WO2012019533A1 - Composition d'atomisation de cigarette électronique avec un gel de pectate de calcium et procédé de préparation et utilisation de celle-ci - Google Patents

Composition d'atomisation de cigarette électronique avec un gel de pectate de calcium et procédé de préparation et utilisation de celle-ci Download PDF

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Publication number
WO2012019533A1
WO2012019533A1 PCT/CN2011/078133 CN2011078133W WO2012019533A1 WO 2012019533 A1 WO2012019533 A1 WO 2012019533A1 CN 2011078133 W CN2011078133 W CN 2011078133W WO 2012019533 A1 WO2012019533 A1 WO 2012019533A1
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Prior art keywords
extract
parts
water
acid
propylene glycol
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PCT/CN2011/078133
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English (en)
Chinese (zh)
Inventor
郑国胜
周霞
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深圳市如烟生物科技有限公司
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Publication of WO2012019533A1 publication Critical patent/WO2012019533A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents

Definitions

  • the invention relates to an electronic aerosolization composition and a preparation method thereof, and also relates to a calcium pectate gel and a preparation method and application thereof.
  • the structure of an electronic cigarette generally includes an atomizer.
  • Conventional electronic cigarettes often bond the atomizer to the mouthpiece to make a disposable atomizer.
  • the structure of the prior art atomizer is a temperature-increasing component, which is heated by a battery to cause the smoke oil adjacent to it to volatilize, forming a smoke, thereby achieving the effect of "swallowing clouds and spitting" when sucking.
  • the technical problem to be solved by the present invention is to provide an electronic aerosolized composition capable of maintaining a solid paste and a preparation method thereof.
  • the present invention also provides a calcium pectate gel which makes the atomization effect more stable, and a preparation method and application thereof.
  • An electronic aerosol composition comprising the following components in a weight ratio: excipient 2 ⁇ 3. 0 parts, curing agent 0. 3 ⁇ 0. 8 parts, propylene glycol or glycerol 10 ⁇ 70 parts, water 5 ⁇ 25 copies.
  • the propylene glycol or glycerol is a commercially available product.
  • water is a solvent, that is, the solvent of the present invention is three kinds, one is a mixture of propylene glycol and water, one is a mixture of glycerin and water, and the other is propylene glycol, glycerin, a mixture of water.
  • the metering of the present invention is measured by mixing together propylene glycol and glycerol.
  • a solvent solution of a mixture of propylene glycol, glycerol, and water is not employed.
  • the excipient comprising the following components: xanthan gum and casein phosphopeptides, the weight ratio of the excipient is 0. 25 ⁇ 0. 67.
  • xanthan gum and casein phosphopeptides are commercially available products having thickening and binding effects.
  • propylene glycol citrate and sodium alginate are commercially available products.
  • the electronic aerosolizing composition can be formed into a solid, creamy substance, similar to a toothpaste. 5 ⁇ The composition of the composition of the weight ratio of the following components: the calcium pectate gel 0. 2 ⁇ 1. 0 parts. This fraction is calculated based on the overall composition of the electronic aerosolized composition.
  • the calcium pectate gel has a raw material comprising 5 to 15% of fruit acid, 20 to 40% of gelatin, 40 to 60% of water, and 15 to 20% of glycerin.
  • the fruit acid is one of glycolic acid, lactic acid, malic acid, tartaric acid, citric acid, mandelic acid or a combination thereof.
  • the role of the calcium pectate gel in the electronic aerosolization composition is to enhance its stability upon atomization. It is to be noted that the parts in the specification of the present invention are calculated based on the overall composition of the electronic aerosolized composition, unless otherwise specified.
  • composition further comprising the following components by weight: 30 ⁇ 35 parts of the medicament, or / and the tobacco extract 3 ⁇ 3. 5 parts, or / and the flavor of the tobacco 3 ⁇ 3.
