WO2011145851A2 - 사이프러스 에센셜 복합 오일을 유효 성분으로 함유하는 기억력 증진 및 인지 기능 장애 개선을 위한 화장료 조성물 - Google Patents
사이프러스 에센셜 복합 오일을 유효 성분으로 함유하는 기억력 증진 및 인지 기능 장애 개선을 위한 화장료 조성물 Download PDFInfo
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- WO2011145851A2 WO2011145851A2 PCT/KR2011/003597 KR2011003597W WO2011145851A2 WO 2011145851 A2 WO2011145851 A2 WO 2011145851A2 KR 2011003597 W KR2011003597 W KR 2011003597W WO 2011145851 A2 WO2011145851 A2 WO 2011145851A2
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- essential oil
- cosmetic composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q13/00—Formulations or additives for perfume preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/06—Preparations for styling the hair, e.g. by temporary shaping or colouring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/10—Preparations for permanently dyeing the hair
Definitions
- the present invention relates to a cosmetic composition containing cypress essential oil and other active ingredients having an effect of improving memory and cognitive function.
- Dementia is a complex clinical syndrome that usually has a marked impairment in human cognitive, intellectual, emotional, and behavioral changes.It causes cerebral cortical dysfunction such as memory, attention, language, and space-time ability to lead daily and social life. It is a state of great difficulty. Dementia is defined as having one or more disorders of other cognitive functions, including memory.
- the causes of dementia include Alzheimer's disease and Parkinson's disease, degenerative brain diseases, hemorrhagic encephalopathy, metabolic diseases, hepatic encephalopathy, Wilson's disease, infectious neuropathy, acquired immunodeficiency, alcohol and alcohol.
- dementia caused by Alzheimer's disease is the most common (50-60%), followed by dementia caused by cerebrovascular disease.
- dementia is a challenge that requires social and national solutions.
- Memory cognitive impairment is the first symptom of Alzheimer's disease, and is also the most common symptom.
- patients experience recent memory impairments that cannot remember the details of recent conversations or work because of damage to the hippocampus' nerve cells and the lack of recent memory. .
- remote long-term memory of events in the distant past is relatively well maintained.
- the cortex associated with the storage of long-term memory is damaged, and this memory of the past becomes gradually impaired.
- Alzheimer's disease are closely related to synaptic disorders of the choline nervous system as well as cytotoxicity due to the deposition of beta-amyloid.
- Dysfunction of the choline nervous system is known to contribute to memory and cognitive dysfunction of people with Alzheimer's disease.
- the basal nucleus of Meynert cholinergic neurons are associated with the temporal lobe, hippocampus, and amygdala, which are involved in memory and cognitive functions.In Alzheimer's disease, 78% in the temporal lobe, 60% in the hippocampus, and Menert In basal ganglia, neurons are known to decrease by 67%.
- Alzheimer's disease When brain cells are damaged by cytotoxicity, there is a disturbance in information transmission, that is, metabolism of neurotransmitters, which causes memory cognitive impairment. Many researchers have consistently reported selective reduction of acetylcholine and its synthesis in choline acetyltransferase in Alzheimer's disease. Moreover, the brains of Alzheimer's disease not only reduce nicotinic acetylcholine receptors and muscarinic acetylcholine receptors compared to normal human brain functions, but also the choline reuptake and acetylcholine Secretory function is also reduced.
- acetylcholinesterase inhibitors AchEI
- donepezil rivastigmine
- galanthamine galanthamine
- these drugs increase the concentration by inhibiting the breakdown of acetylcholine in synaptic clefts. Indicates.
- These drugs initially improve cognitive function and daily life, but do not fundamentally prevent disease progression, returning to pre-administration after nine months to a year. It should be used relatively early to see the effect, and in case of severe dementia, the effect is weak.
- Korean Patent Publication No. 10-2009-0082946 proposes a technique for improving memory or concentration enhancement composition containing a mixture of green tea extract and theanine in a certain ratio as an active ingredient I've done it.
- Korean Patent Registration No. 10-0360674 has suggested a composition for preventing and treating dementia using sewage.
- Korean Patent Registration No. 10-0822887 discloses the treatment of dementia, which comprises baekgulchae extract, 8-hydroxydihydrocerristrin, 8-hydroxydihydrosangjinarin, berberine or a mixture thereof. A composition for prevention has been presented.
