WO2011124493A1 - Composition contenant des ingrédients de rudbeckia, sureau et camomille pour le traitement de refroidissements - Google Patents

Composition contenant des ingrédients de rudbeckia, sureau et camomille pour le traitement de refroidissements Download PDF

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Publication number
WO2011124493A1
WO2011124493A1 PCT/EP2011/054727 EP2011054727W WO2011124493A1 WO 2011124493 A1 WO2011124493 A1 WO 2011124493A1 EP 2011054727 W EP2011054727 W EP 2011054727W WO 2011124493 A1 WO2011124493 A1 WO 2011124493A1
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Prior art keywords
extracts
range
tinctures
plants
fresh
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PCT/EP2011/054727
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German (de)
English (en)
Inventor
Reiner Rittinghausen
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Reiner Rittinghausen
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Priority to EP11710222A priority Critical patent/EP2552466A1/fr
Publication of WO2011124493A1 publication Critical patent/WO2011124493A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Definitions

  • the present invention relates to a composition for use in the treatment of colds.
  • Cold sores are inflammations of the nasal and pharyngeal mucous membranes that are based on an infection by viruses. Colds are also called
  • influenza infection and are the most common human infections. On average, adults develop about two to three times a year. Common colds include respiratory infections such as bronchitis, runny nose and tonsillitis and pharyngitis, which can cause symptoms such as coughing, sore throat and hoarseness. These can occur as part of a normal course or with each other or the common cold can be limited to individual symptoms.
  • compositions for use in the prophylactic and / or therapeutic treatment of colds wherein the composition contains as active ingredients extracts, tinctures and / or extracts of fresh and / or dried plants and / or plant parts of coneflower (Echinacea purpu- rea), elderberry (Sambucus nigra) and chamomile (Chamomilla recucita).
  • common colds which are generally referred to as “influenza infections” are understood to mean infections of the respiratory tract, usually caused by viruses, as well as inflammations of the nasal and pharyngeal mucosa.
  • Cold diseases within the meaning of this invention are preferably selected from the group comprising colds (rhinopharyngitis), infections, influenza infections, influenza, bronchitis, respiratory infections, inflammations of the upper respiratory tract, pneumonia, frontal inflammation, sinusitis (sinusitis), inflammation of the nose (rhinitis) throat mucous membranes (pharyngitis), tonsillitis, inflammation of the larynx (laryngitis) and / or otitis media.
  • Symptoms of colds are in particular selected from the group comprising cold, cough, dry cough, hoarseness, sore throat, itching, burning or tingling in the nose, runny and / or stuffy nose, sneezing, difficulty breathing, scratching in the throat, difficulty swallowing, painful swallowing, Headache, headache, ear pain, middle ear complaints, body aches, muscle aches, toothache, pain in the frontal and maxillofacial, eye pain, pressure in the ears, swollen nasal mucosa, increased temperature, fever, fatigue, weakness, fatigue, malaise, dizziness, Shivering, stomach pressure, stomach cramps, nausea and / or vomiting.
  • Common symptoms include runny nose, cough, dry cough, hoarseness, sore throat, headache, earache, limb and muscle pain, fever, gastric pressure, nausea and vomiting.
  • prophylactic treatment is understood in particular to mean that the composition which can be used according to the invention can be administered prophylactically before symptoms of a common cold disease or the danger of a disease exist.
  • a “prophylactic treatment” is understood as a prevention.
  • composition which can be used according to the invention has a particularly good action in the treatment of colds.
  • coneflower Echinacea purpurea
  • elderberry Sambucus nigra
  • chamomile Chamomilla recucita
  • the selected combination is distinguished by the fact that it positively influences influenza infections and concomitant gastrointestinal complaints or infections, for example by noroviruses and rotaviruses.
  • influenza-like infections occur together with gastrointestinal complaints, which causes patients not only to Cold symptoms such as runny nose, cough, sore throat and headache, but also be further weakened by severe gastrointestinal complaints such as nausea, diarrhea or vomiting diarrhea. Therefore, the combination of the invention is particularly useful in the context of respiratory and cold diseases with involvement of the gastrointestinal tract during a flu epidemic.
