WO2013026989A3 - Liposome comprenant au moins un derive de cholesterol - Google Patents
Liposome comprenant au moins un derive de cholesterol Download PDFInfo
- Publication number
- WO2013026989A3 WO2013026989A3 PCT/FR2012/051924 FR2012051924W WO2013026989A3 WO 2013026989 A3 WO2013026989 A3 WO 2013026989A3 FR 2012051924 W FR2012051924 W FR 2012051924W WO 2013026989 A3 WO2013026989 A3 WO 2013026989A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cholesterol derivative
- liposome
- liposomes
- relates
- cholesterol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/240,990 US20150056269A1 (en) | 2011-08-25 | 2012-08-22 | Liposome comprising at least one cholesterol derivative |
MX2014002228A MX2014002228A (es) | 2011-08-25 | 2012-08-22 | Liposoma que contiene al menos un derivado de colesterol. |
CA2845691A CA2845691A1 (fr) | 2011-08-25 | 2012-08-22 | Liposome comprenant au moins un derive de cholesterol |
BR112014004163A BR112014004163A2 (pt) | 2011-08-25 | 2012-08-22 | lipossoma, composição, uso de pelo menos um composto de fórmula (i) e uso dos lipossomas |
EP12758576.8A EP2747750A2 (fr) | 2011-08-25 | 2012-08-22 | Liposome comprenant au moins un derive de cholesterol |
CN201280041297.5A CN103764122A (zh) | 2011-08-25 | 2012-08-22 | 包含至少一种胆甾醇衍生物的脂质体 |
JP2014526535A JP6162699B2 (ja) | 2011-08-25 | 2012-08-22 | 少なくとも1つのコレステロール誘導体を含むリポソーム |
AU2013203682A AU2013203682B2 (en) | 2011-08-25 | 2013-04-11 | Liposome comprising at least one cholesterol derivative |
US15/184,122 US20160339041A1 (en) | 2011-08-25 | 2016-06-16 | Liposome comprising at least one cholesterol derivative |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1102594A FR2979239A1 (fr) | 2011-08-25 | 2011-08-25 | Liposome comprenant au moins un derive de cholesterol |
FR1102594 | 2011-08-25 | ||
FR1102862A FR2979240A1 (fr) | 2011-08-25 | 2011-09-21 | Liposome comprenant au moins un derive de cholesterol |
FR1102862 | 2011-09-21 |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/240,990 A-371-Of-International US20150056269A1 (en) | 2011-08-25 | 2012-08-22 | Liposome comprising at least one cholesterol derivative |
AU2013203682A Division AU2013203682B2 (en) | 2011-08-25 | 2013-04-11 | Liposome comprising at least one cholesterol derivative |
US15/184,122 Division US20160339041A1 (en) | 2011-08-25 | 2016-06-16 | Liposome comprising at least one cholesterol derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2013026989A2 WO2013026989A2 (fr) | 2013-02-28 |
WO2013026989A3 true WO2013026989A3 (fr) | 2013-08-08 |
Family
ID=45422200
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2012/051924 WO2013026989A2 (fr) | 2011-08-25 | 2012-08-22 | Liposome comprenant au moins un derive de cholesterol |
Country Status (9)
Country | Link |
---|---|
US (2) | US20150056269A1 (fr) |
EP (1) | EP2747750A2 (fr) |
JP (2) | JP6162699B2 (fr) |
CN (1) | CN103764122A (fr) |
BR (1) | BR112014004163A2 (fr) |
CA (1) | CA2845691A1 (fr) |
FR (2) | FR2979239A1 (fr) |
MX (1) | MX2014002228A (fr) |
WO (1) | WO2013026989A2 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11590079B2 (en) * | 2018-01-18 | 2023-02-28 | EndoProtech, Inc. | Treating microvascular dysfunction |
Citations (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2013087A (en) * | 1978-01-27 | 1979-08-08 | Sandoz Ltd | Sterol liposomes containing medicaments |