- 10-0804480 has proposed a memory enhancing composition comprising a mixed extract consisting of Wonji, Seokchangpo, Ginseng, Angelica, Ginkgo biloba, Schisandra chinensis and Cheongung.
- Korean Patent Laid-Open No. 10-2005-0092292 has suggested a herbal composition having a memory enhancing effect, characterized in that consisting of Baekchul extract, Bokryeong extract and Sanjoin extract.
- Korean Patent Registration No. 10-0500029 has suggested a memory-enhancing herbal composition containing the extract of Sukjihwang (Rehmanniae radix preparata) as an active ingredient.
- the composition for oral administration is mainly inconvenient to oral administration in accordance with time in normal life.
- An object of the present invention is to provide a cosmetic composition that can improve memory and cognitive dysfunction through aroma, unlike the composition for improving memory and cognitive dysfunction through conventional oral administration.
- the present invention includes a first essential oil component of cypress essential oil, and at least one second essential oil component selected from fine needle essential oil, lavender essential oil, rosemary essential oil, thyme red essential oil, and veragmott essential oil. It provides a cosmetic composition for improving memory and improving cognitive dysfunction.
- the total total amount of the first essential oil component and the second essential oil component in the total weight of the aromatic composition is preferably 0.01% by weight to 100% by weight.
- the said 2nd essential oil component in the ratio of 0.01 weight part-100 weight part with respect to 100 weight part of said 1st essential oil components.
- the cosmetic composition may further include one or more of a carrier, an excipient, a diluent, a filler, an extender, a binder, a humectant, a lubricant, a disintegrant, and a surfactant.
- the cosmetic composition is preferably a formulation of any one of shampoo, rinse, perfume, lotion, cream, skin, detergent, mousse, spray, hair wax, deodorant, fragrance and hair gel.
- the cypress essential oil complex aromatic cosmetic composition of the present invention can be usefully used as a cosmetic composition for improving memory and preventing and treating cognitive dysfunction by confirming an improvement effect on memory damage and cognitive dysfunction induced by scopolamine. have.
- the cypress complex essential oil of the present invention showed a better effect than a single essential oil as a whole in various cognitive enhancement experiments, and at the same time it was confirmed that this effect is lower than the natural essential oil when using artificial fragrance.
- FIG. 5 and 6 are the results of Experimental Example 3
- FIG. 5 is a result of step-through latency time measurement during the retention trial on the second day
- FIG. 6 is the acquisition test on the first day. This is the result of measuring the time to stay in the bright compartment during the aquisition trial.
- the present invention uses the cypress essential oil as the first essential oil component, at least one selected from fine needle essential oil, lavender essential oil, rosemary essential oil and thyme red essential oil second essential oil It provides an aromatic composition comprising a.
- the essential oils all mean essential oils extracted from natural materials.
- the cosmetic composition of the present invention is characterized in that the treatment or prevention mechanism for memory enhancement and cognitive dysfunction is exerted through a mechanism for enhancing neurotrophic factor, acetylcholine synthase and receptor expression, and inhibiting acetylcholine esterase.
- the cognitive impairment includes Alzheimer's dementia, cerebrovascular dementia, dementia due to head injury, and preferably includes Alzheimer's disease.
- Essential oils such as rosemary, thyme red, bergamot, pine needle, lavender, cypress used as active ingredients in the present invention It has been used as a variety of aromatherapy and cosmetic ingredients. Since the essential oil is separable or commercially available by conventional extraction and separation methods in the art, the extraction method of the essential oil is omitted in the present invention.
- Cypress essential oils have temporary analgesic effects such as muscle spasms, myalgias, arthritis, etc., and are helpful for immune strengthening, tension, stress, lethargy and nervous breakdown. It has been used for skins.
- Rosemary essential oils are known to have tonic, soothing, digestive, astringent, gust, antibacterial effects, headache, cerebral blood circulation, memory enhancement and concentration.
- an anti-aging effect is widely used as a lotion, and when used as a shampoo or rinse has been known to have the effect of suppressing dandruff.
