WO2012001806A1 - Solution désinfectante pour lentille de contact, et système de désinfection de lentille de contact - Google Patents

Solution désinfectante pour lentille de contact, et système de désinfection de lentille de contact Download PDF

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Publication number
WO2012001806A1
WO2012001806A1 PCT/JP2010/061270 JP2010061270W WO2012001806A1 WO 2012001806 A1 WO2012001806 A1 WO 2012001806A1 JP 2010061270 W JP2010061270 W JP 2010061270W WO 2012001806 A1 WO2012001806 A1 WO 2012001806A1
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WIPO (PCT)
Prior art keywords
contact lens
component
hydrogen peroxide
disinfectant
acid
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Application number
PCT/JP2010/061270
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English (en)
Japanese (ja)
Inventor
理 森
真英 角田
Original Assignee
株式会社メニコン
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Priority to PCT/JP2010/061270 priority Critical patent/WO2012001806A1/fr
Priority to JP2011550768A priority patent/JPWO2012001806A1/ja
Publication of WO2012001806A1 publication Critical patent/WO2012001806A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/12—Non-macromolecular oxygen-containing compounds, e.g. hydrogen peroxide or ozone
    • A61L12/124—Hydrogen peroxide; Peroxy compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/12—Non-macromolecular oxygen-containing compounds, e.g. hydrogen peroxide or ozone
    • A61L12/124—Hydrogen peroxide; Peroxy compounds
    • A61L12/128—Hydrogen peroxide; Peroxy compounds neutralised with catalysts

Definitions

  • the present invention relates to a contact lens disinfectant and a contact lens disinfection system using the same, and more particularly to a technique capable of effectively disinfecting and cleaning a contact lens using hydrogen peroxide. is there.
  • a disinfection system using hydrogen peroxide is widely known as one of methods for chemically disinfecting contact lenses, particularly soft contact lenses.
  • Hydrogen peroxide used therein is an effective disinfectant and is particularly attractive for disinfecting contact lenses in that the decomposition product is merely water. Since it is a violent oxidizer, hydrogen peroxide must be completely removed from the lens before the disinfected contact lens is put on the eye again.
  • Patent Document 1 discloses a vertical contact lens case as a contact lens sterilizer. In which a sterilizing solution containing hydrogen peroxide is contained in a contact lens case, while a contact lens to be treated and a catalyst member made of a catalytic metal such as platinum are arranged to form the sterilizing solution.
  • a contact lens to be treated and a catalyst member made of a catalytic metal such as platinum are arranged to form the sterilizing solution.
  • the contact lens In this system, the contact lens must be sterilized with a single solution, and after neutralization, the contact lens must be stored and kept in a state where it can be worn on the eye.
  • isotonic agents and buffering agents that adjust the osmotic pressure and pH of the solution to the same level as tears will be included in the disinfectant solution.
  • Tonicity agents and buffering agents are generally not provided with the function of cleaning contact lenses.
  • contact lenses are contaminated with dirt such as lipids and proteins existing in tear fluid during wearing, and in particular, proteins are left as they are attached to contact lenses.
  • degeneration is an irreversible structural change.
  • the protein thus denatured is recognized as a heterologous protein in the eye, causing conjunctival hyperemia as an allergic reaction, and in severe cases, may cause giant papillary conjunctivitis. It is known. For this reason, it has been desired to add a component that removes protein stains to the disinfecting solution containing hydrogen peroxide as a cleaning component, but products that can fully demonstrate the effect have not yet been developed. The current situation is not.
  • Patent Document 2 discloses a hydrogen peroxide aqueous solution for disinfecting contact lenses, a first peroxide stabilizer composed of alkanols of diphosphonic acid, glycerin, PVA, and propylene glycol. It has been clarified that a disinfectant is constituted by containing a second peroxide stabilizer such as polyacrylic acid and further containing a tension enhancer, a thickener, a buffering agent, and the like. However, it was only intended to stabilize hydrogen peroxide by containing the first and second hydrogen peroxide stabilizers.
  • Patent Document 3 in a contact lens disinfection system using hydrogen peroxide, an aqueous solution containing hydrogen peroxide and a surfactant is rubbed against the surface of the contact lens. A method for removing proteins, lipids, and other deposits on the lens surface by immersing in the aqueous solution for a sufficient period of time has been clarified. It is only described that the foaming action of the surfactant synergistically acts on the dirt on the lens surface, so that the dirt on the lens surface is easily decomposed and removed.
