Classifications

• • C—CHEMISTRY; METALLURGY
  • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
  • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
  • C10M173/00—Lubricating compositions containing more than 10% water
• • C—CHEMISTRY; METALLURGY
  • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
  • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
  • C10M2207/00—Organic non-macromolecular hydrocarbon compounds containing hydrogen, carbon and oxygen as ingredients in lubricant compositions
  • C10M2207/02—Hydroxy compounds
  • C10M2207/021—Hydroxy compounds having hydroxy groups bound to acyclic or cycloaliphatic carbon atoms
  • C10M2207/022—Hydroxy compounds having hydroxy groups bound to acyclic or cycloaliphatic carbon atoms containing at least two hydroxy groups
• • C—CHEMISTRY; METALLURGY
  • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
  • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
  • C10M2207/00—Organic non-macromolecular hydrocarbon compounds containing hydrogen, carbon and oxygen as ingredients in lubricant compositions
  • C10M2207/10—Carboxylix acids; Neutral salts thereof
  • C10M2207/12—Carboxylix acids; Neutral salts thereof having carboxyl groups bound to acyclic or cycloaliphatic carbon atoms
• • C—CHEMISTRY; METALLURGY
  • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
  • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
  • C10M2207/00—Organic non-macromolecular hydrocarbon compounds containing hydrogen, carbon and oxygen as ingredients in lubricant compositions
  • C10M2207/10—Carboxylix acids; Neutral salts thereof
  • C10M2207/14—Carboxylix acids; Neutral salts thereof having carboxyl groups bound to carbon atoms of six-membered aromatic rings
  • C10M2207/141—Carboxylix acids; Neutral salts thereof having carboxyl groups bound to carbon atoms of six-membered aromatic rings monocarboxylic
• • C—CHEMISTRY; METALLURGY
  • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
  • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
  • C10M2207/00—Organic non-macromolecular hydrocarbon compounds containing hydrogen, carbon and oxygen as ingredients in lubricant compositions
  • C10M2207/40—Fatty vegetable or animal oils
  • C10M2207/401—Fatty vegetable or animal oils used as base material
• • C—CHEMISTRY; METALLURGY
  • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
  • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
  • C10M2209/00—Organic macromolecular compounds containing oxygen as ingredients in lubricant compositions
  • C10M2209/02—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
  • C10M2209/04—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds containing monomers having an unsaturated radical bound to an alcohol or ester thereof; bound to an aldehyde, ketonic, ether, ketal or acetal radical
• • C—CHEMISTRY; METALLURGY
  • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
  • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
  • C10M2209/00—Organic macromolecular compounds containing oxygen as ingredients in lubricant compositions
  • C10M2209/02—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
  • C10M2209/08—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds containing monomers having an unsaturated radical bound to a carboxyl radical, e.g. acrylate type
• • C—CHEMISTRY; METALLURGY
  • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
  • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
  • C10M2209/00—Organic macromolecular compounds containing oxygen as ingredients in lubricant compositions
  • C10M2209/10—Macromolecular compoundss obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
  • C10M2209/103—Polyethers, i.e. containing di- or higher polyoxyalkylene groups
• • C—CHEMISTRY; METALLURGY
  • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
  • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
  • C10M2209/00—Organic macromolecular compounds containing oxygen as ingredients in lubricant compositions
  • C10M2209/10—Macromolecular compoundss obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
  • C10M2209/103—Polyethers, i.e. containing di- or higher polyoxyalkylene groups
  • C10M2209/1033—Polyethers, i.e. containing di- or higher polyoxyalkylene groups used as base material
• • C—CHEMISTRY; METALLURGY
  • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
  • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
  • C10M2209/00—Organic macromolecular compounds containing oxygen as ingredients in lubricant compositions
  • C10M2209/12—Polysaccharides, e.g. cellulose, biopolymers
• • C—CHEMISTRY; METALLURGY
  • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
  • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
  • C10M2215/00—Organic non-macromolecular compounds containing nitrogen as ingredients in lubricant Compositions
