WO2012105794A3 - 생체 적합 온도 내에서 큐리 온도를 가지는 자성 나노입자 및 그 제조 방법 - Google Patents

생체 적합 온도 내에서 큐리 온도를 가지는 자성 나노입자 및 그 제조 방법 Download PDF

Info

Publication number
WO2012105794A3
WO2012105794A3 PCT/KR2012/000739 KR2012000739W WO2012105794A3 WO 2012105794 A3 WO2012105794 A3 WO 2012105794A3 KR 2012000739 W KR2012000739 W KR 2012000739W WO 2012105794 A3 WO2012105794 A3 WO 2012105794A3
Authority
WO
WIPO (PCT)
Prior art keywords
magnetic nanoparticle
temperature
temperature range
properties
biocompatible
Prior art date
Application number
PCT/KR2012/000739
Other languages
English (en)
French (fr)
Other versions
WO2012105794A2 (ko
Inventor
김영근
우준화
민지현
이지성
정재호
Original Assignee
고려대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 고려대학교 산학협력단 filed Critical 고려대학교 산학협력단
Priority to US13/982,819 priority Critical patent/US20130309702A1/en
Priority to EP12741665.9A priority patent/EP2671570B1/en
Priority to JP2013551917A priority patent/JP5865396B2/ja
Publication of WO2012105794A2 publication Critical patent/WO2012105794A2/ko
Publication of WO2012105794A3 publication Critical patent/WO2012105794A3/ko
Priority to US15/335,896 priority patent/US20170095579A1/en
Priority to US15/702,062 priority patent/US20180003676A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1851—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1866—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle the nanoparticle having a (super)(para)magnetic core coated or functionalised with a peptide, e.g. protein, polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1875—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle coated or functionalised with an antibody
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G45/00—Compounds of manganese
    • C01G45/12—Complex oxides containing manganese and at least one other metal element
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2002/00—Crystal-structural characteristics
    • C01P2002/70—Crystal-structural characteristics defined by measured X-ray, neutron or electron diffraction data
    • C01P2002/72—Crystal-structural characteristics defined by measured X-ray, neutron or electron diffraction data by d-values or two theta-values, e.g. as X-ray diagram
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2002/00—Crystal-structural characteristics
    • C01P2002/80—Crystal-structural characteristics defined by measured data other than those specified in group C01P2002/70
    • C01P2002/85—Crystal-structural characteristics defined by measured data other than those specified in group C01P2002/70 by XPS, EDX or EDAX data
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/01—Particle morphology depicted by an image
    • C01P2004/04—Particle morphology depicted by an image obtained by TEM, STEM, STM or AFM
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/62—Submicrometer sized, i.e. from 0.1-1 micrometer
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/60—Particles characterised by their size
    • C01P2004/64—Nanometer sized, i.e. from 1-100 nanometer
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/42—Magnetic properties

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

본 발명은 생첵 적합 온도 내에서 큐리 온도를 가지는 자성 나노입자, 이의 제조 방법, 이를 포함하는 나노 복합체 및 표적 물질 탐지용 조성물에 관한 것이다. 본 발명의 자성 나노입자는 0℃ 내지 41℃의 온도 범위에서 큐리 온도를 가지기 때문에, 생물제재가 파괴되지 않는 생체 적합 온도 내에서 강자성 및 상자성 특성을 제어할 수 있고, 생물제재의 검지, 분리 및 전달 등의 분야에서 신호 증폭과 같은 강자성 특성이 요구되는 경우에만 그 특성을 활용할 수 있도록 온도를 조절하여 자성 특성을 제어할 수 있다. 이에 따라, 본 발명의 자성 나노입자는 강자성 특성에 따른 부작용을 최소화할 수 있고, 생물제재의 효과적인 검지 및 분리 등에 활용할 수 있다.
PCT/KR2012/000739 2011-01-31 2012-01-31 생체 적합 온도 내에서 큐리 온도를 가지는 자성 나노입자 및 그 제조 방법 WO2012105794A2 (ko)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US13/982,819 US20130309702A1 (en) 2011-01-31 2012-01-31 Magnetic nanoparticle, having a curie temperature which is whithin biocompatible temperature range, and method for preparing same
EP12741665.9A EP2671570B1 (en) 2011-01-31 2012-01-31 Magnetic nanoparticle, having a curie temperature which is within biocompatible temperature range, and method for preparing same
JP2013551917A JP5865396B2 (ja) 2011-01-31 2012-01-31 生体適合温度内でキュリー温度を有する磁性ナノ粒子の製造方法及びそれを含む標的物質探知用組成物
US15/335,896 US20170095579A1 (en) 2011-01-31 2016-10-27 Composition for target substance detection comprising magnetic nanoparticle having a curie temperature which is within biocompatible temperature range and system for target substance detection
US15/702,062 US20180003676A1 (en) 2011-01-31 2017-09-12 Magnetic nanoparticle, having a curie temperature which is within biocompatible temperature range, and method for preparing same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2011-0009824 2011-01-31
KR1020110009824A KR101379971B1 (ko) 2011-01-31 2011-01-31 생체 적합 온도 내에서 큐리 온도를 가지는 자성 나노입자 및 그 제조 방법

