WO2012131069A1 - Acides gras à chaîne courte et leurs dérivés à utiliser dans le traitement de troubles immunogènes - Google Patents

Acides gras à chaîne courte et leurs dérivés à utiliser dans le traitement de troubles immunogènes Download PDF

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Publication number
WO2012131069A1
WO2012131069A1 PCT/EP2012/055878 EP2012055878W WO2012131069A1 WO 2012131069 A1 WO2012131069 A1 WO 2012131069A1 EP 2012055878 W EP2012055878 W EP 2012055878W WO 2012131069 A1 WO2012131069 A1 WO 2012131069A1
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WO
WIPO (PCT)
Prior art keywords
compound
virus
group
acid
disease
Prior art date
Application number
PCT/EP2012/055878
Other languages
English (en)
Inventor
Bettina ERNST
Original Assignee
Proponent Biotech Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proponent Biotech Gmbh filed Critical Proponent Biotech Gmbh
Publication of WO2012131069A1 publication Critical patent/WO2012131069A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)

Abstract

La présente invention concerne des acides gras à chaîne courte (SCFA) pour moduler une réponse immunitaire Th2 vers une réponse immunitaire Th1 pour la prévention et/ou l'amélioration d'infections virales et en tant qu'adjuvant pour favoriser l'efficacité de vaccins et/ou la prévention de maladies ou troubles allergiques, en particulier d'une maladie ou d'un trouble médié par des cytokines dérivées de lymphocytes T auxiliaires 2 (Th2), comprenant, sans y être limitées, IL-4, IL-5, IL-6, IL-8, IL-10 et IL-13, mais en particulier pour l'utilisation dans le traitement de maladies médiées par IL-4 et/ou IL-8 et/ou IgE et/ou maladies ou troubles des éosinophiles.
PCT/EP2012/055878 2011-03-31 2012-03-30 Acides gras à chaîne courte et leurs dérivés à utiliser dans le traitement de troubles immunogènes WO2012131069A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP11160558 2011-03-31
EP11160595.2 2011-03-31
EP11160595 2011-03-31
EP11160558.0 2011-03-31

Publications (1)

Publication Number Publication Date
WO2012131069A1 true WO2012131069A1 (fr) 2012-10-04

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ID=45922694

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/055878 WO2012131069A1 (fr) 2011-03-31 2012-03-30 Acides gras à chaîne courte et leurs dérivés à utiliser dans le traitement de troubles immunogènes

Country Status (1)

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WO (1) WO2012131069A1 (fr)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014053592A1 (fr) * 2012-10-03 2014-04-10 Proponent Biotech Gmbh Esters d'acides gras à chaînes courtes pour l'utilisation dans le traitement de troubles immunogènes
WO2017137177A1 (fr) * 2016-01-04 2017-08-17 Replicon Health Oy Destiné à la prévention, au traitement et au soulagement de maladies et troubles infectieux
EP3207933A1 (fr) * 2016-02-17 2017-08-23 Proponent Biotech GmbH Utilisations de polyfructanes
EP3092008A4 (fr) * 2014-01-10 2017-09-06 The Regents of The University of California Probiotique pour la peau
US10034937B2 (en) 2015-12-04 2018-07-31 Mead Johnson Nutrition Company Synergistic nutritional compositions and uses thereof
CN109152753A (zh) * 2016-05-17 2019-01-04 拥护者生物技术有限公司 用于治疗/预防皮肤病的羧酸
US10196616B2 (en) * 2017-02-15 2019-02-05 The United States Of America, As Represented By The Secretary Of Agriculture Altered avian virus for in-ovo inoculation and methods of use thereof
CN110475551A (zh) * 2017-01-27 2019-11-19 英联邦高等教育系统天普大学 使用短链脂肪酸治疗和预防疾病和障碍
EP3573612A4 (fr) * 2017-01-27 2020-11-18 Temple University Of The Commonwealth System Of Higher Education Utilisation d'acides gras à chaîne courte pour le traitement et la prévention de maladies et de troubles
WO2021003543A1 (fr) * 2019-07-08 2021-01-14 Universidade Estadual De Campinas Composés immunomodulateurs et/ou leurs sels pharmaceutiquement acceptables, composition pharmaceutique comprenant des composés immunomodulateurs et utilisation de composés immunomodulateurs dans la préparation d'une composition pharmaceutique pour le traitement de maladies virales
WO2021087072A1 (fr) * 2019-10-29 2021-05-06 Mohapatra Shyam S Compositions et procédés de prévention et de traitement de l'infection par le virus respiratoire syncytial
US11065217B2 (en) 2017-01-27 2021-07-20 Temple University—Of the Commonwealth System of Higher Education Use of short chain fatty acids for the treatment and prevention of diseases and disorders
WO2022031787A1 (fr) * 2020-08-04 2022-02-10 Temple University-Of The Commonwealth System Of Higher Education Procédés et compositions pour traiter le syndrome de libération des cytokines
WO2022096637A1 (fr) 2020-11-05 2022-05-12 Aarhus Universitet Esters corporels de lactate/cétone
WO2023213874A1 (fr) 2022-05-04 2023-11-09 Aarhus Universitet Esters de lactate et de corps cétoniques combinés pour une utilisation médicale et nutritionnelle
US11963938B2 (en) 2015-01-23 2024-04-23 Temple University-Of The Commonwealth System Of Higher Education Use of short chain fatty acids in cancer prevention

