EP2509613A1 - Composition pour le traitement de troubles gastro-intestinaux - Google Patents

Composition pour le traitement de troubles gastro-intestinaux

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Publication number
EP2509613A1
EP2509613A1 EP10785455A EP10785455A EP2509613A1 EP 2509613 A1 EP2509613 A1 EP 2509613A1 EP 10785455 A EP10785455 A EP 10785455A EP 10785455 A EP10785455 A EP 10785455A EP 2509613 A1 EP2509613 A1 EP 2509613A1
Authority
EP
European Patent Office
Prior art keywords
vol
range
extract
composition
volume
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10785455A
Other languages
German (de)
English (en)
Inventor
Reiner Rittinghausen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP2509613A1 publication Critical patent/EP2509613A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/51—Gentianaceae (Gentian family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender

Definitions

  • the present invention relates to a composition suitable for the treatment of gastrointestinal disorders, in particular flatulence and mild spasmodic gastrointestinal disorders.
  • stomach / bowel problems occur after eating and are with
  • the object is achieved by a composition containing extracts, tinctures and / or extracts of plants and / or plant parts of Chamomilla recutica (chamomile), Melissa officinalis (lemon balm), Mentha x piperita (peppermint), Carum carvi (caraway) and
  • Centaurium erythraea centaury
  • the composition particularly suitable for the treatment of gastrointestinal disorders comprises, based on the
  • volume contents of the respective components are chosen such that the
  • Total volume of components does not exceed 100% by volume.
  • tincture is understood to mean drug extracts which are prepared using alcohol, in particular ethanol of suitable concentration
  • tincture for the purposes of the present invention also includes so-called “mother tinctures” and mixtures of vegetable press juices with alcohol
  • tincture includes drug extracts according to the Homeopathic Pharmacopoeia (HAB) from fresh or dried plants and / or plant parts, especially fresh plants and / or plant parts.
  • HAB Homeopathic Pharmacopoeia
  • extract means extracts of plants and / or plants, optionally adjusted to a certain active substance content
  • Plant parts of liquid, viscous or dry nature which are obtained, for example, using alcohol, especially ethanol, understood.
  • homeopathic tinctures and extracts in particular liquid alcoholic plant extracts, alcoholic and in particular ethanolic tinctures are used.
  • the composition is preferably a herbal composition.
  • herbal composition for the purposes of this invention, the term "herbal composition" is used
  • compositions understood that are made on a vegetable basis, in particular based on extracts of plants and / or plant parts.
  • gastrointestinal complaints is understood to mean findings which can have a variety of causes and impairments of the patient
  • gastrointestinal complaints is also understood to mean nervous stomach / intestinal disorders and motility disorders of the gastrointestinal tract.
  • compositions of the invention in addition to extracts, tinctures and / or extracts of plants and / or plant parts of Chamomilla recutica (chamomile), Melissa officinalis (lemon balm), Mentha x piperita
  • Centaurium erythraea has an improved action in the treatment of gastrointestinal discomfort, especially mild spasmodic
  • composition according to the invention can be obtained by extracts, tinctures and / or extracts of Centaurium erythraea both in
  • prophylactic as well as therapeutic treatment of gastrointestinal discomfort especially with regard to convulsive gastrointestinal disorders and flatulence can improve an effect.
  • Composition is supported by synergistic effects due to the contained extracts, tinctures and / or extracts of Centaurium erythraea.
  • Components can be dispensed with. This is particularly advantageous since supplied
  • the composition comprises only extracts, tinctures and / or extracts of Chamomilla recutica, Melissa officinalis, Mentha x piperita, Carum carvi and Centaurium erythraea as effective components.