- Time red (thyme red) essential oils are strong, tonic, expectorant, antiparasitic, gusts, increased blood pressure, antitoxicity, antirheumatic, aphrodisiac, bactericidal, insecticidal, antiseptic, edible, painful, diuretic, and activates brain cells. It has been known to improve memory and concentration.
- Bergamot essential oil has antiseptic, antimicrobial action in the leaves of bactericidal substances, imparts a refreshing feeling to the skin, and has a sebum control function, and has been widely used in skin diseases such as acne treatment in the cosmetic field.
- the effect of delaying and preventing skin aging has been reported due to excellent skin soothing and antioxidant effects.
- Fine needle essential oil has expectorant, dry, sweating, antiseptic, antiseptic, anti-inflammatory, diuretic, deodorant, disinfecting effect. It is effective for depressed skin and heales skin inflammation such as eczema, dry swelling and cuts. .
- Lavender essential oils come in a variety of varieties, including English lavender, French lavender, spike lavender, etc.
- the essential oils have been used for aromatherapy since ancient times. Sterilization, disinfection, antiseptic, insect repellent, hypnosis, soothing, pain relief, headache, insomnia, depression, anxiety, anxiety, bronchitis, neuralgia, rheumatism, muscle pain, burns, bites It has been known to have moisturizing, regenerating and cleaning effects.
- synthetic fragrance used to compare the effects of natural essential oils in the present invention is generally used in combination of the aroma of several images, mainly floral (floral), fresh leaves and nature reminiscent of floral fragrance
- floral fragrance A variety of fragrances are used either alone or in combination, such as green, which makes you feel, and fruity, which gives a sweet and fresh feeling.
- the present invention provides a cosmetic composition for preventing and improving memory enhancement and cognitive impairment containing the cypress complex essential oil as an active ingredient.
- the total amount of the first essential oil component and the second essential oil component in the total weight of the aromatic cosmetic composition is preferably 0.01% by weight to 100% by weight. It is preferable to use the said 2nd essential oil component in the ratio of 0.01 weight part-100 weight part with respect to 100 weight part of said 1st essential oil components.
- the present invention is a cosmetic composition for improving memory and cognitive function using aroma, and unlike the oral composition, the composition ratio does not have a significant meaning, and is not limited to the composition ratio as described above, and the type and condition of patients The composition ratio can be freely adjusted according to the progress.
- the aromatic cosmetic composition of the present invention may further comprise a suitable carrier, excipient or diluent according to conventional methods.
- suitable carrier, excipients and diluents include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, microcrystalline Cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil, but are not limited to these examples.
- the aromatic cosmetic composition of the present invention is in the form of external preparations such as shampoos, rinses, perfumes, lotions, creams, skins, fragrances, aerosols, cleaning agents, mousses, hair sprays, deodorants, or ointments applied to the skin according to conventional methods.
- external preparations such as shampoos, rinses, perfumes, lotions, creams, skins, fragrances, aerosols, cleaning agents, mousses, hair sprays, deodorants, or ointments applied to the skin according to conventional methods.
- diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrating agents, and surfactants that are commonly used can be prepared.
- lubricants such as magnesium stearate, talc can also be used.
- mice C57 / BL6 male mice (8 weeks old, Hyochang Science, Daegu) at around 20-25 g body weight were used for a week.
- the test and control groups were divided into 15 groups (see Table 1), 5 each. During the acclimatization period and the experiment period, they were exposed to incense for 3 hours a day. The 12-hour period was 12 hours and 12 hours at night.
- the Y-maze test apparatus consists of the same three passages (6 cm wide, 28 cm long and 18 cm high), each arranged at a constant angle of 120 ° to each other. Mice were placed at the end of one passage and allowed to wander freely in the Y maze for 8 minutes. Spontaneous alteration (%) was assessed by measuring the number and order of entry into each arm. Spontaneous crossover behavior was defined as sequentially entering three pathways, namely ABC, BCA, and CAB. Therefore, the% voluntary crossover behavior was calculated by Equation 1 below.
- the experimental group C to H administered scopolamine after exposure to the scents of rosemary, thyme red, bergamot, pine needle, lavender, and cypress essential oil respectively, 60% control group (B)
- the aromatic composition (I to M) of the present invention using cypress essential oil in combination with any one of rosemary, thyme red, bergamato, pine needle and lavender essential oil although the improvement in cognitive memory was shown, Compared to using only one oil, the effect was better.
