WO2012132720A1 - Appareil d'injection d'un médicament et système d'injection d'un médicament - Google Patents

Appareil d'injection d'un médicament et système d'injection d'un médicament Download PDF

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Publication number
WO2012132720A1
WO2012132720A1 PCT/JP2012/055025 JP2012055025W WO2012132720A1 WO 2012132720 A1 WO2012132720 A1 WO 2012132720A1 JP 2012055025 W JP2012055025 W JP 2012055025W WO 2012132720 A1 WO2012132720 A1 WO 2012132720A1
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Prior art keywords
drug
subject
irradiation
ultrasonic
introduction
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PCT/JP2012/055025
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English (en)
Japanese (ja)
Inventor
玉野　聡
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株式会社 日立メディコ
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Publication of WO2012132720A1 publication Critical patent/WO2012132720A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0047—Ultrasound therapy interstitial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0086—Beam steering
    • A61N2007/0095—Beam steering by modifying an excitation signal

Definitions

  • the present invention relates to a drug introduction device and a drug introduction system, and more particularly to a technique for promoting introduction of a drug using ultrasonic waves.
  • Patent Document 1 proposes that a malignant tumor is treated by introducing a substance such as an anticancer agent or a gene used for gene therapy (hereinafter referred to as a drug) into the cells of the malignant tumor.
  • a substance such as an anticancer agent or a gene used for gene therapy (hereinafter referred to as a drug)
  • a drug a substance used for gene therapy
  • an ultrasonic diagnostic device is used, and when the drug administered from the vein to the subject reaches the treatment area where the malignant tumor exists, the ultrasonic wave is predetermined. It has been proposed to irradiate for a time to facilitate the introduction of drugs into cells of malignant tumors.
  • an ultrasonic probe is brought into close contact with the body surface of a subject, an ultrasonic wave is irradiated to a region having a malignant tumor, and an ultrasonic image is generated based on the reflected echo signal, A treatment area and an ultrasound irradiation plan are set based on the ultrasound image.
  • a drug used in the treatment method as in Patent Document 1 is generally formed so as to specifically bind to a malignant tumor cell and enter the cell. Therefore, when a drug is administered into a blood vessel, the drug circulates in the body together with blood, binds to malignant tumor cells, and is introduced into the cells. At this time, since the drug does not easily enter the cell, the drug accumulates in the treatment area where cells of the malignant tumor are present. Therefore, by irradiating the treatment area where the drug is accumulated with ultrasonic waves, introduction of the drug into the cells of the malignant tumor can be promoted.
  • the problem to be solved by the present invention is to improve the usability by reducing the burden on the operator and the subject when performing a treatment for introducing a drug into cells using ultrasound.
  • the drug introduction device of the present invention includes a vibrator for irradiating a subject with ultrasonic waves, and a drug administered into a blood vessel by irradiating the treatment region of the subject with ultrasound.
  • a control panel for inputting the irradiation conditions to be introduced into the device, a control device for controlling the ultrasonic irradiation position on the treatment area, a control device for controlling the ultrasonic irradiation based on the irradiation conditions, and supplying power to the vibrator and the control device
  • the ultrasonic transmission surface of the vibrator is attached to the body surface in close contact with or embedded in the body corresponding to the treatment area of the subject.
  • the subject since it is possible to perform treatment for introducing a medicine by irradiating ultrasonic waves with a medicine introduction device attached to the subject, the subject can move, and the operator can attach to the subject. There is no need to be attached. As a result, the burden on the operator and the subject can be reduced, and the usability of the apparatus can be improved.
  • the control device irradiates the treatment area with ultrasonic waves based on the ultrasonic irradiation conditions set by the control panel, for example, the ultrasonic irradiation intensity, the irradiation cycle, and the irradiation timing.
  • the ultrasonic irradiation intensity for example, the ultrasonic intensity, the irradiation cycle, and the irradiation timing.
  • the irradiation range of the ultrasonic wave is set based on the depth range and the spread range from the body surface of the treatment area obtained by another medical device.
  • the belt provided on the drug introduction device can be wound around the body surface of the subject.
  • the drug introduction device when mounted in the body of the subject, the subject can be cut open and implanted subcutaneously.
  • medical agent introduction apparatus the position where a treatment area
  • the irradiation range can be set. For example, an ultrasonic image of a reference treatment area is input in advance, and the position of the current treatment area can be obtained by comparing the ultrasonic image with the generated ultrasonic image. Can be irradiated. According to this, even if the treatment region moves due to body movement such as breathing of the subject, the position of the treatment region can be tracked, so that the treatment region can be irradiated with ultrasonic waves reliably.
