WO2011136344A1 - Détecteur chimique - Google Patents

Détecteur chimique Download PDF

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Publication number
WO2011136344A1
WO2011136344A1 PCT/JP2011/060404 JP2011060404W WO2011136344A1 WO 2011136344 A1 WO2011136344 A1 WO 2011136344A1 JP 2011060404 W JP2011060404 W JP 2011060404W WO 2011136344 A1 WO2011136344 A1 WO 2011136344A1
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WO
WIPO (PCT)
Prior art keywords
unit
sample
substance
measured
reaction
Prior art date
Application number
PCT/JP2011/060404
Other languages
English (en)
Japanese (ja)
Inventor
宏明 橘
辻　幸司
Original Assignee
パナソニック電工株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by パナソニック電工株式会社 filed Critical パナソニック電工株式会社
Priority to JP2012512913A priority Critical patent/JP5650728B2/ja
Priority to SG2012079612A priority patent/SG185064A1/en
Priority to EP11775125.5A priority patent/EP2565616B1/fr
Priority to KR1020127029139A priority patent/KR20130028929A/ko
Priority to US13/642,688 priority patent/US20130040374A1/en
Priority to CN201180021331.8A priority patent/CN102869974B/zh
Publication of WO2011136344A1 publication Critical patent/WO2011136344A1/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/22—Devices for withdrawing samples in the gaseous state
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/22—Devices for withdrawing samples in the gaseous state
    • G01N1/2202—Devices for withdrawing samples in the gaseous state involving separation of sample components during sampling
    • G01N1/2214—Devices for withdrawing samples in the gaseous state involving separation of sample components during sampling by sorption
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/0004—Gaseous mixtures, e.g. polluted air
    • G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
    • G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
    • G01N33/0036—Specially adapted to detect a particular component
    • G01N33/0059—Specially adapted to detect a particular component avoiding interference of a gas with the gas to be measured
    • G01N33/006—Specially adapted to detect a particular component avoiding interference of a gas with the gas to be measured avoiding interference of water vapour with the gas to be measured
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/22—Devices for withdrawing samples in the gaseous state
    • G01N1/2202—Devices for withdrawing samples in the gaseous state involving separation of sample components during sampling
    • G01N1/2214—Devices for withdrawing samples in the gaseous state involving separation of sample components during sampling by sorption
    • G01N2001/2217—Devices for withdrawing samples in the gaseous state involving separation of sample components during sampling by sorption using a liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/22—Devices for withdrawing samples in the gaseous state
    • G01N2001/2282—Devices for withdrawing samples in the gaseous state with cooling means