  • the tobacco extract is a commercially available tobacco extract, more preferably a tobacco extract, such as a cloud smoke extract.
  • the tobacco flavor preferably, is a commercially available flavor.
  • the medicament comprises the following components: Gynostemma extract, German chamomile extract, casein phosphopeptide, dandelion extract, astragalus extract, honeysuckle extract, Chuanbei extract, chrysanthemum extract, lily extract, wood
  • Gynostemma extract German chamomile extract, casein phosphopeptide, dandelion extract, astragalus extract, honeysuckle extract, Chuanbei extract, chrysanthemum extract, lily extract, wood
  • the above agents are commercially available agents.
  • the composition of the drug in the weight percentage of the drug is: Gynostemma pentaphyllum extract 25 ⁇ 30. 0%, German chamomile extract 5 ⁇ 20. 0%, casein phosphopeptide 5 ⁇ 20. 0%, Dandelion extract 5 ⁇ 15. 0%, Astragalus extract 3 ⁇ : 15. 0%, honeysuckle extract 5 ⁇ 16. 0%, Chuanbei extract 3. 8 ⁇ 15. 8 %, chrysanthemum extract 5 ⁇ 15 5%, Coenzyme Q10 1 ⁇ , 5%, aspartic acid 0. 8 ⁇ 1. 5 %, Coenzyme Q10 1 ⁇ ⁇ 1. 38%, hyaluronic acid 0. 01 ⁇ , 8%, ⁇ / br> ⁇ / br> ⁇ / br> 4. 09%.
  • the solvent component is: 35 to 45 parts of propylene glycol, 10 to 15 parts of water; or glycerol 35 to 45 Parts, water 10 to 15 parts.
  • the water is pure water or deionized water.
  • the curing agent 0. 3 ⁇ 0.
  • the curing agent 0. 3 ⁇ 0. 8 parts, propylene glycol or glycerol 10 to 70 parts, water 5 to 25 parts;
  • the excipients include the following components: xanthan gum and casein phosphopeptides, their weight ratio in the excipient is 0 . 25 ⁇ 0 67;
  • said curing agent comprises the components: fats and propylene glycol alginate date, in which the weight ratio of the curing agent is from 0. 67 25 ⁇ 0.
  • the preparation method comprises the following steps: (1) mixing the above components and heating to 85 ° C to 90 ° C to obtain a mixed solution; (2) cooling the mixed solution to -10 ° C to - 20 ° C, a solid electronic aerosolized composition.
  • the step (1) is specifically: first adding a curing agent and an excipient to water, mixing uniformly to 85 ° C to 90 ° C until completely dissolved; adding an aqueous solution containing a curing agent and an excipient to propylene glycol or C In the triol, mix well and then heat to 85 ° C ⁇ 90 ° C.
  • the cooling device in the step (2) is a refrigerator.
  • the solvent component is: 35 to 45 parts of propylene glycol, 10 to 15 parts of water, or 35 to 45 parts of glycerin, and 10 to 15 parts of water.
  • the water is pure water or deionized water.
  • the composition further comprises the pectin as described above , wherein the curing agent comprises the following components: propylene glycol citrate and sodium alginate, the weight ratio of the curing agent in the curing agent is 0. 25 ⁇ 0; Calcium acid gel 0. 2 ⁇ 1.
  • the calcium pectate gel the raw materials including 5 ⁇ 15% of fruit acid, 20 ⁇ 40% of gelatin, 40 ⁇ 60% of water, glycerol 15 ⁇ 20%;
  • the fruit acid is one of glycolic acid, lactic acid, malic acid, tartaric acid, citric acid, mandelic acid or a combination thereof.
  • the preparation method comprises the following steps: preparing a calcium pectate gel by uniformly mixing the fruit acid and the gelatin, water and glycerin in the ratio; (I) the atomized composition group containing the calcium pectate gel described above Mix well and heat to 85 ° C ⁇ 90 °C, a mixed solution; ( ⁇ ) The above mixed solution is cooled to _10 ° C ⁇ - 20 ° C to obtain a solid electronic aerosolized composition.
  • the step (I) is specifically: first taking a curing agent, a calcium pectate gel, an excipient into water, mixing uniformly to 85 ° C to 90 ° C until completely dissolved; containing a curing agent, pectin The solution of the calcium acid gel and the excipient is added to propylene glycol or glycerin, mixed uniformly, and then heated to 85 ° C to 90 ° C.
  • the cooling device in the step (II) is a refrigerator.
  • the solvent component is: 35 to 45 parts of propylene glycol, 10 to 15 parts of water; or 35 to 45 parts of glycerin and 10 to 15 parts of water.
  • the water is pure water or deionized water.
  • the curing agent 0. 3 ⁇ 0.
  • the curing agent 0. 3 ⁇ 0. 8 parts, propylene glycol or glycerol 10 to 70 parts, water 5 to 25 parts;
