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  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
  • C07C201/06—Preparation of nitro compounds
  • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
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  • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
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  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
  • C07C41/01—Preparation of ethers
  • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
  • C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
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  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C67/00—Preparation of carboxylic acid esters
  • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
  • C07C67/317—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
  • C07C67/32—Decarboxylation
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  • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
  • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
  • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
  • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
  • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
  • C07D211/38—Halogen atoms or nitro radicals
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  • C07—ORGANIC CHEMISTRY
  • C07J—STEROIDS
  • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
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  • C07—ORGANIC CHEMISTRY
  • C07J—STEROIDS
  • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
  • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
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  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C2601/00—Systems containing only non-condensed rings
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  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C2601/00—Systems containing only non-condensed rings
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  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C2603/00—Systems containing at least three condensed rings
  • C07C2603/56—Ring systems containing bridged rings
  • C07C2603/58—Ring systems containing bridged rings containing three rings
  • C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
  • C07C2603/62—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing three- or four-membered rings
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  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C2603/00—Systems containing at least three condensed rings
  • C07C2603/56—Ring systems containing bridged rings
  • C07C2603/90—Ring systems containing bridged rings containing more than four rings

Definitions

• This invention is directed to a process for the preparation of high yield alkyl or aryl iodide from its corresponding carboxylic acid using N-iodo amides.
• l-Boc-4-iodomethylpiperidine is the starting material for the synthesis of donepezil and icopezil and l-Boc-4-iodopiperidine is used for the synthesis of 4-arylpiperidine moiety, which is a structural feature which can be found in a wide variety of active pharmacologic agents.
• the iodides also find use as intermediates in the preparation of other compounds, especially zinc organic compounds. Nucleophilic displacement reactions of the iodides yield sulfonic acid esters, nitro derivatives and mercaptans.
• Aromatic iodides possess a much higher reactivity than other aromatic halides in Ullmann condensation reactions. Typically, aryl iodides have higher kinetic rates of product formation than other aromatic halides, as illustrated by the reduced reaction times necessary to produce higher yields of highly pure products than with other aromatic halides. Thus, aryl iodides are key substrates in the Ullmann condensation reactions traditionally used to manufacture charge transporting and hole transporting triarylamine compounds (US7,138,555).
• Nucleophilic iodination of organic hydroxy, chloro, and bromo derivatives is usually used for the formation of organic iodides.
• l-Boc-4-iodopiperidine and l-Boc-4- iodomethylpiperidine were prepared from related hydroxy-derivatives by reaction with iodine and triphenylphosphine.
• the disadvantages of such reactions include difficulties in separation and utilization of triphenylphosphine oxide as main by-product of the reactions.
• Carboxylic acids are widely available and cheap raw materials in the organic synthesis, so the oxidative decarboxylation of carboxylic acids with concomitant replacement by iodine (iodo-de-carboxylation) comprises an extremely useful procedure for the syntheses of organic iodides.
• the unreacted acid may be easily recovered by treatment of the iodo-de- carboxylation reaction mixture with aqueous base and then acid. This makes the reaction also attractive for iodo-de-carboxylation of acids with low reactivity.
• the Hunsdiecker reaction (Johnson, Chem. Rev. 1956, v. 56, 219) includes an iodo- de-carboxylation reaction, by treatment of anhydrous silver salt of the acid with iodine in an inert solvent .
• the reaction is extremely sensitive to trace amounts of water, the presence of which leads to the recovery of unreacted acid.
• the preparation of dry silver salts of carboxylic acids is difficult and, such salts are usually quite sensitive to heat also, they are often quite hard to dry thoroughly.
• Another way to perform the Hunsdiecker reaction is by use of a mixture of the acid and I 2 /HgO (Cristol & Firth, J. Org. Chem. 1961, v.
• the Barton iodo-de-carboxylation procedure (Barton et al., Tetrahedron 1985, v. 41, 3901 and Tetrahedron, 1987, v. 43, 4321) includes conversion of carboxylic acids to the esters of N-hydroxypyridine-2-thione.
• the thiohydroxamic esters are iodinated by CHI 3 , and C3 ⁇ 4I 2 in cyclohexene solution.
• Thiopyridines are formed in the reaction as significant byproducts.
• Another method for the conversion of R-COOH to R-I includes reacting carboxylic acids with iodine and dibenzoyl peroxide. High concentration of peroxide in the reaction mixture may promote explosive. Iodobenzene is formed in the reaction as a significant byproduct.
• Additional process for converting carboxylic acids to their corresponding iodides is by treating the carboxylic acid with (diacetoxyiodo)benzene (DIB) and iodine under irradiation conditions (Suarez et al., J. Org. Chem. 1986, v. 51, 402 and Boto et al., Eur. J. Org. Chem. 2005, 673); wherein iodobenzene was formed in the reaction as significant byproduct.
• DIB diacetoxyiodobenzene
• tert-butyl hypoiodite Barton used tert-butyl hypoiodite in a Hunsdieker type reaction to iodo- decarboxylate carboxylic acids.
• tert-Butyl hypoiodite is not commercially available reagent, has low thermal stability of the reagent and should be used immediately after preparation. Therefore, tert-butyl hypoiodite cannot be used for the preparation of aryl-iodide compounds.
• N-iodo amides such as N-iodosuccinimide (NIS), N-iodosaccharine (NISac), 1,3- diiodo-5,5-dimethylhydantoin (DIH), triiodoisocyanuric acid (TICA) ⁇ Tetrahedron Letters 2007, v. 48, 8747), 2,4,6,8-tetraiodoglycoluril (TIG) ⁇ Tetrahedron Letters 2000, v. 41, 9101) etc., are used as efficient reagents for the electrophilic iodination of organic compounds.