  • a reflected echo signal is transmitted by wireless communication to an external drug introduction control device, an ultrasonic image is generated by the external drug introduction control device, and the position of the treatment area on the ultrasonic image is obtained and obtained.
  • This position can be used as an ultrasonic irradiation position.
  • the ultrasonic image is generated by an external device, it is not necessary to provide a device for generating an ultrasonic image in the drug introduction device attached to the subject, and thus the drug introduction device can be miniaturized.
  • the drug introduction device is implanted in the body, it is desirable to reduce the size of the device. Therefore, it is preferable to generate an ultrasonic image using an external device.
  • the ultrasonic wave can be configured to detect the drug concentration in the blood in the treatment area and irradiate ultrasonic waves when the detected concentration reaches the set concentration. According to this, since the irradiation timing of the ultrasonic wave is determined based on the actual drug concentration in the treatment region, the accuracy of the irradiation timing can be improved as compared with the case where the ultrasonic wave irradiation timing is set in advance.
  • it can replace with the chemical
  • a component whose concentration varies depending on the drug such as red blood cells and white blood cells, can be adopted as the indicator component.
  • the ultrasonic contrast agent when a drug is administered into a blood vessel of a subject together with an ultrasonic contrast agent in a bubble, the ultrasonic contrast agent is expanded and contracted to move with the drug.
  • the ultrasonic contrast medium bubbles can be ruptured by irradiating ultrasonic waves with a second intensity higher than the irradiation intensity of 1. According to this, the contact property between the cell to be treated and the drug is enhanced by the ultrasonic wave having the first irradiation intensity, and the drug easily enters the cell.
  • the drug enters the cell due to the impact, so the drug is introduced into the cell. Can be further promoted.
  • a tank for storing a medicine mixed with a medicine or a bubble ultrasound contrast agent, and an administration device for administering the medicine in the tank or a medicine mixed with a bubble ultrasound contrast agent into a blood vessel of a subject. can be provided. According to this, since the medicine can be administered by the medicine introduction device attached to the subject and the medicine can be administered without going to the hospital or the like, the burden on the subject can be further reduced.
  • the administration of the drug can be controlled based on a preset time or cycle. Further, in the case where a sensor for detecting the concentration of a drug in blood or the concentration of a preset index component in blood is provided in the drug introduction device, the drug can be controlled to be administered when the detected concentration falls below a set value.
  • the drug introduction system of the present invention is configured so that the drug introduction device and the drug introduction control device can wirelessly communicate with each other, and the drug introduction device includes a vibrator that transmits and receives ultrasonic waves to and from a subject, A control device that controls the irradiation of the ultrasonic wave based on the treatment area of the subject and the ultrasonic wave irradiation condition transmitted from the communication device of the introduction control device, and a battery that supplies power to the vibrator and the control device,
  • the ultrasonic wave transmission / reception surface of the vibrator is attached to the body surface in close contact with the treatment area of the subject or embedded in the body, and the medicine introduction control device transmits from the communication device of the medicine introduction device.
  • a generation device that generates an ultrasonic image based on the reflected echo signal of the ultrasonic wave, a display device that displays the ultrasonic image, a treatment area of the subject is set on the ultrasonic image, and the treatment area is Apply sound waves
  • the drug administered to the tube characterized in that it comprises a control panel for inputting irradiation conditions to be introduced into the cell.
  • the drug introduction apparatus can be further reduced in size as compared with the drug introduction apparatus having the control panel described above. It should be noted that any one of the above-described drug introduction devices can be appropriately selected and used as the drug introduction device used in the present drug introduction system.
  • the present invention it is possible to reduce the burden on the operator and the subject at the time of performing treatment for introducing a drug into cells using ultrasonic waves, and it is possible to improve usability.
  • FIG. 1 is a block diagram of a drug introduction device according to a first embodiment of the present invention.
  • Conceptual diagram explaining the irradiation range of ultrasonic waves Block diagram of the drug introduction device of Embodiment 2 of the present invention
  • Block diagram of the drug introduction device of Embodiment 5 of the present invention The figure which shows the state which mounted
  • FIG. 9 is a block diagram showing a modification of the medicine introduction device according to the fifth embodiment.
  • the figure which shows the modification of irradiation control of FIG. Block diagram showing a drug introduction system of Embodiment 7 of the present invention
  • Embodiment 1 is a drug introduction device 1 attached to the outer skin (body surface) of a subject.
  • the drug introduction device 1 inputs a transducer unit 3 in which a plurality of transducers are arranged, and an irradiation condition for introducing a drug administered into the blood vessel by irradiating the treatment area 4 of the subject into the cell.