  • composition of the invention is due to unexpected and synergistic effects.
  • beneficial properties of the unexpected and synergistic enhancement result, in particular, from the combination of coneflower, elderberry and chamomile selected specifically for the treatment of respiratory and common cold diseases.
  • an increase in efficacy and an accelerated healing process can be brought about with a rapid attenuation of the symptoms in concomitant gastrointestinal complaints or infections, for example by noro and rotaviruses.
  • coneflower, elderberry and chamomile are advantageous in the treatment of colds against the use of individual plants as well as the combination of two plants. It has furthermore been found that the combination according to the invention of extracts, tinctures and / or extracts of fresh and / or dried plants or parts of the sun (Echinacea purpurea), elderberry (Sambucus nigra) and chamomile (Chamomilla recucita) relieve colds, coughing and hoarseness and / or a mucous congestion of the respiratory tract can significantly better counteract.
  • the combination according to the invention of extracts, tinctures and / or extracts of fresh and / or dried plants or plant parts of the sunhat can treat the inflammation in the area of the pharynx or the bronchial support.
  • the combination according to the invention can continue to be advantageous due to a reduced side-effect potential.
  • composition containing extracts, tinctures and / or extracts of plants and / or parts of plants of coneflower (Echinacea purpurea), Holders (Sambucus nigra) and chamomile (Chamomilla recucita) achieved can be so that can be dispensed with a variety of components.
  • added active ingredients can be associated with side effects or at least unnecessarily influence the body.
  • the composition comprises only extracts, tinctures and / or extracts of fresh and / or dried plants and / or plant parts of Echinacea purpurea, elderberry (Sambucus nigra) and chamomile (Chamomilla recucita) as active ingredients.
  • the active ingredients of the composition consist of extracts, tinctures and / or extracts of fresh and / or dried plants and / or plant parts of coneflower (Echinacea purpurea), elder (Sambucus nigra) and chamomile (Chamomilla recucita).
  • compositions comprising extracts, tinctures and / or extracts of fresh and / or dried plants and / or plant parts of sunhat (Echinacea purpurea), elderberry (Sambucus nigra) and chamomile (Chamomilla recucita ) due to the small number of extracts, tinctures and / or extracts of medicinal plants causes no incompatibilities, as is often the case with known means.
  • compositions comprising extracts, tinctures and / or extracts of fresh and / or dried plants and / or plant parts of sunhat (Echinacea purpurea), elderberry (Sambucus nigra) and chamomile (Chamomilla recucita) as effective ingredients due to low number of extracts, tinctures and / or extracts of effective medicinal plants preferably no or hardly causes allergies.
  • sunhat Echinacea purpurea
  • elderberry Sudbucus nigra
  • chamomile Ceromilla recucita
  • An increasing number of people suffer from allergies or hypersensitivity to ingredients of one or more plants. Hypersensitivity reactions may also occur when taking plant compositions. It is therefore of great advantage that the composition according to the invention reduces the risk of such reactions due to the low number of extracts, tinctures and / or extracts of effective medicinal plants.
  • the composition of the invention has no extracts, tinctures and / or extracts of plants which are not necessary for the efficacy and may even be dangerous.
  • the composition according to the invention does not contain any extracts, tinctures and / or extracts from plants which have benzylisoquinoline alkaloids, such as Canadian blood root (sanguineina). Benzylisoquinoline alkaloids are considered to be of concern even in small amounts and represent a dangerous hepatotoxic risk.
  • the composition according to the invention can develop a good action in the treatment of colds, without containing Canadian bloodroot.
  • the composition according to the invention can very advantageously combine good activity with side effect poverty.
  • the composition according to the invention contains active compounds obtainable from fresh and / or dried plants and / or plant parts of sunhat (Echinacea purpurea), elderberry (Sambucus nigra) and camomile (Chamomilla recucita).
