WO2013066839A3 - Composés et procédés - Google Patents

Composés et procédés Download PDF

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Publication number
WO2013066839A3
WO2013066839A3 PCT/US2012/062514 US2012062514W WO2013066839A3 WO 2013066839 A3 WO2013066839 A3 WO 2013066839A3 US 2012062514 W US2012062514 W US 2012062514W WO 2013066839 A3 WO2013066839 A3 WO 2013066839A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
methods
hdac
enzymes
inhibition
Prior art date
Application number
PCT/US2012/062514
Other languages
English (en)
Other versions
WO2013066839A2 (fr
Inventor
Shomir Ghosh
Mercedes Lobera
Ryan Paul Trump
Cunyu Zhang
Original Assignee
Glaxosmithkline Llc
Tempero Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc, Tempero Pharmaceuticals, Inc. filed Critical Glaxosmithkline Llc
Publication of WO2013066839A2 publication Critical patent/WO2013066839A2/fr
Publication of WO2013066839A3 publication Critical patent/WO2013066839A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des composés ayant la formule : (I) et des sels de ceux-ci, formule dans laquelle A, B, m et n sont tels que définis selon l'invention, et des procédés de fabrication et d'utilisation de ces composés.
PCT/US2012/062514 2011-10-31 2012-10-30 Composés et procédés WO2013066839A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161553757P 2011-10-31 2011-10-31
US61/553,757 2011-10-31
US201261596269P 2012-02-08 2012-02-08
US61/596,269 2012-02-08

Publications (2)

Publication Number Publication Date
WO2013066839A2 WO2013066839A2 (fr) 2013-05-10
WO2013066839A3 true WO2013066839A3 (fr) 2015-06-25

Family

ID=48193011

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/062514 WO2013066839A2 (fr) 2011-10-31 2012-10-30 Composés et procédés

Country Status (1)

Country Link
WO (1) WO2013066839A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108289449A (zh) * 2015-11-19 2018-07-17 巴斯夫欧洲公司 用于防除植物病原性真菌的取代噁二唑
CN108368098B (zh) * 2015-12-18 2022-01-28 先正达参股股份有限公司 杀微生物的噁二唑衍生物