  • the excipients include the following components: xanthan gum and casein phosphopeptides, their weight ratio in the excipient is 0 . 25 ⁇ 0 67;
  • said curing agent comprises the components: fats and propylene glycol alginate date, in which the weight ratio of the curing agent is from 0. 67 25 ⁇ 0. 5 ⁇
  • the electronic aerosolization composition further comprises 30 ⁇ 35 parts of the medicament, or / and the tobacco extract 3 ⁇ 3. 5 parts, or / and the flavor of the tobacco 3 ⁇ 3.
  • the preparation method comprises the following steps: A: adding the curing agent and the excipient to the deionized water according to the above ratio, mixing uniformly and heating to 85 ° C to 90 ° C until completely dissolved to form a mixed solution; B: mixing the solution Add the above ratio of propylene glycol or glycerol, mix well, and then raise the temperature to 85 ° C ⁇ 90 ° C ; C: the final solution in step B is cooled to about 40-75 ° C to add tobacco extract 3 ⁇ 3. 5 parts, or / and tobacco flavor 3 ⁇ 3. 5 parts, or / and 30 ⁇ 35 parts of the drug, mixed evenly; D: the final solution in step C is cooled to ⁇ 10 ° C ⁇ - 20 ° C, A solid electronic aerosolized composition.
  • the pharmaceutical agent comprises the following components: Gynostemma pentaphyllum extract, German chamomile extract, casein phosphopeptide, dandelion extract, astragalus extract, honeysuckle extract, Chuanbei extract Liquid, chrysanthemum extract, lily extract, wood butterfly extract, enzyme, aspartic acid, coenzyme Q10, dipotassium glycyrrhizinate, glycyrrhizic acid monoamine, taurine, hyaluronic acid, or a combination thereof, the weight ratio thereof For any ratio.
  • Casein phosphopeptide 5 ⁇ 20. 0% the content of the composition of the drug is 25 ⁇ 30. 0%, German chamomile extract 5 ⁇ 20. 0%, casein phosphopeptide 5 ⁇ 20. 0% , dandelion extract 5 ⁇ 15. 0%, scutellaria extract 3 ⁇ 15. 0%, honeysuckle extract 5 ⁇ 16. 0%, Chuanbei extract 3. 8 ⁇ 15. 8 %, chrysanthemum extract 5 ⁇ 15 5%, Coenzyme Q10 1 ⁇ , 5%, aspartic acid 0. 8 ⁇ 1. 5 %, Coenzyme Q10 1 ⁇ ⁇ 1. 38%, hyaluronic acid 0. 01 ⁇ , 8%, ⁇ / br> ⁇ / br> ⁇ / br> 4. 09%.
  • the temperature described in step C is 55 °C.
  • the cooling device in the step D is a refrigerator.
  • the solvent component is: 35 to 45 parts of propylene glycol, 10 to 15 parts of water; or 35 to 45 parts of glycerin and 10 to 15 parts of water.
  • the water is pure water or deionized water.
  • the curing agent 0. 3 ⁇ 0.
  • the curing agent 0. 3 ⁇ 0. 8 parts, propylene glycol or glycerol 10 to 70 parts, water 5 to 25 parts;
  • the excipients include the following components: xanthan gum and casein phosphopeptides, their weight ratio in the excipient is 0 . 25 ⁇ 0 67;
  • said curing agent comprises the components: fats and propylene glycol alginate date, in which the weight ratio of the curing agent is from 0. 67 25 ⁇ 0.
  • the electrospray composition further comprises a calcium pectate gel 0. 2 ⁇ 1. 0 parts, the raw materials including 5 ⁇ 15% of fruit acid, 20 ⁇ 40% of gelatin, 40 ⁇ 70% of water, glycerol 15 ⁇ 20%.
  • the electronic aerosolization composition further comprises 30 ⁇ 35 parts of the medicament, or / and the tobacco extract 3 ⁇ 3. 5 parts, or / and the flavor of the tobacco 3 ⁇ 3.
  • the preparation method comprises the following steps: 5 ⁇ 15% of fruit acid, 20 ⁇ 40% of gelatin, 40 ⁇ 70% of water, 15 ⁇ 20% of glycerol, uniformly mixed, and heated to 70 ⁇ 90 °C.
  • the pharmaceutical agent comprises the following components: Gynostemma pentaphyllum extract, German chamomile extract, casein phosphopeptide, dandelion extract, astragalus extract, honeysuckle extract, Chuanbei extract, chrysanthemum extract, One or a combination of lily extract, wood butterfly extract, enzyme, aspartic acid, coenzyme Q10, dipotassium glycyrrhizinate, glycyrrhizic acid monoamine, taurine, hyaluronic acid, in any ratio.
  • Casein phosphopeptide 5 ⁇ 20. 0% the content of the composition of the drug is 25 ⁇ 30. 0%, German chamomile extract 5 ⁇ 20. 0%, casein phosphopeptide 5 ⁇ 20. 0% , dandelion extract 5 ⁇ 15. 0%, scutellaria extract 3 ⁇ : 15. 0%, honeysuckle extract 5 ⁇ 16. 0%, Chuanbei extract 3. 8 ⁇ 15. 8 %, chrysanthemum extract 5 ⁇ 5%, Coenzyme, Coenzyme 0. 8%, Aspartic acid 0. 8 ⁇ 1. 5 %, Coenzyme 8%, ⁇ 0. 1 ⁇ 3. 38%, hyaluronic acid 0 0. 3 ⁇ 3. 8%, taurine 0. 1 ⁇ 3. 38%, hyaluronic acid 0 01 ⁇ 4. 09%.