  • Composition comprising Centaurium erythraea, Chamomilla recutica (chamomile), Melissa officinalis (lemon balm), Mentha x piperita (peppermint) and Carum carvi (cumin) due to the low number of effective medicinal plants preferably little or no allergies triggers. An increasing number of people suffer from allergies or
  • compositions occur and manifest themselves, for example, in the form of skin rash, itching or difficulty in breathing. It is therefore of great advantage that the composition according to the invention reduces the risk of such reactions due to the small number of effective medicinal plants. In particular, for persons with a tendency to allergies, this can result in advantages in use.
  • composition of the invention is excellent for the treatment of
  • composition may continue characterized in that it does not cause photosensitivity of the skin and / or dermatitis.
  • composition this has no extracts, tinctures and / or extracts of plants, which can cause photosensitivity of the skin and / or dermatitis, such as angelica root.
  • angelica root can increase the photosensitivity of the skin due to the furocumarine contained and lead to skin inflammation in connection with UV irradiation.
  • the composition has no extracts, tinctures and / or extracts from plants which have toxic alkaloids, such as celandine.
  • alkaloids such as celandine.
  • celandine for example, more than 30 different alkaloids have been detected.
  • Alkoloids are very complex and difficult to remove from plant extracts. Alkaloids are already considered to be of concern in small quantities and can cause carcinogens and lead to harmful poisoning.
  • the composition according to the invention can have a corresponding effect even without celandine.
  • the composition according to the invention can, contrary to the aforementioned prejudice, also without celandine, have an effect on gastrointestinal complaints, in particular with regard to convulsive gastrointestinal disorders and flatulence.
  • compositions of the invention has no extracts, tinctures and / or extracts of the also commonly used milk thistle. Another advantage of the composition is realized by the fact that the composition is able to produce an equally good effect in the treatment of gastrointestinal discomfort as compositions containing milk thistle
  • composition according to the invention has no extracts, tinctures and / or extracts from licorice. Extracts from licorice root are attributed a soothing and spasmolytic effect on the stomach, as well as a preventive and healing effect on gastric ulcers. However, licorice root has been shown to have glucocorticoid side effects, causing blood pressure increase,
  • composition according to the invention may also have a corresponding effect without licorice.
  • composition of the present invention is as effective in treating gastrointestinal disorders as compositions containing angelica root, celandine and / or licorice, the present invention overcomes a long-standing prejudice in the art.
  • composition according to the invention without extracts, tinctures and / or extracts of angelica root, celandine and / or licorice opens the possibility that the composition can be dosed higher and longer. It is particularly advantageous that there is no danger of unintentional overdosing.
  • a particular advantage of the composition is realized in that the
  • Composition including Centaurium erythraea, ChamomiUa recutica (chamomile), Melissa officinalis (lemon balm), Mentha x piperita (peppermint) and Carum carvi (caraway) is as effective in the treatment of gastrointestinal discomfort as cuneiform compositions and / or angelica root, but the risk of side effects is significantly reduced.
  • composition according to the invention compared with preparations containing a higher number of effective medicinal plants comparable good effect in the treatment of gastrointestinal complaints can be achieved.
  • composition according to the invention can be used in migraine-related gastrointestinal complaints.
  • Migraine sufferers are considered to be particularly difficult to treat, as they often already suffer from migraines due to malaise, nausea or vomiting, and on the other hand often continue to show a disturbance of the gastrointestinal motility.
  • Centaurium erythraea with ChamomiUa recutica (chamomile), Melissa officinalis (lemon balm), Mentha x piperita
  • the composition according to the invention contains active substances obtainable from plants and / or plant parts of ChamomiUa recutica, Melissa officinalis, Mentha x piperita, Carum carvi and Centaurium erythraea.
  • the composition according to the invention is particularly distinguished over known plant-based agents in that the composition comprises a special selection of extracts, tinctures and / or extracts of certain plants and / or plant parts, namely ChamomiUa recutica, Melissa officinalis, Mentha x piperita, Carum carvi and Centaurium erythraea, as effective Ingredients has.
  • the composition according to the invention is particularly suitable for the prophylactic or therapeutic treatment of gastrointestinal complaints and flatulence.