Definitions

  • the present invention relates to a chemical sensor for detecting a gas component in a gas or a substance to be measured such as a virus or an allergen.
  • an electrochemical biosensor test piece uses a body fluid such as blood, a fermented product, or a natural product as a sample, and detects charges generated by enzymatic reaction of this sample with a reagent (see Patent Document 1). .
  • This electrochemical biosensor test piece has a capillary space for introducing a sample by utilizing capillary action, so that even a small amount of sample accurately measures an enzyme reaction with a reagent and a charge. Yes.
  • the sample needs to be liquid due to reaction restrictions. Therefore, it is impossible to detect a substance to be measured such as a gas component in a gas, a virus, or an allergen.
  • a pretreatment for dissolving the substance to be measured in a liquid is required.
  • This pre-processing is a complicated process such as using a large apparatus or manually.
  • the present invention has been made in view of the above problems, and an object thereof is to provide a chemical sensor capable of dissolving a substance to be measured in a gas in a liquid by a simple method.
  • the chemical sensor includes a sensor holding unit, a gas injection hole into which a gas containing a substance to be measured is injected, and a sample collecting part for collecting the substance to be measured contained in the gas injected from the gas injection hole
  • a sample transporting part for transporting the substance to be measured collected by the sample collecting part to the sample reaction part, a sample reaction part having a reactive substance that causes a predetermined reaction with the substance to be measured transported by the sample transporting part, and a sample A detector that detects a substance to be measured that has reacted with the reactant in the reaction unit.
  • the sample collection unit has a Peltier element that liquefies water vapor contained in the gas injected from the gas injection hole.
  • a solution containing a substance to be measured can be created by liquefying water vapor contained in the gas injected from the gas injection hole by the Peltier cooling effect of the Peltier element. Therefore, the sample collection unit can collect a solution containing the substance to be measured from the gas injected from the gas injection hole.
  • the gas injection hole, the sample collection unit, the sample transport unit, the sample reaction unit, and the detection unit are integrally formed with the sensor holding unit.
  • the sample transporting section has a capillary structure, and one end of the capillary structure may be close to the Peltier element.
  • the solution liquefied by the Peltier device by the capillary phenomenon of the capillary structure can be transported to the sample reaction part without using a special structure.
  • the sample reaction unit may have at least one of an antibody, an enzyme, a receptor, and a protein that specifically react with the substance to be measured conveyed by the sample conveyance unit.
  • the substance to be measured can be specifically detected by the antigen-antibody reaction with the substance to be measured.
  • the sample reaction unit may include a heating unit that heats the substance to be measured conveyed by the sample conveyance unit, and a temperature measurement unit that measures the temperature of the substance to be measured.
  • a heating unit that heats the substance to be measured conveyed by the sample conveyance unit
  • a temperature measurement unit that measures the temperature of the substance to be measured.
  • the detection unit may include an antibody that binds to the substance to be measured that has reacted with the reactant and an electrode that carries the antibody, and the electrode may have a porous structure. Thereby, since the immobilization area of the antibody can be increased, the detection sensitivity can be increased.
  • the chemical sensor is composed of a plurality of unit sensors integrally formed on one sensor holding unit, and each unit sensor is composed of a gas injection hole, a sample collection unit, a sample transport unit, a sample reaction unit, and a detection unit. It may be. By disposing a plurality of unit sensors integrally in one sensor holding part, it is possible to suppress the disposable use of the sensor.
  • the substance to be measured in the gas can be dissolved in the liquid by a simple method due to the Peltier cooling effect of the Peltier element.
  • FIG. 1A is a cross-sectional view showing the overall configuration of the chemical sensor according to the first embodiment of the present invention.
  • FIG. 1B is a Peltier provided in the sample collection unit 13 of FIG. It is a schematic diagram which shows an element.
  • FIG. 2A and FIG. 2B are schematic diagrams illustrating specific configuration examples of the sample reaction unit 15 and the detection unit 16 in FIG.
  • FIGS. 3A and 3B are schematic views showing a specific configuration example of the detection unit 16 in FIG.
  • FIGS. 4A and 4B are schematic views showing a specific configuration example of the sample reaction unit 15 according to the second embodiment of the present invention.
  • It is a conceptual diagram which shows the whole structure of the chemical sensor concerning the 3rd Embodiment of this invention.
  • the chemical sensor according to the first embodiment includes a sensor holder 11 having a function as a substrate that supports the entire chemical sensor, a gas injection hole 12 into which a gas such as air containing a substance to be measured is injected, and a gas A sample collection unit 13 that collects a substance to be measured contained in the gas injected from the injection hole 12, a sample conveyance unit 14 that conveys the measurement substance collected by the sample collection unit 13 to the sample reaction unit 15, and a sample conveyance A sample reaction unit 15 having a reaction substance that causes a predetermined reaction with the measurement target substance conveyed by the unit 14 and a detection unit 16 that detects the measurement target substance that has reacted with the reaction substance in the sample reaction unit 15 are provided.
  • the sensor holding unit 11 is a substantially flat substrate, and is made of, for example, a semiconductor (Si, SiC, etc.) substrate or a glass substrate that can be easily processed finely.
  • the sensor holding part 11 and a protective member to be described later can be manufactured by micromachining.
  • On one main surface of the sensor holding unit 11, a sample collection unit 13, a sample transport unit 14, a sample reaction unit 15, and a detection unit 16 are arranged in order.