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US13/982,819 A-371-Of-International US20130309702A1 (en) 2011-01-31 2012-01-31 Magnetic nanoparticle, having a curie temperature which is whithin biocompatible temperature range, and method for preparing same
US15/335,896 Continuation-In-Part US20170095579A1 (en) 2011-01-31 2016-10-27 Composition for target substance detection comprising magnetic nanoparticle having a curie temperature which is within biocompatible temperature range and system for target substance detection
US15/702,062 Division US20180003676A1 (en) 2011-01-31 2017-09-12 Magnetic nanoparticle, having a curie temperature which is within biocompatible temperature range, and method for preparing same

Publications (2)

Publication Number Publication Date
WO2012105794A2 WO2012105794A2 (ko) 2012-08-09
WO2012105794A3 true WO2012105794A3 (ko) 2012-10-26

Family

ID=46603204

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/000739 WO2012105794A2 (ko) 2011-01-31 2012-01-31 생체 적합 온도 내에서 큐리 온도를 가지는 자성 나노입자 및 그 제조 방법

Country Status (5)

Country Link
US (2) US20130309702A1 (ko)
EP (1) EP2671570B1 (ko)
JP (1) JP5865396B2 (ko)
KR (1) KR101379971B1 (ko)
WO (1) WO2012105794A2 (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015095398A1 (en) 2013-12-17 2015-06-25 Kevin Hagedorn Method and apparatus for manufacturing isotropic magnetic nanocolloids
CN106537234A (zh) 2014-04-07 2017-03-22 加利福尼亚大学董事会 高度可调节的磁性液晶
EP3131489A1 (en) 2014-04-17 2017-02-22 Boston Scientific Scimed, Inc. Devices and methods for therapeutic heat treatment
CN104345155A (zh) * 2014-10-29 2015-02-11 深圳市第二人民医院 甲胎蛋白含量的检测方法
FR3027532A1 (fr) * 2015-04-10 2016-04-29 Commissariat Energie Atomique Procede d’elaboration de nanoparticules d’oxyde fonctionnalisees.
US10661092B2 (en) 2015-10-07 2020-05-26 Boston Scientific Scimed, Inc. Mixture of lafesih magnetic nanoparticles with different curie temperatures for improved inductive heating efficiency for hyperthermia therapy
CN106769162B (zh) * 2017-02-20 2023-06-06 广西大学 一种透射电镜磁性样品预处理器
US20180292478A1 (en) * 2017-04-05 2018-10-11 Howard Hughes Medical Institute Magnetic apparatus
CN108241064A (zh) * 2017-12-21 2018-07-03 江苏泽成生物技术有限公司 一种测定甲状腺球蛋白抗体含量的试剂盒及其测试方法
CN110323056A (zh) * 2019-06-28 2019-10-11 武汉理工大学 一种解决磁性纳米颗粒在磁性纳米复合材料中团聚的方法
EP4041084A4 (en) * 2019-09-01 2024-05-15 Academia Sinica NANOCOMPOSITE PARTICLE AND ITS USES
KR102348003B1 (ko) * 2020-10-08 2022-01-07 연세대학교 산학협력단 이중 항체 연결 면역 샌드위치 분석을 이용한 타겟 바이오마커 검출방법
CN112631022B (zh) * 2020-12-25 2022-05-24 深圳扑浪创新科技有限公司 一种量子点显示面板的制备方法及量子点显示面板