  • the composition comprises
  • Total volume of the composition in the range of> 0.5 vol .-% to ⁇ 10 vol .-%, preferably in the range of> 1 vol .-% to ⁇ 8 vol .-%, more preferably in the range of> 2 vol. % to ⁇ 6% by volume, more preferably in the range from> 4% by volume to ⁇ 5% by volume, extract, tincture and / or extract of plants and / or plant parts of Centaurium erythraea.
  • Centaurium erythraea is also referred to as centaury
  • Chamomilla recutica is also referred to as centaury
  • Melissa officinalis is also referred to as chamomile, lemon balm, peppermint and caraway.
  • contents of extract, tincture and / or extract in the range of> 1 vol .-% to ⁇ 10 vol .-%, preferably in the range of> 2 vol .-% to ⁇ 8 vol .-%, particularly preferably in the range of > 4 vol .-% to ⁇ 5 vol .-%, based on the total volume of
  • Composition on plants and / or plant parts of Centaurium erythraea, can advantageously improve the effectiveness of the composition especially in case of feeling of fullness and flatulence.
  • volume contents of the respective components are chosen such that the total volume of the respective components does not exceed 100% by volume, based on the total composition.
  • Concentration profile of the composition For example, it was found that a higher levels of lemon balm, peppermint and cumin can significantly improve the effectiveness of stomach pain and nausea.
  • the composition comprises in the range of> 10% by volume to ⁇ 30% by volume, preferably in the range of> 15% by volume to ⁇ 25% by volume, particularly preferably in the range of> 20% by volume. % to ⁇ 22 vol .-%, based on the total volume of the composition, extract, tincture and / or extract of plants and / or plant parts of Chamomilla recutica.
  • the composition comprises in the range of> 15 vol.% To ⁇ 35 vol.%, Preferably in the range of> 20 vol.% To ⁇ 30 vol.%,
  • the composition comprises in the range of> 20 vol.% To ⁇ 40 vol.%, Preferably in the range of> 25 vol.% To ⁇ 35 vol.%, Preferably in the range of> 28 vol. % to ⁇ 30% by volume, based on the total volume of the composition, extract, tincture and / or extract of plants and / or
  • the composition comprises in the range of> 15 vol.% To ⁇ 40 vol.%, Preferably in the range of> 20 vol.% To ⁇ 35 vol.%,
  • composition of the invention is characterized by a surprisingly improved compatibility.
  • the combination of Chamomilla recutica, Melissa officinalis, Mentha x piperita, Carum carvi and Centaurium erythraea can be characterized by a good efficacy in gastrointestinal complaints and at the same time good tolerability.
  • the composition comprises, based on the total volume of the composition:
  • Centaurium erythraea Centaurium erythraea
  • volume contents of the respective components are chosen such that the
  • Total volume of components does not exceed 100% by volume.
  • Extracts, tinctures and extracts can be prepared from whole plants, preferably extracts, tinctures and extracts of plant parts, for example, from flowers, leaves, stems, roots or seeds of plants can be produced. Extracts, tinctures and extracts of Centaurium erythraea from the aboveground parts of plants, in particular from the herbaceous parts of plants, can preferably be produced. Extracts, tinctures and extracts of Chamomilla recutica from the flowers are preferably produced. Preferably, extracts, tinctures and extracts of Melissa officinalis can be produced from the leaves. Extracts, tinctures and extracts of Mentha x piperita are preferably preparable for the leaves. Extracts, tinctures and extracts of Carum carvi from the fruits are preferably producible.
  • the composition comprises extracts, tinctures and / or extracts of chamomile flowers, lemon balm leaves, peppermint leaves,
  • the composition comprises, based on the total volume of the composition:
  • the composition comprises alcoholic, aqueous, or aqueous-alcoholic extracts of plants and / or plant parts of Chamomilla recutica and Carum carvi. Particularly preferred are extracts of liquid nature, so-called fluid extracts.