  • the present invention has been made in the background as described above, and the problem to be solved is that the contact lens is effectively sterilized with hydrogen peroxide while the contact lens is effectively disinfected. It is an object of the present invention to provide a contact lens disinfecting solution that can advantageously remove protein stains, improve storage stability and enable long-term storage, and further provides a contact lens disinfection solution using such a disinfecting solution. It is to provide an effective disinfection system.
  • the present invention can be suitably implemented in various aspects as listed below.
  • Each aspect described in the above can be employed in any combination.
  • the aspects or technical features of the present invention are not limited to those described below, and can be recognized based on the inventive concept grasped from the description of the entire specification. Should be understood.
  • a hydrogen peroxide-containing aqueous solution having a hydrogen peroxide concentration of 1 to 5% contains an A component composed of a compound having at least one carboxyl group in the molecule.
  • Disinfection system (10) The contact lens disinfection system according to the aspect (9), wherein the metal catalyst is a metal film catalyst. (11) The metal catalyst is disposed in a predetermined processing container for disinfecting the contact lens, and the disinfecting liquid is accommodated in the processing container, and the disinfecting liquid accommodated in the metal catalyst.
  • a predetermined compound (component A) having at least one carboxyl group in the molecule is contained in an aqueous solution containing hydrogen peroxide.
  • a very excellent protein removal ability can be effectively exhibited
  • Inclusion of a predetermined compound (component B) having a plurality of hydroxyl groups in the molecule and further adjusting the pH of the disinfectant solution to near neutrality effectively suppresses the increase in pH of the disinfectant solution.
  • the contact lens disinfecting solution according to the present invention having excellent storage stability is used, so that effective disinfection of contact lenses with hydrogen peroxide can be realized.
  • the component B contained in such a disinfectant solution has a plurality of hydroxyl groups in the molecule, the contact is sterilized by water molecules hydrated to the hydroxyl groups. An effective wetting effect can also be effectively imparted to the lens.
  • the hydrogen peroxide concentration is adjusted to be 1 to 5% (weight basis).
  • the content of hydrogen peroxide is less than the above range, there is a problem that the disinfection effect of the contact lens due to hydrogen peroxide cannot be sufficiently exerted, and conversely, when the content exceeds the above range.
  • it takes time for the neutralization treatment or causes problems such as decomposition of hydrogen peroxide and the need to increase the amount of catalyst used for neutralization. Due to insufficient neutralization treatment, hydrogen peroxide tends to remain on the surface and inside of the contact lens, and there are problems such as concern about adverse effects on the eyes.
  • a hydrogen peroxide concentration of about 2 to 4% by weight is preferably employed.
  • Such a disinfectant solution (hydrogen peroxide-containing aqueous solution) has a carboxyl group in the molecule as an A component having excellent protein removal ability in order to remove protein soil as well as disinfect according to the present invention.
  • the organic carboxylic acid which is a compound is contained. This organic carboxylic acid generally has 1 to 3 carboxyl groups and, under the disinfection treatment with hydrogen peroxide, exhibits an excellent ability to remove protein stains adhering to the contact lens. Effective cleaning (removal of protein stains) can be performed.
  • organic carboxylic acid used as the component A various known organic carboxylic acids that have been conventionally applicable to the treatment of contact lenses can be appropriately selected and used.
  • glycolic acid, lactic acid, tartaric acid, succinic acid, fumaric acid, maleic acid, malic acid, aconitic acid, glutaric acid, citric acid and the like are preferably used.
  • Such a predetermined organic carboxylic acid is generally at least 0.01% or more by weight based on the weight of the disinfecting solution in order to effectively remove the protein soil targeted by the present invention. It is desirable to be included at a ratio of 0.05% or more.
  • the upper limit of the content of the A component is generally about 1% by weight, preferably about 0.8% by weight, particularly preferably about 0.6% by weight. Depending on the type, the concentration is appropriately determined so that the object of the present invention can be sufficiently achieved.
  • the pH of the preparation gradually increases due to the strong oxidizing power of hydrogen peroxide when stored for a long time.
  • it has been found that it becomes strongly alkaline.
  • the generation rate of highly reactive OH radicals increases, and the decomposition rate increases rapidly. Therefore, it becomes difficult to stably store for a long time. Therefore, the present inventors have conducted various studies on components that can suppress the increase in pH of the disinfectant solution due to such component A.
  • the B component is present in the hydrogen peroxide-containing disinfecting solution together with the A component.