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050249817A1 (en) * 2004-05-10 2005-11-10 Yousef Haik Magnetic particle composition for therapeutic hyperthermia
KR100652251B1 (ko) * 2004-09-03 2006-12-01 학교법인연세대학교 다작용기 리간드를 이용한 나노입자의 표면 개질 및수용성 나노입자의 제조방법
KR20070058358A (ko) * 2005-12-02 2007-06-08 연세대학교 산학협력단 망간 산화물 나노입자를 포함하는 자기공명 영상제
KR20070088391A (ko) * 2006-02-24 2007-08-29 (주)에이티젠 양친매성 화합물 및 조직 특이적 결합 성분을 이용한지능형 자성 나노복합체 및 이를 포함하는 조영제
US20070258888A1 (en) * 2003-11-17 2007-11-08 Claus Feldmann Contrast Agent for Medical Imaging Techniques and Usage Thereof
KR20090119867A (ko) * 2007-01-30 2009-11-20 재단법인서울대학교산학협력재단 산화망간 나노입자를 포함하는 자기공명영상 티1 조영제
KR20100030264A (ko) * 2008-09-10 2010-03-18 연세대학교 산학협력단 형광 자성 나노복합체 및 그 제조방법

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2979414B2 (ja) * 1989-09-29 1999-11-15 富士レビオ株式会社 磁性粒子およびそれを用いた免疫測定法
AU2003303954A1 (en) * 2002-10-25 2004-10-11 Emory University Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring
KR20040084468A (ko) 2003-03-28 2004-10-06 주식회사 꾼커뮤니케이션 사용자 편집 및 선택 가능한 3차원 아바타 제공방법 및아바타 편집기를 저장한 저장매체
JP4528959B2 (ja) * 2003-12-12 2010-08-25 国立大学法人 名古屋工業大学 磁性材料及びその製造方法
US20070250139A1 (en) * 2004-05-07 2007-10-25 John Kanzius Enhanced systems and methods for RF-induced hyperthermia II
KR100619590B1 (ko) * 2004-10-21 2006-09-13 학교법인고려중앙학원 나노입자가 충진된 나노구조
JPWO2006070572A1 (ja) * 2004-12-27 2008-06-12 国立大学法人京都大学 規則合金相ナノ微粒子及びその製造方法、並びに超高密度磁気記録用媒体及びその製造方法
WO2006102307A2 (en) * 2005-03-21 2006-09-28 University Of Louisville Research Foundation, Inc. Target specific nanoparticles for enhancing optical contrast enhancement and inducing target-specific hyperthermia
KR100821192B1 (ko) * 2005-09-08 2008-04-11 주식회사바이테리얼즈 형광성을 가지는 자성 나노 입자 및 그 제조방법
BRPI0715904A2 (pt) * 2006-08-14 2013-07-30 Ind Mecanica Tromm Ltda Epp mÉtodo e sistema para monitorar um processo enzimÁtico em uma molÉcula biolàgica
KR100759716B1 (ko) * 2006-09-26 2007-10-04 고려대학교 산학협력단 복합기능 자성체 코어 - 반도체 쉘 나노 입자 및 그의제조방법
WO2008127031A1 (en) * 2007-04-12 2008-10-23 Industry-Academic Cooperation Foundation, Yonsei University Magnetic resonance imaging contrast agents comprising zinc-containing magnetic metal oxide nanoparticles
CN100588701C (zh) * 2007-10-19 2010-02-10 南京理工大学 热致变色可变发射率锰酸镧材料的制备方法
EP2110175A1 (de) * 2008-03-20 2009-10-21 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren und Vorrichtung zur thermischen Steuerung biologischer und chemischer Reaktionen unter Einsatz von magnetischen Partikeln oder magnetischen Beads und Wechselmagnetfeldern
JP2010168606A (ja) * 2009-01-20 2010-08-05 Fuji Electric Holdings Co Ltd 粒子の製造方法及び反応装置