- the Morris water-maze test is an experiment to find out whether essential oils help the animal's spatial perception and short and long-term memory recovery.
- the test equipment consists of a round steel tank (120 cm in diameter and 45 cm in height) and a platform (10 cm in diameter and 30 cm in height). The height of the water in the tank (temperature 22 ⁇ 2 ° C.) was up to 2 cm above the platform, allowing the body to come out of the water when the mouse sat on the shelters.
- the experimental animals kept the label constant during the experiment so that there was no change in the surrounding environment because the animals used the label around the tank to find the escape zone.
- the escape latencies were recorded and observed by computer programs (Ethovision 3.1, Noduls, Netherlands) with cameras mounted on the ceiling above the tank. The experiment was carried out three times daily for four days, at which time the position of placing the experimental animals in the tank was changed sequentially each time to minimize the possibility of visiting the escape by accident. If the test animal did not find the escape zone within 120 seconds, the escape latency was set to 120 seconds, and when the test animal sat in the escape zone, the test animal was placed for 20 seconds to remember the clues of the surroundings.
- the experimental groups C to M exposed to essential oils showed significantly lower mean escape time on average compared to the control group (B) administered with scopolamine alone, indicating a significant spatial cognitive memory recovery effect.
- the experimental groups I to M which are preferred embodiments of the present invention, have an excellent memory recovery effect as compared to the experimental groups C to H having only one component of the control and essence oil.
- the normal group (SHAM) and the experimental group showed a stabilized decrease graph after the third day to form a long-term memory during the experimental period (see Figure 4).
- bergamot, pine needles, lavender essential oil each one and a combination of cypress essential oil inhalation (K, L, M) showed a relatively high memory improvement effect.
- the step-through latency time during the second day retention trial recorded 281.86 ⁇ 4.46 seconds in the normal group (A), and the control group (B) 21.15 ⁇ 3.32 seconds were recorded to show a statistically significant difference. This suggests that memory impairment was clearly induced in the control group.
- the experimental group (N) administered scopolamine and artificial scents combining floral, proty and green scents were exposed for 3 hours.
- the step-through latency time was 146.06 ⁇ 10.91 seconds and 145 ⁇ 3.79 seconds, respectively, showing a weak effect compared to the natural flavor.
- the horror conditioning experiment is a test that evaluates learning and memory as a classical conditioning paradigm that associates environmental contexts or conditional stimuli with electroshock (US) in animal models in which memory loss is caused by scopolamine. This can be divided into contextual fear conditioning and cued fear conditioning.
- Training sessions are presented twice in pairs of sound stimuli (CS, 15 s, 68-80 dB, 30 kHz) and electrical shock (US, 1 s, 0.5 mA). Each is run at 150-second intervals, and 60 seconds after the last US shock is taken, the mouse is removed from the conditioning box. After 24 hours, the following tests are carried out: Contextual Conditioning: An animal is placed in a conditioned box and the cryo-response is measured as a conditional fear response to the context without suggesting a sound stimulus (hippocampus-dependent memory). A freezing reaction is defined as a state in which there is no movement other than the behavior for the animal to breathe.