  • the transducer unit 3 has an ultrasonic transmission surface formed by two-dimensionally arranging a plurality of transducers that are in close contact with the skin of the subject.
  • Each transducer is connected to the ultrasonic transmission circuit 9 so that driving power is supplied from the battery device 15 via the ultrasonic transmission circuit 9.
  • the ultrasonic transmission circuit 9 supplies transmission power to each transducer by performing transmission processing such as focus processing and amplification processing based on a control signal input from the microcomputer 7.
  • the control panel 5 is configured so that an operator such as a doctor can input and set information on the treatment area 4, ultrasonic waves, and irradiation conditions to the microcomputer 7.
  • the information of the treatment region 4 is, for example, a depth range and a spread range from the body surface of the treatment region 4 shown in FIG. 3, and the irradiation conditions are, for example, the irradiation intensity of ultrasonic waves, the repetition cycle of irradiation, It is irradiation timing, such as irradiation start time and irradiation end time.
  • the microcomputer 7 controls the ultrasonic irradiation range within the treatment area 4 based on the input information of the treatment area 4, and transmits a control signal for controlling the ultrasonic irradiation based on the irradiation conditions.
  • the signal is output to the circuit 9.
  • the battery device 15 includes a battery 11 that supplies power to the vibrator unit 3, the microcomputer 7, the ultrasonic transmission circuit 9, and the like, and a battery control circuit 13 that controls charging / discharging of the battery 11.
  • the drug introduction device 1 is formed, for example, by housing the vibrator unit 3, the control panel 5, the microcomputer 7, the battery device 15 and the like in a case. Further, a belt 19 is provided in which the ultrasonic wave transmitting / receiving surface of the transducer unit 3 is brought into close contact with the outer skin of the subject, and the drug introduction device 1 is fixedly attached to the subject. It is preferable that the ultrasonic transmission surface of the transducer unit 3 is exposed from the case.
  • the belt 19 is formed in, for example, a flat belt shape, and is wound around the subject and attached so that the drug introduction device 1 is in close contact with the body surface of the subject.
  • One end of the belt 19 is fixed to the case of the drug introduction device 1.
  • the other end is detachably formed in the case of the drug introduction device 1, and the winding length can be adjusted according to the attachment / detachment position.
  • the wrapping length is adjusted according to the position corresponding to the treatment region, and the drug introduction device 1 can be attached to the subject.
  • the belt 19 since the thickness of the winding position changes due to body movement such as breathing, the belt 19 can be formed of a flexible material so that the change due to the body movement can be absorbed.
  • the operation of the drug introduction device 1 configured as described above will be described along with a treatment method for introducing a drug into cells using ultrasonic waves.
  • the drug used in this treatment method is a drug injected into a blood vessel.
  • an anticancer drug that enters the cancer cell to be treated and suppresses the growth of the cancer cell, or a cancer cell.
  • Such a drug comprises a ligand that specifically binds to a specific receptor (receptor) of a cancer cell.
  • drugs that have come into contact with cancer cells bind to cancer cells, and drugs that have not come into contact return to the treatment area 4 again by blood circulation, so the number of drugs that bind to cancer cells gradually increases. To do. Thereby, the drug is accumulated in a region where cancer cells are present.
  • the drug is introduced into the cancer cell by accelerating the entrance of the drug into the cancer cell by irradiating ultrasonic waves. Therefore, the desired introduction efficiency can be ensured by irradiating the ultrasonic wave after the drug is accumulated in the region where the cancer cells are present and the drug concentration reaches the set concentration.
  • the irradiation of ultrasonic waves is waited until the drug concentration reaches the set concentration.
  • the time until the blood concentration of the drug is halved (half-life) is several hours to several tens of hours, if the treatment is continued during that time, the irradiation time of ultrasonic waves becomes longer.
  • the treatment area 4 and the drug to be used for treatment are determined based on the examination performed before the treatment. Further, the irradiation condition of the ultrasonic wave is determined based on the treatment region 4 and the medicine used for the treatment.
  • Information on the treatment region 4 such as the depth range and spread range from the body surface of the treatment region 4 and the irradiation conditions such as the irradiation intensity of the ultrasonic wave, the repetition period of irradiation, and the irradiation timing are displayed via the control panel 5. Input settings are made to the computer 7.
  • the ultrasonic transmission surface is brought into close contact with the outer skin at a position where the treatment area 4 falls within the ultrasonic irradiation possible range, and the belt 19 is wound around the subject to introduce the drug. Attach 1 to the subject.
  • the information on the mounting position of the drug introduction device 1 and the treatment region 4 can be obtained based on, for example, an image of another medical device such as an X-ray CT device obtained by an examination before treatment.