• this invention is directed to a process for the preparation of iodide, represented by scheme (1): R-COOH ⁇ R-I (1) comprising reacting R-COOH with N-iodo amide to yield R-I; wherein R is saturated, linear or branched, substituted or unsubstituted alkyl; substituted or unsubstituted aryl; saturated or unsaturated, substituted or unsubstituted mono-or poly-carbocyclic or heterocyclic ring.
• this invention is directed to an iodinated compound represented by formula R-I, prepared according to the process of claim 1; wherein said R is saturated, linear or branched, substituted or unsubstituted alkyl; substituted or unsubstituted aryl; saturated or unsaturated, substituted or unsubstituted mono-or poly-carbocyclic or heterocyclic ring.
• this invention is directed to a process for the preparation of iodide R-I, represented by scheme (1):
• R-COOH ⁇ R-I (1) comprising reacting R-COOH with an iodinating agent to yield R-I; wherein R is saturated or unsaturated, linear or branched, substituted or unsubstituted alkyl; substituted or unsubstituted aryl; saturated or unsaturated, substituted or unsubstituted mono- or poly-carbocyclic or heterocyclic ring.
• this invention is directed to a process for the preparation of iodide, represented by scheme (1):
• R-COOH ⁇ R-I (1) comprising reacting R-COOH with a N-iodo amide to yield R-I; wherein R is saturated or unsaturated linear or branched, substituted or unsubstituted alkyl; substituted or unsubstituted aryl; saturated or unsaturated, substituted or unsubstituted mono-or poly-carbocyclic or heterocyclic ring.
• this invention is directed to a process for the preparation of iodide, represented by scheme (1): R-COOH ⁇ R-I (1) comprising reacting R-COOH with a N-iodo amide to yield R-I; wherein R is saturated linear or branched, substituted or unsubstituted alkyl; substituted or unsubstituted aryl; saturated or unsaturated, substituted or unsubstituted mono-or poly-carbocyclic or heterocyclic ring.
• this invention is directed to a process for the preparation of iodide, represented by scheme ( 1 ) :
• R-COOH ⁇ R-I (1) comprising reacting R-COOH with a N-iodo reagent, wherein said reagent includes any N- iodo organic compound or a mixture of one or more N-iodo organic compounds; wherein R is saturated or unsaturated linear or branched, substituted or unsubstituted alkyl; substituted or unsubstituted aryl; saturated or unsaturated, substituted or unsubstituted mono-or poly- carbocyclic or heterocyclic ring.
• this invention is directed to a process for the preparation of iodide, represented by scheme (1):
• R-COOH ⁇ R-I (1) comprising reacting R-COOH with mono or poly N-iodo hydantoins, N-iodo succinimide, N- iodo saccharine, mono or poly N-iodo isocyanuric acid, mono or poly N-iodo glycoluril, or mixture thereof to yield R-I; wherein R is saturated or unsaturated linear or branched, substituted or unsubstituted alkyl; substituted or unsubstituted aryl; saturated or unsaturated, substituted or unsubstituted mono-or poly-carbocyclic or heterocyclic ring.
• this invention is directed to a process for the preparation of iodide, represented by scheme (1):
• R-COOH ⁇ R-I (1) comprising reacting R-COOH with l,3-diiodo-5,5-dimethylhydantoin (DIH), N- iodosuccinimide (NIS), triiodoisocyanuric acid (TICA), 2,4,6,8-tetraiodoglycoluril (TIG), N- iodosaccharine (NISac), l-iodo-5,5-dimethylhydantoin, 3-iodo-5,5-dimethylhydantoin or mixture thereof to yield R-I.
• DIH diiiodo-5,5-dimethylhydantoin
• NPS N- iodosuccinimide
• TICA triiodoisocyanuric acid
• TAG 2,4,6,8-tetraiodoglycoluril
• NSac N- iodosaccharine
• this invention is directed to a process for the preparation of iodide, represented by scheme (1):
• R-COOH l,3-diiodo-5,5-dimethylhydantoin (DIH), l-iodo-5,5- dimethylhydantoin, 3-iodo-5,5-dimethylhydantoin or mixture thereof to yield R-I; wherein R is saturated or unsaturated linear or branched, substituted or unsubstituted alkyl; substituted or unsubstituted aryl; saturated or unsaturated, substituted or unsubstituted mono-or poly- carbocyclic or heterocyclic ring.
• this invention is directed to a process for the preparation of iodide, represented by scheme (1):
• R-COOH ⁇ R-I (1) comprising formation of carbon-centered radical R-, derived formally by removal of carboxyl group from R-COOH, in reaction of R-COOH with a N-iodo amide and following reaction of the free radical R- with N-iodo amide to yield R-I; wherein R is saturated or unsaturated linear or branched, substituted or unsubstituted alkyl; substituted or unsubstituted aryl; saturated or unsaturated, substituted or unsubstituted mono-or poly-carbocyclic or heterocyclic ring.
• this invention is directed to a process for the preparation of iodide, represented by scheme (1):
• R-COOH ⁇ R-I (1) comprising reacting R-COOH with N-iodo reagent to yield R-I; wherein the yield of the reaction is between 80-100%; wherein R is saturated or unsaturated, linear or branched, substituted or unsubstituted alkyl; substituted or unsubstituted aryl; saturated or unsaturated, substituted or unsubstituted mono-or poly-carbocyclic or heterocyclic ring.
• jV-iodo reagent of this invention is used in the iodo-de- carboxylation reaction (1).
• the N-iodo reagent of this invention is a N- iodo organic compound.
• the N-iodo organic compound is a compound which possess a chemically bonded iodine and nitrogen atoms (nitrogen-iodo or "N-I").
• the N-iodo reagent or N-iodo organic compound is N-iodo amide compound.
• the N-iodo amide is a primary amide.
• the N-iodo amide is a secondary amide.
• the amide is carboxamide, sulfonamide, lactame, carbamate, imide or ureide or combination thereof.
