WO2012041705A1 - Anschlussvorrichtung zur fluidischen kontaktierung von mikrofluidikchips - Google Patents
Anschlussvorrichtung zur fluidischen kontaktierung von mikrofluidikchips Download PDFInfo
- Publication number
- WO2012041705A1 WO2012041705A1 PCT/EP2011/065946 EP2011065946W WO2012041705A1 WO 2012041705 A1 WO2012041705 A1 WO 2012041705A1 EP 2011065946 W EP2011065946 W EP 2011065946W WO 2012041705 A1 WO2012041705 A1 WO 2012041705A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sleeve
- flange
- connector
- connecting device
- microfluidic chip
- Prior art date
Links
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L11/00—Hoses, i.e. flexible pipes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/56—Labware specially adapted for transferring fluids
- B01L3/565—Seals
Definitions
- the invention comprises a connection device for the fluidic contacting of microfluidic chips, according to the preamble of claim 1.
- a macrofluidic conduit with an elastic sleeve is lengthened for contacting microfluidic platforms
- the sleeve is inserted in a contact body which has a recess with the outside diameter of the sleeve, and the elastic sleeve is selected so that it projects beyond the contact body in its axial extent
- the elastic sleeve is compressed in its receptacle in the contact body and seals the microfluidic chip and contact body against each other
- the contact body has holes on its side facing away from the microfluidic chip for inserting macrophilic Uidischen lines that correspond to the inner diameter of the sleeve.
- a macrofluidic line can thus be inserted into the elastic sleeve.
- the elastic sleeve undergoes a change in cross-section of the inside diameter and thus seals the transition between the macrofluidic line and the sleeve.
- This embodiment has the disadvantage that the support surface is very small, and the sealing surface is prone to contamination. In addition, inaccuracies in the position of the microfluidic chip can not be compensated.
- connection device for contacting microfluidic chips, which provides a high degree of tightness available, can be quickly and easily connected to the microfluidic chip and released again.
- the object is solved by the features of claim 1.
- the connecting device has at least one connector, wherein a connector comprises a sleeve, at the end of which there is a flange ring.
- the flange ring lies between the facing surfaces of the carrier plate and the microfluidic chip to be contacted.
- This flanged ring attached to the sleeve improves the sealing behavior. Contrary to the prior art, in which only a small footprint, the annular surface between the inner and outer diameter is sealed, the sealing surface is significantly increased by the projections of a flange. In addition, the power line changes such that the received in the contact body sleeve structure undergoes no narrowing of the cross section or its inner diameter. This ensures a reproducibility of the flow properties with improved seal.
- the molding of a flange seal on an elastic sleeve has the advantage that an equivalent seal can be achieved with less contact force.
- a more or less attenuating layer results between the fluid connection plate and the microfluidic chip. This avoids tension of the fluid chip and guarantees its function.
- the flange has a compensation function, which makes it possible to compensate for minor bumps or tolerances in the production of the fluid chip.
- the sleeve and the flange are integrally formed. This has the advantage of an optimal introduction of force. In addition, it avoids a small gap in which dirt particles can penetrate.
- the handling is significantly improved by one-piece fittings.
- the flange rings are glued or sprayed directly onto the carrier surface. This improves both the handling when connecting the carrier plate with the microfluidic chip, as well as during cleaning.
- a microfluidic chip can be contacted very quickly and nevertheless reliably releasably.
- the centering can preferably be done via the connection plate.
- this type of connection several connection points of a fluid chip can be contacted simultaneously. This saves a lot of time compared to conventional screwed connections, which all have to be individually screwed into the respective receptacles.
- the sealing connections are made of PDMS or other resistant and elastic plastic compounds.
- the recess in the flange has a slightly smaller diameter than the sleeve and a slightly larger diameter than the microfluid connection opening to be contacted.
- the opening cross section in the flange corresponds to the inner diameter of the hose. This results in an exceptionally small dead volume.
- the plastic connectors are preferably already integrated into the carrier plate or can be used in an alternative embodiment later in the carrier plate.
- the cross section of the recess in the carrier plate for receiving the sleeve is chosen to be slightly smaller than the outer diameter of the plastic sleeve. This leads to a compression of the sleeve in the radial direction, which significantly improves the tightness relative to the hose.
- the flange ring can be designed so that the inner diameter of the flange ring corresponds to that of the line. In particular, then lies the annular surface of the line on the flange.
- FIG. 1 shows an exploded view of a microfluidic system comprising the connecting device according to the invention
- Fig. 2 is a sectional view of the composite microfluidic system
- Fig. 3 is a detail sectional view of the connecting device.
- FIG. 1 shows an exploded view of a microfluidic system, comprising a base plate, a microfluidic chip, a connection plate with connectors inserted, and a holding device 18 for receiving a quick-release fastener 20.
- the holder 18 is mounted on the base plate 10. Between the holder 18 of the microfluidic chip 12 is inserted.
