WO2011155517A1 - プレフィルドシリンジ - Google Patents
プレフィルドシリンジ Download PDFInfo
- Publication number
- WO2011155517A1 WO2011155517A1 PCT/JP2011/063116 JP2011063116W WO2011155517A1 WO 2011155517 A1 WO2011155517 A1 WO 2011155517A1 JP 2011063116 W JP2011063116 W JP 2011063116W WO 2011155517 A1 WO2011155517 A1 WO 2011155517A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- gasket
- layer
- tip
- barrel
- proximal
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M5/31513—Piston constructions to improve sealing or sliding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
- A61M2005/3104—Caps for syringes without needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M2005/3132—Syringe barrels having flow passages for injection agents at the distal end of the barrel to bypass a sealing stopper after its displacement to this end due to internal pressure increase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
- A61M5/347—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub rotatable, e.g. bayonet or screw
Definitions
- the present invention relates to a prefilled syringe. More specifically, the prefilled syringe is suitable for enclosing a liquid agent and a powder agent in separate chambers partitioned in the syringe, and mixing, dissolving, suspending and administering the liquid agent and the powder agent at the time of use.
- the liquid agent and the powder agent are enclosed in separate chambers in the syringe, respectively.
- an agent is mixed, dissolved, suspended and administered.
- Drugs stored without preparing liquids and powders in this way are those that become unstable when mixed, or have been in contact with moisture for a long period of time. Are often unsuitable for storage in a prepared state.
- the gasket absorbs the liquid agent (or its moisture), and the liquid agent reaches the part that hits the wall of the powder agent chamber, so that the powder There is a possibility of bringing the agent into contact with the liquid agent.
- the powder is unstable with respect to moisture, even if the portion of the gasket that contacts the wall of the powder chamber is not dry, the moisture remaining in the gasket can contact the powder with moisture. There is sex.
- the intermediate gasket is composed of two members so that the moisture remaining by steam sterilization does not affect the powder agent, and the member located on the powder agent chamber side is sufficiently dried. By inserting, moisture is prevented from existing in the powder chamber.
- an intermediate gasket as shown in Patent Document 2 is composed of two members, Adopting a method that prevents contact with each other can prevent moisture contact with the powder regardless of the material characteristics of the gasket.
- the intermediate gasket as disclosed in Patent Document 2 is composed of two members (front end side and rear end side)
- the intermediate gasket enters the region where the bypass of the barrel is formed during the preparation operation.
- the liquid enters between the two parts of the intermediate gasket, and the intermediate gasket on the tip side reaches the tip side of the bypass by being pushed into the tip side by the flowing liquid, and the intermediate gasket on the tip side bypasses the bypass. If it is blocked, the entire amount of the liquid agent cannot be transferred to the first chamber, which may cause a serious problem that preparation becomes impossible.
- the gasket material that is a part of the storage container is in contact with a plurality of drugs for a long period of time, as in the case of the container, it is necessary to select a material that is compatible (not altered) with each drug. Since it is at least in contact with the powder agent, it has low water absorption, and the liquid agent is affected by the rubber material that comes into contact with it, and therefore changes in pH. And it must be a material with good slidability and liquid tightness.
- An object of the present invention is to provide a prefilled syringe having an intermediate gasket which is substantially composed of one member, has good slidability and liquid tightness, has low water absorption, and has little influence on the pH of the liquid agent. There is.
- the present inventors have provided a barrel having an injection needle connecting portion formed at the distal end and an open proximal end, a proximal gasket inserted in the barrel so as to be slidable in a liquid-tight manner, and the proximal gasket.
- a plunger having a plunger rod on the base end side, an intermediate gasket that is slidably inserted into the tip end side of the base end side gasket and is divided into a first chamber and a second chamber, and a barrel
- a prefilled syringe having a bypass circuit that protrudes outward in the radial direction and is longer than the effective seal length of the intermediate gasket with respect to the axial direction of the barrel, and is surrounded by the intermediate gasket and the proximal gasket of the barrel
- a liquid agent is enclosed in the second chamber, and a powder agent is enclosed in the first chamber on the tip side of the intermediate gasket of the barrel, and the intermediate gasket includes at least the first gasket.
