WO2012033291A3 - 자기 영동을 이용한 미세 입자 분리 장치 및 이를 이용하여 미세 입자를 분리하는 방법 - Google Patents

자기 영동을 이용한 미세 입자 분리 장치 및 이를 이용하여 미세 입자를 분리하는 방법 Download PDF

Info

Publication number
WO2012033291A3
WO2012033291A3 PCT/KR2011/006105 KR2011006105W WO2012033291A3 WO 2012033291 A3 WO2012033291 A3 WO 2012033291A3 KR 2011006105 W KR2011006105 W KR 2011006105W WO 2012033291 A3 WO2012033291 A3 WO 2012033291A3
Authority
WO
WIPO (PCT)
Prior art keywords
fine particles
separating fine
magnetophoresis
same
separating
Prior art date
Application number
PCT/KR2011/006105
Other languages
English (en)
French (fr)
Other versions
WO2012033291A2 (ko
Inventor
한기호
이환용
한송이
김선영
최인학
Original Assignee
인제대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 인제대학교 산학협력단 filed Critical 인제대학교 산학협력단
Priority to US13/821,477 priority Critical patent/US10253309B2/en
Priority to EP11823724.7A priority patent/EP2615463B1/en
Publication of WO2012033291A2 publication Critical patent/WO2012033291A2/ko
Priority to KR1020120063111A priority patent/KR101622342B1/ko
Publication of WO2012033291A3 publication Critical patent/WO2012033291A3/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/025—High gradient magnetic separators
    • B03C1/031—Component parts; Auxiliary operations
    • B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/0335—Component parts; Auxiliary operations characterised by the magnetic circuit using coils
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/32—Magnetic separation acting on the medium containing the substance being separated, e.g. magneto-gravimetric-, magnetohydrostatic-, or magnetohydrodynamic separation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B1/00—Devices without movable or flexible elements, e.g. microcapillary devices
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C07H1/08—Separation; Purification from natural products
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • G01N35/085—Flow Injection Analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical applications
    • G01N15/1023—

Abstract

본 발명은 자기 영동을 이용한 미세 입자 분리 장치 및 이를 이용하여 미세 입자를 분리하는 방법에 관한 것으로서, 미세 입자에 결합된 입자의 자성이 미약할 경우에도 우수한 효율로 신속하게 분리가 가능한 패턴화된 자성체 미세 구조물을 포함하는 자기 영동을 이용한 미세 입자 분리 장치 및 이를 이용하여 미세 입자를 분리하는 방법을 제공하는 것을 목적으로 한다.
PCT/KR2011/006105 2010-09-10 2011-08-19 자기 영동을 이용한 미세 입자 분리 장치 및 이를 이용하여 미세 입자를 분리하는 방법 WO2012033291A2 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US13/821,477 US10253309B2 (en) 2010-09-10 2011-08-19 Apparatus for separating fine particles using magnetophoresis, and method for separating fine particles using same
EP11823724.7A EP2615463B1 (en) 2010-09-10 2011-08-19 Apparatus for separating fine particles using magnetophoresis, and method for separating fine particles using same
KR1020120063111A KR101622342B1 (ko) 2011-06-13 2012-06-13 자기 영동을 이용한 미세 입자 분리 장치 및 이를 이용하여 미세 입자를 분리하는 방법

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2010-0088957 2010-09-10
KR20100088957 2010-09-10
KR1020110057095A KR20120026959A (ko) 2010-09-10 2011-06-13 자기 영동을 이용한 미세 입자 분리 장치 및 이를 이용하여 미세 입자를 분리하는 방법
KR10-2011-0057095 2011-06-13

Publications (2)

Publication Number Publication Date
WO2012033291A2 WO2012033291A2 (ko) 2012-03-15
WO2012033291A3 true WO2012033291A3 (ko) 2012-06-14

Family

ID=46132614

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/006105 WO2012033291A2 (ko) 2010-09-10 2011-08-19 자기 영동을 이용한 미세 입자 분리 장치 및 이를 이용하여 미세 입자를 분리하는 방법

Country Status (4)