  • the treatment region 4 is identified on the image, and the position where the treatment region 4 falls within the ultrasonic irradiation possible range is set as the mounting position of the drug introduction device 1. Then, the depth range and the spread range of the treatment region 4 at the mounting position are used as information on the treatment region 4.
  • the microcomputer 7 focuses on the treatment area 4 based on the input information about the treatment area 4 and determines the condition of the focus process.
  • the microcomputer 7 outputs a control signal generated based on the focus processing condition and the irradiation condition to the ultrasonic transmission circuit 9.
  • the ultrasonic transmission circuit 9 applies a voltage to the transducer unit 3 based on the input control signal, and irradiates the treatment region 4 with the convergent beam 17 focused in the treatment region 4 .
  • the entry of the drug into the cancer cell in the treatment region 4 can be promoted by the vibration of the drug near the focal point.
  • the introduction of the drug into the cancer cells in the entire treatment region 4 can be promoted by irradiating the ultrasonic wave with changing the focus to other positions in the treatment region 4.
  • the apparatus for irradiating ultrasonic waves is separated from the ultrasonic diagnostic apparatus and attached to the subject, the subject can move and the operator does not need to stick to the subject. Therefore, the burden on the operator and the subject can be reduced, and the usability of the apparatus used for introducing the drug can be improved.
  • the introduction of the drug into the cells can be promoted by irradiating with ultrasonic waves, the dose of the drug can be suppressed. That is, when a drug that is difficult to be introduced into cells is used, the dose may be increased to promote the introduction of the drug into the cells, which may increase the probability of side effects.
  • the introduction of the drug into the cells can be promoted by irradiating the ultrasonic wave, the dose of the drug can be reduced as compared with the case where the ultrasonic wave is not irradiated, and the probability of occurrence of a side effect can be reduced.
  • the drug when the ultrasonic wave is irradiated, the drug is introduced into the cell and the drug concentration in the treatment area 4 decreases.However, when a drug with a long half-life is used, the drug circulates in the body, so the treatment area 4 The drug accumulates again. By preliminarily obtaining this accumulation period through experiments or the like and setting the obtained period as the repetition period of irradiation, it is possible to irradiate ultrasonic waves each time the medicine is accumulated in the treatment region 4 and to automatically continue the treatment.
  • the irradiation timing of the ultrasonic wave is set such that the time when the drug concentration in the treatment region 4 becomes the set concentration is set as the irradiation start time, and the drug concentration in the body does not reach the set concentration.
  • the time to decrease can be set as the irradiation stop time.
  • the number and arrangement of transducers forming the transducer unit 3 can be appropriately selected depending on the size of the treatment region 4. For example, when the treatment region 4 is narrow, the transducer unit 3 formed by arranging a plurality of transducers in a one-dimensional manner or the transducer unit 3 formed by a single transducer can be used.
  • the vibrator can be appropriately selected from a piezoelectric element (PZT) or a capacitive vibration element (cMUT cell).
  • PZT piezoelectric element
  • cMUT cell capacitive vibration element
  • the vibrator unit 3 can be reduced in size by using the cMUT cell.
  • the cMUT cell is produced using a semiconductor substrate, it does not contain a lead component unlike PZT, and therefore, even if the cMUT cell is destroyed, there is little toxic effect on the living body.
  • the control panel 5 can be a known input device such as a keyboard or a touch panel.
  • the power source of the drug introduction device 1 is not limited to a secondary battery such as the battery 11, and a primary battery can be used.
  • the battery 11 and the charger can be connected by a wire so that the battery 11 can be charged.
  • it can be configured to adjust the transmission waveform and transmission duty of the ultrasonic wave irradiated to the treatment region 4 based on the irradiation conditions.
  • the treatment target of the drug introduction device 1 is not limited to cancer cells, and other diseases can be treated.
  • the drug introduction device 1 is mounted on the outer skin of the subject, but can be implanted in the body of the subject at a position corresponding to the treatment region 4.
  • a communication device capable of wireless communication is provided in the drug introduction device 1, and the treatment region 4 and the irradiation condition of the ultrasonic wave are input and set in the microcomputer 7 with the drug introduction control device provided outside.
  • the drug introduction device 1 of the first embodiment since the drug introduction device 1 of the first embodiment only irradiates the set position with ultrasonic waves having a set intensity, it can be reduced in size as compared with the ultrasonic diagnostic device and can be easily attached to the subject.
  • the fixture for mounting the drug introduction device 1 on the body surface of the subject is not limited to a belt, and a tape or the like can be used.
  • Embodiment 2 With reference to FIG. 4, the drug introduction device 1 of Embodiment 2 will be described.
