EP2533790A2 - Composition pour le traitement et la prophylaxie de troubles nerveux et de troubles du sommeil - Google Patents

Composition pour le traitement et la prophylaxie de troubles nerveux et de troubles du sommeil

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Publication number
EP2533790A2
EP2533790A2 EP11701692A EP11701692A EP2533790A2 EP 2533790 A2 EP2533790 A2 EP 2533790A2 EP 11701692 A EP11701692 A EP 11701692A EP 11701692 A EP11701692 A EP 11701692A EP 2533790 A2 EP2533790 A2 EP 2533790A2
Authority
EP
European Patent Office
Prior art keywords
range
extract
weight
composition
extracts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP11701692A
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German (de)
English (en)
Inventor
Reiner Rittinghausen
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Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP2533790A2 publication Critical patent/EP2533790A2/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/84—Valerianaceae (Valerian family), e.g. valerian
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Definitions

  • Composition for the treatment and prophylaxis of nervous disorders and sleep disorders are provided.
  • the present invention relates to a herbal composition for the treatment and / or prophylaxis and of nervous disorders and sleep disorders.
  • Overstimulation, stress, hectic and permanent pressure to perform are a negative and permanent phenomenon in the modern age.
  • the consequences of this on the human body can be manifold.
  • a frequent or permanent internal restlessness and increased excitability can lead to temporary or permanent nervous disorders, especially sleep disorders.
  • irritability and nervousness can be the consequences, as well as personality disorders, emotional disorders and an increased sense of pain. It is therefore apparent that compositions for the prophylaxis and / or treatment of nervous disorders and sleep disorders are of great importance.
  • a particular disadvantage is that in this case active ingredients are taken, which often take an unnecessary influence on the human body.
  • US Pat. No. 7,476,405 discloses a composition for improving sleep and maintaining sleep.
  • This composition includes, among other components, willow bark extract, which may have some significant side effects.
  • the object is achieved by a herbal composition, wherein the composition extracts, tinctures and / or extracts of plants and / or plant parts of La vandula angustifolia Mill. (lavender), Humulus lupulus L. (hops), Melissa officinalis L. (lemon balm), Passiflora incarnata L. (passion flower) and Valeriana officinalis agg. (Valerian).
  • Advantageous embodiments of the vegetable composition according to the invention are specified in the subclaims.
  • tincture is understood to mean excerpted extracts and extracts from fresh plant parts or whole fresh plants which are produced using alcohol, in particular ethanol of suitable concentration Also known as “mother tinctures” and mixtures of vegetable juices with alcohol and / or water of various concentrations and / or extracts from plants.
  • the term “tincture” in particular includes drug extracts according to the German Pharmacopoeia (HAB), German Pharmacopoeia (DAB) or European Pharmacopoeia (Ph. Eur.) And other European or American pharmacopoeias from fresh or dried plants and / or plant parts, in particular fresh plants and / or plant parts.
  • extract means concentrated extracts of plants and / or plant parts of liquid, viscous or dry nature, which are optionally adjusted to a certain active substance content, which are obtained, for example, using alcohol, in particular ethanol.
  • extract also means purified extracts or extract fractions.
  • Extracts from plants or parts of plants with essential oils can also be prepared in such a way that the essential oils are removed from the plants or plant parts prior to extraction and this is added again after extraction to the respective extract.
  • homeopathic tinctures and extracts in particular liquid alcoholic plant extracts, alcoholic and in particular ethanolic tinctures are used.
  • the term "herbal composition” means compositions which are produced on a vegetable basis, in particular based on extracts and / or tinctures of plants and / or plant parts.
  • the term "nervous disorders” is understood to mean ailments which can be diverse and can be associated with impairments to health and wellbeing.
  • Particularly nervous disorders or vegetative dystonia are understood as disturbances in the interaction of the vegetative nervous system, which are all unconscious Because stimulation conduction in the nervous system is disturbed, dysregulations of autonomic centers in the midbrain and thus dysfunctions of many different organs occur due to many factors.Strategic dystonia is caused by overstimulation, stress, rush, conflicts and problems (Partnership, family, workplace, health, deaths), permanent pressure to perform, mental stress, loneliness or anxiety (exams, problems, arguments).
  • the nervous disorders are expressed in very different symptoms. Examples of such symptoms include inner restlessness, increased excitability, irritability, insomnia, insomnia, depression, resignation, depressive mood, discomfort, listlessness, melancholy, fatigue, anxiety, agitation, nervousness, dizziness, menopausal symptoms, shallow breathing, shortness of breath, headache, Migraine, muscle tension and cramps of the muscles (toe cramps, calf cramps and muscle tremors), heart complaints (heart pain, tachycardia, irregular heartbeat, Feeling of tightness in the chest), cramps in the stomach, in the intestine and in the bladder, diffuse discomfort in the neck (choking sensation, dysphagia), constipation, flatulence or loss of libido. Even in childhood, there are more and more stress states that manifest themselves in over-excitability and behavioral disorders.