Country Link
US (1) US10253309B2 (ko)
EP (1) EP2615463B1 (ko)
KR (1) KR20120026959A (ko)
WO (1) WO2012033291A2 (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9535036B2 (en) * 2012-06-19 2017-01-03 Electronics And Telecommunications Research Institute Multiple discrimination device and method of manufacturing the device
KR101810941B1 (ko) 2012-11-26 2017-12-20 한국전자통신연구원 다중 분리 장치 및 이의 제조 방법
IN2014DN11074A (ko) * 2012-06-25 2015-09-25 Gen Hospital Corp
US10202577B2 (en) 2013-10-18 2019-02-12 The General Hospital Corporation Microfluidic sorting using high gradient magnetic fields
KR20160120416A (ko) * 2015-04-08 2016-10-18 인제대학교 산학협력단 분리 가능한 복수의 패널을 포함하는 미세 입자 분리 장치 어셈블리
US10145906B2 (en) 2015-12-17 2018-12-04 Analog Devices Global Devices, systems and methods including magnetic structures
AU2017345507A1 (en) * 2016-10-18 2019-05-09 Menarini Silicon Biosystems S.P.A. Microfluidic device, microfluidic system and method for the isolation of particles
KR101888636B1 (ko) * 2017-06-02 2018-08-14 지트로닉스 주식회사 자기 영동 바이오 칩
KR20190017389A (ko) 2017-08-11 2019-02-20 경희대학교 산학협력단 자성입자 분리 장치 및 방법
WO2020010471A1 (en) * 2018-07-13 2020-01-16 The Governing Council Of The University Of Toronto Microfluidic devices and methods of use
KR102050685B1 (ko) * 2019-01-21 2019-11-29 인제대학교 산학협력단 분리 가능한 복수의 패널을 포함하는 미세 입자 분리 장치 어셈블리
CN113680524A (zh) * 2021-09-23 2021-11-23 大连海事大学 一种基于Fe-PDMS复合材料的油液磨粒分离装置及其制作方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030044832A1 (en) * 1996-09-04 2003-03-06 Scandinavian Micro Biodevices A/S Microflow system for particle separation and analysis
KR100787234B1 (ko) * 2006-02-17 2007-12-21 한국기계연구원 입자 분리 장치 및 입자 분리 방법
KR100907213B1 (ko) * 2007-12-07 2009-07-10 한국과학기술원 등자기영동 기술을 이용한 미세입자 분리 장치 및등자기영동 기술을 이용한 미세입자 분리 방법
KR20100079045A (ko) * 2008-12-30 2010-07-08 한국과학기술원 밀도차영동 현상을 이용한 미세유체 제어소자 및 미세유체 분석 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US105019A (en) * 1870-07-05 Improvement in distilling pine wood
WO1994007138A1 (en) 1992-09-14 1994-03-31 Fodstad Oystein Detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations
KR100791036B1 (ko) 2006-07-07 2008-01-03 한국과학기술원 연속적인 자기영동을 이용한 순수한 탄소나노튜브와 금속 불순물을 함유한 탄소나노튜브의 분리방법 및 이에 사용되는 자기영동 미세 유체 제어소자
US7807454B2 (en) * 2006-10-18 2010-10-05 The Regents Of The University Of California Microfluidic magnetophoretic device and methods for using the same
IT1392999B1 (it) * 2009-02-12 2012-04-02 Ct De Investigacion Cooperativa En Nanociencias Cic Nanogune Asoc Manipolazione di particelle magnetiche in circuiti per la propagazione di pareti di dominio magnetiche.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030044832A1 (en) * 1996-09-04 2003-03-06 Scandinavian Micro Biodevices A/S Microflow system for particle separation and analysis
KR100787234B1 (ko) * 2006-02-17 2007-12-21 한국기계연구원 입자 분리 장치 및 입자 분리 방법
KR100907213B1 (ko) * 2007-12-07 2009-07-10 한국과학기술원 등자기영동 기술을 이용한 미세입자 분리 장치 및등자기영동 기술을 이용한 미세입자 분리 방법
KR20100079045A (ko) * 2008-12-30 2010-07-08 한국과학기술원 밀도차영동 현상을 이용한 미세유체 제어소자 및 미세유체 분석 방법

Also Published As

Publication number Publication date
US20130189755A1 (en) 2013-07-25
EP2615463A4 (en) 2013-09-25
EP2615463A2 (en) 2013-07-17
US10253309B2 (en) 2019-04-09
WO2012033291A2 (ko) 2012-03-15
KR20120026959A (ko) 2012-03-20
EP2615463B1 (en) 2016-10-12

Similar Documents

Publication Publication Date Title
WO2012033291A3 (ko) 자기 영동을 이용한 미세 입자 분리 장치 및 이를 이용하여 미세 입자를 분리하는 방법
EP2576070A4 (en) Method and apparatus for separating low density particles from feed slurries
WO2012158196A3 (en) Core-shell magnetic particles and related methods
EP2731723A4 (en) DEVICES, SYSTEMS AND METHODS FOR MAGNETIC SEPARATION
EP2669045A4 (en) Fine abrasive particles and process for producing same
PL2580380T3 (pl) Aparat do separacji cząstek i sposób jego użycia
EP2599048A4 (en) METHOD AND DEVICE FOR SORTING SURVEY RESULTS
EP3043903A4 (en) New process and system for magnetic separation
EP3384991A4 (en) Magnetic separator, magnetic separation method, and method for manufacturing iron source
GB2502215B (en) Structure and method for hard mask removal on an soi substrate without using CMP process
TWI561014B (en) Method and apparatus for separating the reference current from the input signal in sigma-delta converter
ZA201409026B (en) Methods for separating and dewatering fine particles
HK1213942A1 (zh) 使用免疫玫瑰花結和磁性粒子分離細胞的方法
WO2015075563A3 (en) Magnetic separation
EP3010074A4 (en) Device for preparing core-shell particles and method for preparing core-shell particles by using same
EP3008203A4 (en) Magnetic separation process using carboxyl-functionalized superparamagnetic nanoclusters
EP3508850A4 (en) MAGNETIC COMPOSITE PARTICLES AND MANUFACTURING METHODS THEREFOR AND PARTICLES FOR IMMUNOASSAY
EP2579973A4 (en) Apparatus and method for the production of particles
EP3248955A4 (en) Method for producing -eucryptite fine particles
GB2510535C (en) Method and magnetic separator for separating magnetic and/or magnetizable particles from a fluid
ZA201401131B (en) Method for solid waste separation and processing
EP3020721A4 (en) Purification method for virus-like particles
EP3521411A4 (en) FINE PARTICLE RECOVERY METHOD AND SYSTEM
EP3325976A4 (en) SYSTEM FOR SEPARATING MAGNETIC IRON PARTICLES
EP3397390A4 (en) APPARATUS AND METHODS FOR PROCESSING MAGNETIC PARTICLES

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11823724

Country of ref document: EP

Kind code of ref document: A2

REEP Request for entry into the european phase

Ref document number: 2011823724

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2011823724

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 13821477

Country of ref document: US