WO2012020840A1 - 肌質改善用組成物 - Google Patents
肌質改善用組成物 Download PDFInfo
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- WO2012020840A1 WO2012020840A1 PCT/JP2011/068439 JP2011068439W WO2012020840A1 WO 2012020840 A1 WO2012020840 A1 WO 2012020840A1 JP 2011068439 W JP2011068439 W JP 2011068439W WO 2012020840 A1 WO2012020840 A1 WO 2012020840A1
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- cassis
- composition
- polysaccharide
- fruit
- skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
Definitions
- the present invention relates to a composition having an effect of improving skin quality, comprising a cassis fruit-derived substance as an active ingredient, and more specifically, a polysaccharide fraction contained in cassis fruit juice, in particular, partially decomposed with a specific enzyme.
- the present invention relates to a cosmetic composition, a pharmaceutical composition and a food for improving skin quality, comprising a polysaccharide which can be obtained as a result of an active ingredient.
- Active oxygen includes superoxide anion, hydrogen peroxide, hydroxyl radical, singlet oxygen and the like. These active oxygens activate various cytokines and cell surface receptors and promote the expression of target genes.
- a typical target gene is epidermal growth factor receptor (EGF-R).
- EGF-R epidermal growth factor receptor
- the activated EGF-R activates the transcription factor AP-1 via Jun N-terminal kinase.
- MMP matrix metalloproteinase
- Non-patent Document 1 a method using a cyclic amide derivative having an active oxygen scavenging action (Patent Document 1), and gold-silver-flower saponin (Patent Document 2), a method using a soot extract having an active oxygen scavenging action (Patent Document 3), and the like are known.
- the active ingredient in any of the methods is used as a coating agent, and few examples have been taken orally (Non-patent Documents 1-3).
- Cis is known as a fruit containing anthocyanins such as cyanidic acid rutinoside and delphinidin rutinoside as a polyphenol excellent in blood flow improving effect (Patent Document 4). Moreover, it has been reported that the polysaccharide contained in cassis has an immunostimulatory ability (Patent Documents 5 and 6, Non-Patent Document 4). However, no skin quality improvement effect by cassis has been reported so far.
- JP-A-8-081442 Japanese Patent Application Laid-Open No. 09-175888 JP 2006-83070 A JP 2004-262878 A JP 2006-137712 A JP 2004-107660 A
- An object of the present invention is to provide cosmetics, pharmaceutical compositions, foods, and the like that have a high effect on improving skin quality using raw materials derived from natural products that are readily available.
- the present inventor has conducted intensive research to solve the above-mentioned problems, and is a natural product that can be easily obtained or edible on a daily basis, especially a cassis fruit, particularly a polysaccharide contained in cassis fruit, more preferably limited and partially degraded. It was found that the polysaccharide has a high effect of improving the skin quality, and the present invention has been completed.
- the present invention includes the following features [1] to [12].
- a composition for improving skin quality comprising a cassis fruit-derived substance as an active ingredient.
- a pharmaceutical composition for improving skin quality comprising the composition according to any one of [1] to [5].
- a cosmetic composition for improving skin quality comprising the composition according to any one of [1] to [5].
- a food and drink for improving skin quality comprising the composition according to any one of [1] to [5].
- a method for producing a composition for improving skin quality comprising adding a product derived from cassis fruit.
- FIG. 1 is a characteristic diagram showing the inhibitory effect on the decrease in the amount of keratinous water caused by ultraviolet irradiation caused by ingestion of cassis fruit juice.
- FIG. 2 is a characteristic diagram showing an inhibitory effect on an increase in skin moisture transpiration due to ultraviolet irradiation, which is caused by ingestion of cassis fruit juice.
- FIG. 3 is a characteristic diagram showing a rough skin improving effect brought about by ingestion of cassis juice in a human test.
- the skin quality improving composition of the present invention contains a cassis fruit-derived material as an active ingredient.
- the cassis that can be used in the present invention is not particularly limited, and various generally available varieties such as BenArd, BenRua, and scope giant can be used.
- the “cassis fruit” may be unripe or fully ripe, but preferably it is fully ripe.
- the state of the “cassis fruit” is not particularly limited, and various forms can be used, which may be raw, dried, or dried powder. .
- a product derived from cassis fruit is a crude product or a purified product of polysaccharides contained in cassis fruit.
- “Roughly purified polysaccharide” refers to a cassis fruit or a crushed or puree thereof (containing a solid component derived from seeds, seed coats, fruits, or a product obtained by removing the solid component by a method such as centrifugation) Fruit juice) etc.) or lyophilized products thereof.