• the amide is 5,5-dimethylhydantoin, 3-benzyl-5,5-dimethylhydantoin, 5- methyl-5-phenylhydantoin, 5,5-diphenylhydantoin, 5,5-hexamethylenehydantoin, 5,5- pentamethylenehydantoin, 5,5-tetramethylenehydantoin, succinimide, phthalimide, saccharine, isocyanuric acid, 5,5-dimethylbarbituric acid, glycoluril, 3a,6a-diphenylglycoluril, 3a,6a- dimethylglycoluril, 4,4,5,5-tetramethyl-2-imidazolidinone, 4,4-dimethyl-2-oxazolidinone or combination thereof.
• the iV-iodo amide is a primary amide.
• the primary amide is carboxamide.
• the N-iodo amide is a primary amide, wherein said primary amide is nitramide.
• the nitramide is 0 2 NNHR.
• the N-iodo amide is a secondary amide.
• the imide is succinimide or phthalimide.
• the N-iodo amide is a secondary amide.
• Non limiting examples of ureides include derivatives of hydantoin (5,5-dimethylhydantoin, 3-benzyl-5,5-dimethylhydantoin, 5-methyl- 5-phenylhydantoin, 5,5-diphenylhydantoin, 5,5-pentamethylenehydantoin, 5,5- hexamethylenehydantoin, 5,5-tetramethylenehydantoin); isocyanuric acid; and derivatives of barbituric acid (5,5-diethylbarbituric acid, 5,5-dimethylbarbituric acid or 5-ethyl-5- isoamylbarbituric acid).
• the amide is sulfonamide. In another embodiment, the amide is lactame. In another embodiment, the amide is carbamate. In another embodiment, the amide is imide. In another embodiment, the amide is ureide. In another embodiment, the amide is 5-dimethylhydantoin. In another embodiment, the amide is 3-benzyl-5,5- dimethylhydantoin. In another embodiment, the amide is 5-methyl-5-phenylhydantoin. In another embodiment, the amide is 5,5-diphenylhydantoin. In another embodiment, the amide is 5,5-hexamethylenehydantoin.
• the amide is 5,5- pentamethylenehydantoin. In another embodiment, the amide is 5,5-tetramethylenehydantoin. In another embodiment, the amide is succinimide. In another embodiment, the amide is phthalimide. In another embodiment, the amide is saccharine. In another embodiment, the amide is isocyanuric acid. In another embodiment, the amide is 5,5-dimethylbarbituric acid. In another embodiment, the amide is glycoluril. In another embodiment, the amide is 3a,6a- diphenylglycoluril. In another embodiment, the amide is 3a,6a-dimethylglycoluril. In another embodiment, the amide is 4,4,5,5-tetramethyl-2-imidazolidinone. In another embodiment, the amide is 4,4-dimethyl-2-oxazolidinone.
• the N-iodo amide is mono or poly iodinated hydantoins, mono or poly iodinated succinimide, mono or poly iodinated saccharine, iodinated cyanuric acid, iodinated glycoluril, or mixture thereof.
• the N-iodo amide is mono or poly iodinated hydantoins.
• the N-iodo amide is mono or poly iodinated succinimide.
• the N-iodo amide is mono or poly iodinated saccharine.
• the N-iodo amide is iodinated mono or poly cyanuric acid.
• the N-iodo amide is cyanuric acid iodinated glycoluril.
• the N-iodo amide is l,3-diiodo-5,5-dimethylhydantoin
• N-iodosuccinimide N-iodosuccinimide
• TICA triiodoisocyanuric acid
• TAG 2,4,6,8-tetraiodoglycoluril
• N-iodosaccharine N-iodosaccharine
• l-iodo-5,5-dimethylhydantoin 3-iodo-5,5- dimethylhydantoin or mixture thereof.
• the N-iodinated reagent is 1,3- diiodo-5,5-dimethylhydantoin (DIH).
• the N-iodinated reagent is N- iodosuccinimide (NIS).
• the N-iodinated reagent is triiodoisocyanuric acid (TICA).
• the N-iodinated reagent is 2,4,6,8-tetraiodoglycoluril (TIG).
• the N-iodinated reagent is N-iodosaccharine (NISac).
• the N-iodinated reagent is l-iodo-5,5-dimethylhydantoin.
• the N-iodinated reagent is 3-iodo-5,5-dimethylhydantoin.
• N-iodinated reagent is selected from N-
• iodocarboxamides represented by formula (2): ;
• the process of this invention does not include a catalyst.
• the iodo-de-carboxylation process of this invention includes a photocatalyst.
• the process of this invention is a radical reaction.
• the N-iodo reagent (“N-I") is being used freshly after its preparation.
• the N-iodo reagent is prepared immediately before the desired iodo-de-carboxylation reaction.
• the N-iodo reagent is prepared in the same reaction pot of the iodo-de-carboxylation reaction (1) (one-pot reaction) or formed in situ in the reaction mixture of the iodo-de-carboxylation reaction (1).
• DIH, NIS and NISac are commercially available and are stable, therefore can be prepared prior to the iodo-de-carboxylation reaction (1).
• DIH l,3-Diiodo-5,5-dimethylhydantoin
• this invention is directed to iodo-de-carboxylation of R-COOH to yield R-I.
• R is a saturated alkyl.
• R is an unsaturated alkyl.
• R is a substituted saturated alkyl.
• R is a substituted unsaturated alkyl.
• R is a linear substituted or unsubstituted saturated alkyl.
• R is a linear substituted or unsubstituted unsaturated alkyl.
• R is a branched substituted or unsubstituted saturated alkyl.
• R is a branched substituted or unsubstituted unsaturated alkyl.
• R is substituted or unsubstituted aryl. In another embodiment R is substituted or unsubstituted phenyl. In another embodiment R is substituted or unsubstituted naphthyl. In another embodiment R is saturated or unsaturated, substituted or unsubstituted mono-or poly-carbocyclic. In another embodiment R is saturated or unsaturated, substituted or unsubstituted mono-or poly heterocyclic ring.
