WO2013079536A1 - A meal intended for human consumption - Google Patents
A meal intended for human consumption Download PDFInfo
- Publication number
- WO2013079536A1 WO2013079536A1 PCT/EP2012/073846 EP2012073846W WO2013079536A1 WO 2013079536 A1 WO2013079536 A1 WO 2013079536A1 EP 2012073846 W EP2012073846 W EP 2012073846W WO 2013079536 A1 WO2013079536 A1 WO 2013079536A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- meal
- flavonoid
- glucoside
- meals
- pal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- This invention relates to a plurality of compositions for dietary health management and its use in the prevention or treatment of cardiovascular disease, type 2 diabetes and obesity; and in weight management and weight loss.
- a method for the prevention or treatment of cardiovascular disease, type 2 diabetes and obesity; and for weight management and weight loss comprising the step of administering to a person in need therefor the meal of the first aspect of the invention.
- dinner extracts expressed as a percentage relative to the activation of the EC80 concentration of reference agonist (40 g/ml aqueous methanol extract, 8 g/ml petroleum ether extract, 8 g/ml dichloromethane extract, 4 g/ml ethyl acetate extract, 40 g/ml 1 -butanol extract and 40 g/ml water extract);
- reference agonist 40 g/ml aqueous methanol extract, 8 g/ml petroleum ether extract, 8 g/ml dichloromethane extract, 4 g/ml ethyl acetate extract, 40 g/ml 1 -butanol extract and 40 g/ml water extract
- a petroleum ether (40-60 °C) extract of an aqueous methanol extract of the meal of the second aspect of the invention has a gallic acid equivalent of 5-40, preferably 15-30, more preferably 20-30 mg,
- a dichloromethane extract of the aqueous methanol extract after petroleum ether (40-60 °C) extraction of the aqueous methanol extract has a gallic acid equivalent of 5-25, preferably 10-20, more preferably 13-18 mg,
- Another aspect of the invention is the use of the claimed meal for the manufacture of a medicament for the prevention or treatment of cardiovascular disease, type 2 diabetes and obesity; and for weight management and weight loss.
- apigenin, cyanidin-3-glucoside, delphinidin-3-glucoside, hesperetin, kaempferol, luteolin, malvidin-3-glucoside, myricetin, naringenin, pelagonidin-3-glucoside and quercetin was carried out by removing lipids from freeze-dried, ground foodstuffs by the method of Meyer, M. D. et al. , (J. Agric. Food Chem. , 56, 7439-7445 (2008)) and assaying the extracted flavanoids by HPLC as detailed in Downes, K. et al. , (Postharvest Biol. Technol.
- Sugars were extracted with water, clarified and chromatographically separated on an amine column with an acetonitrile/water mobile phase. The sugars were detected using an evaporative light scattering detector and quantified with reference to calibration standards. Values were expressed as g.meal "1 .
- Total dietary fibre was determined by precipitating soluble fibre before the removal of insoluble fibre, with the resultant precipitate washed, dried and weighed. Total dietary fibre was then determined gravimetrically and corrected for protein and ash. Values are expressed in units of g.meal "1 .
- Blood samples were centrifuged at 4 degrees Centigrade and two samples of more than 500 ⁇ of EDTA plasma and two samples of more than 500 ⁇ heparin plasma were frozen and stored at -70 degrees Centigrade until analysis.
- Venous plasma glucose analysis was conducted on a Horiba ABX Clinical Chemistry analyser using the commercially available Glucose PAP CP kit (ref A1 1 A01668) from ABX Pentra.
- Table 6 Peak venous blood glucose values (mmol/L) between 0 (baseline before the meals) and 180 minutes after commencing meal consumption. P was calculated at 95 % confidence limits.
- the PAL 2 glucose curve shows a much gentler decline between 30 and 60 minutes than for PAL 1 and Reference, and furthermore, unlike the other two curves, never goes significantly below baseline to show a post prandial "dip". This is likely to be related to the lower insulin peak shown in Figure 1 .
- both PAL 1 and PAL 2 show increases in PYY, GLP-1 and decreases in GIP when compared with the Reference meal. All three of these results can be considered as favourable health outcomes. Whilst not wishing to be bound by any particular theory, the inventors believe that a possible explanation is that flavonoids or other phenolics in PAL 1 and PAL 2 activate receptors in the gut and these are responsible for the changes in hormones in the blood.
- Residual solvent was removed from the remaining unextracted portion by rotary evaporation and the aqueous solution was freeze-dried.
- the lyophilised sample was labelled as 'water extract' and stored at -20 °C under nitrogen in the dark. Extractions yielded the quantities of material set forth in Table 7.