FR2650181A1 (fr) * | 1989-07-27 | 1991-02-01 | Stallergenes Lab | Procede pour combiner un melange de substances heterogenes a des liposomes |
WO1999013816A2 (fr) * | 1997-09-16 | 1999-03-25 | Nexstar Pharmaceuticals, Inc. | Compositions a base de liposomes renfermant de la camptothecine |
US6143321A (en) * | 1997-02-06 | 2000-11-07 | Duke University | Liposomes containing active agents |
WO2004082581A2 (fr) * | 2003-03-11 | 2004-09-30 | Trophos | Application a titre de medicaments de derives de cholest-4-en-3- one, compositions pharmaceutiques les renfermant et nouveaux derives |
WO2006027454A1 (fr) * | 2004-09-07 | 2006-03-16 | Trophos | Nouveaux derives du 3,5-seco-4-nor-cholestane et leurs utilisations |
WO2007080270A2 (fr) * | 2005-12-20 | 2007-07-19 | Trophos | Nouveaux derives de l'oxime de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, et procede de preparation |
WO2007101925A1 (fr) * | 2006-03-09 | 2007-09-13 | Trophos | Utilisation de derives du 3,5-seco-4-nor-cholestane pour l'obtention d'un medicament cytoprotecteur |
WO2007118967A1 (fr) * | 2006-03-31 | 2007-10-25 | Trophos | Utilisation de derives du cholest-4-en-3-one pour l'obtention d'un medicament cytoprotecteur |
WO2008077248A1 (fr) * | 2006-12-22 | 2008-07-03 | Miv Therapeutics Inc. | Revêtements pour des dispositifs médicaux implantables pour une administration de liposomes |
WO2008142231A2 (fr) * | 2007-03-28 | 2008-11-27 | Trophos | Nouvelle composition à base d'oxime de cholest-4-èn-3-one |
WO2009044011A2 (fr) * | 2007-07-25 | 2009-04-09 | Trophos | Utilisation d'au moins un dérivé oxime du 3,5-seco-4-nor-cholestane comme antioxydants |
WO2009044010A2 (fr) * | 2007-07-25 | 2009-04-09 | Trophos | Utilisation d'au moins un dérivé oxime de la cholest-4-èn-3-one comme antioxydants |
WO2009092892A2 (fr) * | 2007-10-30 | 2009-07-30 | Trophos | Nouvelle composition pour traiter les effets secondaires des traitements anticancereux |
WO2010012904A2 (fr) * | 2008-07-30 | 2010-02-04 | Trophos | Nouveaux dérivés de l'oxime de cholest-4-èn-3-one, compositions pharmaceutiques les renfermant, et procédé de préparation |
CN101642431A (zh) * | 2009-08-28 | 2010-02-10 | 海南永田药物研究院有限公司 | 奥扎格雷钠脂质体注射剂 |
WO2010076418A1 (fr) * | 2008-12-29 | 2010-07-08 | Trophos | Nouveaux dérivés d'oxime du 3,5-seco-4-nor-cholestane, compositions pharmaceutiques les renfermant, et procédé de préparation |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4975282A (en) * | 1985-06-26 | 1990-12-04 | The Liposome Company, Inc. | Multilamellar liposomes having improved trapping efficiencies |
DE3542773A1 (de) * | 1985-12-04 | 1987-06-11 | Roehm Pharma Gmbh | Hautwirksame pharmaka mit liposomen als wirkstofftraeger |
US5013556A (en) * | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
DE4432378A1 (de) * | 1994-09-12 | 1996-03-14 | Bayer Ag | Injizierbare liposomale Arzneizubereitungen |
WO1997013500A2 (fr) * | 1995-10-12 | 1997-04-17 | Supergen, Inc. | FORMULATION DE LIPOSOMES CONTENANT DES 5β STEROIDES |
GB0111279D0 (en) * | 2001-05-10 | 2001-06-27 | Nycomed Imaging As | Radiolabelled liposomes |
AR031744A1 (es) * | 2001-11-08 | 2003-10-01 | Paoli Tomas De | Proliposomas en polvo, un procedimiento para la elaboracion de dichas proliposomas en polvo, procedimiento para la preparacion de una composicion farmaceutica empleando proliposomas en polvo y aparato para ser empleado en el procedimiento de elaboracion de dichas proliposomas en polvo |
