WO2012142511A2 - Orthomolecular compositions and their use in stabilizing the extracellular matrix - Google Patents

Orthomolecular compositions and their use in stabilizing the extracellular matrix Download PDF

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Publication number
WO2012142511A2
WO2012142511A2 PCT/US2012/033659 US2012033659W WO2012142511A2 WO 2012142511 A2 WO2012142511 A2 WO 2012142511A2 US 2012033659 W US2012033659 W US 2012033659W WO 2012142511 A2 WO2012142511 A2 WO 2012142511A2
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composition
amount
orthomolecular
weight
aqueous
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PCT/US2012/033659
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English (en)
French (fr)
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WO2012142511A3 (en
Inventor
Joseph F. MCWHERTER
Uzzi REISS
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Md Matrix Health Llc Dba Md Matrix Health Inc
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Application filed by Md Matrix Health Llc Dba Md Matrix Health Inc filed Critical Md Matrix Health Llc Dba Md Matrix Health Inc
Publication of WO2012142511A2 publication Critical patent/WO2012142511A2/en
Priority to US14/054,578 priority Critical patent/US20140193480A1/en
Publication of WO2012142511A3 publication Critical patent/WO2012142511A3/en
Priority to US15/147,715 priority patent/US9610258B2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/121—Ketones acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/26—Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
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    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0041—Mammary glands, e.g. breasts, udder; Intramammary administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
PCT/US2012/033659 2011-04-15 2012-04-13 Orthomolecular compositions and their use in stabilizing the extracellular matrix WO2012142511A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US14/054,578 US20140193480A1 (en) 2011-04-15 2013-10-15 Topical anti-inflammatory compositions and uses thereof
US15/147,715 US9610258B2 (en) 2011-04-15 2016-05-05 Methods of stabilizing the extracellular matrix and compositions therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161476148P 2011-04-15 2011-04-15
US61/476,148 2011-04-15

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WO2012142511A3 WO2012142511A3 (en) 2014-05-30

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CN102961483A (zh) * 2012-12-07 2013-03-13 郭玉玲 一种治疗腰腿痛的中药组合物及其制备方法
CN103550330A (zh) * 2013-11-12 2014-02-05 刘序会 一种治疗子宫肌瘤的中药药剂
WO2015073598A1 (en) * 2013-11-13 2015-05-21 In Ingredients, Inc. Extracts of rosemary or hemerocallis fulva and methods of using same to promote circadian rhythm
WO2015081319A2 (en) 2013-11-27 2015-06-04 Research Foundation Of The City University Of New York Activity enhancing curcumin compositions and methods of use
CN104856980A (zh) * 2014-02-21 2015-08-26 沈阳药科大学 四氢姜黄素的医药用途
WO2015164504A1 (en) * 2014-04-23 2015-10-29 Lifevantage Corporation Topical compositions and methods for reducing oxidative stress
US9504754B2 (en) 2013-03-15 2016-11-29 South Dakota Board Of Regents Curcuminoid complexes with enhanced stability, solubility and/or bioavailability
JP2017524700A (ja) * 2014-07-23 2017-08-31 スキンテック ライフ サイエンス リミテッド 医薬品
WO2017146690A1 (en) 2016-02-24 2017-08-31 Muhammed Majeed Adaptogenic compositions and applications thereof
CN107684590A (zh) * 2017-08-25 2018-02-13 董方红 一种治疗精囊囊肿的中药
US9901616B2 (en) 2011-08-31 2018-02-27 University Of Georgia Research Foundation, Inc. Apoptosis-targeting nanoparticles
EP3166602A4 (en) * 2014-07-09 2018-03-07 McCord, Darlene E. Compositions for anti-inflammatory, antioxidant effects and improved respiratory function by specific histone deacetylase inhibition
JP2018518513A (ja) * 2015-06-26 2018-07-12 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド 天然の化合物および／または規定食を用いた炎症の治療方法
WO2019070865A1 (en) * 2017-10-03 2019-04-11 Board of Supervisors for the University of Louisiana System SULFORAPHANE ACTIVATED SELF-EMULSIFIABLE MEDICATION DELIVERY SYSTEMS
US10398663B2 (en) 2014-03-14 2019-09-03 University Of Georgia Research Foundation, Inc. Mitochondrial delivery of 3-bromopyruvate
US10416167B2 (en) 2012-02-17 2019-09-17 University Of Georgia Research Foundation, Inc. Nanoparticles for mitochondrial trafficking of agents
WO2020043748A1 (en) 2018-08-28 2020-03-05 Perpetuum Ventures Bvba Sulforaphane-melatonin-like compound
US11020372B2 (en) 2015-03-24 2021-06-01 University Of Florida Research Foundation, Incorporated Dietary and natural product management of negative side effects of cancer treatment
CN113509478A (zh) * 2015-12-02 2021-10-19 金印株式会社 育发生发促进剂
EP3955754A4 (en) * 2019-05-08 2023-01-04 Gamot Global Pte. Ltd. USE OF ISOTHIOCYANATE IN SMOKELESS TOBACCO PRODUCTS
US11666549B2 (en) 2013-03-14 2023-06-06 University Of Florida Research Foundation, Incorporated Regulation of cancer using natural compounds and/or diet