  • the composition comprises alcoholic, aqueous, or aqueous-alcoholic tinctures of plants and / or plant parts of Melissa officinalis, Mentha x piperita and Centaurium erythraea.
  • alcoholic, aqueous, or aqueous-alcoholic tinctures of plants and / or plant parts of Melissa officinalis, Mentha x piperita and Centaurium erythraea In further preferred
  • the composition comprises alcoholic, aqueous, or
  • the weight ratio of the macerated or percolated plant parts of Centaurium erythraea to the extract is preferably in the range from 1: 4.2 to 1: 5 (w / w), preferably in the range from 1: 4.5 to 1: 4.8 (w / w). w), more preferably at 1: 5 (w / w).
  • the weight ratio of the macerated or percolored plant parts of ChamomiUa recutica to the extract is in the range of 1: 2 to 1: 4 (w / w). This is preferably
  • Weight ratio of the macerated or percolated plant parts of Melissa officinalis to the extract in the range of 1: 4-5 (w / w), preferably in the range of 1: 4.5-5 (w / w), particularly preferably 1: 5 (w / w).
  • the weight ratio of the macerated or percolored plant parts of Mentha x piperita to the extract is in the range of in the range of 1: 4-5 (w / w), more preferably in the range of 1: 4.5-5 (w / w) preferably at 1: 5 (w / w).
  • the weight ratio of the macerated or percolated plant parts of Carum carvi to the extract is in the range of 1: 2 to 1: 3 (w / w).
  • extracts and tinctures by means of alcoholic, aqueous or
  • Extracts and tinctures according to pharmacopoeia are preferably preparable by means of ethanol-water mixtures.
  • aqueous-alcoholic extracts of plants and / or plant parts of Chamomiua recutica, Melissa officinalis, Mentha x piperita, Carum carvi and / or Centaurium erythraea are aqueous-ethanolic extracts.
  • the extractant used is an ethanol-water mixture, the concentration of ethanol preferably being in the range of 30% (v / v) to 90% (v / v), preferably in the range of 45% (v / v) to 70 % (v / v) is.
  • the ethanol concentration of the aqueous ethanolic tincture of Centaurium erythraea is 45% (v / v) or 70% (v / v).
  • the concentration of ethanol of the aqueous-ethanolic tinctures of Melissa officinalis and Mentha x piperita is 45% (v / v).
  • the ethanol concentration of the aqueous ethanolic extracts of Chamomilla recutica and Carum carvi is 45% (v / v).
  • composition is in preferred embodiments a drug
  • An object of the invention thus relates to a pharmaceutical, pharmaceutical preparation, medical device,
  • Nutritional supplement, dietetic food and / or supplemental balanced diet comprising a composition according to the invention.
  • the composition according to the invention Preferably, the
  • composition in the form of a drug or a pharmaceutical preparation.
  • the composition is useful as a drug, most preferably the composition is a drug.
  • Composition may more preferably be in the form of a dietetic food.
  • the composition may be solid, liquid and / or gel.
  • the composition is in liquid dosage form, preferably selected from the group comprising solution, tincture, juice and / or suspension.
  • the composition is a liquid dosage form.
  • the liquid composition is formulated for oral administration.
  • Liquids is their quick onset and easy intake.
  • liquid dosage forms in the form of drops or small volumes can be administered. This is particularly advantageous when due to gastrointestinal discomfort
  • the composition is in the form of a solid dosage form, preferably selected from the group comprising powder and / or granules.
  • Powders and / or granules contain extracts, tinctures and / or extracts of plants and / or plant parts of Chamomilla recutica (chamomile), Melissa officinalis (lemon balm), Mentha x piperita (peppermint), Carum carvi (caraway) and
  • Centaurium erythraea preferably in dried form.
  • a powder or granules can be used in particular for the preparation of a beverage, for example a tea, in particular a stomach infusion.