  • a protective member is arranged above the main surface of the sensor holding unit 11 so as to cover the sample collection unit 13, the sample transport unit 14, the sample reaction unit 15 and the detection unit 16, and holes are formed in at least two places of the protection member. Is open. The at least two holes are for introducing and discharging the gas containing the substance to be measured.
  • the protective member and the sensor holding unit 11 are arranged so that the gas can be effectively introduced and discharged through the two holes. It is preferable to join by a joining method capable of maintaining airtightness.
  • One of the at least two locations is provided, for example, in front of the sample collection unit 13, and gas is introduced into the protective member from at least one of the holes and led out from the other hole.
  • One hole on the side where the gas is introduced is referred to as a gas injection hole 12.
  • the sample collection unit 13 collects the substance to be measured contained in the gas in the detection space formed by covering the sensor holding unit 11 with the protective member provided with the gas injection hole 12.
  • the sample transport unit 14, the sample reaction unit 15, and the detection unit 16 are integrally formed.
  • the sample collection unit 13 is disposed in the vicinity of the gas injection hole 12 and makes it easy to collect a substance to be measured contained in the gas injected from the gas injection hole 12.
  • examples of the “substance to be measured contained in the gas” include gas components in the gas, viruses, and allergens.
  • FIG. 1A shows an example in which the gas injection hole 12 is provided in front of the sample collection unit 13, but as described above, in the present invention, the sample collection unit 13 is formed in the gas injection hole 12.
  • the gas injection hole 12 may be provided on the sample collection unit 13 as long as they are arranged close to each other.
  • the sample collection part 13 has the Peltier device 131 which liquefies the water vapor
  • One current of the Peltier element 131 absorbs heat from the surrounding gas by causing a current to flow through the joint between the two kinds of metals constituting the Peltier element 131.
  • FIG. 1B is a plan view of the sample collection unit 13 shown in FIG. 1A as viewed from above, and the lower side of FIG. 1B is the gas injection hole 12 side in FIG. 1A. Yes, the upper side of FIG. 1 (b) is the sample carrying part 14 side in FIG. 1 (a).
  • FIG. 1B is a plan view of the sample collection unit 13 shown in FIG. 1A as viewed from above, and the lower side of FIG. 1B is the gas injection hole 12 side in FIG. 1A. Yes, the upper side of FIG. 1 (b) is the sample carrying part 14 side in FIG. 1 (a).
  • FIG. 1B is lique
  • the Peltier element 131 constituting the sample collection unit 13 is supported by the sensor holding unit 11 at both ends so as not to disturb the cooling function, for example, and, for example, two kinds of metal via wiring formed in the support structure Current is injected into the junction.
  • the Peltier material for example, copper oxide or a polysilicon thin film is preferable from the viewpoint of miniaturization.
  • poured from the gas injection hole can be liquefied by the Peltier cooling effect by a Peltier device. Since the substance to be measured is dissolved in the liquefied water vapor, the solution Lqd containing the substance to be measured can be prepared. Therefore, the sample collection unit 13 can automatically collect the solution Lqd containing the substance to be measured from the gas injected from the gas injection hole 12.
  • the sample transport unit 14 has a capillary structure with a width and a depth of about 100 ⁇ m, and one end of the capillary structure is close to the Peltier element of the sample collection unit 13.
  • the solution Lqd containing the substance to be measured collected by the Peltier device can be introduced into the capillary structure.
  • the solution Lqd introduced into the capillary structure is transported to the sample reaction unit 15 by capillary action.
  • the sample transport unit 14 can transport the solution liquefied by the Peltier element by the capillary phenomenon of the capillary structure to the sample reaction unit 15 without using a special structure.
  • a capillary structure with a width t of about 100 ⁇ m can be manufactured by micromachining.
  • the capillary surface is preferably subjected to a hydrophilic treatment so that the solution Lqd can easily move.
  • a method of forming a silicon oxide film on the surface or a method of covering the surface with a water-soluble polymer such as polyethylene glycol is easy to produce.
  • the sample reaction unit 15 has at least one of an antibody, an enzyme, a receptor, and a protein as a reaction substance that specifically reacts with the substance to be measured conveyed by the sample conveyance unit 14.
  • an enzyme-immobilized antibody as an example of an antibody that specifically reacts with a substance to be measured such as a virus or an allergen will be described.
  • the enzyme-immobilized antibody and the virus or allergen specifically bind to form a complex. This complex is transported to the detection unit 16.
  • the enzyme-immobilized antibody include anti-HA antibody and ALP enzyme.
  • the detection unit 16 has an electrode made of a metal thin film such as gold or platinum, and the capture site carries a substrate-immobilized antibody as an example of an antibody that binds to the above complex.
  • the substrate-immobilized antibody include an anti-HA antibody, and examples of the substrate include paraaminophenyl phosphate (pAPP), which is a substrate that specifically reacts with an ALP enzyme.
  • pAPP paraaminophenyl phosphate
  • the substrate-immobilized antibody can capture viruses and allergens bound to the enzyme-immobilized antibody. Thereby, the substrate of the substrate-immobilized antibody and the enzyme of the enzyme-immobilized antibody are brought close to each other at the capture site, and an enzyme-substrate reaction occurs here.
  • the reaction produces paraaminophenol (pAP).
  • the generated pAP can be oxidized to paraquinoneimine (pQI) on the electrode.
  • the detection unit 16 can detect the substance to be measured. Since this redox reaction between pAP and pQI is reversible, the electrode is formed in a comb-like shape facing each other, and on the other hand, pAP is oxidized, and on the other hand, pQI is reduced to form a redox cycle. And the current value obtained can be amplified. Thereby, highly sensitive detection becomes possible.
  • the detection unit 16 includes an antibody (substrate-immobilized antibody) 163 that binds to a substance to be measured (virus or allergen) that has reacted with a reactive substance (enzyme-immobilized antibody), an electrode 162 that supports the antibody 163, and anodized silicon 161.