AU2005302255A1 (en) * | 2004-10-28 | 2006-05-11 | Alza Corporation | Lyophilized liposome formulations and method |
US20070178147A1 (en) * | 2005-12-08 | 2007-08-02 | Desai Narendra R | Liposomal compositions |
EP1975486B1 (fr) | 2007-03-28 | 2014-12-03 | Fillon Technologies (SAS Société par Actions Simplifiée) | Valve de dosage |
EP2424872B1 (fr) * | 2009-04-27 | 2017-05-17 | Medical College of Wisconsin, Inc. | Composés neuroprotecteurs et leur utilisation |
WO2011092708A2 (fr) * | 2010-02-01 | 2011-08-04 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Liposomes comprenant des médicaments amphipathiques et procédé pour leur préparation |
-
2011
- 2011-08-25 FR FR1102594A patent/FR2979239A1/fr active Pending
- 2011-09-21 FR FR1102862A patent/FR2979240A1/fr active Pending
-
2012
- 2012-08-22 WO PCT/FR2012/051924 patent/WO2013026989A2/fr active Application Filing
- 2012-08-22 US US14/240,990 patent/US20150056269A1/en not_active Abandoned
- 2012-08-22 BR BR112014004163A patent/BR112014004163A2/pt not_active Application Discontinuation
- 2012-08-22 MX MX2014002228A patent/MX2014002228A/es unknown
- 2012-08-22 CA CA2845691A patent/CA2845691A1/fr not_active Abandoned
- 2012-08-22 JP JP2014526535A patent/JP6162699B2/ja not_active Expired - Fee Related
- 2012-08-22 CN CN201280041297.5A patent/CN103764122A/zh active Pending
- 2012-08-22 EP EP12758576.8A patent/EP2747750A2/fr not_active Withdrawn
-
2016
- 2016-06-16 US US15/184,122 patent/US20160339041A1/en not_active Abandoned
-
2017
- 2017-03-22 JP JP2017056092A patent/JP2017122119A/ja active Pending
Patent Citations (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2013087A (en) * | 1978-01-27 | 1979-08-08 | Sandoz Ltd | Sterol liposomes containing medicaments |
FR2650181A1 (fr) * | 1989-07-27 | 1991-02-01 | Stallergenes Lab | Procede pour combiner un melange de substances heterogenes a des liposomes |
US6143321A (en) * | 1997-02-06 | 2000-11-07 | Duke University | Liposomes containing active agents |
WO1999013816A2 (fr) * | 1997-09-16 | 1999-03-25 | Nexstar Pharmaceuticals, Inc. | Compositions a base de liposomes renfermant de la camptothecine |
WO2004082581A2 (fr) * | 2003-03-11 | 2004-09-30 | Trophos | Application a titre de medicaments de derives de cholest-4-en-3- one, compositions pharmaceutiques les renfermant et nouveaux derives |
WO2006027454A1 (fr) * | 2004-09-07 | 2006-03-16 | Trophos | Nouveaux derives du 3,5-seco-4-nor-cholestane et leurs utilisations |
WO2007080270A2 (fr) * | 2005-12-20 | 2007-07-19 | Trophos | Nouveaux derives de l'oxime de cholest-4-en-3-one, compositions pharmaceutiques les renfermant, et procede de preparation |
WO2007101925A1 (fr) * | 2006-03-09 | 2007-09-13 | Trophos | Utilisation de derives du 3,5-seco-4-nor-cholestane pour l'obtention d'un medicament cytoprotecteur |
WO2007118967A1 (fr) * | 2006-03-31 | 2007-10-25 | Trophos | Utilisation de derives du cholest-4-en-3-one pour l'obtention d'un medicament cytoprotecteur |
WO2008077248A1 (fr) * | 2006-12-22 | 2008-07-03 | Miv Therapeutics Inc. | Revêtements pour des dispositifs médicaux implantables pour une administration de liposomes |
WO2008142231A2 (fr) * | 2007-03-28 | 2008-11-27 | Trophos | Nouvelle composition à base d'oxime de cholest-4-èn-3-one |
WO2009044011A2 (fr) * | 2007-07-25 | 2009-04-09 | Trophos | Utilisation d'au moins un dérivé oxime du 3,5-seco-4-nor-cholestane comme antioxydants |