  • C10M2215/02—Amines, e.g. polyalkylene polyamines; Quaternary amines
  • C10M2215/04—Amines, e.g. polyalkylene polyamines; Quaternary amines having amino groups bound to acyclic or cycloaliphatic carbon atoms
• • C—CHEMISTRY; METALLURGY
  • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
  • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
  • C10M2215/00—Organic non-macromolecular compounds containing nitrogen as ingredients in lubricant Compositions
  • C10M2215/02—Amines, e.g. polyalkylene polyamines; Quaternary amines
  • C10M2215/04—Amines, e.g. polyalkylene polyamines; Quaternary amines having amino groups bound to acyclic or cycloaliphatic carbon atoms
  • C10M2215/042—Amines, e.g. polyalkylene polyamines; Quaternary amines having amino groups bound to acyclic or cycloaliphatic carbon atoms containing hydroxy groups; Alkoxylated derivatives thereof
• • C—CHEMISTRY; METALLURGY
  • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
  • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
  • C10M2215/00—Organic non-macromolecular compounds containing nitrogen as ingredients in lubricant Compositions
  • C10M2215/22—Heterocyclic nitrogen compounds
  • C10M2215/221—Six-membered rings containing nitrogen and carbon only
  • C10M2215/222—Triazines
• • C—CHEMISTRY; METALLURGY
  • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
  • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
  • C10M2217/00—Organic macromolecular compounds containing nitrogen as ingredients in lubricant compositions
  • C10M2217/02—Macromolecular compounds obtained from nitrogen containing monomers by reactions only involving carbon-to-carbon unsaturated bonds
  • C10M2217/028—Macromolecular compounds obtained from nitrogen containing monomers by reactions only involving carbon-to-carbon unsaturated bonds containing monomers having an unsaturated radical bound to a nitrogen-containing hetero ring
• • C—CHEMISTRY; METALLURGY
  • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
  • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
  • C10M2219/00—Organic non-macromolecular compounds containing sulfur, selenium or tellurium as ingredients in lubricant compositions
  • C10M2219/04—Organic non-macromolecular compounds containing sulfur, selenium or tellurium as ingredients in lubricant compositions containing sulfur-to-oxygen bonds, i.e. sulfones, sulfoxides
  • C10M2219/044—Sulfonic acids, Derivatives thereof, e.g. neutral salts
• • C—CHEMISTRY; METALLURGY
  • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
  • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
  • C10M2219/00—Organic non-macromolecular compounds containing sulfur, selenium or tellurium as ingredients in lubricant compositions
  • C10M2219/10—Heterocyclic compounds containing sulfur, selenium or tellurium compounds in the ring
  • C10M2219/104—Heterocyclic compounds containing sulfur, selenium or tellurium compounds in the ring containing sulfur and carbon with nitrogen or oxygen in the ring
• • C—CHEMISTRY; METALLURGY
  • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
  • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
  • C10M2223/00—Organic non-macromolecular compounds containing phosphorus as ingredients in lubricant compositions
  • C10M2223/06—Organic non-macromolecular compounds containing phosphorus as ingredients in lubricant compositions having phosphorus-to-carbon bonds
• • C—CHEMISTRY; METALLURGY
  • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
  • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
  • C10M2229/00—Organic macromolecular compounds containing atoms of elements not provided for in groups C10M2205/00, C10M2209/00, C10M2213/00, C10M2217/00, C10M2221/00 or C10M2225/00 as ingredients in lubricant compositions
  • C10M2229/02—Unspecified siloxanes; Silicones
• • C—CHEMISTRY; METALLURGY
  • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
  • C10N—INDEXING SCHEME ASSOCIATED WITH SUBCLASS C10M RELATING TO LUBRICATING COMPOSITIONS
  • C10N2030/00—Specified physical or chemical properties which is improved by the additive characterising the lubricating composition, e.g. multifunctional additives
  • C10N2030/12—Inhibition of corrosion, e.g. anti-rust agents or anti-corrosives
• • C—CHEMISTRY; METALLURGY
  • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
  • C10N—INDEXING SCHEME ASSOCIATED WITH SUBCLASS C10M RELATING TO LUBRICATING COMPOSITIONS
  • C10N2040/00—Specified use or application for which the lubricating composition is intended
  • C10N2040/06—Instruments or other precision apparatus, e.g. damping fluids

Definitions

• the present disclosure relates to a rust inhibiting lubricant, and particularly relates to a rust inhibiting lubricant for medical instruments, and further relates to a method for lubricating medical instruments.