• R-COOH if the R group of R-COOH possess an additional functional group such as hydroxyl, amine, aldehyde, thio, or combination thereof, such functional group is protected.
• R-COOH is N-protected 4-piperidinecarboxylic acid, N- protected 4-piperidineacetic acid, N-protected azetidine-3-carboxylic acid, mono-alkyl phthalate, iodobenzoic acid, bromobenzoic acid or biphenyl-4-carboxylic acid.
• R-COOH is not ECH(R)COOH, where E is acyl, SR 2 + , or NR 3 + and R is either an hydrogen, alkyl or an aryl.
• substituted R of R-I is a protected functional groups, such as protected hydroxyl, protected thio and/or protected amino groups which can further be removed by methods known in the art to obtain the free thio, free hydroxyl and/or free amino groups respectively.
• this invention provides a process for the preparation of N- protected 3-iodoazetidine (R-I) from N-protected azetidine-3-carboxylic acid (R-COOH). [0046] In one embodiment, this invention provides a process for the preparation of TV- protected 4-(iodomethyl)piperidine (R-I) from N-protected 4-piperidineacetic (R-COOH).
• this invention provides a process for the preparation of 2- iodobenzoate (R-I) from mono-alkyl phthalate (R-COOH).
• this invention provides a process for the preparation of o- diiodobenzene (R-I) from 2-iodobenzoic acid (R-COOH).
• this invention provides a process for the preparation of 4- iodobiphenyl (R-I) from biphenyl-4-carboxylic acid (R-COOH).
• the process of this invention is conducted in the presence of a solvent.
• the solvent is an organic solvent.
• the solvent is a hydrocarbon.
• the solvent is halocarbon.
• the solvent is an ester.
• Non limiting examples of esters are ethyl acetate or butyl acetate.
• the solvent is nitromethane.
• the solvent is acetonitrile.
• the solvent is hydrocarbon, halocarbon, acetonitrile or any combination thereof.
• the solvent is hydrocarbon solvent, halocarbon solvent, ester, acetonitrile, nitromethane or any combination thereof.
• the reaction between R-COOH and the iodinating reagent is in the presence of a solvent.
• hydrocarbon solvent refers to any solvent consisting of the carbon and hydrogen elements.
• hydrocarbon solvents are cyclohexane, cyclopentane, heptane, pentane hexane, or benzene.
• halocarbon solvent refers to any solvent wherein one or more of the carbons are covalently linked to one or more halogens (fluorine, chlorine, bromine or iodine).
• halocarbon solvents are chloroform, dichloromethane, chlorobenzene, 1,2-dichloroethane, carbon tetrachloride, 1,3-dichloropropane, 1,1,2,2- tertrachlorodifluoroethane, 1,1,2-trichloroethane, trichloroethylene, perchloroethylene, bromobenzene 1,1,2-trichlorotrifluoroethane or 1 ,2-dibromoethane.
• R-I is purified from the reaction mixture by washing, chromatography, crystallization or any combination thereof.
• R-I is purified from the reaction mixture by a washing step.
• the washing step comprises washing with an aqueous reducing agent followed by washing with an aqueous base.
• the washing step comprises washing with an aqueous base followed by washing with an aqueous reducing agent.
• the washing step comprises washing with an aqueous reducing agent and a base.
• the washing step comprises washing of the reaction mixture with aqueous reducing agent, wherein excess of the " ⁇ - ⁇ iodinated reagent is converted to water-soluble N-H compounds, and thereby removed from the organic phase.
• aqueous reducing agent refers to an aqueous solution comprising a reducing agent.
• Non limiting examples of reducing agents are Na 2 S0 3 , NaHS0 3 , Na 2 S 2 0 3 , NaBRj/NaOH or combination thereof.
• the reducing agent is added at a concentration of between 1- 10% w/w to the water to obtain an aqueous reducing agent solution .
• the process of this invention directed to iodo-de- carboxylation (1) comprising a washing step with an aqueous reducing agent.
• a potassium iodide starch paper test is performed to identify traces of the N-iodo reagent.
• a potassium iodide starch paper test refers to a starch iodide test paper that has been wetted with aqueous acetic acid; 1/1 ; v/v].
• SPT potassium iodide starch paper test
• an additional aqueous reducing agent is added to the reaction mixture.
• the washing step comprises washing the reaction mixture with an aqueous base, wherein the unreacted carboxylic acid is removed from the organic phase by washing with an aqueous base.
• the carboxylic acid is recovered by acidifying the aqueous phase.
• an aqueous base refers to an aqueous solution comprising a base.
• Non limiting examples of a base is NaHC0 3 , NaOH, Na 2 C0 3 , KOH, Na 2 S0 3 or combination thereof.
• the base is added at a concentration of between 1-10% w/w to the water to obtain an aqueous base solution.
• the washing step of an aqueous reducing agent is conducted before the washing step of the aqueous base.
• the washing step of the aqueous base is conducted before the washing step of the aqueous reducing agent.
• the washing step comprises washing with an aqueous reducing agent and a base.
• Such a combination of an aqueous reducing agent and a base includes Na 2 S0 3 and NaBtLj/NaOH which are basic reducing agents that combine properties of reducing agent and a base.
• the washing steps of this invention are conducted using the organic solvent of the reaction mixture as the organic phase.
• the washing step of the aqueous base and the washing step of the aqueous reducing agent are independently performed using a) the organic solvent of the reaction mixture, b) a mixture of organic solvents, or c) a different organic solvent, as the organic phase.
• Non limiting examples of organic solvents used as an organic phase in the washing step are hydrocarbon solvent, halocarbon solvent, or esters such as cyclohexane, heptane, hexane, pentane, benzene, toluene, chlorobenzene, 1,2-dichloroethane, carbon tetrachloride, 1,3-dichloropropane, 1,1,2,2-tertrachlorodifluoroethane, 1,1,2-trichloroethane, trichloroethylene, perchloroethylene, dichloromethane, chloroform, ethyl acetate or butyl acetate.
