylinder sealing member 5c shown in FIG. You may comprise by the small protrusion 79 provided in the flat part 54 of the side surface. In this case, the puncture member 6 is provided on the inner surface and includes a recess (not shown) for housing the small protrusion 79.
  • the puncture member mounting portion is constituted by the outer cylinder sealing member 5.
  • the present invention is not limited to this, and the puncture member mounting portion 40a of the prefilled syringe outer cylinder 4a, which is the prefilled syringe cylindrical body shown in FIGS. It may be formed directly at the tip. Therefore, the prefilled syringe outer cylinder 4 a of this embodiment does not include the outer cylinder sealing member 5.
  • the prefilled syringe outer cylinder 4a which is the prefilled syringe cylindrical body of this embodiment, is sealed by a sealing member 10a through which the opening of the puncture member mounting portion 40a can be pierced by the needle portion 61b of the puncture member 6. Yes.
  • the seal member 10a is accommodated in the distal end portion 41a of the outer cylinder 4a.
  • the seal member 10a has an annular groove, engages with an annular rib 49 protruding from the inner surface of the tip portion 41a, and movement within the tip portion is restricted.
  • a member manufactured by injection molding or the like may be mounted on the outer cylinder main body, or may be formed in the outer cylinder main body by insert molding or two-color molding.
  • the puncture member mounting portion 40a is a cylindrical portion, like the outer cylinder sealing member 5 described above, and has a small-diameter opening 48 provided at the tip and a recess 53a (specifically, provided on the side portion).
  • a small-diameter opening 48 provided at the tip and a recess 53a (specifically, provided on the side portion).
  • the cylindrical body side screwing portion (in other words, the outer cylinder side screwing portion) 52 provided on the outer surface on the distal end side from the concave portion 53a.
  • an excessive rotation restricting rib 88 (specifically, two ribs facing each other).
  • the cylindrical body side screwing portion 52 is formed by two spiral ribs.
  • the puncture member 6 includes the protrusions 86 (specifically, two protrusions facing each other) provided on the inner surface in the vicinity of the central portion in the axial direction (slightly from the base end). The protrusion 86 extends a predetermined length in the circumferential direction.
  • the protrusion 86 enters and engages with the recess 53a of the puncture member mounting portion 40a.
  • the mounting state of the puncture member 6 to the outer cylinder 4a becomes stable, the rotation of the puncture member in the direction in which the screwing is retracted is restricted, and the puncture member is unintentionally loosened and detached from the outer cylinder. To prevent.
  • the cylindrical body for prefilled syringes of the present invention is a holder 100 that can be attached to a prefilled syringe 110 whose tip is sealed with a seal member that can be pierced by the needle portion of the puncture member, as shown in FIG. There may be.
  • the prefilled syringe holder 100 is a cylindrical body having a main body portion 101 and a puncture member mounting portion 102 provided at the distal end portion thereof.
  • the holder 100 is a cylindrical body that can receive a pre-prefilled syringe inside, in other words, can be attached to the pre-filled syringe 110.
  • FIG. 33 the cylindrical body for prefilled syringe 110.
  • the prefilled syringe 110 used in the holder 100 fixes the outer cylinder 111, a seal member 112 that seals the distal end portion thereof, and the seal member 112 to the distal end of the outer cylinder 111.
  • a fixing member 114, a gasket 113 that can slide in a liquid-tight manner in the outer cylinder 111, and a medicine 115 filled in the outer cylinder 111 are provided.
  • a plunger 130 capable of pressing the rear end of the gasket 113 is used.
  • the plunger 130 includes a shaft portion 131, a gasket pressing portion 132 that presses the rear end portion of the gasket 113 provided at the tip of the shaft portion 131, and an operation pressing portion 133 provided at the rear end of the shaft portion 131. I have. In this pre-prefilled syringe, the plunger can press the gasket, but is not attached to the gasket.
  • tip part of the main-body part 101 of the holder 100 for prefilled syringes is a cylindrical part similarly to the puncture member mounting part 50 mentioned above, and the opening 104 provided in the front-end
  • the concave portion 105 (specifically, two concave portions facing each other) provided in the side portion, the cylindrical body side screwing portion 103 provided on the outer surface on the distal end side from the concave portion 105, and the distal end surface of the puncture member mounting portion 102 And an excessive rotation restricting rib 106 (specifically, two ribs facing each other).
  • the cylindrical body side screwing portion 103 is formed by two helical ribs.
  • a bulging portion (not shown) is formed at the central portion of the spiral rib, and a bulging portion (not shown) is also formed at the terminal portion of the spiral rib.
  • the cylindrical body side screwing portion 103 is screwed with the puncture member side screwing portion 85 of the puncture member 6 described above.