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4735967A (en) * 1985-05-28 1988-04-05 Neesby Torben E Method for desensitizing the gastrointestinal tract from food allergies
WO2006085983A2 (fr) 2004-07-09 2006-08-17 University Of North Carolina At Chapel Hill Adjuvants viraux
JP2008195713A (ja) * 2007-01-19 2008-08-28 Shunkosha:Kk 免疫調節剤
EP2030616A1 (fr) * 2007-08-31 2009-03-04 Asan Laboratories Company (Cayman) Limited Dérivés d'acides gras à courte chaîne pour améliorer le prurit
WO2012022947A1 (fr) 2010-08-17 2012-02-23 Cmp Therapeutics Limited Compositions nutritionnelles comprenant des microparticules de chitine

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4735967A (en) * 1985-05-28 1988-04-05 Neesby Torben E Method for desensitizing the gastrointestinal tract from food allergies
WO2006085983A2 (fr) 2004-07-09 2006-08-17 University Of North Carolina At Chapel Hill Adjuvants viraux
JP2008195713A (ja) * 2007-01-19 2008-08-28 Shunkosha:Kk 免疫調節剤
EP2030616A1 (fr) * 2007-08-31 2009-03-04 Asan Laboratories Company (Cayman) Limited Dérivés d'acides gras à courte chaîne pour améliorer le prurit
WO2012022947A1 (fr) 2010-08-17 2012-02-23 Cmp Therapeutics Limited Compositions nutritionnelles comprenant des microparticules de chitine

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CAVAGLIERI CLAUDIA R ET AL: "Differential effects of short-chain fatty acids on proliferation and production of pro- and anti-inflammatory cytokines by cultured lymphocytes.", LIFE SCIENCES, vol. 73, no. 13, 15 August 2003 (2003-08-15), pages 1683 - 1690, XP007919115, ISSN: 0024-3205 *
FUKUDA S ET AL: "Immunomodulator e.g. for treating allergosis, autoimmune disease and oral infection disease comprises acetic acid and/or propionic acid as active ingredients", WPI / THOMSON,, vol. 2008, no. 79, 28 August 2008 (2008-08-28), XP002651607 *
FURUHJELM CATRIN ET AL: "Th1 and Th2 chemokines, vaccine-induced immunity, and allergic disease in infants after maternal [omega]-3 fatty acid supplementation during pregnancy and lactation.", PEDIATRIC RESEARCH MAR 2011 LNKD- PUBMED:21099447, vol. 69, no. 3, 1 March 2011 (2011-03-01), pages 259 - 264, XP007919116, ISSN: 1530-0447 *
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SHERRY C L ET AL: "Sickness behavior induced by endotoxin can be mitigated by the dietary soluble fiber, pectin, through up-regulation of IL-4 and Th2 polarization", BRAIN, BEHAVIOR AND IMMUNITY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 24, no. 4, 1 May 2010 (2010-05-01), pages 631 - 640, XP027000812, ISSN: 0889-1591, [retrieved on 20100206] *
VAN ELDEN, L. J.; M. NIJHUIS; P. SCHIPPER; R. SCHUURMAN; A. M. VAN LOON: "Simultaneous detection of influenza viruses A and B using real-time quantitative PCR", J. CLIN. MICROBIOL., vol. 39, 2001, pages 196 - 200, XP002604453, DOI: doi:10.1128/JCM.39.1.196-200.2001
ZHANG Z ET AL: "Valproic acid attenuates inflammation in experimental autoimmune neuritis", CMLS CELLULAR AND MOLECULAR LIFE SCIENCES, BIRKHÄUSER-VERLAG, BA, vol. 65, no. 24, 27 October 2008 (2008-10-27), pages 4055 - 4065, XP019652181, ISSN: 1420-9071, DOI: DOI:10.1007/S00018-008-8521-4 *