• Rust inhibiting lubricant for the medical instruments can be conveniently adhered to the surfaces of the metallic medical instruments by an automatic cleaning machine or by manual soaking to form a protective film.
• the protective film can lubricate pivots of the medical instruments and prevent the metallic medical instruments from contacting oxygen in the air, thus generating rust prevention and lubrication effects.
• the protective film is a water-soluble substance and can be penetrated through by high-pressure steam.
• Rust inhibiting lubricants of prior art are mainly used in metal processing industries and for rust prevention of some industrial metallic reactors.
• US005538654A provides an environmentally friendly oil-based lubricant used for food processing equipment by using a modified vegetable oil and an emulsifier system.
• US20040241309A1 provides a food-grade lubricant also used for the food industry by using triglyceride as base oil.
• rust inhibiting lubricants of prior art are mainly used for lubrication of catheters, cannulae and some puncture needles.
• US20100048759 provides a lubricant for surgical instruments, which is a water-soluble lubricant containing glycerin, polyethylene glycol and water, and is substantially surfactant- free.
• the lubricant is mainly used for manual lubrication, not suitable for automatic cleaning machines. Therefore, in view of practical applications in the health care industry, it is necessary to provide a new rust inhibiting lubricant for metallic medical instruments, which can not only be used for manual lubrication, but also be used for medical cleaning machines.
• One of the objectives of the present disclosure is to provide a rust inhibiting lubricant.
• the rust inhibiting lubricant based on the total weight of the rust inhibiting lubricant, the rust inhibiting lubricant comprises:
• base oil is one or more substances selected from the following group: polyalkelene glycol, fatty glyceride and propanetriol;
• Another objective of the present disclosure is to provide a method for lubricating medical instruments.
• the method comprises steps of treating medical instruments with the rust inhibiting lubricant provided in the present invention.
• the rust inhibiting lubricant provided in the present disclosure is mainly used for lubricating the surfaces and pivots of the metallic medical instruments to ensure the medical instruments can be used maneuverably. Moreover, the rust inhibiting lubricant can form a layer of a rust-proof film on the surfaces of the metallic medical instruments to prevent the metallic medical instruments from corrosion and rusting, thus extending service life of the metallic medical instruments.
• the rust inhibiting lubricant of the present disclosure exhibits the following advantages:
• a concentrated lubricant it can be diluted in high ratios and can be used for lubrication with machine and by manual soaking after dilution.
• Figure 1 is a comparison of foam level test results of various lubricants at the time of 0, 10, 20 and 30 sec at 60°C.
• Figure 2 is a comparison of foam level test results of various lubricants at the time of 0, 10, 20 and 30 sec at 25°C.
• Figure 3 is a comparison of lubricating performance test results between an example of the present invention and the comparison example.
• the present disclosure provides a highly concentrated, durably stable, aqueous, rust inhibiting lubricant.
• the rust inhibiting lubricant provided in the present disclosure can lubricate surfaces and pivots of the metallic medical instruments, and meanwhile form a layer of rust-proof film on the surfaces of the metallic medical instruments to prevent the medical instruments from rusting too quickly, thus extending service life of the medical instruments.