- a “purified polysaccharide” can be prepared based on a known method (Japanese Patent Application Laid-Open No.
- the “cassis fruit-derived product” is preferably a preparation in which the polysaccharide contained in the cassis fruit is limited and partially decomposed.
- the polysaccharide is limitedly and partially decomposed” and “the limited and partial decomposition of the polysaccharide” means that the polysaccharide contained in the cassis fruit has a molecular weight of 10,000 to 200. In the range of 1,000,000, preferably the average molecular weight of the included polysaccharide is about 10,000 to 150,000, more preferably about 10,000 to 96,000, and even more preferably about 10,000. Refers to a size of 000 to 56,000, more preferably about 10,000 to 34,000 (the average molecular weight of the polysaccharide is based on known techniques such as gel filtration analysis by HPLC).
- polysaccharide is limited and partially degraded” and “limited and partial degradation of polysaccharide” means that all polysaccharides contained in the cassis fruit are monosaccharides. It does not mean that the state has been completely decomposed.
- the limited and partial degradation of the polysaccharide contained in the cassis fruit can be carried out by treating the above-mentioned cassis fruit-derived material with an acid or an enzyme. Preferably, it is performed by enzyme treatment.
- the limited and partial enzymatic degradation of the polysaccharide contained in the cassis fruit can be carried out by adding ⁇ -galactosidase to the cassis fruit-derived material.
- the amount of ⁇ -galactosidase added can be appropriately determined in consideration of the type of the product derived from cassis fruit, the pH, the reaction temperature, the reaction time, the origin and degree of purification of ⁇ -galactosidase, and the like. If the amount added is too small, the reaction may take too long, and in some cases, the enzyme may be deactivated in the middle, and a degradation product having the desired molecular weight may not be obtained.
- the addition amount (range) of ⁇ -galactosidase is, for example, 0.01% to 10% (w / v), preferably 0.05% to 5% (w / v). It can be determined appropriately from the range. However, the addition amount (range) of the ⁇ -galactosidase is merely an example, and can be appropriately determined in consideration of the above conditions.
- the ⁇ -galactosidase used in the present invention is not particularly limited as long as the polysaccharide contained in the cassis fruit can be decomposed to the desired size, and various types can be used.
- ⁇ -galactosidase derived from Aspergillus oryzae is used.
- ⁇ -galactosidase other origins can be used as well.
- Examples of ⁇ -galactosidase derived from other sources include ⁇ -galactosidase derived from Kluyveromyces lactis, Saccharomyces fragilis, Escherichia coli, and the like.
- the peak on the saccharide (monosaccharide to oligosaccharide) side of a low molecular weight having a molecular weight of about 1,000 or less is not considered, and the peak on the polysaccharide side (MW> 1,000) has the above desired size.
- the enzymatic reaction is stopped to obtain the desired limited and partially degraded polysaccharide.
- a part of the reaction solution is sampled over time after the reaction is started, and the timing of the reaction stop can be monitored while analyzing by gel filtration by high performance liquid chromatography (HPLC).
- a high-performance liquid chromatography (HPLC) detector uses a differential refractometer, and basically detects only sugars (monosaccharides, disaccharides, oligosaccharides, polysaccharides).
- the enzyme reaction can be performed near the optimum temperature of the enzyme (for example, about 35 to 55 ° C.). However, since the pH of cassis juice is very low at about 2.9, the enzymatic reaction of cassis fruit-derived products including cassis juice should be performed at a lower temperature than the enzymatic degradation of isolated or partially purified polysaccharides. Is preferred.
- the enzyme reaction can be stopped by boiling the enzyme for several minutes, for example, 5 to 10 minutes, because the polysaccharide produced has high thermal stability. This operation can double as sterilization.
- the enzyme-treated cassis fruit has a neutral sugar rhamnose, mannose, arabinose, galactose, xylose and glucose at a ratio of about 18: 3: 19: 30: 1: 29 ( Molar ratio) (WO 2007/125823).
- a polysaccharide having the desired average molecular weight range may be purified as necessary.
- the purification method is not particularly limited, and for example, a small amount of insoluble precipitate generated by boiling can be removed by, for example, centrifugation.
- low molecules (monosaccharide to oligosaccharide) having a molecular weight of 1,000 or less may be removed by, for example, subjecting to ultrafiltration with a molecular weight cut off of 1,000.