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Abstract
Description
실험군 | 비고 |
A | 스코폴라민과 어떠한 방향 물질도 투여되지 않은 정상군 |
B | 스코폴라민을 투여한 대조군 |
C | 로즈마리 에센셜 오일 향에 3시간 노출시킨 후 스코폴라민을 투여한 실험군 |
D | 타임레드 에센셜 오일 향에 3시간 노출시킨 후 스코폴라민을 투여 한 실험군 |
E | 베르가모트 에센셜 오일 향에 3시간 노출시킨 후 스코폴라민을 투여한 실험군 |
F | 파인니들 에센셜 오일 향에 3시간 노출시킨 후 스코폴라민을 투여한 실험군 |
G | 라벤더 에센셜 오일 향에 3시간 노출시킨 후 스코폴라민을 투여한 실험군 |
H | 사이프러스 에센셜 오일 향에 3시간 노출시킨 후 스코폴라민을 투여한 실험군 |
I | 사이프러스 에센셜 오일 + 로즈마리 에센셜 오일 향에 3시간 노출시킨 후 스코폴라민을 투여한 실험군 |
J | 사이프러스 에센셜 오일 + 타임레드 에센셜 오일 향에 3시간 노출시킨 후 스코폴라민을 투여한 실험 |
K | 사이프러스 에센셜 오일 + 베르가모트 에센셜 오일 향에 3시간 노출시킨 후 스코폴라민을 투여한 실험군 |
L | 사이프러스 에센셜 오일 + 파인니들 에센셜 오일 향에 3시간 노출시킨 후 스코폴라민을 투여한 실험군 |
M | 사이프러스 에센셜 오일 + 라벤더 에센셜 오일 향에 3시간 노출시킨 후 스코폴라민을 투여한 실험군 |
N | Floral + Fruity 인공향에 3시간 노출시킨 후 스코폴라민을 투여한 실험군 |
O | Floral + Fruity + Green 인공향에 3시간 노출시킨 후 스코폴라민을 투여한 실험군 |
실험군 | % 자발적 교차행동량(단위 : %) |
A | 79.90 ± 0.69 |
B | 51.30 ± 1.0 |
C | 60.29 ± 3.12 |
D | 60.80 ± 2.80 |
E | 62.13 ± 3.24 |
F | 62.52 ± 1.53 |
G | 60.93 ± 4.65 |
H | 61.67 ± 3.27 |
I | 67.48 ± 3.29 |
J | 68.45 ± 3.06 |
K | 70.45 ± 3.95 |
L | 70.29 ± 2.22 |
M | 71.63 ± 1.83 |
실험군 | 평균탈출시간(단위 : 초) |
A | 17.67 ± 1.58 |
B | 90.63 ± 1.72 |
C | 49.67 ±1.69 |
D | 52.6 ± 2.33 |
E | 42.13 ± 1.18 |
F | 35.87 ± 2.71 |
G | 44.33 ± 11.35 |
H | 40.0 ± 6.22 |
I | 33.6 ± 5.40 |
J | 35.4 ± 4.59 |
K | 27.13 ± 0.98 |
L | 26.93 ± 2.72 |
M | 23.33 ± 2.31 |
N | 61.93 ± 7.27 |
O | 62.2 ± 3.64 |
실험군 | step-through latency time(단위 :초) |
A | 281.86 ± 4.46 |
B | 21.15 ± 3.32 |
C | 166.6 ± 5.15 |
D | 171.12 ± 2.79 |
E | 181.86 ± 5.90 |
F | 202.64 ± 12.88 |
G | 187.04 ± 20.78 |
H | 199.36 ± 28.27 |
I | 183.29 ± 7.48 |
J | 186.38 ± 9.20 |
K | 186.38 ± 9.20 |
L | 205.04 ± 4.19 |
M | 243.52 ± 17.82 |
N | 146.06 ± 10.91 |
O | 145.00 ± 3.79 |
실험군 | 동결반응시간(단위 :초) |
A | 244.5 ± 2.42 |
B | 23.77 ± 2.30 |
C | 184.6 ± 10.52 |
D | 185.4 ± 2.71 |
E | 201.8 ± 1.85 |
F | 209.4 ± 10.10 |
G | 219.2 ± 4.90 |
H | 225.0 ± 5.30 |
I | 213.5 ± 5.24 |
J | 215.7 ± 3.57 |
K | 230.6 ± 3.23 |
L | 233.0 ± 5.66 |
M | 235.4 ± 5.61 |
N | 145.0 ± 6.99 |
O | 147.8 ± 10.11 |
실험군 | 동결반응시간(단위 :초) |
A | 241.42 ± 2.02 |
B | 21.23 ± 1.42 |
C | 178.6 ± 9.87 |
D | 187.8 ± 6.12 |
E | 191.6 ± 3.12 |
F | 207.8 ± 9.40 |
G | 218.0 ± 3.94 |
H | 226.3 ± 7.14 |
I | 216.3 ± 4.23 |
J | 219.2 ± 5.57 |
K | 223.4 ± 3.89 |
L | 225.2 ± 5.53 |
M | 234.2 ± 3.06 |
N | 136.6 ± 9.37 |
O | 144.0 ± 8.44 |
Claims (5)
- 사이프러스 에센셜 오일의 제1 에센셜 오일 성분과, 파인니들 에센셜 오일, 라벤더 에센셜 오일, 로즈마리 에센셜 오일, 타임레드 에센셜 오일 및 베라그모트 에센셜 오일 중에서 선택되는 1종 이상의 제2 에센셜 오일 성분을 포함하는 기억력 증진 및 인지 기능 장애 개선 효과를 갖는 화장료 조성물.