- the support plate 14 has on the microchip zugewanden side recesses into which the connectors 16 are inserted. Recesses are provided on the side remote from the microchip into which a macrofluidic line or a hose can be inserted.
- the macrofluidic tube is inserted into the sleeve 22 of a connector.
- centering pins 24 are provided, which extend through the bottom plate, the microfluidic chip and the carrier plate, in order to ensure that the connection openings of the microfluidic chip and that of the connectors 16 are aligned with one another.
- microfluidic chips can be contacted in a simple manner. This is especially true when all microfluidic chips have the openings for access to the microfluidic system within the chip at the same position. In this way, different chips can be quickly and easily inserted and removed in an appropriate device.
- the connections have a high flexibility with high seal and low dead volume.
- Fig. 2 shows a sectional view in which also the tube inserted into a connector is shown.
- This illustration shows the bottom plate 10, the microfluidic chip 12, the carrier plate 14, an adjusting pin 22 and a connector 16 installed in the carrier unit.
- the carrier is braced against the bottom plate. This results in a compression of the integrally formed on the sleeve 22 flange 26 in the area in which this is between the support plate 14 and the microfluidic chip 12.
- In the opening of the microfluidic chip 12 is aligned or coaxially aligned with the associated connector 16.
- FIG. 3 shows a detailed sectional view of a connector 16 in a carrier plate 14, wherein the connector 16 is placed on a microfluidic chip 12.
- the connector 16 comprises a sleeve 22 and a flange ring 26 integrally formed on it.
- the end of a macrofluidic hose 28 is inserted into the sleeve.
- the inner diameter of the recess in Make the flange so that it corresponds to the inner diameter of the hose. This ensures that no dead volume between tube 30 and sleeve 22 is formed, provided that the tube 30 is pushed up to the flange 26.
- the inner diameter of the flange ring 26 is dimensioned such that it is slightly larger than the opening of the fluid chip. As a result, tolerances in the connection can be compensated and a contact can be ensured despite inaccuracies.
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mechanical Engineering (AREA)
- Quick-Acting Or Multi-Walled Pipe Joints (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Micromachines (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013527649A JP2013543427A (ja) | 2010-09-14 | 2011-09-14 | マイクロ流体チップの流体接触のための接続構造 |
US13/821,398 US20130206268A1 (en) | 2010-09-14 | 2011-09-14 | Connecting device for the fluidic contacting of microfluidic chips |
EP11769806.8A EP2616179A1 (de) | 2010-09-14 | 2011-09-14 | Anschlussvorrichtung zur fluidischen kontaktierung von mikrofluidikchips |
CN2011800438415A CN103260761A (zh) | 2010-09-14 | 2011-09-14 | 用于微流控芯片的流体接触的连接装置 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102010037532A DE102010037532A1 (de) | 2010-09-14 | 2010-09-14 | Anschlussvorrichtung zur fluidischen Kontaktierung von Mikrofluidikchips |
DE102010037532.2 | 2010-09-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2012041705A1 true WO2012041705A1 (de) | 2012-04-05 |
Family
ID=44799996
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2011/065946 WO2012041705A1 (de) | 2010-09-14 | 2011-09-14 | Anschlussvorrichtung zur fluidischen kontaktierung von mikrofluidikchips |
Country Status (6)
Country | Link |
---|---|
US (1) | US20130206268A1 (de) |
EP (1) | EP2616179A1 (de) |
JP (1) | JP2013543427A (de) |
CN (1) | CN103260761A (de) |
DE (1) | DE102010037532A1 (de) |
WO (1) | WO2012041705A1 (de) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103406164A (zh) * | 2013-07-15 | 2013-11-27 | 广东凯普生物科技股份有限公司 | 可移动带磁力载膜平台 |
CN103878038A (zh) * | 2012-12-19 | 2014-06-25 | 中国科学院大连化学物理研究所 | 一种通用型微流控芯片夹具 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105536904B (zh) * | 2015-12-15 | 2018-04-10 | 苏州汶颢芯片科技有限公司 | 可逆微流控芯片夹具 |
CN105772125B (zh) * | 2016-04-23 | 2018-09-21 | 北京化工大学 | 基于3d打印的微流控芯片夹具实验平台 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2812959A (en) * | 1953-08-21 | 1957-11-12 | Westinghouse Air Brake Co | Flange union fitting with gland expandible into an opening |