- the base end layer is required for the intermediate gasket by using a prefilled syringe formed of a material having low water absorption and not lowering the pH of the liquid agent, by combining a plurality of raw materials in layers in the axial direction.
- the tip layer may be formed of a material having low water absorption.
- An intermediate layer may be formed between the tip layer and the base layer.
- the front end layer may be formed of chlorinated butyl rubber or brominated butyl rubber, and the base end layer may be formed of normal butyl rubber.
- a tip gasket is inserted into the barrel tip in a liquid-tight and slidable manner to form a first chamber in the barrel space surrounded by the tip gasket and intermediate gasket, and a syringe needle is connected to the tip of the barrel.
- a liquid passage that extends in the axial direction to an inner peripheral wall through which a chemical solution can pass when the distal gasket is accommodated in the distal gasket accommodating portion. You may provide the nozzle member in which was formed.
- An injection needle may be attached in advance to the injection needle connecting portion.
- the prefilled syringe of the present invention is equipped with an intermediate gasket in which the pH of the liquid during storage and no moisture contact with the powder are maintained, it is suitable for medical use because it maintains a good storage state and is excellent in use. Can be used.
- FIG. 1 It is a longitudinal cross-sectional view of the example of one embodiment of the prefilled syringe of this invention. It is a side view of the intermediate gasket of the prefilled syringe shown by FIG. It is a side view of one Example of the intermediate gasket which has an intermediate
- FIG. 1 is a vertical cross-sectional view of an embodiment of a rubber stopper for a drug solution dropping container vial of the present invention.
- FIG. 2 is a longitudinal sectional view of another embodiment of the prefilled syringe of the present invention.
- FIG. 3 is a side view of an embodiment of the intermediate gasket of the prefilled syringe of the present invention.
- the prefilled syringe A of the present invention will be described with reference to FIG.
- the barrel 1 has an injection needle connecting portion 24 on the distal end side, and a bypass portion 11 that protrudes along the axis in the radially outward direction is formed in a substantially central portion, the proximal end is opened, and the flange 3 is provided.
- a base end gasket 41 is housed in the barrel 1 in a liquid-tight and slidable manner, and a plunger rod 42 is connected to the base end of the base end gasket 41 (the base end gasket 41 and the plunger rod). 42 to form a plunger 4).
- an intermediate gasket 6 is accommodated in a liquid-tight and slidable manner on the base end side from the bypass 11, and defines a space in the barrel.
- the powder agent D is accommodated in the space (first chamber 7) on the tip side from the intermediate gasket in the barrel, and the liquid agent is contained in the space (second chamber 5) surrounded by the intermediate gasket and the proximal gasket in the barrel.
- L is accommodated.
- a rubber cap 9 is attached to the injection needle connecting portion 24, and the first chamber 7 is sealed.
- the intermediate gasket 6 is composed of a seal portion 61 of the tip layer and a spiral groove 62 of the base layer, and the tip layer is made of chlorinated butyl rubber and the base layer is made of normal butyl rubber. .
- Chlorinated butyl rubber is preferable because it has good sealing properties and slidability, and normal butyl rubber has low water absorption and neutral properties.
- the effective seal length of the intermediate gasket 6 is a portion where liquid tightness is substantially maintained on the sliding surface between the barrel 1 and the intermediate gasket 6.
- the axis of the hatched portion of the intermediate gasket 6 (The spiral groove 62 is not maintained liquid-tight because, for example, the liquid enters the spiral groove 62 by pressing the plunger.)
- Chlorinated butyl rubber with good sealing and slidability that is the tip layer is preferably used because of its low water absorption, but the rubber itself is acidic, so the liquid agent is neutral or alkaline For this reason, it is not preferable to provide it at a position where it will come into contact with the liquid agent for a long time. Therefore, the base end layer is formed of normal butyl rubber having low water absorption and neutrality, thereby providing an intermediate gasket suitable for contact with these liquid agents.