  • the temperature in the step C is 55 °C.
  • the device for cooling in step D described therein is a refrigerator.
  • the solvent component is: 35 to 45 parts of propylene glycol, 10 to 15 parts of water; or 35 to 45 parts of glycerin and 10 to 15 parts of water. More preferably, the water is pure water or deionized water.
  • the invention also provides a calcium pectate gel, the raw material comprising 5 ⁇ 15% of fruit acid, 20 ⁇ 40% of gelatin, 40 ⁇ 70% of water and 15 ⁇ 20% of glycerol.
  • the fruit acid described therein is one of glycolic acid, lactic acid, malic acid, tartaric acid, citric acid, mandelic acid or a combination thereof.
  • the preparation method of the calcium pectate gel taking 5 ⁇ 15% of fruit acid, 20 ⁇ 40% of gelatin, 40 ⁇ 70% of water, 15 ⁇ 20% of glycerol, mixing evenly, and heating to 70 ⁇ 90° C, maintaining the time, the reaction produces a calcium pectate gel.
  • the fruit acid is one of glycolic acid, lactic acid, malic acid, tartaric acid, citric acid, mandelic acid or a combination thereof.
  • the retention time described therein is 1-20 hours.
  • the invention also discloses the use of the calcium pectate gel as an atomization stabilizer in an electronic aerosolized composition.
  • the medicinal health-care solid electronic atomized composition of the present invention is complicated by a curing agent, an excipient and a solvent (propylene glycol or glycerin, water) due to the use of an excipient, a curing agent, propylene glycol or glycerin.
  • the gel reacts and produces a synergistic effect, so that a solid-like gel can be formed which is much more convenient for the user than the liquid atomized composition.
  • the addition of a calcium pectate gel to the composition enables the atomized composition to form a network-like microcapsule structure, so that the atomized droplet size distribution is more uniform and finer, compared to the original atomization. Liquid, a greatly increased aerosol stability upon atomization.
  • the excipients are 3.0 parts, the curing agent is 0.8 parts, the propylene glycol is 60 parts, and the deionized water is 20 parts; the excipient consists of: xanthan gum and casein phosphopeptide, which are in the excipient
  • the weight ratio is 0.5, that is, 1 part of xanthan gum, 2 parts of casein phosphopeptide (of course, other components may be included in other embodiments);
  • the curing agent includes the following components: Acid propylene glycol ester and sodium alginate, they are solid 2 ⁇ Sodium alginate 0. 6 ⁇ The weight ratio of 0. 33, that is, propylene glycol methacrylate 0. 2 parts, sodium alginate 0. 6 parts.
  • the composition of the medicinal health-type solid electronic atomization composition comprising: propylene glycol 60 parts, deionized water 20 parts, excipients 3. 0 parts, curing agent 0. 8 parts, calcium pectate gel 1. 0 5 ⁇ ,
  • the tobacco extract is a liquid-type cloud smoke extract, a tobacco flavor 3. 5 parts, is a rose essence, a medicament 33. 2 parts.
  • the medicinal composition of the ginseng extract is 10. 0%, the casein phosphopeptide 1.0. 0%, the dandelion extract 8. 0%, the scutellaria extract 8. 0%, the honeysuckle extract 6. 0%,1,5 %, Aspartic acid 1. 5 %, ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 %%, the total amount of the coenzyme Q10 1. 33%, dipotassium glycyrrhizinate 1. 0%, glycyrrhizic acid monoamine 0. 8%, taurine 0. 38%, hyaluronic acid 0. 09%, their total amount is 33. 2 servings.
  • Medicinal health-type solid electronic atomization composition the main composition is: propylene glycol 45 parts, 35 parts of medicament, is a Gynostemma extract 30. 0, deionized water 10. 0 parts, the remaining components and preparation method is the same as in the second embodiment , Gynostemma-type electronic aerosolized cream. Can maintain a solid paste, easy to use, stable atomization
  • the medicinal health-type solid electronic atomization composition is: propylene glycol, 42 parts, 32 parts of the medicament, is a solution of Gynostemma pentaphyllum 32.0 parts, deionized water 15.0 parts, the remaining components and preparation method and Example 2
  • the Gynostemma-type electronic aerosolized paste can maintain a solid paste shape, is convenient to use, and has stable atomization.