• a water soluble base oil suitable for food apparatus or medical instruments is used to substitute conventional mineral oil as a lubricating ingredient for the rust inhibiting lubricant of the present invention to obtain a transparent aqueous rust inhibiting lubricant without an emulsifier.
• the rust inhibiting lubricant is physically stable.
• the term "physically stable” herein means that the rust inhibiting lubricant will not change significantly at room temperature and therefore become different from its initial state in at least 3 months due to obvious precipitation, crystallization, phase separation, and the like.
• Cleaning and lubricating procedures generally required in hospitals may be carried out by machine or manually. Requirement for the lubricants can be different depending on different operating methods.
• a general procedure for cleaning with automatic cleaning machine is as follows: first of all, a pre-cleaning process of a medical instrument is carried out at room temperature, and then temperature is raised to, for example, 45°C, and then cleaning is carried out after a detergent is added. After the cleaning is carried out once or twice, temperature is further raised to, for example, above 45°C, preferably above 60°C but below 85°C. Preferably, a lubricant is added at a temperature below 75°C for a final cleaning, and then the medical instrument is dried.
• Conventional automatic cleaning machines in the art may be used. Their examples include but are not limited to products of Getinge, Belimed, Xinhua and other brands.
• Manual cleaning process may be carried out in two ways: (1) the lubricant is diluted with water in a vessel, and a medical instrument is immersed in the vessel for a period of time, for example, 5 min, and then the medical instrument is taken out and dried; or (2) The diluted lubricant is sprayed directly onto pivots of the medical instrument. Manual cleaning has no special requirement for operating temperatures and is normally carried out at ambient temperatures.
• the rust inhibiting lubricant has low foaming ability, and withstands high temperatures, therefore is suitable for lubricating with machines.
• the rust inhibiting lubricant is a water-based lubricant and can be easily diluted with water; meanwhile it still keeps good stability after dilution. Therefore, it is also suitable for manual lubricating.
• dilution ratio by weight may vary in a range from adding 1 part of rust inhibiting lubricant into 10 parts of water to adding 1 part of rust inhibiting lubricant into 600 part of water.
• 1 part of lubricant when used for automatic cleaning machine, 1 part of lubricant can be diluted with 200 to 600 parts of water by weight; when used for manual cleaning, 1 part of lubricant can be diluted with 10 to 20 parts of water by weight.
• the automatic cleaning machine is operated in a spraying manner, the lubricant can be sprayed onto pivots of the medical instruments; therefore the dilution ratio is relatively high.
• manual lubricating is carried out by soaking, and the lubricant will normally be used for a whole day after dilution and relatively more medical instruments will be soaked, the dilution ratio is relatively low.
• Major ingredients of the rust inhibiting lubricant comprise base oil, corrosion inhibitor, anti-corrosion agent and solvent.
• the rust inhibiting lubricant may also comprise one or more anti-foaming agents, solubilizing agents, thickening agents and chelating agents.
• the base oil may be oil or a mixture of several types of oils.
• the selected base oil is well compatible with human bodies, and is environmentally friendly and easy to biodegrade. All of the selected base oils are water soluble, and may be esters, ethers or amines and the like.
• the base oil may contain one or more polyethylene glycol (PEG) or polyglyceryl groups in its structure.
• the base oil is preferably polyalkelene glycol, fatty glyceride, propanetriol and the like.
• weight percentage of the base oil in a rust inhibiting lubricant is from 5% to 45%, preferably from 5% to 40%, more preferably from 10% to 35%, even more preferably from 10% to 30%, and most preferably from 15 to 25% based on total weight of the rust inhibiting lubricant.
• polyalkelene glycol may be selected as the base oil.
• the polyalkelene glycol may be polyalkelene glycol homopolymer, polyalkelene glycol monoether, polyalkelene glycol diether, polyalkelene glycol co-polymer, esters of polyalkelene glycol and the like.
• the alkylene glycol may be ethylene oxide, propylene oxide and the like.