  • the composition according to the invention is distinguished from known plant-based agents in that the composition comprises a special dosage of extracts, tinctures, and / or extracts of certain plants and / or plant parts, namely the sunhat (Echinacea purpurea), elder (Sambucus nigra ) and chamomile (Chamomilla recucita), as effective ingredients.
  • the term "sun hat” in the context of this invention includes plants and / or plant parts of Echinacea purpurea, the purple sunhat. Preferably also usable is the species Echinacea purpurea Moench.
  • the term "elderberry” for the purposes of this invention includes plants and / or plant parts of Sambucus nigra, black elderberry.
  • the term "chamomile” in the context of this invention comprises plants and / or plant parts of Chamomilla recucita, real chamomile. Synonyms are Chamomilla officinalis and Matricaria recucita.
  • the term “tincture” is understood to mean excerpted medicaments and extracts from fresh or dried plant parts or whole fresh or dried plants which are produced using alcohol, in particular ethanol of suitable concentration.
  • the term “tincture” in the context of the present invention also includes so-called “mother tinctures” and mixtures of vegetable juices with alcohol, water and / or their mixture and / or herbal extracts.
  • the term “tincture” includes drug extracts according to the Homeopathic Pharmacopoeia (HAB), German Pharmacopoeia (DAß) or European Pharmacopoeia (Ph. Eur.) And others European or American pharmacopoeias from fresh or dried plants and / or plant parts, in particular fresh plants and / or plant parts.
  • extract means extracts of fresh and / or dried plants and / or plant parts of liquid, viscous or dry nature, optionally adjusted to a certain active ingredient content, which are prepared, for example, using alcohol, in particular ethanol, be won, understood.
  • extract for the purposes of this invention, in addition to liquid extracts viscous so-called spissum extracts and dry or Siccum extracts.
  • extract is also understood as meaning purified extracts or extract fractions. Extracts from plants or parts of plants with essential oils can also be prepared in such a way that the essential oils are removed from the plants or plant parts prior to extraction and this is added again after extraction to the respective extract.
  • extract for the purposes of the present invention also includes a so-called press juice.
  • press juice is understood as meaning a juice which is obtained from pressed plants or parts of plants.
  • the plants or plant parts can be washed, read and crushed before they are pressed. Solid residues are separated.
  • a pressed juice can be a concentrate concentrate or a pure vegetable juice.
  • composition is preferably a herbal composition.
  • herbal composition is to be understood as meaning compositions which contain herbal extracts, tinctures and / or extracts from fresh and / or dried plants and / or plant parts.
  • homeopathic extracts and / or mother tinctures may be used.
  • Advantageous embodiments result from the selection and amount of the individual substances that have been selected especially for the treatment of respiratory and cold sores, in particular from a selected dosage of coneflower (Echinacea purpurea), elder (Sambucus nigra) and chamomile (Chamomilla recucita).
  • coneflower Echinacea purpurea
  • elder Sambucus nigra
  • chamomile Chamomilla recucita
  • the composition comprises, based on a single dose of the composition as active ingredients, the following extracts, tinctures and / or extracts:
  • Extracts, tinctures and / or extracts of fresh and / or dried plants or plant parts of coneflower in the range of> 2 mg to ⁇ 300 mg, preferably in the range of> 5 mg to ⁇ 100 mg, preferably in the range of> 10 mg to ⁇ 40 mg, more preferably 20 mg;
  • dry substance is understood to mean the dry residue of extracts, tinctures and / or extracts which, after deduction of the extraction remains.
  • the dry substance may contain a residual proportion of extractant, for example water or alcohol-water mixture, for example in the range of> 1 wt .-% to ⁇ 10 wt .-%, preferably in the range of> 1 wt .-% to ⁇ 5 Wt .-%, based on the total weight of the dry substance.
  • the dry substance can therefore also be present in viscous form.
  • the dry substance is preferably a native dry matter from the extracts, tinctures and / or extracts without additives.
  • dry extract is understood to mean the dry residue of an extract.
  • a single dose is understood to mean an administration unit of the composition.
  • a single dose corresponds to a tablet, a capsule, a dragee, or a single unit of administration of another form of preparation, such as a given volume of a solution.