  • an ultrasonic wave receiving circuit that forms a vibrator unit 3 with a vibrator capable of transmitting and receiving ultrasonic waves and receives a reflected echo signal of the ultrasonic wave received by the vibrator unit 3 21 is provided, an ultrasonic image is generated based on the reflected echo signal received by the ultrasonic receiving circuit 21, the treatment region 4 is set based on the generated ultrasonic image, and the irradiation position is determined. It is. Since other configurations are the same as those of the first embodiment, the same reference numerals are given and description thereof is omitted.
  • the ultrasonic receiving circuit 21 receives a reflected echo signal and performs reception processing such as amplification.
  • the reflected echo signal received and processed by the ultrasonic receiving circuit 21 is input to the microcomputer 7, and the microcomputer 7 generates an ultrasonic image based on the input reflected echo signal.
  • the microcomputer 7 stores a reference ultrasonic image of the treatment area 4 and identifies the current position of the treatment area 4 as compared with the generated ultrasonic image.
  • the microcomputer 7 compares the reference ultrasonic image of the treatment area 4 with the generated ultrasonic image to obtain the current position of the treatment area 4, and uses that position as the ultrasonic irradiation position. Sound wave irradiation can be controlled. For example, when the treatment area 4 moves due to body movement such as respiration, it is necessary to track the treatment area 4 and change the irradiation position of the ultrasonic waves.
  • the treatment region 4 can be reliably irradiated with the ultrasonic wave.
  • the treatment region 4 can be tracked using a known method such as a method used for wall motion analysis in the circulatory region.
  • a communication device may be provided in the medicine introduction device 1 so that the generated ultrasonic image is transmitted to an external display device for display.
  • the position of the drug introduction device 1 can be adjusted while looking at the ultrasonic image in the body of the subject, so it is surely attached to the position corresponding to the treatment region 4 it can.
  • the operator can surround the treatment area 4 on the ultrasonic image and set the treatment area 4 in the microcomputer 7, the usability can be improved as compared with the case where the coordinate information of the treatment area 4 is input.
  • Embodiment 3 The drug introduction device 1 of Embodiment 3 will be described with reference to FIG.
  • the difference between the third embodiment and the second embodiment is that the microcomputer 7 does not generate an ultrasonic image and transmits the reflected echo signal wirelessly to the medicine introduction control device 25 provided outside via the communication device 23.
  • the medicine introduction control device 25 generates an ultrasonic image.
  • the generated ultrasonic image is input and set to the microcomputer 7 via the communication device, and the irradiation position of the ultrasonic wave is determined. Since other configurations are the same as those of the second embodiment, the same reference numerals are given and description thereof is omitted.
  • the ultrasonic image generation function can be omitted from the microcomputer 7, the drug introduction device 1 can be downsized as compared with the second embodiment.
  • the drug introduction device 1 when the drug introduction device 1 is implanted in the body, it is preferable to reduce the size of the device. Therefore, it is preferable to generate an ultrasonic image using an external device.
  • the generated ultrasonic image is displayed on the medicine introduction control device 25, the operator specifies the treatment region 4 on the ultrasonic image, and only the coordinate information of the specified treatment region 4 is micro-transmitted via the communication device 23.
  • the irradiation range can be set by inputting settings to the computer 7. According to this, since it is not necessary to store the reference ultrasonic image of the treatment region 4 in the microcomputer 7, the drug introduction device 1 can be further downsized.
  • an ultrasonic image display device can be provided in the medicine introduction control device 25, and ultrasonic waves can be transmitted and received while the medicine introduction device 1 is moved, and the ultrasonic image can be displayed on the display device.
  • the mounting position of the drug introduction device 1 is determined while observing the ultrasonic image at the current position of the drug introduction device 1, and the treatment such as the expansion range and depth range of the treatment region 4 from the ultrasonic image at the mounting position is determined.
  • the information on the area 4 can be obtained and the irradiation position of the ultrasonic wave can be set.
  • the irradiation position can be set while viewing the actual ultrasonic image at the mounting position of the drug introduction device 1, it is possible to reliably irradiate the treatment region 4 with ultrasonic waves.
  • the drug introduction device 1 according to the fourth embodiment will be described with reference to FIG.
  • the difference between the fourth embodiment and the first embodiment is that a concentration sensor 27 that detects a drug concentration in the blood in the vicinity of the treatment region 4 is provided, and ultrasonic irradiation is controlled according to the detection value of the concentration sensor 27. Is a point. Since other configurations are the same as those of the first embodiment, the same reference numerals are given and description thereof is omitted.