• a non-limiting example of the polyalkelene glycol is a block co-polymer of ethylene oxide and propylene oxide. There are no particular restrictions on molecular weight of polyalkelene glycol.
• 1% aqueous solution of the polyalkelene glycol has a cloud point range of 50°C to 70°C.
• the polyalkelene glycol is an FDA approved substance.
• Examples of commercially available polyalkelene glycol that can be used include: UCON 50-HB-5100, UCON 50-HB-660, UCON 50-HB-3520 and UCON 75-H-450 manufactured by Dow Chemicals, and PLURASAFE® POLYGLYCOLS WS-660, WS-2000, WS-3520 and WS-5100 manufactured by BASF Auxiliary Chemicals Co., Ltd., and HydramolTM PGPL manufactured by Lubrizol, and the like.
• weight percentage of polyalkelene glycol in a rust inhibiting lubricant is from 3% to 20%, preferably from 3% to 15% based on total weight of the rust inhibiting lubricant.
• fatty glyceride may be selected as the base oil.
• the fatty glyceride may be a long chain fatty glyceride.
• the term "long chain fatty acid” refers to fatty acids containing from 6 to 20 carbon atoms, preferably from 6 to 12 carbon atoms. Their examples include but are not limited to hexanoic acid, heptanoic acid, octanoic acid, nonanoic acid, decanoic acid, undecanoic acid, dodecanoic acid, and the like.
• the fatty glyceride is an ester of glycerin formed with one or more above acids or a mixture thereof, or a polyglycerol ester, such as caprylic/capric triglyceride, polyglyceryl-3 laurate and the like.
• a polyglycerol ester such as caprylic/capric triglyceride, polyglyceryl-3 laurate and the like.
• examples of commercially available fatty glyceride that can be used include: HydramolTM TGL ester and the like manufactured by Lubrizol.
• weight percentage of fatty glyceride in a rust inhibiting lubricant is from 5% to 30%, preferably from 10% to 20% based on total weight of the rust inhibiting lubricant.
• propanetriol may be selected as the base oil.
• weight percentage of propanediol in a rust inhibiting lubricant is from 5% to 30%, preferably from 10% to 20% based on total weight of the rust inhibiting lubricant.
• the rust inhibiting lubricant contains a corrosion inhibitor.
• a rust-proof film will be formed on the surfaces of the metallic medical instruments.
• the rust-proof film adhered to the surfaces of the medical instruments can prevent the metallic medical instruments from contacting with oxygen in the air, thus achieving effects of rust prevention.
• the corrosion inhibitor includes an organic poly(carboxylic acid), an organic polycarboxylate salt, or an alkyl amine.
• Preferred corrosion inhibitor is nitrogen-containing organic compounds. Their examples include nitrogen-containing organic poly(carboxylic acid), triethanolamine, monoethanolamine, aniline, pyridine, quinoline, diethylamine, cyclohexylamine, thiourea, thiourea derivatives and the like.
• molecular weight of organic poly(carboxylic acids) and organic polycarboxylate salts used as a corrosion inhibitor are no particular restrictions on molecular weight of organic poly(carboxylic acids) and organic polycarboxylate salts used as a corrosion inhibitor.
• the molecular weight may be in a range of from 210 to 800g/mol, preferably from 339 to 760 g/mol, more preferably from 468 to 580g/mol.
• organic poly(carboxylic acids) and organic polycarboxylate salts include but are not limited to 2,4,6-(l,3,5-triazine)-organic poly(carboxylic acid), and their salts formed with alkaline metal, alkaline earth metal and the like, such as 2,4,6-(l,3,5-triazine)-organic poly(sodium carboxylate) .
• weight percentage of the corrosion inhibitor in a rust inhibiting lubricant is from 0.1% to 15%, preferably from 0.1% to 10%, more preferably from 0.1% to 6%, even more preferably from 0.2% to 4%, most preferably from 1% to 3% based on total weight of the rust inhibiting lubricant.