  • a beverage for example a tea, in particular a stomach infusion.
  • the composition is in the form of a gelatinous dosage form, for example in the form of a carbohydrate-based gel.
  • a gel may be in a gel form for direct administration or, more preferably, may be useful in the preparation of a beverage.
  • the advantage of a gelatinous administration form lies in the easy swallowability of the gel and in particular in a comparably small amount
  • Preferred dosages of a liquid composition according to the invention for oral administration to humans are in the range of> 0.5 ml / day to ⁇ 25 ml / day, preferably in the range of> 5 ml / day to ⁇ 20 ml / day, still preferably in the range from> 10 ml / day to ⁇ 15 ml / day.
  • the dosages per day are administrable in the form of a single dose, preferably the dosages are in the form of several doses
  • administrable for example, 5 ml of composition three times a day.
  • a dosage in the range of> 0.5 ml / day to ⁇ 25 ml / day, preferably in the range of> 5 ml / day to ⁇ 20 ml / day, more preferably in the range of> 10 ml / day to ⁇ 15 ml / day of a composition comprising:
  • volume contents of the respective components are chosen such that the
  • Total volume of components does not exceed 100% by volume.
  • Solid and gelatinous administration forms are preferably in the form of sachets which preferably contain a single dose.
  • the composition consists of extracts, tinctures and / or extracts of Chamomilla recutica, Melissa officinalis, Mentha x piperita, Carum carvi and Centaurium erythraea, as active ingredients and usual excipients of the formulation.
  • Another object of the present invention relates to an inventive
  • a composition for use in the prophylactic and / or therapeutic treatment of gastrointestinal disorders in particular selected from the group comprising flatulence, convulsive gastrointestinal disorders, gastrointestinal influenza,
  • gastrointestinal flu or gastroenteritis is to be understood as one of the most prevalent and common diseases of the gastrointestinal tract, which is associated with abdominal pain and abdominal cramps, vomiting and diarrhea.
  • motion sickness or kinetosis is understood to mean so-called movement diseases, which are caused by unusual movement and acceleration of means of transport, for example cars, ships (seasickness), trains or airplanes. Symptoms are dizziness or vomiting, especially nausea.
  • composition of the invention in addition to extracts, tinctures and / or extracts of plants and / or plant parts of Chamomilla recutica (chamomile), Melissa officinalis (lemon balm), Mentha x piperita (peppermint), Carum carvi (caraway), extracts , Tinctures and / or extracts of Centaurium erythraea
  • composition according to the invention compared to preparations containing a higher number of effective medicinal plants comparable good effect in the treatment of gastrointestinal discomfort can be achieved without angelica root, celandine and / or licorice are included, which can develop side effects.
  • the composition of the invention allows a comparable effect with significantly better safety and lower risk for patients.
  • migraine-related stomach pain and dysmotility Composition in migraine-related stomach pain and dysmotility is useful.
  • Migraine sufferers are considered to be particularly difficult to treat, as they often already suffer from migraines due to malaise, nausea or vomiting, and on the other hand often continue to show a disturbance of the gastrointestinal motility.
  • Due to the lack of intestinal motility the patients are orally untreatable over the duration of this disorder, which is a particularly severe limitation of the acute therapy for the patient and may require the visit of a physician for the performance of a parenteral therapy. It is therefore of particular advantage that it was surprisingly found that by administering the composition according to the invention, migraine patients can again show an intestinal motility. Since migraine therapeutics almost without any hepatotoxic potential, the present composition without hepatotoxic potential of particular importance for migraineurs.
  • composition according to the invention it is particularly advantageous that by avoiding the occurrence of side effects a longer-term administration of the composition according to the invention and / or administration in higher doses is made possible. This allows in particular the
  • composition of the invention in an acute treatment as a single and / or multiple, time-limited administration, not before
  • Occurrence of a disease must be started or used in the long term to achieve an effect.