  • the composition for the prophylactic and / or therapeutic treatment of colds comprises as active ingredients:
  • Extracts, tinctures and / or extracts of fresh and / or dried plants or plant parts of chamomile in the range of> 0.1 ml to ⁇ 50 ml, preferably in the range of> 0.5 ml to ⁇ 10 ml, preferably in the range of> 0.7 ml to ⁇ 5 ml, particularly preferably in the range of> 1.35 ml to ⁇ 2.25 ml, wherein the Quantities are based on liquid-like extracts, tinctures and / or
  • the composition comprises extracts of fresh and / or dried plants and / or parts of plants of Echinacea purpurea, Elderberry (Sambucus nigra) and chamomile (Chamomilla recucita) in the form of dry extracts and / or liquid extracts.
  • the composition comprises extracts of fresh and / or dried plants and / or parts of the plant of Echinacea purpurea, elderberry (Sambucus nigra) and chamomile (Chamomilla recucita) in the form of dry extracts, extracts of dry nature.
  • Such a dry extract is advantageously obtainable on the basis of an aqueous, alcoholic or aqueous-alcoholic extract, preferably based on an aqueous-alcoholic extract, especially aqueous-ethanolic extract.
  • Conventional methods for the preparation of a dry extract include, for example, the removal of the water and / or alcohol in vacuo, optionally with heating.
  • a dry extract can be produced under lyophilization.
  • Dry extracts have many advantages over liquid and semi-solid extracts. They have better stability, are easier to handle and can be used for the production of solid galenic dosage forms.
  • the use of a dry extract over aqueous-ethanolic liquid extract is particularly preferred in those cases where a non-alcoholic dosage forms is desired, especially for use in children.
  • dry extracts can be advantageously reduced to liquid, semi-solid and gelatinous administration forms in the production of finished products.
  • the composition comprises, based on a single dose of the composition, as active ingredients, the following extracts:
  • Dry extract of fresh and / or dried plants or plant parts of coneflower in the range of> 2 mg to ⁇ 300 mg, preferably in the range of> 5 mg to ⁇ 100 mg, preferably in the range of> 10 mg to ⁇ 40 mg , more preferably 20 mg;
  • Dry extract of fresh and / or dried plants or plant parts of chamomile of> 30 mg to ⁇ 3 g, preferably in the range of> 100 mg to ⁇ 1 g, preferably in the range of> 150 mg to ⁇ 600 mg, especially preferably of 300 mg.
  • the composition comprises extracts of fresh and / or dried plants and / or percentages of centaury (Echinacea purpurea), elder (Sambucus nigra) and chamomile (Chamomilla recucita) in the form of liquid extracts.
  • centaury Echinacea purpurea
  • elder Sambucus nigra
  • chamomile Chamomilla recucita
  • the composition for the prophylactic and / or therapeutic treatment of colds comprises as active ingredients: a. Liquid extract of fresh and / or dried plants or parts of the sunhat (Echinacea purpurea) in the range of> 0.03 ml to ⁇ 10 ml, preferably in the range of> 0.1 ml to ⁇ 2.5 ml, preferably in the range of> 0.15 ml to ⁇ 1 ml, more preferably in the range of> 0.3 ml to ⁇ 0.5 ml;
  • Elderberry in the range of> 0.1 ml to ⁇ 50 ml, preferably in the range of> 0.5 ml to ⁇ 10 ml, preferably in the range of> 0.7 ml to ⁇ 5 ml, particularly preferably in the range from> 1.35 ml to ⁇ 2.25 ml;
  • Liquid extract of fresh and / or dried plants or plant parts of chamomile in the range of> 0.1 ml to ⁇ 50 ml, preferably in the range of> 0.5 ml to ⁇ 10 ml, preferably in the range of> 0, 7 ml to ⁇ 5 ml, more preferably in the range of> 1.35 ml to ⁇ 2.25 ml.
  • extracts can be prepared by means of alcoholic, aqueous or aqueous-alcoholic extraction or extraction agents. Extracts and tinctures according to pharmacopoeia are preferably preparable by means of ethanol-water mixtures.