• the anti-corrosion agents may include one or more anti-corrosion agents of benzoic acids or anti-corrosion agents of isothiazo lines, such as 5-chloro-2-methyl-4-isothiazolin-3-one, sodium benzoate and the like.
• weight percentage of the anti-corrosion agent in a rust inhibiting lubricant is from 0.05% to 10%, preferably from 0.05% to 5%, more preferably from 0.05% to 2%, and most preferably from 0.1% to 1% based on total weight of the rust inhibiting lubricant.
• Weight percentage of water in a rust inhibiting lubricant is from 30% to 90%, preferably from 35% to 85%, more preferably from 40% to 85%, and most preferably from 50% to 80% based on total weight of the rust inhibiting lubricant.
• an anti-foaming agent may be added to the rust inhibiting lubricant, and the anti-foaming agent can effectively reduce the foam at room temperature.
• Anti-foaming agents that can be used include one or more epoxy polyvinyl ethers, siloxanes or polyalkelene glycols (when temperature is higher than the cloud point of polyalkelene glycol, polyalkelene glycol can be used as the anti-foaming agent).
• Examples of commercially available anti-foaming agents include: Surfynol MD20, Surfynol DF-75 and Surfynol DF-110 manufactured by Air Products and Chemicals, Dow Corning DC544 and Dow Corning DB-100 manufactured by Dow Corning.
• weight percentage of the anti-foaming agent in a rust inhibiting lubricant is from 0.01% to 4%, preferably from 0.05% to 2% based on the total weight of the rust inhibiting lubricant.
• solubilizing agent can be added to the rust inhibiting lubricant.
• Solubilizing agents that can be used include ionic surfactants, non-ionic surfactants and alcoholic surfactants and the like, such as one or more of solubilizing agents selected from ionic sulfonate, alkyl amine, ammonium salt, isopropanol or ethanol, such as secondary alkyl sodium sulfonate, alkyl dimethyl ammonium chloride and the like.
• solubilizing agents include: Genaminox OC (manufactured by Clariant, octyldimethylamine oxide, CAS No.
• the solubilizing agent can also be used to resolve anti-foaming agent.
• ethanol is used in combination with other solubilizing agents.
• weight percentage of the solubilizing agent in a rust inhibiting lubricant is from 0.1% to 40%, preferably from 2% to 30%, more preferably from 5% to 15% based on total weight of the rust inhibiting lubricant.
• the rust inhibiting lubricant may also contain a thickening agent.
• the thickening agent can help improve fluidity of the rust inhibiting lubricant and generate wetting effect. Normally, there are no particular restrictions on selection of the thickening agent. It may include one or more thickening agents selected from polyvinyl alcohol, water soluble cellulose, derivatives of the water soluble cellulose, polyvinyl pyrrolidone. The derivatives of the water soluble cellulose include but are not limited to carboxyalkylated or hydroxyalkylated cellulose, such as carboxymethyl cellulose, carboxyethyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxymethylpropyl cellulose and the like.
• weight percentage of the thickening agent in a rust inhibiting lubricant is from 0.01% to 2%, preferably from 0.05% to 0.5% based on the total weight of the rust inhibiting lubricant.
• the rust inhibiting lubricant may also contain a chelating agent.
• the chelating agent has a function of inhibiting fouling formation, and chelating calcium and magnesium ions in water, and softening hard water.
• the chelating agent may include one or more compounds selected from aminocarboxylic acid, aminocarboxylate salt, organic phosphinic acid, organic phosphonate, such as EDTA, EDTA-2Na, EDTA-4Na, methylnitrilotriacetic acid, DTPMP, DTPMP-Na, DTPMP-2Na and the like.
• weight percentage of the chelating agent in a rust inhibiting lubricant is from 0.1% to 6%, preferably from 0.1% to 3%, more preferably from 0.1% to 1% based on total weight of the rust inhibiting lubricant.
• a formulation containing low foam ingredient is preferably selected.