• the aqueous phase is treated with an acid or an aqueous acid solution and extracted by organic solvent to isolate starting carboxylic acid.
• the acidified aqueous phase is cooled to 0-5 °C to precipitate solid starting carboxylic acid.
• the organic iodine product is soluble in organic phase and not soluble in the aqueous phase.
• the crude organic iodide is isolated from reaction mixture by standard organic solvent extractive work-up.
• removing the solvent from the organic phase give crude desired iodide (R-I) as the residue.
• the residue is pure desired iodide (R-I).
• the iodide is purified by crystallization, rectification or chromatography of the residue.
• the process of this invention provides a process for the preparation of pure iodide.
• the "pure iodide” refers to about 95 to 100% purity.
• the “pure iodide” refers to about 90% to 100% purity.
• the “pure iodide” refers to about 85% to 100% purity.
• the “pure iodide” refers to about 99% to 100%.
• the pure iodide refers to about 98% to 100%.
• the pure iodide refers to about 97% to 100%.
• this invention is directed to iodide compound represented by the formula R-I having purity of between about 99% to 100%, prepared according to the process of this invention, wherein R is saturated or unsaturated, linear or branched, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, saturated or unsaturated, substituted or unsubstituted mono-or poly-carbocyclic or heterocyclic ring.
• R is saturated, linear or branched, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, saturated or unsaturated, substituted or unsubstituted mono-or poly-carbocyclic or heterocyclic ring.
• this invention is directed to iodide compound represented by the formula R-I having purity of between about 98% to 100%, prepared according to the process of this invention. In another embodiment, this invention is directed to iodide compound represented by the formula R-I having purity of between about 90% to 100%, prepared according to the process of this invention. In another embodiment, this invention is directed to iodide compound represented by the formula R-I having purity of between about 95% to 100%, prepared according to the process of this invention. In another embodiment, this invention is directed to iodide compound represented by the formula R-I having purity of between about 85% to 100%, prepared according to the process of this invention. In another embodiment, this invention is directed to iodide compound represented by the formula R-I having purity of between about 97% to 100%, prepared according to the process of this invention.
• this invention is directed to iodide compound represented by the formula R-I having purity of between about 99% to 100%. In another embodiment, this invention is directed to iodide compound represented by the formula R-I having purity of between about 98% to 100%. In another embodiment, this invention is directed to iodide compound represented by the formula R-I having purity of between about 90% to 100%. In another embodiment, this invention is directed to iodide compound represented by the formula R-I having purity of between about 95 to 100%. In another embodiment, this invention is directed to iodide compound represented by the formula R-I having purity of between about 85% to 100%.
• the process of this invention provides a process for the preparation of R-I with a yield of between about 60-100%. In another embodiment, the process of this invention provides a process for the preparation of R-I with a yield of between about 70-100%. In another embodiment, the process of this invention provides a process for the preparation of R-I with a yield of between about 80-100%. In another embodiment, the process of this invention provides a process for the preparation of R-I with a yield of between about 85-100%. In another embodiment, the process of this invention provides a process for the preparation of R-I with a yield of between about 90-100%). In another embodiment, the process of this invention provides a process for the preparation of R-I with a yield of between about 95-100%.
• this invention is directed to a process comprising a reaction between N-iodo reagent and R-COOH.
• the molar ratio between the N- iodo reagent /R-COOH is between 0.5 to 2 moles N-iodo reagent per 1 mol of R-COOH.
• the molar ratio between the N-iodo reagent /R-COOH is between 1 to 2 moles N-iodo reagent per 1 mol of R-COOH.
• the molar ratio between the N-iodo reagent /R-COOH is between 0.5 to 1.5 moles N-iodo reagent per 1 mol of R- COOH.
• this invention is directed to a process comprising a reaction between DIH and R-COOH.
• the molar ratio between DIH/R-COOH is between 0.5 to 2 moles DIH per 1 mol of R-COOH.
• the molar ratio between DIH R-COOH is between 1 to 2 moles DIH per 1 mol of R-COOH.
• the molar ratio between DIH/R-COOH is between 0.5 to 1.5 moles DIH per 1 mol of R-COOH.
• the molar ratio of the N-iodo reagent depends on the acids used. Alkylcarboxylic acid is converted into the corresponding iodide in good yield at 0.5:1 to 1.2:1 molar ratio DIH/R-COOH, while aromatic carboxylic acids required excess of DIH (1 :1 to 2:1 molar ratio DIH/R-COOH).
• this invention provides a process for the preparation of R-I.
• the process of this invention is a radical reaction.
• all factors that promote radical reaction may stimulate the process of this invention.
• the process of this invention is initiated thermally. In another embodiment, the process of this invention is conducted at a temperature between about 50 °C and about 200 °C. In another embodiment, the process of this invention is conducted at a temperature between about 70 °C and about 200 °C. In another embodiment, the process of this invention is conducted at a temperature between about 80 °C and about 200 °C. In another embodiment, the process of this invention is conducted at a temperature between about 90 °C and about 200 °C. In another embodiment, the process of this invention is conducted at a temperature between about 100 °C and about 200 °C. In another embodiment, the process of this invention is conducted at a temperature between about 80 °C and about 100 °C.
• the process of this invention is conducted at a temperature between about 70 °C and about 150 °C. In another embodiment, the process of this invention is conducted at a temperature between about 80 °C and about 150 °C. In another embodiment, the process of this invention is conducted at a temperature between about 90 °C and about 150 °C. In another embodiment, the process of this invention is conducted at a temperature between about 100 °C and about 150 °C.