- the liquid agent may be formed so as to maintain a sealing property such that the liquid agent does not directly touch the tip layer, and chlorinated butyl rubber as the tip layer may act on the substantial sliding property. That is, for the slidability, either the front end layer or the base end layer (the one that is excellent in these characteristics) may be applied.
- the combination of the front end layer 61 and the base end layer 62 of the intermediate gasket is an example, but as shown in FIG. 3, an intermediate layer 63 having excellent slidability and sealability is provided, and the front end layer and the base end layer are brought into contact with each other. Only the compatibility with the drug may be taken into account, or the intermediate layer 63 is formed of a low water-absorbing rubber when a compatible low water-absorbing rubber material cannot be used due to the liquid agent to be contacted. It is also possible to do. If necessary, the intermediate layer 63 may be composed of two or more layers.
- each layer may be connected to form a single member, for example, each layer may be connected by screw screw or wedge fitting, and are substantially separated without being separated during storage and use. Anything that acts as a member may be used.
- the tip layer of the intermediate gasket is preferably sufficiently dried, and if the material itself has a low water absorption, it is possible to further prevent the transmission of moisture.
- the prefilled syringe A of the present invention is also effective for a prefilled syringe with a needle connected in advance as shown in FIG.
- a prefilled syringe is not provided with an injection needle connecting portion in the barrel 1 itself, but is provided in a sealed state by providing a tip gasket 8 at the tip of the substantially cylindrical barrel 1 in a liquid-tight and slidable manner.
- the chamber 7 is formed, and at the tip of the barrel, the injection needle connecting portion 23 is provided at the tip, the tip gasket accommodating portion 22 capable of accommodating the tip gasket at the base end, and the tip gasket is accommodated in the tip gasket accommodating portion.
- the nozzle member 2 having the axially extending liquid passage 21 formed in the inner peripheral wall through which the drug solution can pass is provided, and the injection needle 91 is connected to the injection needle connecting portion, and the injection needle 91 is capped by the protector 92 Has been.
- a cap 9 may be fitted to the injection needle connecting portion of the prefilled syringe as shown in FIG. 2 as in the prefilled syringe shown in FIG. 1 without connecting the injection needle in advance.
- the prefilled syringe of the present invention includes an intermediate gasket in which there is no pH change of the liquid during storage and no moisture contact with the powder, so that the storage state is kept good and excellent in use. It can be suitably used for medical treatment.