  • the concentration sensor 27 is provided with a needle 31, and blood in the blood vessel is collected through the needle 31 at a set cycle.
  • the concentration sensor 27 detects the concentration of the drug in the collected blood and inputs it to the microcomputer 7.
  • the microcomputer 7 determines whether or not the input drug concentration is within the set concentration range, and when the concentration detected by the concentration sensor 27 is within the set concentration range, the irradiation of ultrasonic waves is started. On the other hand, when the concentration detected by the concentration sensor 27 is outside the set concentration range, control is performed so as not to irradiate the ultrasonic wave or to stop the irradiation of the ultrasonic wave.
  • the irradiation timing of the ultrasonic wave is determined based on the actual drug concentration in the treatment region 4, it is possible to improve the accuracy of the irradiation timing as compared with the case where the ultrasonic wave irradiation timing is set in advance. it can.
  • concentration sensor 27 for example, a known sensor such as a sensor that detects a concentration by detecting a label such as a fluorescent label of a drug can be used.
  • the drug concentration in the blood it is possible to detect the preset concentration of the indicator component in the blood in the treatment region 4 and irradiate the ultrasonic wave when the detected concentration reaches the set concentration.
  • a component whose concentration varies depending on the drug such as red blood cells and white blood cells, can be used as an indicator component.
  • the drug optical sensor 33 is connected to the concentration sensor 27, light is irradiated from the drug optical sensor 33 toward the blood vessel, and based on the reflected light, It is possible to detect a drug concentration or a preset concentration of an indicator component in blood. According to this, the risk of infectious disease by collecting blood can be reduced.
  • the range of the drug concentration in the blood for controlling the irradiation of the ultrasonic wave can be appropriately selected depending on the cell to be treated, the type of drug used for the treatment, and the like. Further, as the drug concentration in the blood decreases, control such as increasing the number of times of ultrasonic irradiation can be performed.
  • the drug introduction device 1 according to the fifth embodiment will be described with reference to FIGS.
  • the difference between the fifth embodiment and the fourth embodiment is that the drug introduction device 1 is embedded in the body of the subject.
  • the control panel 5 is installed outside the body, and the control panel 5 and the microcomputer 7 are formed so as to be capable of wireless communication with each other.
  • a tank 45 in which a medicine is stored, and an administration device 43 that administers the medicine in the tank 45 into the blood vessel of the subject are provided.
  • the battery device 15 is provided with a charging coil 53 capable of wireless charging. Since other configurations are the same as those of the fourth embodiment, the same reference numerals are given and description thereof is omitted.
  • the information on the treatment area 4 and the irradiation condition information input to the control panel 5 are input and set to the microcomputer 7 wirelessly via the communication device 41.
  • the administration device 43 is provided with a pump 47 for sucking out the medicine in the tank 45.
  • a needle 49 is connected to the pump 47 so that a drug can be administered from the needle 49 into the blood vessel.
  • the battery 11 can be charged with the electric power generated by the charging coil 53 of the battery device 15.
  • the microcomputer 7 controls the administration of the drug into the blood vessel by driving the administration device 43. Thereafter, when the drug concentration in the blood exceeds the set concentration, control for stopping the drug administration is performed.
  • the drug can be administered under the administration conditions set by the microcomputer 7 by inputting and setting the administration conditions of the drug, for example, the administration speed and the like from the control panel 5 to the microcomputer 7.
  • the drug can be administered by the drug introduction device 1 attached to the subject and the drug can be administered without going to a hospital or the like, for example, the burden on the subject when performing home treatment can be further reduced.
  • the administration of the drug is controlled based on the drug concentration in the blood, but instead, the drug can be administered based on a preset time or cycle.
  • the administration time or administration cycle is input and set from the control panel 5 to the microcomputer 7.
  • the drug introduction device 1 of Embodiment 5 can be attached outside the body instead of inside the body.
  • the drug introduction device 1 without the tank 45 and the administration device 43 can be provided in the body of the subject.
  • the medicine can be regularly administered by a doctor or the like.
  • a medicine mixed with the bubble ultrasound contrast agent can be stored in the tank 45 and administered to the subject.
  • Embodiment 6 As Embodiment 6, an example of irradiation control of ultrasonic irradiation will be described.
  • the sequence of ultrasonic irradiation in FIG. 11 is an example in the case of using the drug introduction device 1 of Embodiment 5 and administering a drug mixed with a bubble ultrasonic contrast agent to a subject.
  • the ultrasonic contrast agent for bubbles used in Embodiment 6 can move with the agent and pass through the vessel wall of the blood vessel, for example, a contrast agent that can modify the agent or a contrast agent that can enclose the agent inside.
  • a contrast agent can be used.