• a foam level test (STM 100) is carried out for screening the base oil.
• a 5% oil solution is diluted with distilled water having temperature of 25°C or 60°C in a ratio of
• Foam height total height at the time of recording - initial solution height.
• the base oil is preferred.
• Ruhof lubricant is a commercially available lubricant for medical instruments and used as a control.
• Figure 1 shows results of the foam level test at 60°C. It can be seen from the figure that foam height for all the samples 2 to 8 is lower than 50 mL in a period of 20 sec.
• the operation of the automatic cleaning machine also includes a pre-cleaning process. Since the pre-cleaning is carried out at room temperature (25°C), it is necessary to control foam level during the pre-cleaning at 25°C.
• Figure 2 shows the test results at 25°C. It can be seen from the figure that foam height for samples 2, 3 and 8 is lower than 50 mL in a period of 20 sec.
• a rust inhibiting lubricant Ingredients are mixed according to the formula in the table below to prepare a rust inhibiting lubricant. All the raw materials used in the examples are commercially available. All the chemicals with no manufacturer indicated are commercially available conventional chemical materials.
• Comparison example another commercially available lubricant (Ruhof lubricant for medical instruments, an emulsion type of lubricant).
• the rust inhibiting lubricant is diluted with pure water according to a required dilution ratio
• the tinplate is taken out, thoroughly washed and dried;
• Lubricating performance test A lubricating performance test is carried out according to GB/T 3142-1982 as follows:
• test solution 10 mL is poured into the clean oil bath to be used;
• the oil bath is carefully placed under an abrasion shaft, and part of the abrasion shaft is dipped in the test solution, and the oil bath is fixed with a supporting rack;
• a steel cylinder is cleaned with absolute ethanol and placed in the ventilation cabinet. After being dried completely, the steel cylinder is measured with a vernier caliper and its diameter is recorded as D 1. Then the steel cylinder is fixed on a press bar with screws;
• Abrasion testing machine is started and diameter D2 of the abrasion steel cylinder is measured after a certain period of time. Wear of the steel cylinder is calculated;
• BI #1292 (3M biological indicator) is used for this test.
• the biological indicator #1292 is immersed in a lubricant sample
• the biological indicator #1292 is sterilized with steam at 132°C for 8 min;
• the rust inhibiting lubricant oils as shown in the examples of the present invention is used. Control result before the sterilization is positive, but the result obtained with incubation after the sterilization is negative. The test results indicate that the lubricant oil film doesn't block steam penetration.
• a medical tray is lubricated in an automatic cleaning machine, and then oil stain left on surfaces of the medical tray is visually inspected. Results show that none of the lubricants of the embodiments leaves too much oil stain on the surfaces of the medical tray.
• the aqueous rust inhibiting lubricant of the present disclosure is physically stable. Compared with the emulsion type lubricant of the comparison example, this product has equivalent lubricating effects. Since the rust inhibiting lubricant of the present invention contains a corrosion inhibitor, it can effectively prevent oxidation-reduction reaction on metal surfaces, and alleviate corrosion of protein and electrolytic substances to metal, and generate better rust preventing effects. Since the product can be diluted with water in various ratios, lubrication can be performed not only with a medical cleaning machine but also manually. The rust inhibiting lubricant has water soluble low viscosity formulas, which do not contain an emulsifier, with less residual substances being left on the surfaces of the instruments.

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• Chemical & Material Sciences (AREA)
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• Oil, Petroleum & Natural Gas (AREA)
• Organic Chemistry (AREA)
• Lubricants (AREA)

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• 2011
  • 2011-11-11 CN CN201110358105.0A patent/CN103087811B/zh not_active Expired - Fee Related
• 2012
  • 2012-11-08 WO PCT/US2012/064147 patent/WO2013070913A1/en active Application Filing
  • 2012-11-08 IN IN3450CHN2014 patent/IN2014CN03450A/en unknown

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