WO2012157898A3 - Ｆ-18 표지 방사성의약품 합성 장치 및 방법 - Google Patents

Ｆ-18 표지 방사성의약품 합성 장치 및 방법 Download PDF

Info

Publication number
WO2012157898A3
WO2012157898A3 PCT/KR2012/003706 KR2012003706W WO2012157898A3 WO 2012157898 A3 WO2012157898 A3 WO 2012157898A3 KR 2012003706 W KR2012003706 W KR 2012003706W WO 2012157898 A3 WO2012157898 A3 WO 2012157898A3
Authority
WO
WIPO (PCT)
Prior art keywords
synthesizing
labeled radioactive
radioactive pharmaceuticals
synthetizing
container
Prior art date
Application number
PCT/KR2012/003706
Other languages
English (en)
French (fr)
Other versions
WO2012157898A2 (ko
Inventor
이철수
지대윤
허은영
김종민
이병세
길희섭
Original Assignee
서강대학교산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 서강대학교산학협력단 filed Critical 서강대학교산학협력단
Priority to US14/117,622 priority Critical patent/US9254471B2/en
Publication of WO2012157898A2 publication Critical patent/WO2012157898A2/ko
Publication of WO2012157898A3 publication Critical patent/WO2012157898A3/ko

Links

Classifications

    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G4/00—Radioactive sources
    • G21G4/04—Radioactive sources other than neutron sources
    • G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
    • G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0006—Controlling or regulating processes
    • B01J19/004—Multifunctional apparatus for automatic manufacturing of various chemical products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/002—Compounding apparatus specially for enteral or parenteral nutritive solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G7/00—Conversion of chemical elements not provided for in other groups of this subclass
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2037—Separating means having valve means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00132—Controlling the temperature using electric heating or cooling elements
    • B01J2219/00135—Electric resistance heaters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00139—Controlling the temperature using electromagnetic heating
    • B01J2219/00141—Microwaves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00164—Controlling or regulating processes controlling the flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/0005—Isotope delivery systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Manufacturing & Machinery (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nuclear Medicine (AREA)

Abstract

본 발명은 F-18 표지 방사성의약품 합성 장치에 관한 것이다. F-18 표지 방사성의약품 합성 장치는, F-18 방사성 동위원소 공급부, 시약 공급부, 고분자 전구체 카트리지, 제1 가열 유닛, 고분자 화합물 카트리지, 합성 용기, 제2 가열 유닛, 폐용액 용기, 수거 용기, 이송 가스 공급부, 세척액 공급부, 연결 튜브, 복수의 제어 밸브, 그리고 컨트롤러를 포함한다.
PCT/KR2012/003706 2011-05-13 2012-05-11 Ｆ-18 표지 방사성의약품 합성 장치 및 방법 WO2012157898A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US14/117,622 US9254471B2 (en) 2011-05-13 2012-05-11 Apparatus and method for synthesizing F-18 labeled radioactive pharmaceuticals

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2011-0045388 2011-05-13
KR20110045388A KR101221483B1 (ko) 2011-05-13 2011-05-13 Ｆ-18 표지 방사성의약품 합성 장치 및 방법

Publications (2)

Publication Number Publication Date
WO2012157898A2 WO2012157898A2 (ko) 2012-11-22
WO2012157898A3 true WO2012157898A3 (ko) 2013-01-24

Family

ID=47177452

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/003706 WO2012157898A2 (ko) 2011-05-13 2012-05-11 Ｆ-18 표지 방사성의약품 합성 장치 및 방법

Country Status (3)