  • Dry extracts and liquid extracts based on an aqueous-ethanolic extract are preferably available.
  • the extractant of the extracts of fresh and / or dried plants and / or plant parts of Echinacea purpurea, elderberry (Sambucus nigra) and / or chamomile (Chamomilla recucita) is an ethanol-water mixture, the concentration of Ethanol for:
  • Extracts, tinctures and / or extracts of fresh and / or dried plants or plant parts of coneflower preferably in the range of> 20% (v / v) to ⁇ 86% (v / v), preferably 65% (v / v);
  • the weight ratio of the macerated or percolated plant parts to the extract for liquid extracts is:
  • Extracts, tinctures and / or extracts of fresh and / or dried plants or plant parts of coneflower in the range from 1: 1 to 1: 8 (m / m), preferably in the range from 1: 1 to 1: 5 ( m / m), preferably in the range of 1: 1.5 to 1: 2 (m / m);
  • Extracts, tinctures and / or extracts of fresh and / or dried plants or parts of plants of elderberry in the range from 1: 1 to 1:10 (m / m), preferably in the range from 1: 1 to 1: 5 ( m / m), preferably in the range of 1: 1.5 to 1: 2.5 (mm);
  • Extracts, tinctures and / or extracts of fresh and / or dried plants or plant parts of chamomile in the range from 1: 1 to 1:15 (m / m), preferably in the range from 1: 1 to 1:10 ( mm), preferably in the range of 1: 1.5 to 1: 4 (m / m).
  • the weight ratio of the macerated or percolated plant parts to the extract is also referred to as the drug / extract ratio (DEV).
  • the composition comprises extracts, tinctures and / or extracts of fresh and / or dried plants and / or pennyte portions of sunhat (Echinacea purpurea), elderberry (Sambucus nigra) and chamomile (Chamomilla recucita) as active ingredients.
  • sunhat Echinacea purpurea
  • elderberry Sambucus nigra
  • chamomile Chamomilla recucita
  • the weight ratio of the macerated or percolated plant parts of fresh and / or dried plants or plant parts to the extract for:
  • Extracts, tinctures and / or extracts of plants or parts of elderberry plants ranging from 2: 1 to 39: 1 (m m);
  • the weight ratio of macerated or percolated plant parts of fresh plants or plant parts to the extract in the case of dry extracts is:
  • Extracts, tinctures and / or extracts of plants or plant parts of sunhat in the range from 2: 1 to 75: 1 (m / m), preferably in the range from 7: 1 to 60: 1 (m / m ), preferably in the range of 13: 1 to 44: 1 (m / m);
  • Extracts, tinctures and / or extracts of plants or parts of plants of elderberry in the range of 1: 1 to 60: 1 (m / m), preferably in the range of 5: 1 to 45: 1 (m / m), preferably in the range of 11: 1 to 39: 1 (m / m);
  • the weight ratio of macerated or percolated plant parts of dried plants or plant parts to the extract for dry extracts is: a. Extracts, tinctures and / or extracts of plants or plant parts of coneflower (Echinacea purpurea) in the range from 2: 1 to 30: 1 (m / m), preferably in the range from 2: 1 to 20: 1 (m / m), preferably in the range of 3: 1 to 11: 1 (mm);
  • Extracts, tinctures and / or extracts of plants or parts of plants of chamomile in the range from 1: 1 to 35: 1 (m / m), preferably in the range from 2: 1 to 20: 1 (m / m), preferably in the range of 3: 1 to 13: 1 (mm).
  • Extracts, tinctures and extracts can be prepared from whole plants, preferably extracts, tinctures and extracts of parts of peas, for example of flowers, leaves, stems, roots or seeds of the plants can be produced.
  • extracts, tinctures and extracts of the sunhat (Echinacea purpurea) from the flowering herb and / or the roots are produced.
  • Extracts, tinctures and extracts of elderberry (Sambucus nigra) from the flowers and / or leaves are preferably produced.
  • extracts, tinctures and extracts of chamomile (ChamomiUa recucita) from the flowers or the whole plant can be produced.