WO2009044010A2 (fr) * | 2007-07-25 | 2009-04-09 | Trophos | Utilisation d'au moins un dérivé oxime de la cholest-4-èn-3-one comme antioxydants |
WO2009092892A2 (fr) * | 2007-10-30 | 2009-07-30 | Trophos | Nouvelle composition pour traiter les effets secondaires des traitements anticancereux |
WO2010012904A2 (fr) * | 2008-07-30 | 2010-02-04 | Trophos | Nouveaux dérivés de l'oxime de cholest-4-èn-3-one, compositions pharmaceutiques les renfermant, et procédé de préparation |
WO2010076418A1 (fr) * | 2008-12-29 | 2010-07-08 | Trophos | Nouveaux dérivés d'oxime du 3,5-seco-4-nor-cholestane, compositions pharmaceutiques les renfermant, et procédé de préparation |
CN101642431A (zh) * | 2009-08-28 | 2010-02-10 | 海南永田药物研究院有限公司 | 奥扎格雷钠脂质体注射剂 |
Non-Patent Citations (8)
Title |
---|
DATABASE WPI Week 201018, Derwent World Patents Index; AN 2010-C10744, XP002672816 * |
DEMEL R A ET AL: "Structural requirements of sterols for the interaction with lecithin at the air-water interface", BIOCHIMICA ET BIOPHYSICA ACTA. BIOMEMBRANES, AMSTERDAM, NL, vol. 255, no. 1, 17 January 1972 (1972-01-17), pages 311 - 320, XP023350899, ISSN: 0005-2736, [retrieved on 19720117], DOI: 10.1016/0005-2736(72)90030-2 * |
DEMEL R A ET AL: "The effect of sterol structure on the permeability of lipomes to glucose, glycerol and Rb<+>", BIOCHIMICA ET BIOPHYSICA ACTA. BIOMEMBRANES, AMSTERDAM, NL, vol. 255, no. 1, 17 January 1972 (1972-01-17), pages 321 - 330, XP023350900, ISSN: 0005-2736, [retrieved on 19720117], DOI: 10.1016/0005-2736(72)90031-4 * |
MAERKER, G. ET AL: "A-ring oxidation products from .gamma.-irradiation of cholesterol in liposomes", JOURNAL OF THE AMERICAN OIL CHEMISTS' SOCIETY , 70(3), 255-9 CODEN: JAOCA7; ISSN: 0003-021X, vol. 70, no. 3, 1993 - 1993, pages 255 - 259, XP009166580 * |
MARTIN LEE J: "Olesoxime, a cholesterol-like neuroprotectant for the potential treatment of amyotrophic lateral sclerosis.", IDRUGS : THE INVESTIGATIONAL DRUGS JOURNAL AUG 2010, vol. 13, no. 8, August 2010 (2010-08-01), pages 568 - 580, XP007921500, ISSN: 2040-3410 * |
NAKAGAWA Y ET AL: "Transfer of steroids and alpha-tocopherol between liposomal membranes.", JOURNAL OF BIOCHEMISTRY FEB 1980 LNKD- PUBMED:6892636, vol. 87, no. 2, February 1980 (1980-02-01), pages 497 - 502, XP002686453, ISSN: 0021-924X * |
RAMSAMMY L S ET AL: "Association of cholestanol and cholestanone with lysophosphatidylcholine", CHEMISTRY AND PHYSICS OF LIPIDS, LIMERICK, IR, vol. 34, no. 2, 1 February 1984 (1984-02-01), pages 127 - 138, XP025198071, ISSN: 0009-3084, [retrieved on 19840201], DOI: 10.1016/0009-3084(84)90038-0 * |
SCHALLER SOPHIE ET AL: "TRO40303, a New Cardioprotective Compound, Inhibits Mitochondrial Permeability Transition", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 333, no. 3, June 2010 (2010-06-01), pages 696 - 706 URL, XP007920460, ISSN: 0022-3565 * |
Also Published As
Publication number | Publication date |
---|---|
BR112014004163A2 (pt) | 2017-03-14 |
WO2013026989A2 (fr) | 2013-02-28 |
JP2014524460A (ja) | 2014-09-22 |
JP2017122119A (ja) | 2017-07-13 |
FR2979239A1 (fr) | 2013-03-01 |
MX2014002228A (es) | 2014-05-28 |
US20150056269A1 (en) | 2015-02-26 |
CA2845691A1 (fr) | 2013-02-28 |
FR2979240A1 (fr) | 2013-03-01 |
EP2747750A2 (fr) | 2014-07-02 |
US20160339041A1 (en) | 2016-11-24 |
JP6162699B2 (ja) | 2017-07-12 |
CN103764122A (zh) | 2014-04-30 |
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