- the content of the polysaccharide in the desired average molecular weight range in the cassis fruit-derived material is, for example, in the range of 50 to 95% by mass, in the range of 60 to 95% by mass, or in the range of 80 to 95% by mass. Can be increased to a range or more.
- the enzyme-treated cassis fruit-derived product may contain proteins and polyphenol compounds in addition to polysaccharides.
- the enzyme-treated cassis fruit-derived material or the purified polysaccharide having the above-mentioned desired average molecular weight range may be concentrated to give a concentrate, or freeze-dried to obtain a dried product. it can.
- skin quality improvement refers to prevention or repair of skin damage caused by external factors such as ultraviolet rays, detergents, irritating substances such as chemical substances, and internal factors such as hormonal balance disturbance.
- Means. Skin damage is accompanied by phenomena such as a decrease in stratum corneum barrier function, a decrease in stratum corneum moisture content, an increase in epidermis turnover, and roughening of the keratin due to the generation of scaling (scaling). It is possible to diagnose and / or evaluate the effects of damage and skin quality improvement.
- the decrease in the stratum corneum barrier function and the decrease in the stratum corneum water content can be grasped by measuring the stratum corneum water content and the transdermal water loss (TEWL).
- the skin quality improving composition of the present invention contains the above-mentioned cassis fruit-derived material as an active ingredient.
- the skin quality improving composition of the present invention contains the above-mentioned cassis fruit-derived material as an active ingredient.
- Damage specifically, desquamation, dusting, dryness, cracks, scratches, keratinization, hardening, facial fine lines, reduced skin flexibility, rough skin, itching, dry skin (dry skin) ), Sensitive skin, rash, atopic skin, etc. (not limited to these) can be prevented and / or improved.
- the skin quality improving composition of the present invention can be provided in various forms as long as the above effects are not impaired.
- a skin quality improving composition can be provided as a cosmetic composition.
- cosmetic composition includes cosmetics and quasi-drugs in the Pharmaceutical Affairs Law, and includes cosmetics, bath preparations, fragrances and the like used on the skin.
- Such cosmetic compositions include, for example, soap, synthetic cosmetic soap, liquid body cleanser (body soap), cleanser such as facial cleanser, cleansing cream, cleansing lotion, lotion, milky lotion, cosmetic liquid, lotion. , Liquid packs, paste packs, etc., white powder such as white powder, water white powder, white powder, cosmetics such as dust, foundation, lipstick, blush, cosmetics around the eyes such as eyeliner, eye shadow, sunscreen Cosmetics such as cosmetics, suntan cosmetics, and hair removal cosmetics, and shaving cosmetics such as shaving lotions and after-shaving lotions may be mentioned, but are not limited thereto.
- the cosmetic composition according to the present invention comprises an effective amount of the above-mentioned cassis fruit-derived substance, and can prevent and / or improve skin damage by use.
- the cosmetic composition can contain a cassis fruit-derived material in the range of 0.01 to 10% by weight, and the amount can be appropriately selected and determined according to the form of the cosmetic composition.
- ingredients usually used in cosmetics can be appropriately selected and added to the cosmetic composition as long as the object, action and effect of the present invention are not impaired.
- examples of such components include surfactants, oils, moisturizers, softeners, feel improvers, oiliness agents, emulsifiers, antioxidants, antiseptics, antifungal agents, emollients, pH adjusters, chelating agents, and stable agents.
- Agent ultraviolet absorber, alcohol, silicon compound, thickener, viscosity modifier, solubilizer, pearlizing agent, fragrance, refreshing agent, bactericidal agent, antibacterial agent, natural extract, colorant, anti-fading agent
- examples include, but are not limited to, purified water and other solvents, propellants, and the like.
- the skin quality improving composition can be provided as a pharmaceutical composition.
- the pharmaceutical composition of the present invention is capable of preventing, alleviating and treating skin damage, and skin diseases or symptoms associated with skin damage (for example, senile xerosis, childhood dry skin, vulgaris scale) It is effective in preventing, alleviating and / or treating scabies, atopic dermatitis, allergic dermatitis, sensitive skin, seasonal psoriasis, housewife eczema and the like.
- the pharmaceutical composition can be prepared as an oral preparation or a parenteral preparation, but an oral preparation is preferred.
- Oral preparations include granules, powders, tablets (including sugar-coated tablets), pills, capsules, syrups, emulsions, and suspensions.
- parenteral preparations include injections (for example, subcutaneous injections, intravenous injections, intramuscular injections, intraperitoneal injections), drops, and external preparations (for example, nasal preparations, transdermal preparations, ointments) ), Suppositories (for example, rectal suppositories, vaginal suppositories).