  • the microcomputer 7 When the administration of the medicine in which the ultrasound contrast agent is mixed into the blood vessel is started from the administration device 43 by the microcomputer 7 (T0-0), the concentration of the medicine in the blood increases.
  • the blood drug concentration is input from the concentration sensor 27 to the microcomputer 7.
  • the microcomputer 7 stops the administration device 43 and stops the administration of the medicine.
  • the microcomputer 7 performs control to irradiate the ultrasonic wave (medium sound pressure ultrasonic wave) set to the first irradiation intensity ( T1-0).
  • the medium sound pressure ultrasonic wave is set to an irradiation intensity at which bubbles of the ultrasonic contrast agent are repeatedly compressed and expanded, so that the drug mixed with the ultrasonic contrast agent moves in the blood vessel due to expansion and contraction of the bubbles.
  • the drug can be diffused toward the vessel wall of the blood vessel together with the ultrasound contrast agent, and the probability that the drug and the cell to be treated (target cell) come into contact with each other can be increased. it can.
  • the microcomputer 7 sets the ultrasonic wave set to the second irradiation intensity higher than the first irradiation intensity (high sound pressure super (Sound wave) is controlled (T2-0). Thereby, the ultrasonic contrast agent of the bubble of the medicine couple
  • the microcomputer 7 controls the administration device 43 to resume the administration of the drug (T0-1), as described above. Repeat the ultrasonic irradiation control.
  • the drug flowing along the blood vessel can be diffused to increase the probability that the cell to be treated is in contact with the drug, the drug concentration in the treatment region 4 can be increased.
  • the bubbles of the ultrasonic contrast agent are ruptured in this state, the drug enters the cell due to the impact, so that the introduction of the drug into the cell can be further promoted.
  • the pyrogen concentration in the blood of the subject may increase due to the drug administration.
  • the concentration of the pyrogen in the blood can be detected by the concentration sensor 27, and the detected value can be input to the microcomputer 7 to control the irradiation of ultrasonic waves.
  • Embodiment 7 A drug introduction system in which the drug introduction device 1 attached to the subject and the drug introduction control device 61 provided outside are configured to be capable of wireless communication will be described as Embodiment 7 with reference to FIG.
  • the same thing as the above-mentioned embodiment attaches
  • the drug introduction system is configured such that the drug introduction device 1 attached to the subject and the drug introduction control device 61 operated by the operator can communicate with each other wirelessly.
  • the drug introduction device 1 is transmitted from the vibrator unit 3 that transmits / receives ultrasonic waves to / from the subject and the communication device 63 of the drug introduction control device 61 to the information on the treatment area 4 of the subject and the irradiation conditions of the ultrasonic waves.
  • a microcomputer 7 that controls the irradiation of ultrasonic waves based on the above, and a battery that supplies power to the vibrator unit 3 and the microcomputer 7 are provided.
  • the transducer unit 3 is connected to the ultrasonic transmission circuit 9 and the ultrasonic reception circuit 21, and emits ultrasonic waves based on the control signal of the microcomputer 7 and outputs a reflected echo signal to the microcomputer 7. ing.
  • a communication device 55 is connected to the microcomputer 7 so that it can communicate with the medicine introduction control device 61 wirelessly.
  • the drug introduction device 1 configured as described above is mounted with the ultrasonic wave transmitting / receiving surface of the transducer unit 3 in close contact with the body surface corresponding to the treatment region 4 of the subject or embedded in the body.
  • the drug introduction control device 61 sets the treatment region 4 on the ultrasonic image, and the generation device 65 that generates an ultrasonic image based on the reflected echo signal of the ultrasonic wave transmitted from the communication device 55 of the drug introduction device 1.
  • a control panel 5 is also provided for inputting irradiation conditions for irradiating the treatment region 4 with ultrasonic waves and introducing a drug administered into the blood vessel into the cells.
  • the generation device 65 receives the reflected echo signal received by the communication device 63, and generates an ultrasonic image based on the input reflected echo signal.
  • the control panel 5 is, for example, a touch panel, and displays an ultrasonic image generated by the generation device 65 so that a doctor or the like can specify information on the treatment region 4 on the ultrasonic image.
  • the control panel 5 can input irradiation conditions.
  • the control panel 5 is configured to input and set the irradiation range and irradiation conditions to the microcomputer 7 via the communication devices 55 and 63.