  • an "acute treatment” is understood to mean administration with the effect of producing an advantageous effect at the time shortly before, during or after the onset of the disease, without any preceding long-term administration being independent of disease states, ie. H. over several days, weeks or months, is necessary.
  • an "acute treatment” in the context of this invention thus comes to relieve the symptoms, without this one of disease states
  • Another object of the present invention therefore relates to a composition according to the invention for use in the acute treatment of gastrointestinal complaints, in particular selected from the group comprising flatulence, convulsive gastrointestinal disorders, gastrointestinal influenza, motion sickness and / or stomach pain Migraines, especially the acute treatment of gastrointestinal influenza and / or motion sickness.
  • Another object of the present invention relates to a pharmaceutical
  • Food and / or supplementary balanced diet comprising a composition according to the invention.
  • composition of the invention for use in the prophylactic and / or therapeutic treatment of gastrointestinal disorders, especially selected from the group comprising flatulence, convulsive gastrointestinal disorders, gastrointestinal influenza, motion sickness and / or stomach pain in migraine, the Composition according to the invention for use in the acute treatment of gastrointestinal disorders and of the medicament, pharmaceutical preparation, medical device,
  • Dietary supplement, dietetic food and / or supplemental balanced diet comprising a composition of the invention, based on the
  • volume contents of the respective components are chosen such that the
  • Total volume of components does not exceed 100% by volume.
  • the composition contains active ingredients obtainable from plants and / or plant parts of Chamomilla recutica, Melissa officinalis, Mentha x piperita, Carum carvi and Centaurium erythraea.
  • the composition comprises
  • Total volume of the composition in the range of> 0.5 vol .-% to ⁇ 10 vol .-%, preferably in the range of> 1 vol .-% to ⁇ 8 vol .-%, more preferably in the range of> 2 vol. % to ⁇ 6% by volume, more preferably in the range from> 4% by volume to ⁇ 5% by volume, extract, tincture and / or extract of plants and / or plant parts of Centaurium erythraea.
  • the composition comprises in the range of> 10% by volume to ⁇ 30% by volume, preferably in the range of> 15% by volume to ⁇ 25% by volume, particularly preferably in the range of> 20% by volume. % to ⁇ 22 vol .-%, based on the total volume of the composition, extract, tincture and / or extract of plants and / or plant parts of Chamomilla recutica.
  • the composition comprises in the range of> 15 vol.% To ⁇ 35 vol.%, Preferably in the range of> 20 vol.% To ⁇ 30 vol.%,
  • the composition comprises in the range of> 20 vol.% To ⁇ 40 vol.%, Preferably in the range of> 25 vol.% To ⁇ 35 vol.%, Preferably in the range of> 28 vol. % to ⁇ 30% by volume, based on the total volume of the composition, extract, tincture and / or extract of plants and / or
  • the composition comprises in the range of> 15 vol.% To ⁇ 40 vol.%, Preferably in the range of> 20 vol.% To ⁇ 35 vol.%, Preferably in the range of> 25 vol. % to ⁇ 30% by volume, based on the total volume of the composition, extract, tincture and / or extract of plants and / or
  • the composition comprises, based on the total volume of the composition:
  • Centaurium erythraea Centaurium erythraea
  • volume contents of the respective components are chosen such that the
  • Extracts, tinctures and extracts of Centaurium erythraea from the aboveground parts of plants, in particular from the herbaceous parts of plants, can preferably be produced. Extracts, tinctures and extracts of Chamomilla recutica from the flowers are preferably produced. Preferably, extracts, tinctures and extracts of Melissa officinalis can be produced from the leaves. Extracts, tinctures and extracts of Mentha x piperita are preferably preparable for the leaves. Extracts, tinctures and extracts of Carum carvi from the fruits are preferably producible.