- These preparations can be formulated using a pharmaceutically acceptable carrier by a technique usually performed in this field.
- Pharmaceutically acceptable carriers include excipients, binders, diluents, additives, fragrances, buffers, thickeners, colorants, stabilizers, emulsifiers, dispersants, suspending agents, preservatives, etc.
- excipients include excipients, binders, diluents, additives, fragrances, buffers, thickeners, colorants, stabilizers, emulsifiers, dispersants, suspending agents, preservatives, etc.
- magnesium carbonate, magnesium stearate, talc, sugar, lactose, pectin, dextrin, starch, gelatin, tragacanth, methylcellulose, sodium carboxymethylcellulose, a low melting wax, cocoa butter and the like can be used as a carrier.
- the dose or intake of a substance derived from cassis fruit, which is an active ingredient in a pharmaceutical composition is an amount that can give a therapeutic effect for a given symptom or usage.
- the amount is appropriately determined by those skilled in the art based on animal studies and clinical trials, but the age, sex, body weight, applicable disease and symptoms, dosage form, administration method, etc. of the subject should be considered. It is.
- the pharmaceutical composition of the present invention is an oral preparation
- the dose or intake is 0.01 to 100 mg / Kg body weight / day, preferably 0.01 to 40 mg / Kg body weight / day. be able to.
- the skin quality improving composition can be provided as a food or drink.
- the food or drink of the present invention comprises an effective amount of the above-mentioned cassis fruit-derived material.
- the above-mentioned cassis fruit-derived material can be blended as it is or in the form of a composition containing them.
- the foods and drinks according to the present invention are those prepared from foods derived from cassis fruits as foods and drinks, and further blended with various proteins, sugars, fats, trace elements, vitamins and the like. can give.
- the said cassis fruit origin thing added to the general food-drinks may be used.
- the shape of the food or drink in the present invention may be liquid, semi-liquid or solid, or paste.
- “food and beverage” is classified into beauty food / health food, functional food, food for specified health use, dietary supplement, food with a disease risk reduction label, or food for the sick.
- Examples of the disease risk reduction display include a display indicating that it is for treating, improving, suppressing and / or preventing skin damage.
- foods and drinks in the present invention include carbohydrate-containing foods and drinks such as rice, rice cakes, noodles, breads and pasta; Western confectionery such as cookies and cakes; Japanese confectionery such as buns and sheep candy; Various sweets such as gums, jelly, yogurt and pudding, frozen desserts and ice confections; juices, soft drinks, milk drinks, tea drinks, functional drinks, nutritional supplement drinks, non-alcoholic beers, etc .; beer, foaming Alcoholic beverages such as liquor; Liquid foods and drinks such as soup, miso soup and soup; processed products using eggs, processed products of seafood and livestock meat; seasonings;
- the food / beverage products in this invention can contain other components, such as a nutritional supplement component, besides the cassis fruit origin.
- a nutritional supplement component such as a nutritional supplement component
- Such ingredients include vitamins, minerals, various plants and extracts thereof, purified products and fractions, microorganisms and growth factors and microorganism products thereof, dietary fiber and enzyme degradation products thereof, animal bodies and extracts thereof. , Purified products, degradation products and products, various oligosaccharides, lipids, various proteins and protein degradation products.
- the content of the product derived from cassis fruit, which is an active ingredient in the food and drink of the present invention, is usually about 0.01 to 50% by weight, preferably about 1 to 30% by weight, and about 0.1 per day per adult. Ingestion should be in the range of 5 to 500 g.
- the skin quality improving composition of the present invention contains a natural product-derived component as an active ingredient as described above, there is little concern about side effects, etc., and it is cheap and continues for a long period of time, regardless of the form. Can be used, administered and / or ingested.
- Example 1 Preparation of Cassis Fruit Juice by Polysaccharide Decomposing Enzyme Treatment
- Cassis fruit (BenRua) is crushed and solids such as the peel are separated to form cassis juice.
- a cassis juice in which the contained polysaccharide was partially decomposed was obtained (hereinafter referred to as “partially decomposed cassis juice”).
- the cassis juice was subjected to an enzyme treatment for 18 hours under the above conditions to obtain a cassis juice in which the contained polysaccharide was completely decomposed to monosaccharides (hereinafter referred to as “fully decomposed cassis juice”).