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US10441561B2 (en) 2012-07-26 2019-10-15 The William M. Yanbrough Foundation Method for treating benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer
US10434081B2 (en) 2012-07-26 2019-10-08 The William M. Yarbrough Foundation Inhibitors of macrophage migration inhibitory factor
US10434082B2 (en) 2012-07-26 2019-10-08 The William M. Yarbrough Foundation Isothiocyanate functional compounds augmented with secondary antineoplastic medicaments and associated methods for treating neoplasms
US10335387B2 (en) 2012-07-26 2019-07-02 The William M. Yarbrough Foundation Method for treating infectious diseases with isothiocyanate functional compounds
US20140275235A1 (en) * 2013-03-15 2014-09-18 Loic Pierre Deleyrolle Treatment of Proliferative Disorders
AU2016245984B2 (en) 2015-04-10 2021-03-25 Bioresponse, L.L.C. Self-emulsifying formulations of DIM-related indoles
US11576853B2 (en) 2015-04-29 2023-02-14 CSI: Create.Solve. Innovate. LLC Antioxidant compositions and methods of protecting skin, hair and nails against high energy blue-violet light
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JP6662643B2 (ja) * 2016-01-13 2020-03-11 金印株式会社 抗酸化剤
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CN109419634B (zh) * 2017-08-31 2023-01-31 富士胶片株式会社 水包油型乳化组合物以及皮肤外用剂
CA3090394A1 (en) 2018-02-09 2019-08-15 Shaoyun LIU Methods for treating mitochondrial disorders
CN108403740A (zh) * 2018-04-18 2018-08-17 厦门中药厂有限公司 八宝丹及其制剂在制备治疗血精症的药物中的应用
US20220054397A1 (en) * 2020-08-18 2022-02-24 Adriana Strimbu Compositions for Treatment of Nails and skin
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CN112891344A (zh) * 2021-02-18 2021-06-04 安徽医科大学第一附属医院 一种褪黑素在制备治疗自身免疫性前列腺炎药物中的应用、治疗自身免疫性前列腺炎的药物
US20230277498A1 (en) * 2022-01-13 2023-09-07 Topix Pharmaceuticals, Inc. Botanical calming composition
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Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9901616B2 (en) 2011-08-31 2018-02-27 University Of Georgia Research Foundation, Inc. Apoptosis-targeting nanoparticles
US10416167B2 (en) 2012-02-17 2019-09-17 University Of Georgia Research Foundation, Inc. Nanoparticles for mitochondrial trafficking of agents
US10845368B2 (en) 2012-02-17 2020-11-24 University Of Georgia Research Foundation, Inc. Nanoparticles for mitochondrial trafficking of agents
CN102961483A (zh) * 2012-12-07 2013-03-13 郭玉玲 一种治疗腰腿痛的中药组合物及其制备方法
US11666549B2 (en) 2013-03-14 2023-06-06 University Of Florida Research Foundation, Incorporated Regulation of cancer using natural compounds and/or diet
US9504754B2 (en) 2013-03-15 2016-11-29 South Dakota Board Of Regents Curcuminoid complexes with enhanced stability, solubility and/or bioavailability
CN103550330B (zh) * 2013-11-12 2014-10-29 刘序会 一种治疗子宫肌瘤的中药药剂
CN103550330A (zh) * 2013-11-12 2014-02-05 刘序会 一种治疗子宫肌瘤的中药药剂
WO2015073598A1 (en) * 2013-11-13 2015-05-21 In Ingredients, Inc. Extracts of rosemary or hemerocallis fulva and methods of using same to promote circadian rhythm
US10039798B2 (en) 2013-11-13 2018-08-07 In Ingredients, Inc. Extracts of rosemary or hemerocallis fulva and methods of using same to promote circadian rhythm
WO2015081319A3 (en) * 2013-11-27 2015-11-19 Research Foundation Of The City University Of New York Activity enhancing curcumin compositions and methods of use
WO2015081319A2 (en) 2013-11-27 2015-06-04 Research Foundation Of The City University Of New York Activity enhancing curcumin compositions and methods of use
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