  • the composition comprises extracts, tinctures, and / or extracts of sunhat and / or coneflower roots, elderflower, and / or chamomile flowers.
  • a liquid composition based on the total volume of the composition, contains:
  • a single dose of the liquid composition for prophylactic and / or therapeutic treatment of colds comprises from 3 ml to 5 ml of the liquid composition.
  • a daily dose of the liquid composition for prophylactic and / or therapeutic treatment of colds diseases comprises 3 times 3 ml to 5 ml of the liquid composition.
  • the dosages of the composition according to the invention can effectively alleviate the symptoms of colds and can serve for the prophylaxis as well as for a longer-term or permanent administration.
  • the composition comprises, with respect to a daily dose of the composition as active ingredients, the following extracts, tinctures and / or extracts:
  • Extracts, tinctures and / or extracts of fresh and / or dried plants or plant parts of coneflower in the range of> 6 mg to ⁇ 900 mg, preferably in the range of> 15 mg to ⁇ 300 mg, preferably in the range of> From 30 mg to ⁇ 120 mg, more preferably from 60 mg
  • Extracts, tinctures and / or extracts of fresh and / or dried plants or plant parts of elderberry in the range of> 60 mg to ⁇ 6 g, preferably in the range of> 150 mg to ⁇ 2.4 g, preferably in the range from> 300 mg to ⁇ 1.2 g, more preferably from 600 mg;
  • the composition comprises, based on a daily dose of the composition as active ingredients, the following extracts, tinctures and / or extracts:
  • Coneflower in the range of> 6 mg to ⁇ 900 mg, preferably in the range of> 15 mg to ⁇ 300 mg, preferably in the range of> 30 mg to ⁇ 120 mg, particularly preferably of 60 mg;
  • the composition comprises, based on a daily dose of the composition as active ingredients, the following extracts, tinctures and / or extracts:
  • the composition comprises, based on a daily dose of the composition as active ingredients, the following extracts:
  • Liquid extract of fresh and / or dried plants or parts of the sunhat in the range of> 0.1 ml to ⁇ 30 ml, preferably in the range of> 0.3 ml to ⁇ 7.5 ml, preferably in the range of> 0.45 ml to ⁇ 3 ml, more preferably in the range of> 0.9 ml to ⁇ 1.5 ml;
  • Liquid extract of fresh and / or dried plants or parts of plants of elderberry in the range> 0.3 ml to ⁇ 150 ml, preferably in the ranging from> 1.5 ml to ⁇ 30 ml, preferably in the range of> 2.1 ml to ⁇ 20.25 ml, particularly preferably in the range of> 4.05 ml to ⁇ 6.75 ml;
  • Liquid extract of fresh and / or dried plants or plant parts of chamomile in the range of> 0.3 ml to ⁇ 150 ml, preferably in the range of> 1.5 ml to ⁇ 30 ml, preferably in the range of> 2, 1 ml to ⁇ 20.25 ml, more preferably in the range of> 4.05 ml to ⁇ 6.75 ml.
  • the term "daily dose” is understood to mean the amount of the composition which is supplied per day, the amount of substance which should be supplied per day being within the respective stated quantitative ranges of the respective substances.
  • daily dose can be understood as a daily intake.
  • the dosage forms contain the extracts, tinctures and / or extracts preferably in the amount of a single dose. Preferably, a daily dose is divided into three single doses.
  • the composition is a pharmaceutical, pharmaceutical preparation, medical device, dietary supplement, dietetic food and / or a supplemented balanced diet.
  • the composition is in the form of a drug or a pharmaceutical preparation.
  • the composition is useful as a drug, most preferably the composition is a herbal drug.
  • the composition may further be in the form of a dietetic food.
  • the composition according to the invention is preferably a cold remedy.
  • the composition may be solid, liquid, and / or gel.
  • the composition is present in a dosage form selected from the group consisting of tablet, lozenge, dragee, capsule, powder, granules, gel, solution, drops, juices, syrups, effervescent tablet and / or spray, preferably in the form of tablets, lozenges - dragees, capsules, drops, juices, syrups or solutions.