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- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Life Sciences & Earth Sciences (AREA)
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Abstract
Description
前記基端層は、低吸水性且つ液剤のpHを低下させない材質で形成されてなるプレフィルドシリンジ、を用いることにより、中間ガスケットを複数の素材を軸方向に層状に組み合わせることによって、中間ガスケットに要求される特性を持たせることを見出し、本願発明に至った。
11 バイパス
2 ノズル部材
21 通液路
22 先端ガスケット収容部
23 注射針接続部
3 フランジ
4 プランジャー
41 基端ガスケット
42 プランジャーロッド
5 第二室
6 中間ガスケット
61 先端層
62 基端層
63 中間層
7 第一室
8 先端ガスケット
9 キャップ
91 注射針
92 プロテクター
Claims (8)
- 先端に注射針接続部が形成され基端が開口したバレルと、
前記バレル内基端側に液密に摺動可能に挿入された基端ガスケットと、
該基端ガスケットの基端側にプランジャーロッドが設けられたプランジャーと、
基端ガスケットの先端側に液密に摺動可能に挿入されバレル内を第一室及び第二室に分割する中間ガスケットと、
バレルの径外方向に突出し且つバレルの軸方向基準で中間ガスケットの実効シール長より長く形成されたバイパス回路を有するプレフィルドシリンジであって、
前記バレルの前記中間ガスケットと前記基端側ガスケットとで囲まれる前記第二室には液剤が封入されると共に、
前記バレルの前記中間ガスケットより先端側の前記第一室には粉末剤が封入され、
前記中間ガスケットは、
少なくとも前記第一室の壁となる先端層及び前記第二室の壁となる基端層の二つの層を有するとともに、
前記先端層より基端側の層に低吸水性の層を設け、
且つ前記基端層は、低吸水性且つ液剤のpHを低下させない材質で形成されてなる
プレフィルドシリンジ。 - 前記先端層は、低吸水性の材質で形成されてなる、請求項1に記載のプレフィルドシリンジ。
- 前記先端層と前記基端層の間に、中間層が形成されてなる、請求項2に記載のプレフィルドシリンジ。
- 前記先端層が塩素化ブチルゴム又は臭素化ブチルゴムで形成され、前記基端層がノーマルブチルゴムで形成されてなる、請求項3に記載のプレフィルドシリンジ。
- 先端及び基端が開口したバレルと、
前記バレル内先端に液密かつ摺動可能に挿入された先端ガスケットと、
前記バレル先端に設けられた、先端に注射針接続部が形成され、基端に前記先端ガスケットを収容可能な先端ガスケット収容部と、該先端ガスケット収容部に前記先端ガスケットを収容した際に薬液が通過可能な内周壁に軸方向に延びる通液路が形成されたノズル部材と、
前記バレル内基端側に液密に摺動可能に挿入された基端ガスケットと、
該基端ガスケットの基端側にプランジャーロッドが設けられたプランジャーと、
基端ガスケットの先端側に液密に摺動可能に挿入されバレル内を第一室及び第二室に分割する中間ガスケットと、
バレルの径外方向に突出し且つバレルの軸方向基準で中間ガスケットの実効シール長より長く形成されたバイパス回路を有するプレフィルドシリンジであって、
前記バレルの前記中間ガスケットと前記基端ガスケットとで囲まれる前記第二室には液剤が封入されると共に、
前記バレルの前記中間ガスケットと前記先端ガスケットとで囲まれる前記第一室には粉末剤が封入され、
前記中間ガスケットは、
少なくとも前記第一室の壁となる先端層及び前記第二室の壁となる基端層の二つの層を有するとともに、
前記先端層より基端側の層に低吸水性の層を設け、
且つ前記基端層は、低吸水性且つ液剤のpHを低下させない材質で形成されてなる
プレフィルドシリンジ。 - 前記先端層は、低吸水性の材質で形成されてなる、請求項5に記載のプレフィルドシリンジ。
- 前記先端層と前記基端層の間に、中間層が形成されてなる、請求項6に記載のプレフィルドシリンジ。
- 前記先端層が塩素化ブチルゴム又は臭素化ブチルゴムで形成され、前記基端層がノーマルブチルゴムで形成されてなる、請求項7に記載のプレフィルドシリンジ。
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11792474.6A EP2581102A4 (en) | 2010-06-11 | 2011-06-08 | PRE-FILLED SYRINGE |
US13/703,319 US8764703B2 (en) | 2010-06-11 | 2011-06-08 | Pre-filled syringe |
JP2012519408A JP5900332B2 (ja) | 2010-06-11 | 2011-06-08 | プレフィルドシリンジ |
KR1020137000828A KR101688685B1 (ko) | 2010-06-11 | 2011-06-08 | 사전 충전된 주사기 |
CN201180028553.2A CN102958551B (zh) | 2010-06-11 | 2011-06-08 | 预充填的注射器 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010-134505 | 2010-06-11 | ||
JP2010134505 | 2010-06-11 |
Publications (1)
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WO2011155517A1 true WO2011155517A1 (ja) | 2011-12-15 |
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Application Number | Title | Priority Date | Filing Date |