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US9199962B2 (en) * 2011-07-07 2015-12-01 Merck Patent Gmbh Substituted azaheterocycles for the treatment of cancer
EP2729454B1 (fr) 2011-07-08 2015-09-16 Novartis AG Nouveaux dérivés de trifluorométhyl-oxadiazole et leur utilisation pour le traitement de maladies
WO2015187088A1 (fr) 2014-06-04 2015-12-10 Thomas Helledays Stiftelse För Medicinsk Forskning Inhibiteurs mth1 pour le traitement du cancer
CA2948601A1 (fr) 2014-06-04 2015-12-10 Thomas Helledays Stiftelse For Medicinsk Forskning Inhibiteurs de mth1 destines au traitement des etats inflammatoires et auto-immuns
JP6556146B2 (ja) * 2014-08-26 2019-08-07 武田薬品工業株式会社 複素環化合物
US10308643B2 (en) 2015-07-17 2019-06-04 Takeda Pharmaceutical Company Limited Heterocyclic compound
US10357484B2 (en) 2015-07-17 2019-07-23 Takeda Pharmaceutical Company Limited Heterocyclic compound
BR112017027798B1 (pt) 2015-07-27 2023-12-19 Chong Kun Dang Pharmaceutical Corp Compostos de derivado de 1,3,4-oxadiazol sulfamida como inibidor de histona desacetilase 6 e a composição farmacêutica que compreende os mesmos
JP6560436B2 (ja) 2015-07-27 2019-08-14 チョン クン ダン ファーマシューティカル コーポレーション ヒストン脱アセチル化酵素６阻害剤としての１，３，４−オキサジアゾールスルホンアミド誘導体化合物及びこれを含有する薬剤学的組成物
AU2016299485B2 (en) 2015-07-27 2019-02-07 Chong Kun Dang Pharmaceutical Corp. 1,3,4-oxadiazole amide derivative compound as histone deacetylase 6 inhibitor, and pharmaceutical composition containing same
ES2903214T3 (es) * 2015-08-04 2022-03-31 Chong Kun Dang Pharmaceutical Corp Compuestos derivados de 1,3,4-oxadiazol como inhibidores de la histona desacetilasa 6 y la composición farmacéutica que comprende los mismos
EP3342772A4 (fr) 2015-08-25 2019-03-27 Takeda Pharmaceutical Company Limited Composé hétérocyclique
US10501425B2 (en) 2015-10-02 2019-12-10 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
HUE050030T2 (hu) 2015-10-02 2020-11-30 Syngenta Participations Ag Mikrobiocid oxadiazol-származékok
PL3362445T3 (pl) 2015-10-12 2023-08-07 Chong Kun Dang Pharmaceutical Corp. Związki będące pochodnymi oksadiazoloamin jako inhibitor deacetylazy histonowej 6 oraz kompozycja farmaceutyczna obejmujące takie związki
MX2018005388A (es) 2015-11-05 2018-08-16 Basf Se Oxadiazoles sustituidos para combatir hongos fitopatogenos.
US10499644B2 (en) 2015-11-19 2019-12-10 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
UY36999A (es) 2015-12-02 2017-06-30 Syngenta Participations Ag Derivados de aryl oxadiazol fungicidas
US20180368410A1 (en) * 2015-12-17 2018-12-27 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
UY37062A (es) 2016-01-08 2017-08-31 Syngenta Participations Ag Derivados de aryl oxadiazol fungicidas
EP3433252B1 (fr) 2016-03-24 2021-10-27 Syngenta Participations AG Derives d'oxadiazole microbicides
US10986839B2 (en) 2016-04-11 2021-04-27 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
CN109071522B (zh) * 2016-04-12 2022-04-12 先正达参股股份有限公司 杀微生物的噁二唑衍生物
EP3468958B1 (fr) 2016-06-09 2020-12-16 Basf Se Oxadiazoles substitués pour lutter contre des champignons phytopathogènes
US11066396B2 (en) 2016-06-23 2021-07-20 Merck Sharp & Dohme Corp. 3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors
CN106243083B (zh) * 2016-07-12 2018-10-30 浙江宏冠生物药业有限公司 一种伊马替尼制备方法
US10357493B2 (en) 2017-03-10 2019-07-23 Selenity Therapeutics (Bermuda), Ltd. Metalloenzyme inhibitor compounds
MX2019011239A (es) 2017-03-31 2019-10-21 Syngenta Participations Ag Composiciones fungicidas.
WO2018177880A1 (fr) 2017-03-31 2018-10-04 Syngenta Participations Ag Compositions fongicides
WO2018185013A1 (fr) 2017-04-03 2018-10-11 Syngenta Participations Ag Dérivés d'oxadiazole microbiocides
WO2018184985A1 (fr) 2017-04-05 2018-10-11 Syngenta Participations Ag Dérivés d'oxadiazole microbiocides
WO2018184986A1 (fr) 2017-04-05 2018-10-11 Syngenta Participations Ag Dérivés d'oxadiazole microbiocides
BR112019020819B1 (pt) 2017-04-05 2023-12-05 Syngenta Participations Ag Composto de fórmula (i), composição agroquímica, método para controlar ou prevenir a infestação de plantas úteis por micro-organismos fitopatogênicos e uso de um composto de fórmula (i)
BR112019021019B1 (pt) 2017-04-05 2023-12-05 Syngenta Participations Ag Compostos derivados de oxadiazol microbiocidas, composição agrícola, método para controlar ou prevenir a infestação de plantas úteis por microrganismos fitopatogênicos e uso de um composto derivado de oxadiazol
WO2018184984A1 (fr) 2017-04-05 2018-10-11 Syngenta Participations Ag Dérivés d'oxadiazole microbiocides
WO2018184982A1 (fr) 2017-04-05 2018-10-11 Syngenta Participations Ag Dérivés d'oxadiazole microbiocides
TW202334101A (zh) * 2017-04-06 2023-09-01 美商富曼西公司 殺真菌之噁二唑
WO2019027054A1 (fr) 2017-07-31 2019-02-07 Takeda Pharmaceutical Company Limited Composé hétérocyclique
WO2019110663A1 (fr) * 2017-12-05 2019-06-13 Oryzon Genomics, S.A. Dérivés de 1,2,4-oxadiazole en tant qu'inhibiteurs de l'histone désacétylase 6
BR112020021645A2 (pt) 2018-04-26 2021-01-26 Syngenta Participations Ag derivados de oxadiazol microbicidas
KR102316234B1 (ko) 2018-07-26 2021-10-22 주식회사 종근당 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물
CN111285861B (zh) * 2018-12-10 2021-08-17 浙江省化工研究院有限公司 一种含三氟甲基噁二唑取代的嘧啶胺类化合物、其制备方法及应用
AR118673A1 (es) 2019-04-18 2021-10-20 Syngenta Crop Protection Ag Procedimiento para la preparación de derivados de oxadiazol microbiocidas
TWI748491B (zh) 2019-05-31 2021-12-01 韓商鐘根堂股份有限公司 作為組蛋白去乙醯酶6抑制劑之1,3,4-㗁二唑高鄰苯二甲醯亞胺衍生化合物及包含彼之醫藥組合物
WO2020254494A1 (fr) * 2019-06-21 2020-12-24 Bayer Aktiengesellschaft Oxadiazoles fongicides
CA3156060A1 (fr) 2019-09-27 2021-04-01 Takeda Pharmaceutical Company Limited Derives de 2-isoindol-1,3,4-oxadiazole utiles en tant qu'inhibiteurs de hdac6