Country Link
US (1) US9254471B2 (ko)
KR (1) KR101221483B1 (ko)
WO (1) WO2012157898A2 (ko)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101465655B1 (ko) * 2013-05-09 2014-12-10 성균관대학교산학협력단 중간블록이 포함된 온도조절유닛을 갖는 방사성 화합물 합성시스템
KR101413629B1 (ko) * 2013-05-10 2014-07-04 성균관대학교산학협력단 일회용 키트로 구성된 저장부를 포함하는 방사성 화합물 합성 시스템
WO2014175714A1 (ko) * 2013-04-26 2014-10-30 성균관대학교 산학협력단 방사성 화합물 합성모듈 제조방법 및 방사성 화합물 합성 시스템
KR101409893B1 (ko) * 2013-05-10 2014-06-19 성균관대학교산학협력단 밀폐성이 향상된 방사성 화합물 합성 시스템
PL3084774T3 (pl) * 2013-12-20 2020-11-02 Ge Healthcare Limited Sposoby i układy do opróżniania zbiornika na odpady
KR101668724B1 (ko) * 2014-05-30 2016-10-24 성균관대학교산학협력단 방사성 화합물 합성모듈
KR102321419B1 (ko) * 2014-11-24 2021-11-04 한국원자력의학원 I-123 방사성 의약품 fp-cit 원격 합성장치
CN104787435B (zh) * 2015-04-30 2016-03-02 中国石油大学(华东) 自主式防污染危化品物流容器
KR101745879B1 (ko) 2015-07-14 2017-06-12 서강대학교산학협력단 방사성 의약품 제조 카세트의 내부 순환 반응용기 및 그를 이용한 방사성 의약품 제조방법
WO2017095666A1 (en) * 2015-12-04 2017-06-08 Carefusion 303, Inc. Tube management structures for automatic drug compounder
KR101903695B1 (ko) * 2016-11-28 2018-10-04 가천대학교 산학협력단 고온 불활성 기체를 이용한 불소-18 화합물 합성장치
US20180209921A1 (en) * 2017-01-20 2018-07-26 Mallinckrodt Nuclear Medicine Llc Systems and methods for assaying an eluate of a radionuclide generator
EP3600216B1 (en) * 2017-03-24 2021-04-28 CareFusion 303, Inc. Waste container for automatic drug compounder
CN110662523B (zh) * 2017-03-24 2021-11-23 康尔福盛303公司 用于自动药剂复配机的注射器泵
KR101909869B1 (ko) * 2018-04-27 2018-10-18 최정윤 국소지방 분해용 주사제 조성물 및 이의 스마트 조성 시스템
CN110356604B (zh) * 2019-06-26 2021-09-24 康美药业股份有限公司 一种智能中药包装方法
CN110606227B (zh) * 2019-08-05 2021-09-03 上海盛榕医疗器械科技有限公司 一种全自动核素分装系统及方法
CN116812208B (zh) * 2023-08-29 2023-10-31 成都中核高通同位素股份有限公司 锝[99mTc]注射液定量分装装置及分装方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09263594A (ja) * 1996-03-29 1997-10-07 N K K Plant Kensetsu Kk 標識反応および加水分解反応をカラムで行うｆｄｇ合成装置
JP2008515793A (ja) * 2004-10-05 2008-05-15 ジーイー・ヘルスケア・リミテッド 脱保護の方法
KR20080078233A (ko) * 2007-02-22 2008-08-27 (주)퓨쳐켐 양성자성 용매와 이에 녹는 염들을 이용한 음이온 교환고분자 지지체로부터의 플루오린-18 플루오라이드 용리와이를 이용한 플루오린-18의 표지방법
JP2009165597A (ja) * 2008-01-15 2009-07-30 Sumitomo Heavy Ind Ltd Ｒｉ化合物合成装置

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932178A (en) * 1996-03-29 1999-08-03 Nkk Plant Engineering Corporation FDG synthesizer using columns

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09263594A (ja) * 1996-03-29 1997-10-07 N K K Plant Kensetsu Kk 標識反応および加水分解反応をカラムで行うｆｄｇ合成装置
JP2008515793A (ja) * 2004-10-05 2008-05-15 ジーイー・ヘルスケア・リミテッド 脱保護の方法
KR20080078233A (ko) * 2007-02-22 2008-08-27 (주)퓨쳐켐 양성자성 용매와 이에 녹는 염들을 이용한 음이온 교환고분자 지지체로부터의 플루오린-18 플루오라이드 용리와이를 이용한 플루오린-18의 표지방법
JP2009165597A (ja) * 2008-01-15 2009-07-30 Sumitomo Heavy Ind Ltd Ｒｉ化合物合成装置