- Cassis juice that has not been subjected to enzyme treatment is hereinafter referred to as “untreated cassis juice”.
- Example 2 Molecular Weight Analysis of Polysaccharides in Untreated, Partially Degraded and Completely Degraded Cassis Juices Molecular weight analysis of polysaccharides contained in untreated, partially degraded cassis juice or fully degraded cassis juice was performed as follows. Molecular weight analysis was performed by gel filtration analysis using high performance liquid chromatography (HPLC) (column: OHpak SB-804 HQ (manufactured by Showa Denko KK)).
- HPLC high performance liquid chromatography
- Table 1 below shows the molecular weight analysis results of polysaccharides contained in untreated cassis juice, partially decomposed cassis juice, and fully decomposed cassis juice.
- Example 3 Protective effect against ultraviolet irradiation using hairless mice A mouse feed containing untreated cassis juice, partially degraded cassis juice or fully degraded cassis juice was prepared. When preparing the mouse feed, each fruit juice was in a powder state obtained by freeze-drying.
- composition of each feed is shown below.
- mice Four groups of 10 hairless mice (Hos: HR-1, 5 weeks old, female, Japan SLC) per group, each containing untreated cassis juice, partially degraded cassis juice or fully degraded cassis juice
- the contained feed or control feed was ingested for 2 weeks. Feeding was carried out so that the average was 4 g / day, and oral administration was performed. Thereafter, the back of each group of mice was each irradiated with 90 mJ / cm 2 of UV light once. Three days after irradiation with ultraviolet rays, the amount of horny water and transdermal moisture transpiration were measured, and the damage to the skin caused by ultraviolet irradiation was evaluated.
- ultraviolet irradiation was performed using SAN-EI SUPERCURE-204S (Sanei Electric Manufacturing Co., Ltd.), and Corneometer CM825 and Tewmeter TN300 (Integral Co., Ltd.) were used for the measurement of keratin moisture and transdermal moisture transpiration, respectively.
- the method of using each device is based on the manufacturer's instructions.
- the test was performed using a multiple test (Dunnett method).
- the amount of stratum corneum in mice exposed to ultraviolet rays was significantly lower than that in mice not irradiated with ultraviolet light, but a decrease in the amount of stratum corneum was observed in the fruit juice intake group. did it.
- Example 4 Production of test beverage Partially decomposed cassis juice was produced by the same production method as in Example 1, and 50 ml of each beverage (low dose group and high dose group) was prepared with the composition shown in the following table.
- Example 5 Human test 36 healthy women aged 35 to 50 were divided into 3 groups of 12 each, and the beverage of Example 4 (a beverage containing a low dose or a high dose of partially degraded cassis juice) ) Or a control beverage (beverage that does not contain partially degraded cassis juice) for 50 weeks per day for 8 weeks, and a questionnaire regarding rough skin was conducted at the start of the test, at the end of 4 weeks, and at the end of 8 weeks. If you have a higher score).
- Example 5 Human test 36 healthy women aged 35 to 50 were divided into 3 groups of 12 each, and the beverage of Example 4 (a beverage containing a low dose or a high dose of partially degraded cassis juice) ) Or a control beverage (beverage that does not contain partially degraded cassis juice) for 50 weeks per day for 8 weeks, and a questionnaire regarding rough skin was conducted at the start of the test, at the end of 4 weeks, and at the end of 8 weeks. If you have a higher score).
- Example 6 Cookies (30 pieces) are produced by the conventional method with the following composition.
- Example 7 A bread (4 parts) is produced in the following manner by a conventional method.
- Example 8 A chewing gum (for 30 pieces) is produced by the conventional method with the following composition.
- Example 9 A candy (for 20 pieces) is produced by the conventional method with the following composition.
- composition containing the cassis fruit-derived substance in the present invention as an active ingredient exhibits an effect of preventing or repairing skin damage through a moisturizing action on the skin. From this feature, the present invention is expected to be used as new cosmetics, pharmaceutical compositions, beauty foods, health foods and the like for preventing or repairing skin damage.