  • the composition is in the form of juice, syrup, solution, drops, dragees, capsules or as a tablet.
  • sucing tablet is understood to mean a tablet containing active ingredients which is taken orally but not swallowed but left in the mouth and is intended to dissolve there.
  • the composition is in the form of a liquid or solid dosage form.
  • a liquid composition is formulated for oral administration.
  • the advantage of liquids is their quick onset of action and easy intake.
  • liquid dosage forms in the form of juice, syrup or solution for example in the form of drops in very small volumes or Abmeßbares volume in small volumes in the range of several milliliters are administered several times daily.
  • liquid dosage forms are easily and reliably dosed by volume.
  • Liquid dosage forms are also advantageous if the swallowing of solid dosage forms is perceived as unpleasant.
  • a daily dose is divided into three single doses.
  • a daily dose may be administrable in the form of a triple administration of a given number of drops or a defined volume of a syrup or juice.
  • the composition may alternatively be present as a solid dosage form.
  • the solid dosage forms contain extracts, tinctures and / or extracts of fresh and / or dried plants or parts of the plant of Echinacea (Echinacea purpu- rea), elderberry (Sambucus nigra) and chamomile (Chamomilla recucita) preferably in dried form.
  • solid-shaped dosage forms have a particularly good compatibility.
  • Solid dosage forms may have better stability than liquid dosage forms.
  • solid dosage forms are easier to handle.
  • Tablets can also be made with excipients to an easy-to-handle size. Dragees may be provided with a coating which facilitates swallowing and / or protects the active ingredient against decomposition. Further, tablets and capsules can be made to produce sustained release of the agent (s).
  • Solid dosage forms contain the extracts, tinctures and / or extracts, preferably in the amount of a single dose.
  • a daily dose is divided into three single doses.
  • a daily dose may be included in three tablets or dragees.
  • the composition consists of extracts, tinctures and / or extracts of fresh and / or dried plants and / or plant parts of sunhat (Echinacea purpurea), elderberry (Sambucus nigra) and chamomile (Chamomilla recucita) as active ingredients and conventional excipients Formulation.
  • sunhat Echinacea purpurea
  • elderberry Sambucus nigra
  • chamomile Chamomilla recucita
  • the composition according to the invention is preferably a cold remedy.
  • Another object of the present invention therefore relates to a cold remedies.
  • the cold remedies comprise as active ingredients extracts, tinctures and / or extracts of fresh and / or dried plants and / or plant parts of Echinacea purpurea, elderberry (Sambucus nigra) and chamomile (Chamomilla recucita).
  • the cold remover preferably comprises as active ingredients a composition according to the invention.
  • the cold remover preferably comprises the active ingredients together with a harmless, in particular pharmacologically acceptable, carrier.
  • a further aspect of the present invention relates to the use of a composition according to the invention for the production of a medicament, pharmaceutical preparation, medical device, dietary supplement, dietetic food and / or a supplementary balanced diet, in particular a herbal medicament.
  • the composition is useful for the treatment of colds.
  • composition can be used for the preparation of an agent for the prophylactic and / or therapeutic treatment of colds.
  • the composition is particularly suitable for the production of a medicament, pharmaceutical preparation, medical device, dietary supplement, dietetic food and / or a supplemented balanced diet, in particular a herbal medicament for the prophylactic and / or therapeutic treatment of colds. Examples of compositions which serve to illustrate the present invention are given below.
  • the formulation included aqueous or aqueous-ethanolic dry extracts of sunhat (Echinacea purpurea), elderberry (Sambucus nigra) and chamomile (Matricaria recucita).
  • Echinacea purpurea Extractum Echinaceae e herba rec. 20 mg
  • the formulation included aqueous or aqueous-ethanolic extracts of coneflower (Echinacea purpurea), elderberry (Sambucus nigra) and chamomile (Matricaria recucita), which were obtained from fresh plants or plant parts.
