WO2012060624A3 - 폴리옥틸시아노아크릴레이트를 이용하여 제조한 생체 인공 구조물 및 그 제조방법 - Google Patents

폴리옥틸시아노아크릴레이트를 이용하여 제조한 생체 인공 구조물 및 그 제조방법 Download PDF

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Publication number
WO2012060624A3
WO2012060624A3 PCT/KR2011/008284 KR2011008284W WO2012060624A3 WO 2012060624 A3 WO2012060624 A3 WO 2012060624A3 KR 2011008284 W KR2011008284 W KR 2011008284W WO 2012060624 A3 WO2012060624 A3 WO 2012060624A3
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WO
WIPO (PCT)
Prior art keywords
bio
octyl cyanoacrylate
artificial structure
octyl
manufacturing same
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PCT/KR2011/008284
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English (en)
French (fr)
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WO2012060624A2 (ko
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김동진
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(주)인튜이티브메디코프
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Publication of WO2012060624A2 publication Critical patent/WO2012060624A2/ko
Publication of WO2012060624A3 publication Critical patent/WO2012060624A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/427—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of other specific inorganic materials not covered by A61L27/422 or A61L27/425
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L35/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L35/04—Homopolymers or copolymers of nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

본 발명은 폴리옥틸시아노아크릴레이트를 이용하여 제조한 생체 인공 구조물 및 그 제조방법에 관한 것으로, 옥틸시아노아크릴레이트 제조 시 부산물로 생성되는 폴리옥틸시아노아크릴레이트 및 골전도성 무기물질(osteoconductive inorganic materials)을 혼합하여 제조함으로써 골 전도성 및 골 유도성이 우수한 생체 인공 구조물 및 그 제조방법에 관한 것이다. 본 발명에 따르면, 용매 존재 하에 시아노아세트산(cyannoacetic acid)과 옥탄 알콜을 1:1 당량비로 반응시켜 옥틸시아노아세테이트를 제조하는 단계, 용매 존재 하에 상기 옥틸시아노아세테이트와 파라포름알데히드를 1:1 당량비로 반응시키는 단계, 반응이 완료되면 용매를 제거한 후 옥틸시아노아크릴레이트를 분리,정제하는 단계, 옥틸시아노아크릴레이트를 정제하고 남은 부산물에서 폴리옥틸시아노아크릴레이트를 수득하는 단계, 및 폴리옥틸시아노아크릴레이트 및 골전도성 무기물질을 1:4 내지 1:7로 혼합하는 단계를 포함하는 생체 인공 구조물의 제조방법 및 그 제조 방법으로 제조된 생체 인공 구조물을 제공한다.
PCT/KR2011/008284 2010-11-02 2011-11-02 폴리옥틸시아노아크릴레이트를 이용하여 제조한 생체 인공 구조물 및 그 제조방법 WO2012060624A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2010-0108336 2010-11-02
KR1020100108336A KR20120046597A (ko) 2010-11-02 2010-11-02 폴리옥틸시아노아크릴레이트를 이용하여 제조한 생체 인공 구조물 및 그 제조방법

Publications (2)

Publication Number Publication Date
WO2012060624A2 WO2012060624A2 (ko) 2012-05-10
WO2012060624A3 true WO2012060624A3 (ko) 2012-07-05

Family

ID=46024950

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/008284 WO2012060624A2 (ko) 2010-11-02 2011-11-02 폴리옥틸시아노아크릴레이트를 이용하여 제조한 생체 인공 구조물 및 그 제조방법

Country Status (2)

Country Link
KR (1) KR20120046597A (ko)
WO (1) WO2012060624A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101427305B1 (ko) * 2013-03-26 2014-08-06 조선대학교산학협력단 골 이식재 및 그의 제조방법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050245966A1 (en) * 1997-12-17 2005-11-03 Hammerslag Julius G Controlled viscosity tissue adhesive
KR100650453B1 (ko) * 2005-06-04 2006-11-27 주식회사 예스바이오 골대체용 복합재료
KR20100030007A (ko) * 2008-09-09 2010-03-18 주식회사 예스바이오 골대체용 복합재료의 제조방법

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050245966A1 (en) * 1997-12-17 2005-11-03 Hammerslag Julius G Controlled viscosity tissue adhesive
KR100650453B1 (ko) * 2005-06-04 2006-11-27 주식회사 예스바이오 골대체용 복합재료
KR20100030007A (ko) * 2008-09-09 2010-03-18 주식회사 예스바이오 골대체용 복합재료의 제조방법

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KIM, SEONG BEOM: "Development of Instant Adhesives for Biological Tissue Closure", FINAL REPORT FOR R&D OF MINISTRY OF HEALTH & WELFARE, 2002, pages 8 - 9 *

Also Published As

Publication number Publication date
KR20120046597A (ko) 2012-05-10
WO2012060624A2 (ko) 2012-05-10

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