  • the composition comprises extracts, tinctures and / or extracts of chamomile flowers, lemon balm leaves,
  • the composition comprises, based on the total volume of the composition:
  • the composition comprises alcoholic, aqueous, or aqueous-alcoholic extracts of plants and / or plant parts of Chamomilla recutica and Carum carvi. Particularly preferred are extracts of liquid nature, so-called fluid extracts. In also preferred embodiments, the
  • the composition comprises alcoholic, aqueous, or aqueous-alcoholic extracts of plants and / or plant parts of Chamomilla recutica and Carum carvi and alcoholic, aqueous, or aqueous-alcoholic Tinctures of plants and / or plant parts of Melissa officinalis, Mentha x piperita and Centaurium erythraea on.
  • the weight ratio of the macerated or percolated plant parts of Centaurium erythraea to the extract is preferably in the range from 1: 4.2 to 1: 5 (w / w), preferably in the range from 1: 4.5 to 1: 4.8 (w / w). w), more preferably at 1: 5 (w / w).
  • the weight ratio of the macerated or percolored plant parts of ChamomiUa recutica to the extract is in the range of 1: 2 to 1: 4 (w / w). This is preferably
  • Weight ratio of the macerated or percolated plant parts of Melissa officinalis to the extract in the range of 1: 4-5 (w / w), preferably in the range of 1: 4.5-5 (w / w), particularly preferably 1: 5 (w / w).
  • the weight ratio of the macerated or percolored plant parts of Mentha x piperita to the extract is in the range of in the range of 1: 4-5 (w / w), more preferably in the range of 1: 4.5-5 (w / w) preferably at 1: 5 (w / w).
  • the weight ratio of the macerated or percolated plant parts of Carum carvi to the extract is in the range of 1: 2 to 1: 3 (w / w).
  • aqueous-alcoholic extracts of plants and / or plant parts of Chamomiua recutica, Melissa officinalis, Mentha x piperita, Carum carvi and / or Centaurium erythraea are aqueous-ethanolic extracts.
  • the extractant used is an ethanol-water mixture, the concentration of ethanol preferably being in the range of 30% (v / v) to 90% (v / v), preferably in the range of 45% (v / v) to 70 % (v / v) is.
  • the ethanol concentration of the aqueous ethanolic tincture of Centaurium erythraea is 45% (v / v) or 70% (v / v).
  • the concentration of ethanol of the aqueous-ethanolic tinctures of Melissa officinalis and Mentha x piperita is 45% (v / v).
  • the ethanol concentration of the aqueous ethanolic extracts of ChamomiUa recutica and Carum carvi is 45% (v / v).
  • the composition may be solid, liquid and / or gel.
  • the composition is in liquid dosage form, preferably selected from the group comprising solution, tincture, juice and / or suspension.
  • the composition is a liquid dosage form.
  • the liquid composition is formulated for oral administration.
  • the composition is in the form of a solid
  • Dosage form before preferably selected from the group comprising powder and / or granules.
  • Powders and / or granules contain extracts, tinctures and / or extracts of plants and / or plant parts of Chamomilla recutica (chamomile), Melissa officinalis (lemon balm), Mentha x piperita (peppermint), Carum carvi (caraway) and Centaurium erythraea (centaury) preferably in dried form.
  • a powder or granules can be used in particular for the preparation of a beverage, for example a tea, in particular a stomach infusion.
  • the composition is in the form of a gelatinous dosage form, for example in the form of a carbohydrate-based gel.
  • a gel may be in a gel form for direct administration or, more preferably, may be useful in the preparation of a beverage.
  • Preferred dosages of a liquid composition according to the invention for oral administration to humans are in the range of> 0.5 ml / day to ⁇ 25 ml / day, preferably in the range of> 5 ml / day to ⁇ 20 ml / day, still preferably in the range from> 10 ml / day to ⁇ 15 ml / day.
  • the dosages per day are administrable in the form of a single dose, preferably the dosages are in the form of several doses
  • administrable for example, 5 ml of composition three times a day.