Abstract

La présente invention concerne une composition d'atomisation de cigarette électronique qui comprend les composants suivants en parties en poids : 2 à 3,0 parties d'un excipient, 0,3 à 0,8 partie d'un agent durcissant, 10 à 70 parties de propylèneglycol ou de glycérol, et 5 à 25 parties d'eau ; l'excipient comprend les composants suivants : gomme xanthane et phosphopeptide de caséine dans un rapport en poids de 0,25 à 0,67 ; l'agent durcisseur comprend les composants suivants : alginate de propylèneglycol et alginate de sodium dans un rapport en poids de 0,25 à 0,67, le propylèneglycol ou le glycérol et l'eau étant des solvants. Dans un gel de pectate de calcium et un procédé de préparation et l'utilisation de celui-ci, le gel de pectate de calcium comprend de 5 à 15 % d'acide de fruit, de 20 à 40 % de gélatine, de 40 à 70 % d'eau, et de 15 à 20 % de glycérol. La composition d'atomisation de cigarette électronique peut être maintenue sous la forme d'une pâte solide, par conséquent elle est commode à utiliser, et a des effets d'atomisation stables.
PCT/CN2011/078133 2010-08-09 2011-08-08 Composition d'atomisation de cigarette électronique avec un gel de pectate de calcium et procédé de préparation et utilisation de celle-ci WO2012019533A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201010249133.4 2010-08-09
CN201010249133A CN101933653B (zh) 2010-08-09 2010-08-09 药用保健型固体电子烟雾化液及制备方法

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WO2012019533A1 true WO2012019533A1 (fr) 2012-02-16

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PCT/CN2010/076374 WO2012019372A1 (fr) 2010-08-09 2010-08-26 Solution de pulvérisation pour cigarette électronique à base de particules solides d'un produit de soins de santé médicinal et sa préparation
PCT/CN2011/078133 WO2012019533A1 (fr) 2010-08-09 2011-08-08 Composition d'atomisation de cigarette électronique avec un gel de pectate de calcium et procédé de préparation et utilisation de celle-ci

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Application Number Title Priority Date Filing Date
PCT/CN2010/076374 WO2012019372A1 (fr) 2010-08-09 2010-08-26 Solution de pulvérisation pour cigarette électronique à base de particules solides d'un produit de soins de santé médicinal et sa préparation

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CN (1) CN101933653B (fr)
WO (2) WO2012019372A1 (fr)

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