  • an antibody substrate-immobilized antibody
  • a reactive substance enzyme-immobilized antibody
  • an electrode 162 that supports the antibody 163, and anodized silicon 161.
  • a plurality of concave portions are formed on the main surface of the anodized silicon 161.
  • the electrode 162 is made of a thin film of gold (Au) that is contacted with a uniform thickness along the concavo-convex shape of the main surface of the anodized silicon 161.
  • Au gold
  • the electrode 162 has a porous structure.
  • the antibody 163 is supported on the surface of the electrode 162. Since the antibody 163 is also carried in the recess, the detection unit 16 can carry a large number of antibodies 163. Since the electrode 162 has a porous structure, the immobilization area of the antibody 163 can be increased, so that the detection sensitivity can be increased.
  • a method for immobilizing the antibody 163 for example, a method such as a self-assembled monolayer (SAM) that binds to the gold surface via a thiol group may be used.
  • SAM self-assembled monolayer
  • a solution containing a substance to be measured (virus or allergen) is created by liquefying water vapor contained in the gas injected from the gas injection hole 12 by the Peltier cooling effect of the Peltier element. Can do. Therefore, the sample collection unit 13 can collect the substance to be measured from the gas injected from the gas injection hole 12.
  • the chemical sensor according to the present invention includes the sample collection unit 13, the sample transport unit 14, the sample reaction unit 15, and the detection in a narrow detection space formed by covering the sensor holding unit 11 with a protective member. Since the unit 16 is integrated and integrally formed, it can be reduced in size and weight, and a small amount of sample can be detected with a small amount of a reactive substance such as an antibody or an enzyme, thereby reducing the amount of expensive reactive substance used. Can be detected at low cost.
  • a reactive substance such as an antibody or an enzyme
  • the sample transport unit 14 has a capillary structure, and one end of the capillary structure is close to the Peltier element. Thereby, the solution liquefied by the Peltier device by the capillary phenomenon of the capillary structure can be transported to the sample reaction unit 15 without using a special structure.
  • the sample reaction unit 15 has an antibody (an enzyme-immobilized antibody) that specifically reacts with the substance to be measured conveyed by the sample conveyance unit 14.
  • the substance to be measured can be specifically detected by the antigen-antibody reaction between the enzyme-immobilized antibody and the substance to be measured.
  • the detection unit 16 includes an antibody 163 (substrate-immobilized antibody) that binds to a substance to be measured that has reacted with a reactive substance (enzyme-immobilized antibody), and an electrode 162 that carries the antibody 163.
  • the electrode 162 has a porous structure. Since the electrode 162 has a porous structure, the immobilization area of the antibody 163 can be increased, so that the detection sensitivity can be increased.
  • FIG. 4B is an exploded perspective view of the sample reaction unit 15 and the detection unit 16.
  • the sample reaction unit 15 includes a heating unit (for example, a heater 151) for heating the solution containing the virus carried by the sample carrying unit 14, and a temperature measurement unit (for example, a temperature sensor) for measuring the temperature of the solution containing the virus. 152).
  • the heater 151 and the temperature sensor 152 are formed on the lower surface of the upper substrate constituting the protective member and provided in the detection space (sample reaction unit 15) between the sensor holding unit. Show.
  • the sample reaction unit 15 includes a control unit that controls the value of a current flowing through the heater 151 based on the temperature of the solution measured by the temperature sensor 152.
  • a plurality of heaters 151 and temperature sensors 152 are prepared, respectively, and are arranged in the sample reaction unit 15 in a distributed manner.
  • An electrode 16a forming a part of the detection unit is formed on the lower surface of the upper substrate.
  • the sample reaction unit 15 is provided with a primer, a DNA polymerase, deoxynucleotide triphosphate (dNTP), which is a DNA synthesis material (substrate), and a buffer solution which are dried.
  • dNTP deoxynucleotide triphosphate
  • the control unit controls the heater 151 to perform a PCR (polymerase chain reaction) method.
  • a PCR polymerase chain reaction
  • a high temperature of about 90 to 98 ° C. and a low temperature of about 50 to 65 ° C. are repeated about 20 to 50 times for the extracted DNA.
  • DNA of a to-be-measured substance can be amplified.
  • the solution containing the amplified DNA is carried to the detection unit, and the presence or absence of virus in the initial solution can be measured by an oxidation-reduction reaction at the electrode.
  • the sample reaction unit 15 includes a heating unit (heater 151) for heating the substance to be measured conveyed by the sample conveyance unit 14, and a temperature for measuring the temperature of the substance to be measured.
  • a measurement unit temperature sensor 1502. Since a specific temperature cycle is generated using the heater 151, a PCR method for amplifying the DNA of the substance to be measured can be performed, so that the substance to be measured can be detected with high sensitivity.
  • the chemical sensor according to the second embodiment includes a plurality of unit sensors CS1 to CS4,... Arranged in an array.
  • Each of the unit sensors CS includes the gas injection hole 12, the sample collection unit 13, the sample transport unit 14, the sample reaction unit 15, and the detection unit 16 shown in FIG.
  • the plurality of unit sensors CS are formed integrally with one sensor holding unit 11.
  • unit sensor CS By arranging a plurality of unit sensors CS in an array on one sensor holding unit 11, only the necessary chip (unit sensor CS) can be used when necessary, reducing the number of sensor replacements, Disposal of the chip can be suppressed.
  • home appliances such as an air cleaner and an air conditioner to which the function of the chemical sensor described above is added, and the chemical sensor described above are formed in a size that can be carried by the user.
  • home appliances such as an air cleaner and an air conditioner to which the function of the chemical sensor described above is added, and the chemical sensor described above are formed in a size that can be carried by the user.
  • portable virus sensors and portable devices such as cellular phones to which the above-described chemical sensor functions are added.