  • Example 3 aqueous or aqueous-ethanolic extracts of coneflower (Echinacea purpurea), elderberry (Sambucus nigra) and chamomile (Matricaria recucita), which were obtained from fresh plants or plant parts.
  • composition according to the invention described in the preceding preparation example was observed, with a single dose of three dragees being administered three times a day. It was found that the administration of the composition according to the invention according to Example 2 achieved a significant improvement in the symptoms of colds. In particular, it was found that colds, coughing and hoarseness could be alleviated and / or mucous congestion could be markedly improved by the composition. Even with repeated and / or long-term intake no contraindications or side effects were observed, in particular no allergies occurred.
  • composition according to the invention led to an impressive improvement in symptoms in the treatment of colds. In particular, no side effects were observed.
  • the recipe included dry extracts of coneflower (Echinacea purpurea), elder (Sambucus nigra) and chamomile (Matricaria recucita), which were obtained from dried plants or plant parts.
  • the recipe included aqueous-ethanolic extracts of coneflower (Echinacea purpurea), elderberry (Sambucus nigra) and chamomile (Matricaria recucita).
  • Example 6 The effect of the composition according to the invention in a cold illness involving the gastrointestinal tract was observed in a comparative experiment, wherein a daily dose of the composition according to the invention corresponding to three dragees was administered over a short period of one to two days as described in Example 4 above.
  • the control group received a daily dose of 1 capsule of the comparator.
  • Table I shows a comparison of the effect of administering the combination of extracts of coneflower, elder and chamomile according to the invention to a combination of coneflower and elderberry in the treatment of a common cold involving the gastrointestinal tract, which in addition to common cold symptoms such as sore throat and hoarseness. / Intestinal complaints such as nausea and diarrhea were added.
  • composition according to the invention comprising extracts of coneflower, elderberry and chamomile with regard to the cold symptoms of sore throat and hoarseness compared to a combination of coneflower and chamomile were improved.

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Abstract

L'invention concerne une composition à utiliser dans le traitement prophylactique et/ou thérapeutique de refroidissements, la composition comprenant comme éléments constitutifs actifs des extraits, des teintures et/ou extraits de plantes fraîches et/ou séchées et/ou des parties de plantes de rudbeckia, sureau et camomille.
PCT/EP2011/054727 2010-03-29 2011-03-28 Composition contenant des ingrédients de rudbeckia, sureau et camomille pour le traitement de refroidissements WO2011124493A1 (fr)

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EP11710222A EP2552466A1 (fr) 2010-03-29 2011-03-28 Composition contenant des ingrédients de rudbeckia, sureau et camomille pour le traitement de refroidissements

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DE102010003398 2010-03-29
DE102010003398.7 2010-03-29

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014062892A1 (fr) * 2012-10-19 2014-04-24 Flutrends International, Llc Compositions antivirales

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EP1236466A1 (fr) * 2001-02-28 2002-09-04 Efrat Biopolymers Ltd. Compositions absorbables solides pour le traitement topique des troubles de la muqueuse orale
WO2002094300A1 (fr) * 2001-05-23 2002-11-28 Herbal Synthesis Corporation Compositions a base d'herbes medicinales destinees au traitement des lesions muqueuses

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EP1236466A1 (fr) * 2001-02-28 2002-09-04 Efrat Biopolymers Ltd. Compositions absorbables solides pour le traitement topique des troubles de la muqueuse orale
WO2002094300A1 (fr) * 2001-05-23 2002-11-28 Herbal Synthesis Corporation Compositions a base d'herbes medicinales destinees au traitement des lesions muqueuses

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CARLE R ET AL: "DIE KAMILLE - WIRKUNG UND WIRKSAMKEIT EIN KOMMENTAR ZUR MONOGRAPHIC MATRICARIAE FLOS (KAMILLENBLUETEN)", ZEITSCHRIFT FUER PHYTOTHERAPIE, STUTTGART, DE, vol. 8, no. 3, 1 January 1987 (1987-01-01), pages 67 - 77, XP009004100 *
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014062892A1 (fr) * 2012-10-19 2014-04-24 Flutrends International, Llc Compositions antivirales

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