Abstract
Description
カシス果実(BenRua)を破砕し果皮等の固形分を分離してカシス果汁とした後、酵素剤スミラクトL(新日本科学製)を0.3%(w/v)添加し、42℃で6時間処理する事によって、含有する多糖類が部分分解されたカシス果汁を得た(以下、「部分分解カシス果汁」と記載する)。また、カシス果汁を上記条件において18時間酵素処理することによって、含有する多糖類が単糖類まで完全に分解されたカシス果汁を得た(以下、「完全分解カシス果汁」と記載する)。なお、酵素処理に付されていないカシス果汁を、以下「未処理カシス果汁」と記載する。
未処理、部分分解カシス果汁または完全分解カシス果汁に含まれる多糖類の分子量分析を以下の通りに行った。分子量分析は高速液体クロマトグラフィー(HPLC)(カラム:OHpak SB-804 HQ(昭和電工株式会社製))を用いたゲルろ過分析によって行った。
未処理カシス果汁、部分分解カシス果汁または完全分解カシス果汁を含有するマウス飼料を調製した。マウス飼料の調製に際しては、各果汁は凍結乾燥して得られた粉末状態のものを用いた。
実施例1と同様の製法にて部分分解カシス果汁を製造し、以下の表に示す調合組成で飲料(低用量群および高用量群)をそれぞれ50ml調製した。
健常な35歳から50歳までの女性36名を12名ずつ3つの群に分け、実施例4の飲料(部分分解カシス果汁を低用量含有する飲料あるいは高用量含有する飲料)または対照の飲料(部分分解カシス果汁を含有しない飲料)を1日当たり50mlずつ8週間摂取させ、試験開始時・4週経過時・8週経過時に肌荒れに関するアンケートを実施した(肌荒れが気になる場合はスコアが高くなる)。
次の配合で常法によりクッキー(30個分)を製造する。
次の配合で常法により食パン(4斤分)を製造する。
次の配合で常法によりチューインガム(30個分)を製造する。
次の配合で常法によりキャンディー(20個分)を製造する。
Claims (12)
- カシス果実由来物を有効成分として含んでなる、肌質改善用組成物。
- カシス果実由来物がカシス果実に含まれる多糖類を含む、請求項1に記載の組成物。
- カシス果実に含まれる多糖類が限定的かつ部分的に分解されている、請求項2に記載の組成物。
- 多糖類の平均分子量が10,000~200,000の範囲にある、請求項3に記載の組成物。
- 皮膚に対する保湿作用効果を有する、請求項1~4のいずれか1項に記載の組成物。
- 請求項1~5のいずれか1項に記載の組成物を含む、肌質改善するための医薬組成物。
- 請求項1~5のいずれか1項に記載の組成物を含む、肌質改善するための化粧品組成物。
- 請求項1~5のいずれか1項に記載の組成物を含む、肌質改善するための飲食品。
- カシス果実由来物を添加することを含む、肌質改善用組成物の製造方法。
- カシス果実由来物がカシス果実に含まれる多糖類を含む、請求項9に記載の方法。
- さらに、カシス果実に含まれる多糖類を限定的かつ部分的に分解することを含む、請求項10に記載の方法。
- 多糖類の平均分子量を10,000~200,000の範囲とする、請求項11に記載の方法。
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AU2011290175A AU2011290175B2 (en) | 2010-08-13 | 2011-08-12 | Composition for improving skin quality |
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WO2014112607A1 (ja) * | 2013-01-21 | 2014-07-24 | 国立大学法人名古屋大学 | 細胞製剤及び細胞の活性を高める方法 |
JP2015065927A (ja) * | 2013-09-30 | 2015-04-13 | キリン株式会社 | カシス果実由来の多糖含有組成物の製造方法 |
JP2015097475A (ja) * | 2013-11-18 | 2015-05-28 | アサヒビール株式会社 | ルイボスティーエキス含有ノンアルコール飲料 |
JP2018148919A (ja) * | 2018-06-01 | 2018-09-27 | アサヒビール株式会社 | ルイボスティーエキス含有ノンアルコール飲料 |
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WO2014112607A1 (ja) * | 2013-01-21 | 2014-07-24 | 国立大学法人名古屋大学 | 細胞製剤及び細胞の活性を高める方法 |
JP2015065927A (ja) * | 2013-09-30 | 2015-04-13 | キリン株式会社 | カシス果実由来の多糖含有組成物の製造方法 |
JP2015097475A (ja) * | 2013-11-18 | 2015-05-28 | アサヒビール株式会社 | ルイボスティーエキス含有ノンアルコール飲料 |
JP2018148919A (ja) * | 2018-06-01 | 2018-09-27 | アサヒビール株式会社 | ルイボスティーエキス含有ノンアルコール飲料 |
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AU2011290175A1 (en) | 2013-04-04 |
JP2016084356A (ja) | 2016-05-19 |
JPWO2012020840A1 (ja) | 2013-10-28 |
AU2011290175B2 (en) | 2014-08-07 |
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