  • a dosage in the range of> 0.5 ml / day to ⁇ 25 ml / day, preferably in the range of> 5 ml / day to ⁇ 20 ml / day, more preferably in the range of> 10 ml / day to ⁇ 15 ml / day of a composition comprising:
  • volume contents of the respective components are chosen such that the
  • Total volume of components does not exceed 100% by volume.
  • Solid and gelatinous administration forms are preferably in the form of sachets which preferably contain a single dose.
  • the composition consists of extracts, tinctures and / or extracts of Chamomilla recutica, Melissa officinalis, Mentha x piperita, Carum carvi and Centaurium erythraea as effective components and excipients of the
  • Another aspect of the present invention relates to the use of a
  • composition according to the invention for the manufacture of a medicament
  • composition is useful for the treatment of gastrointestinal disorders, in particular flatulence and spasmodic gastrointestinal disorders.
  • composition may be used for the preparation of an agent for the prophylactic and / or therapeutic treatment of gastrointestinal disorders, in particular selected from the group consisting of flatulence and / or convulsive gastrointestinal disorders.
  • the composition is particularly suitable for the preparation of a medicament, pharmaceutical preparation, medical device,
  • Nutritional supplement, dietetic food and / or a supplementary balanced diet for the prophylactic and / or therapeutic treatment of Gastrointestinal complaints in particular selected from the group comprising flatulence and / or convulsive gastrointestinal disorders.
  • the formulation included ethanolic tinctures of Centaurium erythraea, Melissa officinalis and Mentha x piperita as well as ethanolic extracts of Chamomilla recutica and Carum carvi.
  • Example 2 The effect of the composition of the invention on flatulence and mild spasmodic gastrointestinal disturbances was observed. It was found that the administration of the composition of the invention according to Example 1, a significant reduction of stomach cramps was achieved. In particular, it could be shown that the perceived pain and the resulting flatulence could be significantly improved by the composition. Even with repeated and / or long-term intake no contraindications or side effects were observed, in particular no allergies or increased photosensitivity of the skin occurred.
  • composition on flatulence and mild spasmodic gastrointestinal disturbances was observed in a comparative experiment, in which 5 ml of the composition according to Example 1 were administered three times daily.
  • Table I shows a comparison of the effect of various agents on nausea and gastric pressures in gastrointestinal complaints. It can be seen from Table I that a significant reduction in nausea and gastric pressures was achieved by the administration of the composition according to the invention. In particular, it has been shown that the effects were better than administration of chamomile, peppermint and cumin only ingredients and as well as administration of

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Abstract

La présente invention concerne une composition convenant particulièrement au traitement de troubles gastro-intestinaux. Cette composition comprend des essences, teintures et/ou extraits de plantes et/ou de parties de plantes, notamment de Chamomilla recutica, Melissa officinalis, Mentha x piperita, Carum carvi et Centaurium erythraea.
EP10785455A 2009-12-10 2010-12-09 Composition pour le traitement de troubles gastro-intestinaux Withdrawn EP2509613A1 (fr)

Applications Claiming Priority (2)

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DE102009054509 2009-12-10
PCT/EP2010/069237 WO2011070096A1 (fr) 2009-12-10 2010-12-09 Composition pour le traitement de troubles gastro-intestinaux

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EP2509613A1 true EP2509613A1 (fr) 2012-10-17

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DE102014016158A1 (de) * 2014-07-11 2016-01-14 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh Zusammensetzung zur Behandlung von Magenbeschwerden
IT201700006355A1 (it) * 2017-01-20 2018-07-20 Neilos S R L Composizione per il trattamento dei disturbi gastrointestinali

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AU2002222747A1 (en) * 2000-12-12 2002-06-24 Angiolab, Inc. Composition comprising melissa leaf extract for anti-angiogenic and matrix metalloproteinase inhibitory activity

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