  • such a compound having a plurality of hydroxyl groups as the B component is hydrated with water due to the presence of the plurality of hydroxyl groups, and is effective for contact lenses to be treated. A wetting effect can also be imparted.
  • the B component that suppresses the increase in pH due to such an A component is an organic compound having a plurality of OH groups in the molecule and can be applied to the treatment of contact lenses.
  • a polyvalent polyhydric group having a hydrocarbon group having 3 to 20 carbon atoms such as propylene glycol, glycerin, hexanetriol, and 1,2-pentanediol can be selected and used as appropriate.
  • Those selected from alcohols, various monosaccharides, oligosaccharides of 2 to 5 sugars such as trehalose, sugar alcohols such as erythritol and sorbitol, and polyethylene glycol are preferably used.
  • the content of the B component in the disinfectant is appropriately selected according to the content ratio of the A component, and is generally a ratio of 5/1 to 1/3 in terms of the weight ratio of the A component / B component. It will be made to contain so that it may become.
  • the suppression effect of the pH rise by B component may not fully be exhibited when the ratio of A component with respect to B component increases, and when the ratio of B component with respect to A component increases, This is because it becomes difficult to sufficiently exert the treatment effect by the component A, and problems such as an increase in the liquid pH due to the component B are likely to be caused.
  • the pH of the disinfectant solution containing the above-mentioned specific A component and B component together with the predetermined concentration of hydrogen peroxide is adjusted to 6-8.
  • An acid or an alkali agent is used for this pH adjustment.
  • a commercially available appropriate aqueous hydrogen peroxide solution is used in the preparation of a hydrogen peroxide-containing disinfectant.
  • a known appropriate alkaline agent such as sodium hydroxide or potassium hydroxide is preferably added together with the above-described A component and B component because it is maintained in an acidic state.
  • the pH of such an aqueous hydrogen peroxide solution is adjusted, so that the resulting disinfectant solution is prepared to have a pH of 6-8.
  • the pH of the disinfectant solution is lower than 6, it becomes impossible to wear the disinfected contact lens on the eye as it is, and if the pH is too low, the stability of hydrogen peroxide.
  • problems such as adversely affecting the neutralization efficiency of hydrogen peroxide are caused, and the pH exceeds 8.
  • the stability of the disinfecting solution decreases, and problems such as difficulty in long-term storage of the disinfecting solution are caused.
  • the chelating agent can further improve the stability of the disinfectant according to the present invention and can be advantageously stored for a long period of time.
  • EDTA ethylenediaminetetraacetic acid
  • DTPMP diethylenetriaminepenta (methylenephosphonic acid)]
  • sodium stannate sodium stannate and the like are advantageously used.
  • Such a chelating agent is generally contained in the disinfectant solution at a concentration of about 0.01 to 0.5% by weight.
  • surfactants may be further incorporated for the purpose of cleaning contact lenses.
  • Such surfactants have conventionally been used in contact lens solutions and the like. Any of known anionic surfactants, nonionic surfactants, amphoteric surfactants, and cationic surfactants that are commonly used can be advantageously employed. An effective cleaning effect such as lipid removal action is provided. Among them, in the present invention, nonionic surfactants are preferably used.
  • polyethylene glycol ethers of higher alcohols polyethylene glycol esters of higher fatty acids, polyglycerol esters of higher fatty acids, polyethylene glycol ethers of alkylphenols, Polyethylene glycol sorbitan alkyl ester, polyoxyethylene-polyoxypropylene glycol (poloxamer), ethylenediaminetetrapolyoxyethylene polyoxypropylene (poloxamine), and the like.
  • blocks of polyoxyethylene and polyoxypropylene Copolymers or derivatives thereof are advantageously used.
  • an isotonic agent is added to easily adjust the osmotic pressure of the disinfecting solution before disinfecting the contact lens, and thus the disinfecting solution after disinfecting, and is added to the contact lens solution. It is appropriately selected from various known isotonic agents that are generally used.
  • each component is added to the aqueous medium in the same manner as in the case of preparing a normal contact lens solution.
  • the desired disinfectant solution can be easily obtained by adding them sequentially or simultaneously or in combination as appropriate and dispersing or dissolving them.
  • a solution mainly composed of water may be used, for example, physiological saline, contact lens storage solution, cleaning solution Needless to say, it is also possible to use a known aqueous solution such as the above.