• the process of this invention is conducted for between 1- 24h. In another embodiment, the process of this invention is conducted for between 1-1 Oh. In another embodiment, the process of this invention is conducted for between 5-1 Oh. In another embodiment, the process of this invention is conducted for between 6-1 Oh. In another embodiment, the process of this invention is conducted for between 7-1 Oh. In another embodiment, the process of this invention is conducted for between 8-1 Oh. In another embodiment, the process of this invention is conducted at a temperature between about 50 °C and about 200 °C for about 1 h to about 24 h. In another embodiment, the process of this invention is conducted at a temperature between about 70 °C and about 150 °C for about 1 h to about 24 h.
• the process of this invention is conducted at a temperature between about 100 °C and about 150 °C for about 1 h to about 24 h. In another embodiment, the process of this invention is conducted at a temperature of between 50 °C and about 200 °C for about 1 h to about 5 h. In another embodiment, the process of this invention is conducted at a temperature of between 50 °C and about 200 °C for about 1 h to about 10 h. In another embodiment, the process of this invention is conducted at a temperature of between 50 °C and about 200 °C for about 1 h to about 15 h.
• this invention provides a process for the preparation of R-I.
• the process of this invention is a radical reaction.
• all factors that promote radical reaction may stimulate the process of this invention.
• Factors that promote radical reaction heating, radiation, addition of radical initiators. The same factors promote the reaction of this invention.
• Some reagents e.g. TEMPO
• TEMPO react with carbon-centered radicals to give nonreactive products. If addition of TEMPO inhibit reaction this fact indicate that the reaction is radical chain reaction. Addition of TEMPO inhibits iodo-de-carboxylation reaction and indicates that the reaction of this invention has a radical nature.
• the process of this invention is conducted under radiation.
• the process of this invention is conducted under electromagnetic radiation.
• the process of this invention is conducted under actinic radiation.
• the radiation may be infrared (IR) radiation, visible radiation (light), microwave radiation, or ultraviolet (UV) radiation.
• the electromagnetic radiation is visible light.
• the process of this invention is conducted in the presence of electromagnetic radiation for about 1 h to about 5 h.
• the process of this invention is conducted in the presence of electromagnetic radiation for about 1 h to about 5 h.
• the process of this invention is conducted in the presence of electromagnetic radiation for about 1 h to about 10 h.
• the process of this invention is conducted in the presence of electromagnetic radiation for about 1 h to about 15 h.
• the process of this invention is conducted in the presence of radical initiator.
• the radical initiators are substances that can produce radical species.
• Non limiting examples of radical species are azo compounds such as azobisisobutyronitrile (AIBN) or 1, -azobis(cyclohexanecarbonitrile) (ABCN), and organic peroxides such benzoyl peroxide.
• the process of this invention is conducted in the presence of radical initiator for about 1 h to about 24 h.
• the process of this invention is conducted in the presence of ultrasound. In another embodiment, the process of this invention is conducted in the presence of microwave irradiation. In another embodiment, the process of this invention is conducted in the presence of radical initiator, electromagnetic radiation or combination thereof. In another embodiment, the process of this invention is conducted in the presence of radical initiator, ultrasound, electromagnetic radiation or combination thereof.
• the process of this invention is conducted in the presence of iodine catalyst.
• the iodine catalyst is organic iodide, inorganic iodide or molecular iodine or mixture thereof.
• the organic iodide is saturated, linear or branched, substituted or unsubstituted alkyl iodide, or substituted or unsubstituted aryl iodide.
• the inorganic iodide is HI, IC1, Nal, KI, Lil, or any mixture thereof.
• the iodine catalystxarboxylic acid molar ratio is between 0.1 to 50 %.
• the iodine catalystxarboxylic acid molar ratio is between 0.1 to 20 %. In another embodiment, the iodine catalystxarboxylic acid molar ratio is between 0.1 to 2 mole %.
• the organic iodide catalyst may be the product of the iododecarboxylation reaction or play role solvent or co-solvent of the iododecarboxylation reaction.
• the preferred iodine catalyst is molecular iodine.
• radical refer in this invention to molecular entities possessing an unpaired electron, such as H 3 C-, C 6 H 5 -, I ⁇ . (In these formulae the dot, symbolizing the unpaired electron, should be placed so as to indicate the atom of highest spin density, if this is possible).
• the radicals can be described as carbon-, oxygen-, nitrogen-, iodine-centered radicals. Subclasses are e.g. alkyl (e.g. propyl CH 3 CH 2 CH 2 ), aryl (e.g. phenyl C 6 H 5 ), acyloxyl (e.g.
• Electromagnetic radiation refers to radiation consisting of waves of energy associated with electric and magnetic fields resulting from the acceleration of an electric charge.
• Actinic radiation refers to electromagnetic radiation that can produce photochemical reactions.
• Ultrasound refers to cyclic mechanical vibrations with a frequency greater than 20 kilohertz (20,000 hertz).
• Ultraviolet radiation refers to electromagnetic radiation with wavelengths 100 to 400 nm.
• Visible radiation refers to electromagnetic radiation with wavelengths 400 to 780 nm.
• Infrared radiation refers to electromagnetic radiation with wavelengths 780 to 20000 nm.
• Microwave radiation refers to electromagnetic radiation with wavelengths 2 to 1000 mm.
• Devices serving as a source of the electromagnetic radiation include a mercury lamp, a xenon lamp, a carbon arc lamp, a tungsten lamp, a fluorescent lamp, light-emitting diode (LED), and sunlight, and the like.
• Tungsten lamp refers to incandescent lamp that generates light by passing an electric current through a thin filament wire (usually of wolfram) until it is extremely hot.
• the lamps are often filled by a halogen gas such as iodine and bromine that allow filaments to work at higher temperatures and higher efficiencies.
• LED refers to a semiconductor (often a combination of gallium, arsenic, and phosphorous or gallium and nitrogen) containing an n region (where electrons are more numerous than positive charges) separated from a p region (where positive charges are more numerous than negative charges).
• n region where electrons are more numerous than positive charges
• p region where positive charges are more numerous than negative charges
• an LED emits incoherent monochromatic light, normally a very narrow frequency range is obtained.