  • the said recessed part 105 forms the cylindrical body side engaging part.
  • a flange 109 is formed at the rear end of the main body 101.
  • the operation of the prefilled syringe 1 of the present invention will be described with reference to FIGS. 1 to 3 and FIGS. 22 to 27.
  • the syringe body 2 is sealed with an outer cylinder sealing member 5 attached to the tip, and the puncture device 3 is punctured in the storage member 7.
  • the member 6 is housed, and the syringe body 2 and the puncture device 3 are not attached.
  • the outer cylinder sealing member 5 is attached to the distal end portion 41 of the outer cylinder main body 40 so that it cannot rotate and cannot be detached.
  • the puncture member 6 is in a state of rotating in the storage member 7 with the rotation of the storage member 7.
  • the tip side portion of the prefilled syringe 1 of the present invention is composed of a tip portion 41 of the outer cylinder main body 40, an outer cylinder sealing member 5, a puncture member 6 and a storage member 7 as shown in FIG.
  • the puncture member side engaging portion (on the inner surface of the puncture member 6 in the vicinity of the central portion in the axial direction (slightly from the base end)) (
  • the protruding portion 86 enters and engages with the cylindrical body side engaging portion (window portion) 53 of the outer cylinder sealing member 5. Since there is some resistance during this engagement, the operator can recognize the end of the mounting operation and prevent overtightening.
  • the rib 59 of the outer cylinder sealing member 5 is formed in the annular recess 87 provided on the inner surface near the proximal end of the puncture member 6 at the same time or slightly before the above engagement.
  • the small diameter portion 62 of the puncture member 6 is interposed between the plurality of bulging portions 74 formed on the inner surface of the central portion in the axial direction of the storage member 7 by attaching the storage member 7 to the syringe body.
  • the bulging portion 65 provided on the outer surface of the first member enters, engages, and becomes the state of FIG. 24 again. Although it may be discarded in this state, the puncture device 3 may be detached from the syringe body and discarded separately. In this case, when the storage member 7 is rotated in the direction opposite to the arrow in FIG.
  • the joint portion (projecting portion) 86 is separated from the tubular body side engaging portion (window portion) 53 of the outer cylinder sealing member 5, and the rib 59 of the outer cylinder sealing member 5 is inserted from the annular recess 87 of the puncture member 6.
  • the puncture member 6 is detached from the syringe body 2 in a state of being accommodated in the accommodation member 7. In addition, even if this puncture tool detachment operation is performed, the outer cylinder sealing member 5 does not detach from the outer cylinder.
  • the cylindrical body for prefilled syringes of the present invention is as follows. (1) A cylindrical body having a puncture member mounting portion, a hollow needle having needle portions at both ends, and the hollow needle is mounted and detachable from the puncture member mounting portion, and the puncture member side screwing portion and puncture A tubular body for a prefilled syringe to which a puncture member comprising a puncture member main body having a member side engagement portion can be attached,
  • the puncture member mounting portion includes: a cylindrical body side screwing portion that can be screwed with the puncture member side screwing portion; and the cylindrical body side screwing portion and the puncture member side screwing portion that are screwed together,
  • a tubular body for a prefilled syringe having a tubular body-side engaging portion that engages with a member-side engaging portion and restricts the backward movement of screwing.
  • the puncture member is attached to the prefilled syringe tubular body by screwing and engagement.
  • the puncture member does not loosen during the syringe administration operation, etc., and there is no liquid leakage due to the loosening.
  • the cylindrical body for a prefilled syringe is an outer cylinder for a prefilled syringe, and the outer cylinder for a prefilled syringe seals an outer cylinder body having a tip portion provided with an opening, and an opening of the tip portion. And an outer cylinder sealing member attached to the distal end portion of the outer cylinder main body, and the puncture member mounting portion is constituted by the outer cylinder sealing member.
  • tip part of the said outer cylinder main body and the said outer cylinder sealing member have the control part which controls the detachment
  • the distal end portion of the outer cylinder main body and the outer cylinder sealing member have a rotation restricting engagement portion and a detachment restricting engagement portion as the restricting portion.
  • the cylindrical body for a prefilled syringe is an outer cylinder for a prefilled syringe, the puncture member mounting portion of the prefilled syringe outer cylinder has an opening of the puncture member mounting portion, and the needle portion of the puncture member
  • the cylindrical body for a prefilled syringe according to the above (1) which is sealed by a sealing member that can be pierced by the above.