  • the disinfecting solution according to the present invention thus obtained is stored for a long time after its preparation, the increase in pH due to the presence of the A component is effectively suppressed by the B component.
  • a disinfecting solution can be advantageously used for disinfecting contact lenses over a long period of time.
  • the contact lens can also have an effective wetting effect.
  • the contact lens to be disinfected is immersed in the disinfectant solution thus prepared, so that the contact lens is disinfected with hydrogen peroxide. And protein soil removal treatment (washing treatment) are performed simultaneously.
  • the hydrogen peroxide is decomposed so that the hydrogen peroxide does not remain in the disinfectant solution.
  • the disinfecting solution in which the contact lens is immersed is brought into contact with a predetermined decomposition / neutralizing agent in the same manner as before, so that the decomposition / neutralization treatment by contact with hydrogen peroxide is performed. Will be done.
  • decomposition / neutralizing agents such as metal catalysts such as platinum, enzyme agents such as peroxidase and catalase, or sodium sulfite, pyruvic acid, sodium thiosulfate, etc.
  • metal catalysts such as platinum
  • enzyme agents such as peroxidase and catalase
  • sodium sulfite pyruvic acid, sodium thiosulfate, etc.
  • a metal catalyst is advantageously used.
  • a metal catalyst that realizes a neutralization process that comes in contact with hydrogen peroxide present in the disinfectant solution, decomposes it, and renders it harmless so as not to adversely affect the eyes.
  • various known ones that have been conventionally used for the decomposition and neutralization treatment of hydrogen peroxide are appropriately selected.
  • platinum is preferably used as such a metal catalyst, but other metals such as palladium, silver, copper, manganese, cobalt, and aluminum, or oxides of such metals can also be used. It is.
  • metals or their oxides can be formed as metal catalysts in the same catalyst form as in the prior art, but in the present invention, in particular, a metal film catalyst, in other words, the aforementioned metal Alternatively, a catalyst in which the oxide is deposited and formed on a predetermined base material is advantageously used.
  • a metal film catalyst is formed by coating the above-described catalyst metal on the surface of a substrate of various shapes such as a disk or a flat plate having a predetermined size by a known thin film forming method such as plating or sputtering. What is formed is used, and when placed in the disinfecting solution, it is brought into contact with hydrogen peroxide present in the disinfecting solution.
  • plastic materials include acrylonitrile / butadiene / styrene (ABS) resin, polyurethane, modified polyphenylene ether, polystyrene, polycarbonate, polyethylene terephthalate (PET), polybutylene terephthalate (PBT), polyvinyl chloride, polyetherimide, Polysulfone, polymethyl methacrylate, and copolymer resins thereof can be suitably used.
  • ABS acrylonitrile / butadiene / styrene
  • PC polyurethane
  • modified polyphenylene ether polystyrene
  • polycarbonate polyethylene terephthalate
  • PET polyethylene terephthalate
  • PBT polybutylene terephthalate
  • polyvinyl chloride polyetherimide
  • Polysulfone polymethyl methacrylate
  • copolymer resins thereof can be suitably used.
  • a contact lens and a decomposition / neutralizing agent such as a metal catalyst are charged or immersed in the disinfecting solution simultaneously or sequentially in a state where a predetermined amount of the disinfecting solution is contained in a predetermined processing container.
  • a contact lens and a decomposition / neutralizing agent such as a metal catalyst are charged or immersed in the disinfecting solution simultaneously or sequentially in a state where a predetermined amount of the disinfecting solution is contained in a predetermined processing container.
  • disinfecting solution is injected into the processing container in a state where decomposition / neutralizing agents such as contact lenses and metal catalysts are placed in the container.
  • the contact lens and the neutralization treatment are performed in parallel or the contact lens and the decomposition / neutralizing agent are placed in the treatment container, the disinfectant is contained, and then the contact lens and the decomposition / neutralization agent are stored.
  • a method of immersing one of the other in a disinfecting solution and bringing it into contact with each other will be appropriately employed.
  • a known processing container for contact lens processing using a liquid agent can be appropriately selected and used. More specifically, The sterilizer having the structure as disclosed in Patent Document 1 can be used as it is. In any case, if the contact lens and the decomposition / neutralizing agent such as a metal catalyst are accommodated and disposed, they can be immersed in the disinfecting solution and brought into contact with each other. Processing containers can also be employed.
  • the disinfecting solution according to the present invention maintains the pH of 6 to 8 due to the presence of the A component and the B component.