• the term "about” as used herein means within an acceptable error range for the particular value as determined by one of ordinary skill in the art, which will depend in part on how the value is measured or determined, i.e., the limitations of the measurement system. For example, “about” can mean within 1 or more than 1 standard deviations, per the practice in the art. Alternatively, “about” can mean a range of up to about 5%, up to about 10% or up to about 20% of a given value.
• alkyl refers, in one embodiment, to an univalent groups derived from alkanes by removal of a hydrogen atom from any carbon atom: C n H2 n+ i--
• the groups derived by removal of a hydrogen atom from a terminal carbon atom of unbranched alkanes form a subclass of normal alkyl (n-alkyl) groups:
• the groups RCH 2 -, R 2 CH- (R ⁇ H), and R 3 C- (R ⁇ H) are primary, secondary and tertiary alkyl groups respectively
• alkyl refers to an unsaturated hydrocarbon, including straight-chain, branched-chain.
• the alkyl group has 1-20 carbons.
• the alkyl group has 10-20 carbons. In another embodiment, the alkyl group has 1-6 carbons. In another embodiment, the alkyl group has 2-7 carbons. In another embodiment, the cyclic alkyl group has 3-8 carbons. In another embodiment, the cyclic alkyl group has 3-12 carbons. In another embodiment, the branched alkyl is an alkyl substituted by alkyl side chains of 1 to 5 carbons. In another embodiment, the branched alkyl is an alkyl substituted by haloalkyl side chains of 1 to 5 carbons.
• the alkyl group may be unsubstituted or unsubstituted by one or more groups selected from halogen, phenyl, aryl, haloalkyl, protected hydroxyl, cyano, azide, carboxylic acid, aldehyde, alkoxy, carbonyl, amido, alkylamido, nitro, protected amino, alkylamino, protected thio and/or thioalkyl.
• aryl group refers, in one embodiment, to groups derived from arenes by removal of a hydrogen atom from a ring carbon atom.
• an aryl group refers to an aromatic group having at least one carbocyclic aromatic group or heterocyclic aromatic group, which may be unsubstituted or substituted by one or more groups selected from halogen, aryl, haloalkyl, protected hydroxyl, cyano, azide, carboxylic acid, aldehyde, alkoxy, carbonyl, amido, alkylamido, nitro, protected amino, alkylamino, protected thio and/or thioalkyl.
• Nonlimiting examples of aryl groups are phenyl, biphenyl, naphthyl, pyranyl, pyrrolyl, pyrazinyl, pyrimidinyl, pyrazolyl, pyridinyl, furanyl, thiophenyl, thiazolyl, imidazolyl, isoxazolyl, and the like.
• a "mono-or poly-carbocyclic ring” refers to in one embodiment to cycloalkyl groups (Univalent groups derived from cycloalkanes by removal of a hydrogen atom from a ring carbon atom) In another embodiment, refers to a saturated or unsaturated mono-ring or poly- carbocyclic rings consisting of the carbon and hydrogen elements.
• the poly-carbocyclic rings are 2-7 fused rings. In another embodiment, the poly-carbocyclic rings are 2-4 fused rings. In another embodiment, the poly-carbocyclic rings are 2-7 rings attached by a single bond or a double bond.
• the poly-carbocyclic ring is combination of fused rings and rings which are attached by a single bond.
• mono or poly-carbocyclic ring are phenyl, biphenyl, cycloheptane, cyclohexane, cyclopentane, cyclobutane, naphthalene, norcholane, and cyclopropane.
• the mono- or poly-carbocyclic ring may be unsubstituted or substituted by one or more groups selected from halogen, alkyl, aryl, haloalkyl, protected hydroxyl, cyano, azide, carboxylic acid, aldehyde, alkoxy, carbonyl, amido, alkylamido, nitro, protected amino, alkylamino, protected thio-and/or thioalkyl.
• a "mono-or poly-heterocyclic ring” refers to a heterocyclyl group which is formed by removing a hydrogen atom from any ring atom of a heterocyclic compound.
• heteroaryl group which derives from heteroarenes by removal of a hydrogen atom from any ring atom; an alternative term is hetaryl.
• hetaryl refers to a saturated or unsaturated mono-ring or poly-cyclic rings consisting of carbon, hydrogen and at least one of nitrogen, sulfur, oxygen, phosphorous or combination thereof.
• the poly-heterocyclic rings are 2-7 fused rings. In another embodiment, the poly-heterocyclic rings are 2-4 fused rings.
• the poly-heterocyclic rings are 2-7 rings attached by a single bond. In another embodiment, the poly-heterocyclic ring is combination of fused rings and rings which are attached by a single bond.
• Non limiting examples of mono or poly-heterocyclic ring are 4-pyridyl, pyrrolidin-l-yl, pyrrolidin-2-yl, pyridyl, bi-pyridyl, piperidyl, E.g. 2-pyridyl (pyridin-2-yl), indol-l-yl and quinoline.
• the mono- or poly-heterocyclic ring may be unsubstituted or substituted by one or more groups selected from halogen, alkyl, aryl, haloalkyl, protected hydroxyl, cyano, azide, carboxylic acid, aldehyde, alkoxy, carbonyl, amido, alkylamido, nitro, protected amino, alkylamino, protected thio and/or thioalkyl.
• amides include carboxamides (benzamide, secondary amide, imides, lactams, peptides etc.), phosphoramides (phenylphosphonamidic acid), and sulfonamides (N- methanesulfonamide).
• a “diacylamine” refers, in one embodiment, to a compounds having two acyl groups substituted on ammonia or a primary amine: acyl-NH-acyl. They are also known as secondary amides and, especially the cyclic examples derived from diacids, as imides. E.g.
• An "acyl” group is formed by removing one or more hydroxy groups from oxoacids that have the general structure RkE(-0)i(OH) m ( 1 ⁇ 0), and replacement analogues of such acyl groups.