Citations (4)

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US20050137212A1 (en) * 2002-03-01 2005-06-23 Rodolfo Cadilla Hppars activators
US20080227834A1 (en) * 2005-09-29 2008-09-18 Sanofi-Aventis Derivatives of 2-aminothiazoles and 2-amino-oxazoles, processes for their preparation and their use as pharmaceutical compositions
US20090062252A1 (en) * 2007-08-27 2009-03-05 Helicon Therapeutics, Inc. Therapeutic isoxazole compounds
WO2011088192A1 (fr) * 2010-01-13 2011-07-21 Tempero Pharmaceuticals, Inc. Composés et procédés

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050137212A1 (en) * 2002-03-01 2005-06-23 Rodolfo Cadilla Hppars activators
US20080227834A1 (en) * 2005-09-29 2008-09-18 Sanofi-Aventis Derivatives of 2-aminothiazoles and 2-amino-oxazoles, processes for their preparation and their use as pharmaceutical compositions
US20090062252A1 (en) * 2007-08-27 2009-03-05 Helicon Therapeutics, Inc. Therapeutic isoxazole compounds
WO2011088192A1 (fr) * 2010-01-13 2011-07-21 Tempero Pharmaceuticals, Inc. Composés et procédés

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SHERMETEV ET AL.: "Synthesis of secondary and tertiary aminofurazans.", RUSSIAN CHEMICAL BULLETIN, INTERNATIONAL EDITION, vol. 53, no. 3, March 2004 (2004-03-01), pages 596 - 614 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108289449A (zh) * 2015-11-19 2018-07-17 巴斯夫欧洲公司 用于防除植物病原性真菌的取代噁二唑
CN108368098B (zh) * 2015-12-18 2022-01-28 先正达参股股份有限公司 杀微生物的噁二唑衍生物

Also Published As

Publication number Publication date
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