  • the disinfection solution used for disinfection / neutralization of contact lenses (unused) is advantageously such that the disinfection solution after neutralization has an osmotic pressure of 250 to 350 mOsm.
  • the content of these components is adjusted, the addition amount of the additive component added is adjusted as necessary, and a known isotonic agent is added and contained as necessary. .
  • the osmotic pressure of the sterilizing solution after such neutralization the osmotic pressure of the sterilizing solution becomes substantially equal to the osmotic pressure of tear fluid.
  • the contact lens targeted in the disinfectant solution or disinfection system according to the present invention is not limited in any way, and may be, for example, water-containing or non-water-containing, soft or hard materials. Regardless, all types of contact lenses can be targeted, and the material of the contact lenses is not questioned when applying the present invention. However, since the conventional disinfection system using hydrogen peroxide is used for disinfecting soft contact lenses, even in the present invention, it is mainly applied to disinfection of soft contact lenses. .
  • the soft contact lens one made of a hydrous hydrogel is known, and representative examples thereof include 2-hydroxyethyl methacrylate, N, N-dimethylacrylamide, N-vinyl-2- These are formed from polymers or copolymers of hydrophilic monomers such as pyrrolidone and methacrylic acid. Recently, however, these hydrophilic monomers are combined with a hydrophobic monomer containing silicone to form a copolymer.
  • a contact lens made of silicon hydrogel, which is a copolymer produced by polymerization, is also included in the soft contact lens, and the present invention can also be applied to such a soft contact lens. .
  • the contact lens subjected to the disinfection treatment is usually taken out from the disinfecting solution and worn on the eyes.
  • the hydrogen peroxide in the solution has been subjected to neutralization treatment using a metal catalyst decomposition / neutralizing agent, so the amount of hydrogen peroxide remaining in the disinfectant is extremely small, and contact Since the hydrogen peroxide attached to the lens or remaining in the lens is almost negligible, no matter what happens even if the contact lens taken out from the disinfectant is put on the eye as it is. This problem will not be caused, and it can be safely worn.
  • Example 1- First, use a commercially available aqueous hydrogen peroxide solution, dilute it with distilled water to adjust to the various concentrations shown in Tables 1 to 6 below, and add various additive components shown in those tables. In this manner, various disinfectant solution samples according to Experimental Examples 1 to 41 were prepared. Moreover, when preparing such a disinfectant solution sample, hydrochloric acid was used as the acid, or caustic soda was used as the alkaline agent to obtain a disinfectant solution sample having a target pH value.
  • DTPMP diethylenetriaminepenta (methylenephosphonic acid)
  • sodium stannate is used as chelating agents
  • glycolic acid, tartaric acid, succinic acid, malic acid and citric acid are used as the A component.
  • PG propylene glycol
  • PEG polyethylene glycol 1500
  • PEG 4000 erythritol and trehalose
  • NaCl and hydrogen phosphate Na are added as other auxiliary components such as an isotonic agent and a buffer, It can be contained.
  • the residual rate of hydrogen peroxide in each disinfectant solution sample is determined by measuring with the “oxide titration method” described in the Japanese Pharmacopoeia, and when the residual rate is 90% or more Is evaluated as ⁇ , when it is 70% or more and less than 90%, ⁇ when it is 50% or more and less than 70%, and ⁇ when it is less than 50%.
  • the results are shown in Tables 1 to 6 below. Also shown.
  • the solution pH is measured, and the value is 6.9 or more and less than 7.5. ⁇ , ⁇ if 6.6 or more and less than 6.9 and 7.5 or more and less than 7.8, ⁇ , if 6.2 or more and less than 6.6 and 7.8 or more and less than 8.2 In other cases, it was evaluated as “x”, and the results were also shown in Tables 1 to 6 below.
  • Example 2- Using the disinfectant sample prepared in the composition shown in Table 7 below together with the disinfectant sample prepared in Example 1 (Experimental Examples 1, 4, 11, 12, 13, 18, and 28), each disinfectant was used. The removal effect of the protein soil of the liquid sample was evaluated. The results are shown in Table 7 below.
  • the contact lens “Acuvue 2 lens” (manufactured by Johnson & Johnson), which is an ionic high water content contact lens classified as group IV which is easily contaminated with protein, was used.