  • the cylindrical body for a prefilled syringe is a holder that can be attached to a prefilled syringe whose tip is sealed by a seal member that can be pierced by the needle portion of the puncture member. Cylindrical body for prefilled syringe.
  • the prefilled syringe puncture device of the present invention is as follows. (6) A prefilled syringe puncture device detachable from the puncture member mounting portion of the prefilled syringe tubular body according to any one of (1) to (5) above,
  • the puncture device includes the hollow needle having the needle portions at both ends, the hollow needle is mounted, is detachable from the puncture member mounting portion, and the puncture member side screwing portion and the puncture member side engaging portion are
  • the puncture member having the puncture member main body and a storage member for detachably storing the puncture member, and the storage member and the puncture member receive a rotational force applied to the storage member.
  • the storage member has a rotational force transmitting portion that transmits to the puncture member, and the storage member is detached from the puncture member by pulling in the distal direction after the puncture member is mounted on the puncture member mounting portion.
  • a prefilled syringe puncture device For this reason, the mounting operation to the cylindrical body for prefilled syringe is easy, and the puncture member is mounted to the cylindrical body for prefilled syringe by screwing and engagement. The puncture member does not loosen. Furthermore, after administration of the medicine by the prefilled syringe, the puncture tool can be easily detached from the prefilled syringe cylindrical body by re-inserting the storage member into the puncture member and rotating in the direction in which the screwing is released. it can.
  • the syringe for prefilled syringes of the present invention is as follows. (7) A prefilled syringe outer cylinder which is a cylindrical body for a prefilled syringe according to any one of (2) to (4) above, a slidable gasket housed in the outer cylinder, A syringe body provided with a plunger attached to or attachable to a rear end, the puncture member detachably attached to the puncture member mounting portion of the prefilled syringe outer cylinder, and a storage member for detachably storing the puncture member
  • a prefilled syringe syringe comprising a puncture device comprising:
  • the puncture member mounting portion includes the cylindrical body side screwing portion and the cylindrical body side engaging portion, and the puncture member is screwed to the cylindrical body side screwing portion so that the puncture member side screwing is possible.
  • the puncture member side engaging portion that engages with the cylindrical body side engaging portion and regulates the backward movement of the screwing after the cylindrical portion, the cylindrical body side screwed portion and the puncture member side screwed portion are screwed together
  • the storage member and the puncture member have a rotational force transmitting portion that transmits a rotational force applied to the storage member to the puncture member
  • the storage member has the puncture member A syringe for a prefilled syringe that is detached from the puncture member by being pulled in the distal direction after being mounted on the puncture member mounting portion.
  • the puncture member is attached to the syringe body by screwing and engagement, so that the puncture member is used during the prefilled syringe administration operation (for example, when the storage member is removed). There is no loosening and there is no leakage due to the loosening.
  • the storage member can be attached to the puncture member again, and the storage member attached again to the puncture member is connected to the tubular body side screwing portion and the puncture member.
  • the engagement between the cylindrical body side engaging part and the puncturing member side engaging part is released, and the puncturing member is placed in the storage member.
  • the cylindrical body side screwing portion and the puncture member side screwing portion are arranged so that the cylindrical body side screwing portion and the puncture member side after the needle portion of the hollow needle pierces the seal member.
  • the puncture member mounting portion includes a first cylindrical body side engaging portion and a second cylindrical body side engaging portion that is located closer to the proximal end side or the distal end side of the puncture member mounting portion than the first cylindrical body side engaging portion.
  • a cylindrical body side engaging portion; and the puncture member includes a first puncture member side engaging portion that engages with the first cylindrical body side engaging portion, and the first puncture member side engaging portion.
  • the puncture member mounting portion includes an excessive rotation restricting rib, and the puncture member is engaged with the cylindrical body side screwing portion and the puncture member side screwing portion, and then the excessive rotation restriction rib.
  • the prefilled syringe of the present invention is as follows. (12) A prefilled syringe comprising the prefilled syringe injector according to any one of (7) to (11) above and a medicine stored in the syringe body.