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PCT/JP2011/063116 WO2011155517A1 (ja) | 2010-06-11 | 2011-06-08 | プレフィルドシリンジ |
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US (1) | US8764703B2 (ja) |
EP (1) | EP2581102A4 (ja) |
JP (1) | JP5900332B2 (ja) |
KR (1) | KR101688685B1 (ja) |
CN (1) | CN102958551B (ja) |
WO (1) | WO2011155517A1 (ja) |
Families Citing this family (8)
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KR101699985B1 (ko) * | 2010-01-25 | 2017-01-25 | 테크레스 에스.피.에이. | 2성분 혼합물의 조제 및 투여 장치 |
JP6643901B2 (ja) * | 2013-11-27 | 2020-02-12 | ニプロ株式会社 | プレフィルドシリンジ |
ITUA20164317A1 (it) * | 2016-06-13 | 2017-12-13 | Orofino Pharmaceuticals Group Srl | Dispositivo di iniezione pre-riempito a tripla camera |
JP2018023467A (ja) * | 2016-08-08 | 2018-02-15 | 住友ゴム工業株式会社 | ガスケット |
US11614381B2 (en) | 2018-02-09 | 2023-03-28 | Takeda Pharmaceutical Company Limited | Syringe screening device |
EP3643399B1 (de) * | 2018-10-25 | 2022-04-27 | Heraeus Medical GmbH | Vorrichtung und verfahren zum bereitstellen von knochenzement |
DE102018131268B4 (de) | 2018-12-07 | 2021-11-25 | Heraeus Medical Gmbh | Vorrichtung zum Mischen eines Knochenzements mit Hohlraum zum Monomertransfer |
EP4382151A3 (en) * | 2020-03-17 | 2024-07-03 | Becton Dickinson France | Stopper for a medical injection device |
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JP2009061343A (ja) * | 2008-12-26 | 2009-03-26 | Nihon Medi Physics Co Ltd | 薬液充填済み注射器内の放射性医薬品の有効成分の損失防止方法 |
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JP3387775B2 (ja) | 1997-05-22 | 2003-03-17 | 株式会社大協精工 | 注射器用密封栓及びプレフィルド注射器 |
JP2006181027A (ja) * | 2004-12-27 | 2006-07-13 | Daikyo Seiko Ltd | 注射器用ピストン |
JP2006271938A (ja) * | 2005-03-30 | 2006-10-12 | Fukoku Co Ltd | プレフィルドシリンジ |
JP5129735B2 (ja) * | 2005-04-13 | 2013-01-30 | コユール インコーポレイテッド | 膨張シール付きシリンジ・プランジャ・ジャケット |
JP2010528792A (ja) * | 2007-06-14 | 2010-08-26 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 二重チャンバーカルプル |
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JPH06142203A (ja) | 1992-04-30 | 1994-05-24 | Takeda Chem Ind Ltd | プレフィルドシリンジ |
WO2005089837A1 (ja) | 2004-03-23 | 2005-09-29 | Nipro Corporation | プレフィルドシリンジ |
JP2007185319A (ja) * | 2006-01-12 | 2007-07-26 | Nipro Corp | プレフィルドシリンジ |
WO2008156216A1 (ja) * | 2007-06-20 | 2008-12-24 | Daikyo Seiko, Ltd. | 注射器内に装備される摺動弁及び該摺動弁を装備した注射器 |
JP2009061343A (ja) * | 2008-12-26 | 2009-03-26 | Nihon Medi Physics Co Ltd | 薬液充填済み注射器内の放射性医薬品の有効成分の損失防止方法 |
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JPWO2011155517A1 (ja) | 2013-08-01 |
EP2581102A1 (en) | 2013-04-17 |
US8764703B2 (en) | 2014-07-01 |
CN102958551B (zh) | 2015-06-24 |
CN102958551A (zh) | 2013-03-06 |
US20130090596A1 (en) | 2013-04-11 |
KR20130120442A (ko) | 2013-11-04 |
EP2581102A4 (en) | 2013-11-20 |
KR101688685B1 (ko) | 2016-12-21 |
JP5900332B2 (ja) | 2016-04-06 |
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