  • the protein stain removal effect test was performed as follows: First, six of the above-mentioned test lenses were put into a test tube, and they were cut into pieces using a pulverizer. Next, the fragmented lens piece is accommodated in an injection container with a filter for holding the lens piece on the bottom surface, washed thoroughly with purified water, and then the injection container containing the lens piece. After sealing the tip, 2 mL of a separately prepared artificial protein solution was added to the injection container, mixed with the lens piece, and sufficiently infiltrated using a vortex mixer. After that, discard the artificial protein solution in the injection container, and after pouring the remaining artificial protein solution lightly with purified water, add 2 mL of each disinfectant sample and mix well with a vortex mixer. Was washed.
  • each disinfectant sample after such washing was collected, and the absorbance at a wavelength of 281 nm was measured to calculate the amount of lysozyme removed per lens [ ⁇ g / lens].
  • the same operation was performed using a blank without a lens piece as a blank, and the calculated value was corrected.
  • the artificial protein solution used above 100 mL scale was prepared by accurately weighing lysozyme derived from egg white: 0.12 g and calcium chloride: 0.011 g, and dissolving them in purified water. was carried out by setting the weight to 100 g.
  • Example 3- Along with each disinfectant sample obtained in Example 1 (Experimental Examples 1, 11, 12 and 13), each disinfectant sample of Experimental Examples 44 to 47 prepared with the composition shown in Table 8 below was used. In each case, disinfection / neutralization of contact lenses to be disinfected was carried out.
  • a commercially available soft contact lens Monthwear (Group II: manufactured by Menicon Co., Ltd.)
  • a commercially available soft contact lens Monthwear (Group II: manufactured by Menicon Co., Ltd.)
  • 10 mL of each disinfectant solution sample is accommodated in a processing container
  • a commercially available platinum catalyst Cibavision, Aocept
  • catalase enzyme AMO, Concept One Step
  • sodium thiosulfate Off-Tex, Bioclenchemcept
  • the residual amount of hydrogen peroxide was subjected to oxidation-reduction titration using a 0.02 mol / L potassium permanganate solution.
  • the residual amount is less than 100 ppm, ⁇ , when 100 ppm or more and less than 200 ppm, ⁇ , when 200 ppm or more and less than 500 ppm, ⁇ , when 500 ppm or more, evaluation of neutralization rate
  • Table 8 The results are also shown in Table 8 below.

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Abstract

La présente invention concerne une solution désinfectante pour lentille de contact qui peut désinfecter efficacement une lentille de contact par l'action du peroxyde d'hydrogène contenu dans celle-ci et peut également éliminer avantageusement les dépôts protéiniques de la lentille de contact , et qui a une stabilité de stockage améliorée et par conséquent, peut être conservée pendant une longue durée. La présente invention concerne spécifiquement une solution désinfectante qui peut être utilisée pour la désinfection d'une lentille de contact. La solution désinfectante comprend une solution aqueuse contenant du peroxyde d'hydrogène qui a une concentration de peroxyde d'hydrogène de 1 à 5 %, un composant (A) qui comprend un composé ayant au moins un groupe carboxyle dans la molécule, et un composant (B) qui comprend un composé ayant des groupes hydroxyle multiples dans la molécule. La solution désinfectante a une valeur de pH de 6 à 8.
PCT/JP2010/061270 2010-07-01 2010-07-01 Solution désinfectante pour lentille de contact, et système de désinfection de lentille de contact WO2012001806A1 (fr)

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PCT/JP2010/061270 WO2012001806A1 (fr) 2010-07-01 2010-07-01 Solution désinfectante pour lentille de contact, et système de désinfection de lentille de contact
JP2011550768A JPWO2012001806A1 (ja) 2010-07-01 2010-07-01 コンタクトレンズ用消毒液及びコンタクトレンズの消毒システム

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Citations (5)

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JPH09206362A (ja) * 1996-02-05 1997-08-12 Tomey Technol Corp コンタクトレンズ用消毒洗浄組成物及びそれを用いたコンタクトレンズの消毒洗浄方法
GB2323180A (en) * 1997-01-23 1998-09-16 Waverley Pharma Ltd Hydrogen peroxide contact lens solution
JP2001506507A (ja) * 1996-06-17 2001-05-22 エムディーエルイー メディカル デバイス ラボラトリーズ ヨーロッパ ゲーエムベーハー 過酸化水素触媒分解装置
JP2004024715A (ja) * 2002-06-27 2004-01-29 Lion Corp コンタクトレンズ洗浄剤組成物
JP4499830B1 (ja) * 2009-06-29 2010-07-07 株式会社メニコン コンタクトレンズの消毒システム

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