Abstract

La présente invention concerne une seringue préremplie (1) formée des éléments suivants : un corps principal de seringue (2) comprenant un corps principal de cylindre externe (40) et un élément d'étanchéité de cylindre externe (5) pourvu d'un élément d'étanchéité (10) ; et un instrument de perforation (3), qui comprend un élément de perforation (6) possédant une aiguille creuse (61), elle-même pourvue d'une partie d'aiguille de perforation (61a) sur une extrémité et d'une partie d'aiguille de perforation pour élément d'étanchéité (61b) sur une autre extrémité, ainsi qu'un élément de boîtier (7) abritant de manière détachable l'élément de perforation (6). Le cylindre externe et l'élément d'étanchéité du cylindre externe comprennent en outre des parties de restriction qui limitent le détachement et la rotation de l'élément d'étanchéité de cylindre externe. L'élément d'étanchéité de cylindre externe et l'élément de perforation comprennent respectivement des parties de vis et des parties de verrouillage qui verrouillent et limitent le mouvement vers l'avant et vers l'arrière des vis, une fois les parties de vis vissées ensemble. L'élément de boîtier comprend également une partie de transmission de force de rotation à la partie de perforation qui est accueillie à l'intérieur.
PCT/JP2012/082075 2011-12-15 2012-12-11 Corps cylindrique de seringue préremplie, instrument de perforation pour seringue préremplie, appareil d'injection pour seringue préremplie, et seringue préremplie WO2013089105A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011-274758 2011-12-15
JP2011274758 2011-12-15

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WO2013089105A1 true WO2013089105A1 (fr) 2013-06-20

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PCT/JP2012/082075 WO2013089105A1 (fr) 2011-12-15 2012-12-11 Corps cylindrique de seringue préremplie, instrument de perforation pour seringue préremplie, appareil d'injection pour seringue préremplie, et seringue préremplie

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WO (1) WO2013089105A1 (fr)

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CN105873626A (zh) * 2013-10-24 2016-08-17 美国安进公司 注射器和组装方法
US10537681B2 (en) 2011-10-14 2020-01-21 Amgen Inc. Injector and method of assembly
US10850037B2 (en) 2013-03-22 2020-12-01 Amgen Inc. Injector and method of assembly

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Publication number Priority date Publication date Assignee Title
JPH0231763A (ja) * 1988-06-24 1990-02-01 Habley Medical Technol Corp 皮下注射器と皮下注射器用の針カニューレとカニューレロックの組合せ
WO2009043000A1 (fr) * 2007-09-27 2009-04-02 Becton, Dickinson And Company Cartouche pour poudre et médicament liquide

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Publication number Priority date Publication date Assignee Title
JPH0231763A (ja) * 1988-06-24 1990-02-01 Habley Medical Technol Corp 皮下注射器と皮下注射器用の針カニューレとカニューレロックの組合せ
WO2009043000A1 (fr) * 2007-09-27 2009-04-02 Becton, Dickinson And Company Cartouche pour poudre et médicament liquide

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10537681B2 (en) 2011-10-14 2020-01-21 Amgen Inc. Injector and method of assembly
US10537682B2 (en) 2011-10-14 2020-01-21 Amgen Inc. Injector and method of assembly
US11058821B2 (en) 2011-10-14 2021-07-13 Amgen Inc. Injector and method of assembly
US11110225B2 (en) 2011-10-14 2021-09-07 Amgen Inc. Injector and method of assembly
US11129941B2 (en) 2011-10-14 2021-09-28 Amgen Inc. Method of assembling and filling a drug delivery device
US11160931B2 (en) 2011-10-14 2021-11-02 Amgen Inc. Method of assembling and filling a drug delivery device
US11273260B2 (en) 2011-10-14 2022-03-15 Amgen Inc. Injector and method of assembly
US11298463B2 (en) 2011-10-14 2022-04-12 Amgen Inc. Method of assembling and filling a drug delivery device
US10850037B2 (en) 2013-03-22 2020-12-01 Amgen Inc. Injector and method of assembly
US11759571B2 (en) 2013-03-22 2023-09-19 Amgen Inc. Injector and method of assembly
CN105873626A (zh) * 2013-10-24 2016-08-17 美国安进公司 注射器和组装方法
US11097055B2 (en) 2013-10-24 2021-08-24 Amgen Inc. Injector and method of assembly

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