WO2000052376A1 (en) * | 1999-03-02 | 2000-09-08 | Perseptive Biosystems, Inc. | Microfluidic connector |
WO2003081113A1 (de) * | 2002-03-25 | 2003-10-02 | Evotec Oai Ag | Vorrichtung und verfahren zur leitungsankopplung an fluidische mikrosysteme |
WO2009002152A1 (en) * | 2007-06-26 | 2008-12-31 | Micronit Microfluidics B.V. | Device and method for fluidic coupling of fluidic conduits to a microfluidic chip, and uncoupling thereof |
EP2230015A1 (de) * | 2009-03-13 | 2010-09-22 | Samsung Electronics Co., Ltd. | Schlauchanschlusskomponente und mikrofluidisches System damit |
WO2011057711A1 (de) * | 2009-11-13 | 2011-05-19 | Karlsruher Institut für Technologie | Mikrofluidischer multiport-busstecker |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5061635A (en) * | 1987-07-13 | 1991-10-29 | City Of Hope | Protein or peptide sequencing method |
EP0617278A1 (de) * | 1993-03-12 | 1994-09-28 | Orion Research, Incorporated | Kapillarverbindungen zur Anwendung bei Trennverfahren |
DE9413553U1 (de) * | 1994-08-23 | 1994-10-13 | Hewlett-Packard GmbH, 71034 Böblingen | Verbindungskapillare |
US7311882B1 (en) * | 2003-01-24 | 2007-12-25 | Sandia National Laboratories | Capillary interconnect device |
US7553455B1 (en) * | 2003-04-02 | 2009-06-30 | Sandia Corporation | Micromanifold assembly |
EP1854543B1 (de) * | 2006-05-11 | 2011-04-06 | Corning Incorporated | Modulares Halte- und Verbindungssystem für microfluidische Vorrichtungen |
US8337783B2 (en) * | 2009-06-23 | 2012-12-25 | The United States of America as represented by the Secretary of Commerce, the National Institute of Standards and Technology | Magnetic connectors for microfluidic applications |
US8569070B2 (en) * | 2010-07-16 | 2013-10-29 | Idex Health & Science Llc | Connection assembly for ultra high pressure liquid chromatography |
JP5906935B2 (ja) * | 2012-05-15 | 2016-04-20 | 株式会社島津製作所 | ニードルとニードルポートの接続構造 |
-
2010
- 2010-09-14 DE DE102010037532A patent/DE102010037532A1/de not_active Ceased
-
2011
- 2011-09-14 EP EP11769806.8A patent/EP2616179A1/de not_active Withdrawn
- 2011-09-14 US US13/821,398 patent/US20130206268A1/en not_active Abandoned
- 2011-09-14 CN CN2011800438415A patent/CN103260761A/zh active Pending
- 2011-09-14 WO PCT/EP2011/065946 patent/WO2012041705A1/de active Application Filing
- 2011-09-14 JP JP2013527649A patent/JP2013543427A/ja not_active Withdrawn
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2812959A (en) * | 1953-08-21 | 1957-11-12 | Westinghouse Air Brake Co | Flange union fitting with gland expandible into an opening |
WO2000052376A1 (en) * | 1999-03-02 | 2000-09-08 | Perseptive Biosystems, Inc. | Microfluidic connector |
WO2003081113A1 (de) * | 2002-03-25 | 2003-10-02 | Evotec Oai Ag | Vorrichtung und verfahren zur leitungsankopplung an fluidische mikrosysteme |
WO2009002152A1 (en) * | 2007-06-26 | 2008-12-31 | Micronit Microfluidics B.V. | Device and method for fluidic coupling of fluidic conduits to a microfluidic chip, and uncoupling thereof |
EP2230015A1 (de) * | 2009-03-13 | 2010-09-22 | Samsung Electronics Co., Ltd. | Schlauchanschlusskomponente und mikrofluidisches System damit |
WO2011057711A1 (de) * | 2009-11-13 | 2011-05-19 | Karlsruher Institut für Technologie | Mikrofluidischer multiport-busstecker |
Non-Patent Citations (1)
Title |
---|
ANIRUDDHA PUNTAMBEKAR ET AL: "Self-aligning microfluidic interconnects for glass- and plastic-based microfluidic systems; Self-aligning microfluidic interconnects for glass- and plastic-based microfluidic systems", JOURNAL OF MICROMECHANICS & MICROENGINEERING, INSTITUTE OF PHYSICS PUBLISHING, BRISTOL, GB, vol. 12, no. 1, 1 January 2002 (2002-01-01), pages 35 - 40, XP020068724, ISSN: 0960-1317, DOI: 10.1088/0960-1317/12/1/306 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103878038A (zh) * | 2012-12-19 | 2014-06-25 | 中国科学院大连化学物理研究所 | 一种通用型微流控芯片夹具 |
CN103878038B (zh) * | 2012-12-19 | 2015-09-09 | 中国科学院大连化学物理研究所 | 一种通用型微流控芯片夹具 |
CN103406164A (zh) * | 2013-07-15 | 2013-11-27 | 广东凯普生物科技股份有限公司 | 可移动带磁力载膜平台 |
CN103406164B (zh) * | 2013-07-15 | 2015-04-01 | 广东凯普生物科技股份有限公司 | 可移动带磁力载膜平台 |
Also Published As
Publication number | Publication date |
---|---|
CN103260761A (zh) | 2013-08-21 |
US20130206268A1 (en) | 2013-08-15 |
EP2616179A1 (de) | 2013-07-24 |
JP2013543427A (ja) | 2013-12-05 |
DE102010037532A1 (de) | 2012-03-15 |
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