  • Preferred examples of such symptoms are selected from the group comprising vegetative dystonia, feeling of tightness in the heart, nervous exhaustion, over-excitability, physical and mental fatigue, convalescence and / or menopausal symptoms.
  • compositions according to the invention show an improved effect in the treatment of mild nervous disorders and sleep disorders.
  • Lavender Humulus lupulus L. (hops), Melissa officinalis L (melissa ), Passiflora incarnata L. (passion flower) and / or Valeriana officinalis agg. (Valerian)
  • Lavender La vandula angustifolia Mill.
  • Humulus lupulus L. hops
  • Melissa officinalis L melissa
  • Passiflora incarnata L. passion flower
  • Valeriana officinalis agg. Valeriana officinalis agg.
  • a particular advantage is that a good effect in nervous disorders and sleep disorders alone by the composition containing extracts, tinctures and / or extracts of plants and / or plant parts of Lavandula angustifolia Mill., Humulus lupulus L., Melissa officinalis L., Passiflora incarnata L. and Valeriana officinalis agg. can be achieved, so that can be dispensed with a variety of components.
  • This is particularly advantageous since added active ingredients can be associated with side effects or at least unnecessarily influence the body.
  • the composition comprises only extracts, tinctures and / or extracts of plants and / or plant parts of Lavandula angustifolia Mill., Humulus lupulus L., Melissa officinalis L., Passiflora incarnata L. and Valeriana officinalis agg. as effective ingredients.
  • composition comprising extracts, tinctures and / or extracts of plants and / or plant parts of Lavandula angustifolia Mill., Humulus lupulus L., Melissa officinalis L., Passiflora incarnata L. and Valeriana officinalis agg. due to the small number of extracts, tinctures and / or extracts of medicinal plants has no heart rate-increasing effect, as is the case with known herbal remedies. Therefore, it is particularly suitable for nervous disorders and sleep disorders.
  • composition according to the invention comprising extracts, tinctures and / or extracts of plants and / or plant parts of Lavandula angustifolia Mill., Humulus lupulus L., Melissa officinalis L., Passiflora incarnata L. and Valeriana officinalis agg. as active ingredients no side effects, such as abdominal pain or a stimulating effect.
  • This is particularly advantageous in the treatment of nervous disorders and sleep disorders, since just a stimulating effect of the treatment of nervous disorders and sleep disorders counteracts.
  • the constituents of the composition according to the invention comprising extracts, tinctures and / or extracts of plants and / or plant parts of Lavandula angustifolia Mill., Humulus lupulus L., Melissa officinalis L., Passiflora incarnata L. and Valeriana officinalis agg. as active ingredients no toxins that would need to be separated before use.
  • the production of the composition according to the invention is simplified and thereby inexpensive.
  • compositions comprising extracts, tinctures and / or extracts of plants and / or plant parts of Lavandula angustifolia Mill., Humulus lupulus L., Melissa officinalis L., Passiflora incarnata L. and Valeriana officinalis agg , as active ingredients due to the small number of extracts, tinctures and / or extracts of effective medicinal plants preferably little or no allergies triggers.
  • An increasing number of people suffer from allergies or hypersensitivity to ingredients of one or more plants. Hypersensitivity reactions may also occur with the ingestion of herbal compositions and manifest, for example, in the form of rash, itching or difficulty breathing. It is therefore of great advantage that the composition according to the invention reduces the risk of such reactions due to the small number of extracts, tinctures and / or extracts of effective medicinal plants.
  • the composition according to the invention can also have a corresponding effect even without willow bark extract.
  • the composition according to the invention has a good effect on nervous disorders.
  • side effects such as nausea, stomach pain or skin reddening can be avoided.
  • the composition according to the invention can, contrary to the aforementioned prejudice, also without willow bark extract, have an effect on sleep disorders and furthermore on nervous disorders.
  • composition according to the invention without extracts, tinctures and / or extracts of willow bark extract opens the possibility that the composition can be dosed higher and longer. It is particularly advantageous that there is no danger of unintentional overdosing.
  • composition of the invention shows a good activity in all nervous disorders, especially sleep disorders. This is especially noteworthy because nervous disorders can be so diverse. Again, it is believed that the good effect on the interaction of extracts, tinctures and / or extracts of plants and / or plant parts of Lavandula angustifolia Mill. With Humulus lupulus L., Melissa officinalis L., Passiflora incarnata L. and Valeriana officina- lis agg. can be returned.