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070258888A1 (en) * 2003-11-17 2007-11-08 Claus Feldmann Contrast Agent for Medical Imaging Techniques and Usage Thereof
US20050249817A1 (en) * 2004-05-10 2005-11-10 Yousef Haik Magnetic particle composition for therapeutic hyperthermia
KR100652251B1 (ko) * 2004-09-03 2006-12-01 학교법인연세대학교 다작용기 리간드를 이용한 나노입자의 표면 개질 및수용성 나노입자의 제조방법
KR20070058358A (ko) * 2005-12-02 2007-06-08 연세대학교 산학협력단 망간 산화물 나노입자를 포함하는 자기공명 영상제
KR20070088391A (ko) * 2006-02-24 2007-08-29 (주)에이티젠 양친매성 화합물 및 조직 특이적 결합 성분을 이용한지능형 자성 나노복합체 및 이를 포함하는 조영제
KR20090119867A (ko) * 2007-01-30 2009-11-20 재단법인서울대학교산학협력재단 산화망간 나노입자를 포함하는 자기공명영상 티1 조영제
KR20100030264A (ko) * 2008-09-10 2010-03-18 연세대학교 산학협력단 형광 자성 나노복합체 및 그 제조방법

Also Published As

Publication number Publication date
KR20120099553A (ko) 2012-09-11
JP2014508743A (ja) 2014-04-10
WO2012105794A2 (ko) 2012-08-09
EP2671570B1 (en) 2018-05-30
KR101379971B1 (ko) 2014-04-10
JP5865396B2 (ja) 2016-02-17
US20180003676A1 (en) 2018-01-04
US20130309702A1 (en) 2013-11-21
EP2671570A4 (en) 2015-05-27
EP2671570A2 (en) 2013-12-11

Similar Documents

Publication Publication Date Title
WO2012105794A3 (ko) 생체 적합 온도 내에서 큐리 온도를 가지는 자성 나노입자 및 그 제조 방법
MX362637B (es) Sistema emulsionante.
WO2016210373A3 (en) Recombinant bacteria engineered for biosafety, pharmaceutical compositions, and methods of use thereof
MX363123B (es) Produccion de productos de la proteina de leguminosa con astringencia reducida.
WO2015058008A3 (en) Enhanced nucleic acid identification and detection
UA104373C2 (ru) Способ и устройство для определения магнитного параметра в сердечнике
IN2015DN02377A (ko)
WO2012022300A3 (de) Verfahren und vorrichtung zur erfassung von magnetfeldern
EP3637060A3 (en) Contoured-field magnets
EP2352041A4 (en) Method for quantitatively separating the effects of electromagnetic induction and induced polarization
BR112012012339A2 (pt) método para controlar micro-organismos fitopatogênicos, suspensão aquosa de partículas de sal de cobre e uso de suspensão
WO2014144721A3 (en) Treating th2-mediated diseases by inhibition of bromodomain-comprising proteins brd7 and brd9
WO2011068364A3 (ko) 전자기 영동성을 이용한 표시 방법 및 장치
MX2014002767A (es) Adsorbente nanoparticulado de fosfato en base a maghemita o maghemita/magnetita, su produccion y usos.
WO2012010974A3 (en) Combination pharmaceutical compositions and method of treatment of vertigo, kinetosis and vegetative-vascular dystonia
WO2012033291A3 (ko) 자기 영동을 이용한 미세 입자 분리 장치 및 이를 이용하여 미세 입자를 분리하는 방법
MX2015000525A (es) Ph ajustado a un producto de proteina de pulso.
WO2007137192A3 (en) Apparatus and system for adjusting settings of a power system device using a magnetically coupled actuator
EP3212106A4 (en) Magnetic injection of therapeutic agents by addition of material extrusions with differing magnetization and magnetic permeability
WO2012149160A3 (en) Viruses modified with unnatural moieties and methods of use thereof
WO2013040478A3 (en) Hyr1-derived compositions and methods of treatment using same
WO2011032896A3 (de) Verkapselung unter verwendung von wachsartigen substanzen
IN2014CN02659A (ko)
EP3527229A4 (en) LIPID NANOPARTICLES MADE FROM ANTISENSE OLIGONUCLEIC ACID FOR THE INHIBITION OF BCL-2 AND THE MANUFACTURING METHOD FOR IT
NZ701115A (en) Cobalt nanoparticle adjuvant

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12741665

Country of ref document: EP

Kind code of ref document: A2

ENP Entry into the national phase

Ref document number: 2013551917

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 13982819

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2012741665

Country of ref document: EP