Also Published As

Publication number Publication date
KR20120127111A (ko) 2012-11-21
US9254471B2 (en) 2016-02-09
WO2012157898A2 (ko) 2012-11-22
US20150087868A1 (en) 2015-03-26
KR101221483B1 (ko) 2013-01-16

Similar Documents

Publication Publication Date Title
WO2012157898A3 (ko) Ｆ-18 표지 방사성의약품 합성 장치 및 방법
EP2534096A4 (en) CHEMICAL PROCESSES AND REACTORS FOR EFFICIENTLY PRODUCING HYDROGEN-BASED FUELS AND STRUCTURAL MATERIALS, AND ASSOCIATED SYSTEMS AND METHODS
MX351101B (es) Sistema y metodo para la preparacion de catalizadores.
MX2014010549A (es) Plan maestro para el sistema de automatizacion de maquina de fase dinamica.
ZA201403518B (en) Apparatus, process, and system for monitoring the integrity of containers
AP3747A (en) Temperature control system, hydrocarbon synthesis reaction apparatus, hydrocarbon synthesis reaction system, and temperature control process
MX2013007699A (es) Solucion de eluyente.
MY180633A (en) Solid particles, containing lactam, activator, and catalyst, method for producing said solid particles, and use of said solid particles
ZA201408696B (en) A high rate chemical softening process
PL3476807T3 (pl) Sposób działania instalacji zmiękczania wody, z ważeniem zasobnika
UA117984C2 (uk) Спосіб і установка для витягання радіоактивних нуклідів з відпрацьованих смоляних матеріалів
PL2408726T3 (pl) Sposób dostarczania ciepła do konwersji chemicznej oraz proces i układ, w których stosuje się sposób wytwarzania olefiny
EP2686228A4 (en) DEVICE, SYSTEM AND METHOD FOR CYCLE IMPROVEMENTS
ZA201305390B (en) Catalyst recovery system, hydrocarbon synthesis reaction apparatus,hydrocarbon synthesis reaction system,and catalyst receovery process
GB2495138B (en) Access control apparatus for a bicycle, bicycle sharing system, and method for operating bicycle sharing system
PT2908934T (pt) Método utilizando um sistema pneumático de carregamento denso de catalisador em tubos de baioneta para reator permutador de reforma a vapor com tubo de abastecimento de gás amovível
GB201612397D0 (en) A method for producing a carbon containing product from a gaseous carbon containing educt using microorganisms in a reaction vessel
EP2834345C0 (en) APPARATUS, SYSTEM & METHOD PROVIDING FLUID FLOW FOR CELL GROWTH
AP4062A (en) Hydrocarbon synthesis reaction apparatus, start-up process thereof, and hydrocarbon synthesis reaction system
PL2908935T3 (pl) Sposób stosujący system pneumatyczny gęstego ładowania katalizatora w rurach bagnetowych dla reaktora-wymiennika do reformingu parowego przy zastosowaniu dodatkowej rury do wprowadzania cząstek stałych
FR2984407B1 (fr) Procede de chauffage d'un module de transfert d'un systeme de catalyseur scr
GB201208901D0 (en) Method and apparatus for reaction chromatography
ZA201404692B (en) Suitable control method for a system of photovoltaic concentration modules
ZA201303337B (en) Apparatus,process and system for delivering fluid to a distillation column or reactor
EP2520393C0 (de) Überwachungsvorrichtung für dampfphasen-lötanlage ; dampfphasen-lötanlage mit einer solchen vorrichtung ; verfahren zum überwachen einer dampfphasen-lötanlage

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 14117622

Country of ref document: US

122 Ep: pct application non-entry in european phase

Ref document number: 12785332

Country of ref document: EP

Kind code of ref document: A2