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014053592A1 (fr) * 2012-10-03 2014-04-10 Proponent Biotech Gmbh Esters d'acides gras à chaînes courtes pour l'utilisation dans le traitement de troubles immunogènes
US9415033B2 (en) 2012-10-03 2016-08-16 Proponent Biotech Gmbh Esters of short chains fatty acids for use in the treatment of immunogenic disorders
US9884032B2 (en) 2012-10-03 2018-02-06 Proponent Biotech Gmbh Esters of short chains fatty acids for use in the treatment of immunogenic disorders
EP2903608B1 (fr) * 2012-10-03 2019-08-28 Proponent Biotech GmbH Composition pharmaceutique comprenant de l'acide propionique pour son utilisation dans le traitement d'infections virales
EP3092008A4 (fr) * 2014-01-10 2017-09-06 The Regents of The University of California Probiotique pour la peau
US11590092B2 (en) 2014-01-10 2023-02-28 The Regents Of The University Of California Skin probiotic
EP3903824A1 (fr) * 2014-01-10 2021-11-03 The Regents of The University of California Probiotique pour la peau
US11963938B2 (en) 2015-01-23 2024-04-23 Temple University-Of The Commonwealth System Of Higher Education Use of short chain fatty acids in cancer prevention
US10034937B2 (en) 2015-12-04 2018-07-31 Mead Johnson Nutrition Company Synergistic nutritional compositions and uses thereof
WO2017137177A1 (fr) * 2016-01-04 2017-08-17 Replicon Health Oy Destiné à la prévention, au traitement et au soulagement de maladies et troubles infectieux
EP3207933A1 (fr) * 2016-02-17 2017-08-23 Proponent Biotech GmbH Utilisations de polyfructanes
CN109152753A (zh) * 2016-05-17 2019-01-04 拥护者生物技术有限公司 用于治疗/预防皮肤病的羧酸
EP3573612A4 (fr) * 2017-01-27 2020-11-18 Temple University Of The Commonwealth System Of Higher Education Utilisation d'acides gras à chaîne courte pour le traitement et la prévention de maladies et de troubles
US11065217B2 (en) 2017-01-27 2021-07-20 Temple University—Of the Commonwealth System of Higher Education Use of short chain fatty acids for the treatment and prevention of diseases and disorders
JP2020505471A (ja) * 2017-01-27 2020-02-20 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイションＴｅｍｐｌｅ Ｕｎｉｖｅｒｓｉｔｙ−Ｏｆ Ｔｈｅ Ｃｏｍｍｏｎｗｅａｌｔｈ Ｓｙｓｔｅｍ Ｏｆ Ｈｉｇｈｅｒ Ｅｄｕｃａｔｉｏｎ 疾患及び障害の処置及び予防のための短鎖脂肪酸の使用
JP7161731B2 (ja) 2017-01-27 2022-10-27 テンプル・ユニバーシティ－オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション 疾患及び障害の処置及び予防のための短鎖脂肪酸の使用
CN110475551A (zh) * 2017-01-27 2019-11-19 英联邦高等教育系统天普大学 使用短链脂肪酸治疗和预防疾病和障碍
US11759442B2 (en) 2017-01-27 2023-09-19 Temple University-Of The Commonwealth System Of Higher Education Use of short chain fatty acids for the treatment and prevention of diseases and disorders
US10196616B2 (en) * 2017-02-15 2019-02-05 The United States Of America, As Represented By The Secretary Of Agriculture Altered avian virus for in-ovo inoculation and methods of use thereof
WO2021003543A1 (fr) * 2019-07-08 2021-01-14 Universidade Estadual De Campinas Composés immunomodulateurs et/ou leurs sels pharmaceutiquement acceptables, composition pharmaceutique comprenant des composés immunomodulateurs et utilisation de composés immunomodulateurs dans la préparation d'une composition pharmaceutique pour le traitement de maladies virales
WO2021087072A1 (fr) * 2019-10-29 2021-05-06 Mohapatra Shyam S Compositions et procédés de prévention et de traitement de l'infection par le virus respiratoire syncytial
WO2022031787A1 (fr) * 2020-08-04 2022-02-10 Temple University-Of The Commonwealth System Of Higher Education Procédés et compositions pour traiter le syndrome de libération des cytokines
WO2022096637A1 (fr) 2020-11-05 2022-05-12 Aarhus Universitet Esters corporels de lactate/cétone
WO2023213874A1 (fr) 2022-05-04 2023-11-09 Aarhus Universitet Esters de lactate et de corps cétoniques combinés pour une utilisation médicale et nutritionnelle

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