  • the drug introduction device 1 is mounted outside or inside the subject by an operator such as a doctor. At this time, the operator can input an ultrasonic image generation command to the control panel 5 and adjust the mounting position of the drug introduction device 1 while viewing the ultrasonic image of the subject. After mounting the drug introduction device 1, based on the ultrasound image generation command input to the control panel 5, the subject is irradiated with ultrasound of the set conditions, and the ultrasound image is based on the reflected echo signal. Generate. The generated ultrasonic image is displayed on the control panel 5, and the control panel 5 determines the irradiation range of the ultrasonic wave based on the information on the treatment area 4 designated on the displayed ultrasonic image.
  • the control panel 5 inputs and sets the irradiation condition information input by the operator to the microcomputer 7 via the communication devices 55 and 63 together with the irradiation range information. After the setting from the drug introduction control device 61 is completed, the drug introduction device 1 irradiates the subject with ultrasonic waves based on the set irradiation range and irradiation conditions.
  • the ultrasonic wave irradiation necessary for the drug introduction into the cell is automatically performed by the drug introduction device 1 attached to the subject, the burden on the operator and the subject can be reduced. Furthermore, since the control panel 5 and the generation device 65 are provided in the medicine introduction control device 61 provided outside, the medicine introduction device 1 attached to the subject can be reduced in size. In particular, when the drug introduction device 1 is embedded in the body of a subject, it is desired to reduce the size, and therefore it is preferable to provide the control panel 5, the generation device 65, and the like outside.
  • the drug introduction device used in the drug introduction system can be applied by appropriately selecting the drug introduction device of the above-described first to sixth embodiments.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Surgical Instruments (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

L'invention concerne un appareil d'injection d'un médicament qui permet de réduire le stress d'un opérateur et de son patient lorsqu'un traitement doit être effectué consistant à injecter un médicament dans des cellules à l'aide d'ondes ultrasoniques. L'invention concerne également une utilisation améliorée de l'appareil d'injection qui comporte : une unité (3) vibrante qui diffuse des ondes ultrasoniques dans le patient ; un panneau (5) de commande pour saisir des paramètres de diffusion pour la diffusion d'ondes ultrasoniques sur une zone (4) de traitement du patient, et l'injection du médicament administré dans les vaisseaux sanguins à l'intérieur des cellules ; un micro-ordinateur (7) qui commande la position de diffusion des ondes ultrasoniques devant être dans la zone (4) de traitement, et qui commande aussi la diffusion des ondes ultrasoniques en se basant sur les paramètres de diffusion ; et une batterie (11) alimentant en énergie l'unité (3) vibrante et le micro-ordinateur (7). Ainsi, en utilisant l'appareil d'injection d'un médicament de l'invention avec lequel la surface transmettant les ondes ultrasoniques de l'unité (3) vibrante est soit placée de manière très serrée sur la surface du corps soit placée à l'intérieur du corps en fonction de la zone (4) à traiter, le stress de l'opérateur et de son patient est allégé et la facilité d'emploi est améliorée.
PCT/JP2012/055025 2011-03-25 2012-02-29 Appareil d'injection d'un médicament et système d'injection d'un médicament WO2012132720A1 (fr)

Applications Claiming Priority (2)

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JP2011068586A JP2012200454A (ja) 2011-03-25 2011-03-25 薬剤導入装置及び薬剤導入システム
JP2011-068586 2011-03-25

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CN105944246A (zh) * 2016-06-01 2016-09-21 华南理工大学 一种美容养生超声聚焦按摩棒
JPWO2016147297A1 (ja) * 2015-03-16 2017-06-22 株式会社日立製作所 薬液投与装置、及びその作動方法

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JP6297781B2 (ja) * 2013-02-22 2018-03-20 フクダ電子株式会社 超音波骨折治療器およびその制御方法
JP6192001B2 (ja) * 2013-02-22 2017-09-06 フクダ電子株式会社 超音波骨折治療器
JP6496529B2 (ja) * 2014-11-11 2019-04-03 株式会社Ｆｕｊｉ 特定方法、および特定装置
CN106621024B (zh) * 2017-01-17 2023-11-21 湖南省健缘医疗科技有限公司 超声药透诊疗装置
US11484647B2 (en) 2017-05-31 2022-11-01 Piolax Medical Devices, Inc. Medicinal liquid injection port and medicinal liquid injection device
CN111511440B (zh) * 2017-12-22 2022-08-23 自由波有限公司 诱导使药物进入癌细胞内的声孔效应的系统及其方法

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JP2004081645A (ja) * 2002-08-28 2004-03-18 Hitachi Ltd 超音波治療装置
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JPWO2016147297A1 (ja) * 2015-03-16 2017-06-22 株式会社日立製作所 薬液投与装置、及びその作動方法
CN105944246A (zh) * 2016-06-01 2016-09-21 华南理工大学 一种美容养生超声聚焦按摩棒

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