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Pediatric Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN932MUN2014 IN2014MN00932A (https=) | 2011-11-29 | 2012-11-28 | |
| CA2852032A CA2852032A1 (en) | 2011-11-29 | 2012-11-28 | A meal intended for human consumption |
| EA201491050A EA027364B1 (ru) | 2011-11-29 | 2012-11-28 | Набор продуктов для полного завтрака, обеда и ужина |
| BR112014010107A BR112014010107A2 (pt) | 2011-11-29 | 2012-11-28 | refeição destinada ao consumo humano, uso da refeição e método para a prevenção ou tratamento de doença cardiovascular, diabetes o tipo 2 e obesidade; e para o controle de peso e perda de peso |
| AU2012343964A AU2012343964B2 (en) | 2011-11-29 | 2012-11-28 | A meal intended for human consumption |
| US14/359,487 US9386792B2 (en) | 2011-11-29 | 2012-11-28 | Meal intended for human consumption |
| EP12791209.5A EP2785201A1 (en) | 2011-11-29 | 2012-11-28 | A meal intended for human consumption |
| CN201280058728.9A CN104039170A (zh) | 2011-11-29 | 2012-11-28 | 旨在用于人食用的膳食 |
| ZA2014/02770A ZA201402770B (en) | 2011-11-29 | 2014-04-15 | A meal intended for human consumption |
| US15/179,203 US9750272B2 (en) | 2011-11-29 | 2016-06-10 | Meal intended for human consumption |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11191182 | 2011-11-29 | ||
| EP11191182.2 | 2011-11-29 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US14/359,487 A-371-Of-International US9386792B2 (en) | 2011-11-29 | 2012-11-28 | Meal intended for human consumption |
| US15/179,203 Continuation US9750272B2 (en) | 2011-11-29 | 2016-06-10 | Meal intended for human consumption |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2013079536A1 true WO2013079536A1 (en) | 2013-06-06 |
Family
ID=47226200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2012/073846 Ceased WO2013079536A1 (en) | 2011-11-29 | 2012-11-28 | A meal intended for human consumption |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9386792B2 (https=) |
| EP (1) | EP2785201A1 (https=) |
| CN (1) | CN104039170A (https=) |
| AU (1) | AU2012343964B2 (https=) |
| BR (1) | BR112014010107A2 (https=) |
| CA (1) | CA2852032A1 (https=) |
| EA (1) | EA027364B1 (https=) |
| IN (1) | IN2014MN00932A (https=) |
| WO (1) | WO2013079536A1 (https=) |
| ZA (1) | ZA201402770B (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015182955A (ja) * | 2014-03-20 | 2015-10-22 | 学校法人中部大学 | Glp−1分泌促進剤 |
| WO2021252467A1 (en) * | 2020-06-09 | 2021-12-16 | H.J. Heinz Company Brands Llc | Modular meal system |
| USD1057556S1 (en) | 2021-10-29 | 2025-01-14 | H. J. Heinz Company Brands Llc | Tray |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111096972B (zh) * | 2020-02-25 | 2023-07-14 | 成都医学院 | 一种预防和/或治疗阿尔茨海默症的药物组合物 |
| CN115645431B (zh) * | 2022-12-12 | 2023-03-21 | 汤臣倍健股份有限公司 | 一种组合物及其应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011147862A1 (en) * | 2010-05-28 | 2011-12-01 | Unilever Plc | Compositions for dietary health management |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6039989A (en) | 1995-06-06 | 2000-03-21 | Campbell Soup Company | Prepackaged therapeutic meal for treatment of diet-responsive conditions |
| WO1996039053A2 (en) | 1995-06-06 | 1996-12-12 | Campbell Soup Company | Mineral supplements for dietetic food |
| WO2001001962A1 (en) * | 1999-07-05 | 2001-01-11 | Idea Ag. | A method for the improvement of transport across adaptable semi-permeable barriers |
| US20020054924A1 (en) * | 2000-04-13 | 2002-05-09 | Leahy Margaret M. | Novel compositions derived from cranberry and grapefruit and therapeutic uses therefor |
| WO2002011562A2 (en) | 2000-08-08 | 2002-02-14 | Advanced Functional Foods International, Inc. | Nutritional supplement for the management of weight |
| US6808727B2 (en) | 2001-07-20 | 2004-10-26 | Emanuel S. Kemeny | Meal-equivalent food bar |
| US7030092B1 (en) * | 2001-08-24 | 2006-04-18 | Small Giant L.L.C. | Ultra-high fiber supplement and method of reducing weight cardiovascular risks and ingested toxins. |
| US6585998B2 (en) * | 2001-11-13 | 2003-07-01 | Rudolph Cartwright | Nutraceutical composition |
| US20040001817A1 (en) * | 2002-05-14 | 2004-01-01 | Giampapa Vincent C. | Anti-aging nutritional supplement |
| US7767245B2 (en) | 2003-09-12 | 2010-08-03 | Ray And Terry's Health Products, Inc. | Meal replacement beverage |