• a “lactam” refers, in one embodiment, to a cyclic amide of amino carboxylic acid, for example having a l-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
• a “peptide” refers, in one embodiment, to amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon to the nitrogen atom of another with formal loss of water.
• a sulfonamide includes a "sultam”.
• a “sultam” refers, in one embodiment to a sulfonamide which the S-N bond is part of a ring.
• a nitramine refers, in one embodiment to an amines substituted at N with a nitro group (a contracted form of N-nitroamines); they are thus amides of nitric acid, and the class is composed of nitramide, 0 2 NH 2 , and its derivatives formed by substitution.
• Reagents tra «5-2-Phenyl-l-cyclopropanecarboxylic acid was purchased from TCI. N-Boc-4-piperidineacetic, l-Boc-piperidine-4-carboxylic, and l-Boc-azetidine-3- carboxylic acids were purchased from Chem-Impex International. 4- Methoxycarbonylcubanecarboxylic acid was purchased from Boron Molecular. All other reagents and solvents were purchased from Aldrich Chemical Company unless specified otherwise and used without further purification.
• ABCN l,r-azobis(cyclohexanecarbonitrile)
• AIBN azobisisobutyronitrile
• Alk alkyl
• Boc tert-butoxycarbonyl protective group
• NIS N-iodosuccinimide
• NISac iV-iodosaccharine
• NMP l-methyl-2-pyrrolydinone
• TEMPO 2,2,6,6-tetramethyl-I-piperidinyloxy, free radical
• TICA triiodoisocyanuric acid
• TIG 2,4,6,8-tetraiodoglycoluril
• Ph(CH 2 ) 4 COOH A hv - Ph(CH 2 ) 4 l
• a mixture of Ph(CH 2 ) 4 COOH (0.25 mmol), DIH (0.25 mmol), and solvent (1 mL) was refluxed ( ⁇ ) for 1 h under irradiation with 500 W tungsten lamp (TL). Conversion degree was determined by ⁇ NMR spectra of the reaction mixture.
• Entry 3 gives example of radical trap effect when the reaction was provided presence of 10 mol % of TEMPO.
• Entry 16 1-Bromo-l-iodopentane: 1H NMR ⁇ 5.53 (t, 1H), 2.38 (m, 2H), 1.47 (m, 2H), 1.37 (m, 2H), 0.93 (t, 3H); 13 C NMR ⁇ 47.0, 32.1, 21.3, 14.0, 12.9.
• Entry 17 tra «s-2-Phenyl-l-cyclopropyl iodide: 1H NMR ⁇ 7.29 (m, 2H), 7.21 (m, 1H), 7.06 (d, 2H), 2.56 (m, 1H), 2.33 (m, 1H), 1.49 (m, 1H), 1.41 (m, 1H); 13 C NMR ⁇ 140.4, 128.7, 126.6, 125.9, 27.9, 20.0, -13.1 (C-I).
• Entry 24 (S)-methyl 2-(benzyloxycarbonyl)amido-4-iodobutanoate: ⁇ NMR: ⁇ 7.36 (m, 5H), 5.32 (br d, J 6 Hz, 1H), 5.12 (s, 2H), 4.44 (br m, 1H), 3.77 (s, 3H), 3.17 (t, J 7 Hz, 2H), 2.45 (m, 1H), 2.23 (m, 1H); 13 C NMR: ⁇ 171.7, 155.9, 136.0, 128.5, 128.2, 128.1, 60.4, 54.6, 62.7, 36.7, -0.68.
• Entries 29-31 Methyl 4-iodocubanecarboxylate: 1H NMR ⁇ 4.39 (m, 3H), 4.30 (m, 3H), 3.71 (s, 3H); 13 C NMR ⁇ 172.0, 56.3, 55.0, 51.8, 50.4, 36.3 (C-I).
• Entry 15 4-Nitroiodobenzene: 1H NMR ⁇ 7.95 (d, 2H), 7.91 (d, 2H); 13 C NMR ⁇ 147.9, 138.8, 125.0, 102.8 (C-I).
• Entry 17 1-Iodonaphthalene: 1H NMR ⁇ 8.09 (m, 2H), 7.84 (m, IH), 7.77 (m, IH), 7.58 (m, IH), 7.52 (m, IH), 7.18 (m, IH); 13 C NMR ⁇ 137.6, 134.5, 134.3, 132.3, 129.1, 128.7, 127.9, 127.0, 126.9, 99.7 (C-I).
• Entries 18-19 4-Iodobiphenyl: 1H NMR ⁇ 7.77 (m, 2H), 7.55 (m, 2H), 7.44 (m, 2H), 7.37 (m, IH), 7.33 (m, 2H); 13 C NMR ⁇ 140.9, 140.2, 138.0, 129.2, 129.0, 127.8, 127.0, 93.2 (C-I).
• Entry 21 3-Iodotoluene: 1H NMR ⁇ 7.56 (s, 1H), 7.50 (d, 1H), 7.13 (m, 1H), 6.99 (m, 1H), 2.31 (s, 3H); 13 C NMR 5 140.3, 138.1, 134.5, 130.0, 128.4, 94.4 (C-I), 21.0.
• Entry 22 2-Methoxyiodobenzene: 1H NMR ⁇ 7.77 (m, 1H), 7.31 (m, 1H), 6.83 (m, 1H), 6.71 (m, 1H), 3.88 (s, 3H); 13 C NMR ⁇ 158.1, 139.5, 129.5, 122.5, 111.0, 86.0 (C-I), 56.3.
• Entry 23 3-Methoxyiodobenzene: 1H NMR ⁇ 7.28 (d, 1H), (m, 2H), 7.26 (d, 1H), 7.00 (t, 1H), 6.87 (dd, 1H), 3.78 (s, 3H); 13 C NMR ⁇ 160.2, 130.8, 129.9, 123.0, 113.8, 94.4 (C-I), 55.4.

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