Abstract

Un analyte dans un gaz peut être dissous dans un liquide de manière simple. La présente invention concerne ainsi un détecteur chimique qui comprend une section de support de détecteur (11), un trou d'injection du gaz (12) par lequel un gaz contenant un analyte est injecté, une section de collecte d'échantillon (13) de laquelle l'analyte contenu dans le gaz injecté dans le trou d'injection du gaz (12) est collecté, une section de délivrance d'échantillon (14) par laquelle l'analyte collecté dans la section de collecte d'échantillon (13) est délivré à une section de réaction d'échantillon (15), la section de réaction d'échantillon (15) qui contient une substance réactive qui peut entraîner une réaction prédéterminée avec l'analyte qui a été délivré par la section de délivrance d'échantillon (14), et une section de détection (16) dans laquelle l'analyte qui a réagi avec la substance réactive dans la section de réaction d'échantillon (15) est détecté. La section de collecte d'échantillon (13) est dotée d'un élément de Peltier qui peut liquéfier la vapeur d'eau contenue dans le gaz injecté par le trou d'injection du gaz (12).
PCT/JP2011/060404 2010-04-28 2011-04-28 Détecteur chimique WO2011136344A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2012512913A JP5650728B2 (ja) 2010-04-28 2011-04-28 化学センサ
SG2012079612A SG185064A1 (en) 2010-04-28 2011-04-28 Chemical sensor
EP11775125.5A EP2565616B1 (fr) 2010-04-28 2011-04-28 Détecteur chimique
KR1020127029139A KR20130028929A (ko) 2010-04-28 2011-04-28 화학 센서
US13/642,688 US20130040374A1 (en) 2010-04-28 2011-04-28 Chemical sensor
CN201180021331.8A CN102869974B (zh) 2010-04-28 2011-04-28 化学传感器

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010-104252 2010-04-28
JP2010104252 2010-04-28

Publications (1)

Publication Number Publication Date
WO2011136344A1 true WO2011136344A1 (fr) 2011-11-03

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PCT/JP2011/060404 WO2011136344A1 (fr) 2010-04-28 2011-04-28 Détecteur chimique

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US (1) US20130040374A1 (fr)
EP (1) EP2565616B1 (fr)
JP (1) JP5650728B2 (fr)
KR (1) KR20130028929A (fr)
CN (1) CN102869974B (fr)
SG (1) SG185064A1 (fr)
TW (1) TWI497072B (fr)
WO (1) WO2011136344A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013132761A1 (fr) * 2012-03-05 2013-09-12 パナソニック株式会社 Dispositif de capteur
JP2015141198A (ja) * 2014-01-29 2015-08-03 國立屏東科技大學 蒸気蒸留用マイクロ流体チップ
US10173182B2 (en) 2013-08-08 2019-01-08 Panasonic Corporation Nucleic acid amplification device, nucleic acid amplification apparatus, and nucleic acid amplification method for transporting reaction solution including target nucleic acid via capillary force to amplify target nucleic acid
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