- 제1항에서, 상기 화장료 조성물 총 중량 중 제1 에센셜 오일 성분과 제2 에센셜 오일 성분의 합계 총 사용량은 0.01 중량% 내지 100 중량%인 것을 특징으로 하는 기억력 증진 및 인지 기능 장애 개선 효과를 갖는 화장료 조성물.
- 제1항에서, 상기 제1 에센셜 오일 성분 100 중량부에 대하여, 상기 제2 에센셜 오일 성분은 0.01 중량부 내지 100 중량부의 비율로 사용하는 것을 특징으로 하는 기억력 증진 및 인지 기능 장애 개선 효과를 갖는 화장료 조성물.
- 제1항에서, 상기 화장료 조성물은 담체, 부형제, 희석제, 충진제, 증량제, 결합제, 습윤제, 윤활제, 붕해제 및 계면활성제 중의 1종 이상을 더 포함하는 것을 특징으로 하는 기억력 증진 및 인지 기능 장애 개선 효과를 갖는 화장료 조성물.
- 제1항에서, 상기 화장료 조성물은 샴푸, 린스, 향수, 로션, 크림, 스킨, 세정제, 무스, 스프레이, 헤어왁스, 방향제, 소취제 및 헤어젤 중 어느 하나의 제형인 것을 특징으로 하는 화장료 조성물.
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US13/698,594 US20130115318A1 (en) | 2010-05-19 | 2011-05-16 | Cosmetic composition containing a cypress essential oil complex as an active ingredient for enhancing memory and improving cognitive dysfunction |
CN2011800349318A CN103002902A (zh) | 2010-05-19 | 2011-05-16 | 含有丝柏复合精油作为有效成分的用于增进记忆力及改善认知功能障碍的化妆品组合物 |
JP2013511106A JP2013526566A (ja) | 2010-05-19 | 2011-05-16 | サイプレスエッセンシャル複合オイルを有効成分として含有する、記憶力増進及び認知機能障害改善のための化粧料組成物 |
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KR10-2010-0046784 | 2010-05-19 | ||
KR1020100046784A KR101001867B1 (ko) | 2010-05-19 | 2010-05-19 | 사이프러스 에센셜 복합 오일을 유효 성분으로 함유하는 기억력 증진 및 인지 기능 장애 개선을 위한 화장료 조성물 |
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WO2011145851A3 WO2011145851A3 (ko) | 2012-05-18 |
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US (1) | US20130115318A1 (ko) |
JP (1) | JP2013526566A (ko) |
KR (1) | KR101001867B1 (ko) |
CN (1) | CN103002902A (ko) |
WO (1) | WO2011145851A2 (ko) |
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CN104784287B (zh) * | 2015-04-28 | 2017-12-19 | 苏州大学 | 一种早期预防阿尔茨海默病的嗅觉刺激液及其制备方法 |
CN106620626A (zh) * | 2017-01-23 | 2017-05-10 | 钟苏 | 一种身体护理精油 |
CN109875922A (zh) * | 2019-04-01 | 2019-06-14 | 北京爸爸的选择科技有限公司 | 一种男士松纯露护肤水及其制备方法 |
CN110179695A (zh) * | 2019-06-27 | 2019-08-30 | 东莞怀朴植物精油有限公司 | 一种改善记忆复方精油及其制备方法 |
CN115678696A (zh) * | 2022-09-20 | 2023-02-03 | 杭州禾沐堂生物科技发展有限责任公司 | 一种基于天然提取物的洁面皂及其制备方法 |
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- 2011-05-16 US US13/698,594 patent/US20130115318A1/en not_active Abandoned
- 2011-05-16 CN CN2011800349318A patent/CN103002902A/zh active Pending
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JP2013526566A (ja) | 2013-06-24 |
US20130115318A1 (en) | 2013-05-09 |
CN103002902A (zh) | 2013-03-27 |
WO2011145851A3 (ko) | 2012-05-18 |
KR101001867B1 (ko) | 2010-12-17 |
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