| CA2577984C (en) | 2004-08-25 | 2012-01-24 | Regents Of The University Of Minnesota | Compositions and methods to lower glycohemoglobin levels |
| US20060188590A1 (en) * | 2005-01-05 | 2006-08-24 | Mitsunori Ono | Compositions for treating diabetes or obesity |
| US7977319B1 (en) * | 2006-04-03 | 2011-07-12 | Scott David Levine | Ultra-high fiber supplement and method of reducing weight, cardiovascular risks and ingested toxins |
| US20080305096A1 (en) | 2007-06-07 | 2008-12-11 | Unicity International, Inc. | Method and composition for providing controlled delivery of biologically active substances |
| US20100093678A1 (en) * | 2008-10-10 | 2010-04-15 | The University Of Georgia Research Foundation, Inc | Compositions and methods of the treatment of obesity and osteoporosis |
| WO2010105253A2 (en) * | 2009-03-13 | 2010-09-16 | The Salk Institute For Biological Studies | Methods and compositions for treating complications of diabetes and vascular diseases using flavones |
| EP2316271A1 (fr) | 2009-10-26 | 2011-05-04 | ET & DS Company Ltd | Substitut de repas sous forme d'un aliment à cuire de type pain et d'un aliment d'accompagnement de type pâte à tartiner. |
| WO2011060307A2 (en) | 2009-11-13 | 2011-05-19 | Jingxuan Kang | Food products having multiple health benefits |
| EP2509434A4 (en) | 2009-12-07 | 2015-06-24 | Leonardo Carella | CALORIE ARMS, PROPERTY-FRIENDLY MOLDED FORMING AND MANUFACTURING METHOD |
| MX2013003985A (es) * | 2010-10-14 | 2014-05-01 | Asha Nutrition Sciences Inc | Formulaciones nutritivas optimizadas, metodos para la seleccion de dietas adaptadas a partir de las mismas, y metodos para utilizar las mismas. |
| CN102077949B (zh) | 2011-01-27 | 2013-01-16 | 北京康比特体育科技股份有限公司 | 一种减肥代餐营养棒及其制备方法 |
| CN102224933B (zh) | 2011-05-13 | 2013-07-17 | 烟台新时代健康产业有限公司 | 辅助调节血脂的组合物、保健食品及其应用 |
| US20130095204A1 (en) * | 2011-10-14 | 2013-04-18 | Zeina Jouni | Nutritional phytonutrient compositions |
| JP2015505320A (ja) * | 2012-01-16 | 2015-02-19 | グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー2、リミテッドGlaxosmithkline Intellectual Property No.2 Limited | 糖尿病及び/又は肥満の治療のための組成物及び方法 |
| US9132117B2 (en) * | 2013-06-17 | 2015-09-15 | Kgk Synergize, Inc | Compositions and methods for glycemic control of subjects with impaired fasting glucose |
-
2012
- 2012-11-28 CA CA2852032A patent/CA2852032A1/en not_active Abandoned
- 2012-11-28 IN IN932MUN2014 patent/IN2014MN00932A/en unknown
- 2012-11-28 EP EP12791209.5A patent/EP2785201A1/en not_active Withdrawn
- 2012-11-28 BR BR112014010107A patent/BR112014010107A2/pt not_active Application Discontinuation
- 2012-11-28 WO PCT/EP2012/073846 patent/WO2013079536A1/en not_active Ceased
- 2012-11-28 US US14/359,487 patent/US9386792B2/en not_active Expired - Fee Related
- 2012-11-28 CN CN201280058728.9A patent/CN104039170A/zh active Pending
- 2012-11-28 EA EA201491050A patent/EA027364B1/ru not_active IP Right Cessation
- 2012-11-28 AU AU2012343964A patent/AU2012343964B2/en not_active Ceased
-
2014
- 2014-04-15 ZA ZA2014/02770A patent/ZA201402770B/en unknown
-
2016
- 2016-06-10 US US15/179,203 patent/US9750272B2/en not_active Expired - Fee Related
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| WO2011147862A1 (en) * | 2010-05-28 | 2011-12-01 | Unilever Plc | Compositions for dietary health management |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015182955A (ja) * | 2014-03-20 | 2015-10-22 | 学校法人中部大学 | Glp−1分泌促進剤 |
| WO2021252467A1 (en) * | 2020-06-09 | 2021-12-16 | H.J. Heinz Company Brands Llc | Modular meal system |
| USD1057556S1 (en) | 2021-10-29 | 2025-01-14 | H. J. Heinz Company Brands Llc | Tray |
| USD1085868S1 (en) | 2021-10-29 | 2025-07-29 | H. J. Heinz Company Brands Llc | Tray |
Also Published As
| Publication number | Publication date |
|---|---|
| EA201491050A1 (ru) | 2014-09-30 |
| AU2012343964A1 (en) | 2014-04-24 |
| IN2014MN00932A (https=) | 2015-04-17 |
| US9386792B2 (en) | 2016-07-12 |
| AU2012343964B2 (en) | 2015-02-05 |
| US20160286841A1 (en) | 2016-10-06 |
| US20140308392A1 (en) | 2014-10-16 |
| CA2852032A1 (en) | 2013-06-06 |
| EA027364B1 (ru) | 2017-07-31 |
| ZA201402770B (en) | 2015-11-25 |
| CN104039170A (zh) | 2014-09-10 |
| BR112014010107A2 (pt) | 2017-04-25 |
| EP2785201A1 (en) | 2014-10-08 |
| US9750272B2 (en) | 2017-09-05 |
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