  • composition according to the invention contains active substances obtainable from plants and / or plant parts of Lavandula angustifolia MilL, Humulus lupulus L., Melissa officinalis L., Passiflora incarnata L. and / or Valeriana officinalis agg.
  • the composition according to the invention is distinguished from known plant-based agents in that the composition has a particular selection in a particular dosage of extracts, tinctures, and / or extracts of certain plants and / or plant parts, namely Lavandula angustifolia MilL, Humulus lupulus L. , Melissa officinalis L., Passiflora incarnata L. and Valeriana officinalis agg., As effective ingredients.
  • the composition according to the invention is particularly suitable for the prophylaxis and treatment of nervous disorders and sleep disorders.
  • the proportions by weight of the respective components are chosen such that the total weight of the respective components does not exceed 100% by weight, based on the total composition.
  • the composition comprises in the range of> 5 wt .-% to ⁇ 60 wt .-%, preferably in the range of> 10 wt .-% to ⁇ 35 wt .-%, preferably in the range of> 13 wt .-% to ⁇ 23 wt.
  • % more preferably in the range of> 16% by weight to ⁇ 18% by weight, based on the total weight of the composition, extract, tincture and / or extract of plants and / or plant parts of Lavandula angustifolia Mill .; and / or in the range of> 1 wt .-% to ⁇ 35 wt .-%, preferably in the range of> 4 wt .-% to ⁇ 20 wt .-%, preferably in the range of> 7 wt .-% to ⁇ 15% by weight, more preferably in the range of> 9% by weight to ⁇ 11% by weight, based on the total weight of the composition, extract, tincture and / or extract of plants and / or plant parts of Humulus lupulus L.
  • composition of the invention is characterized by a surprisingly improved compatibility.
  • the combination of extracts, tinctures and / or extracts of plants and / or plant parts of Lavandula angustifolia Mill., Humulus lu- pulus L., Melissa officinalis L., Passiflora incarnata L. and Valeriana officinalis agg. can be characterized by a good efficacy in nervous disorders and sleep disorders and at the same time good tolerability.
  • the composition comprises, based on the total weight of the composition:
  • weight contents of the respective components are chosen so that the total weight of the components does not exceed 100% by weight.
  • composition according to the invention it is possible to avoid pronounced side effects of Melissa officinalis L, for example, in contrast to excessive dosage of Melissa officinalis L.
  • side effects such as memory impairment, weight gain or constipation (hyperthyroidism). thyroid function) or uncontrolled weight loss, hair loss, increased sweating, heat intolerance or diarrhea (overactive thyroid gland).
  • side effects such as memory impairment, weight gain or constipation (hyperthyroidism). thyroid function) or uncontrolled weight loss, hair loss, increased sweating, heat intolerance or diarrhea (overactive thyroid gland). According to the invention it is therefore possible to prevent such side effects with at least the same effect.
  • Extracts, tinctures and extracts can be prepared from whole plants; extracts, tinctures and extracts from plant parts, for example from flowers, leaves, stalks, roots or seeds of the plants, are preferably producible.
  • extracts, tinctures and extracts of Lavandula angustifolia Mill. Be produced from the flowers.
  • extracts, tinctures and extracts of Humulus lupulus L. from the flowers, hop cones, and / or hop glands can be produced.
  • extracts, tinctures and extracts of Melissa officinalis L. from the leaves and / or above-ground parts can be produced.
  • Extracts, tinctures and extracts of Passiflora incarnata L. from the aboveground parts of plants, in particular from the herbaceous parts of plants are preferably preparable.
  • extracts, tinctures and extracts of Valeriana officinalis agg. can be produced from the roots.
  • the composition comprises extracts, tinctures and / or extracts of lavender flowers, hops flowers, lemon balm leaves, from the herbaceous parts of plants of passion flowers and / or valerian roots.
  • the composition comprises, based on the total weight of the composition:
  • the composition comprises alcoholic, aqueous or aqueous-alcoholic extracts of plants and / or plant parts of Lavandula angustifolia Mill., Humulus lupulus L., Melissa officinalis L., Passiflora incarnata L. and / or Valeriana officinalis agg. on.
  • the weight ratio of macerated or percolated plant parts of Humulus lupulus L. to the extract is in the range of 1: 1 to 30: 1 (m / m), preferably in the range of 3: 1 to 20: 1 (m / m), particularly preferred at 4.5: 1 to 8.5: 1 (m / m).
  • the weight ratio of macerated or percolated plant parts of Melissa officinalis to the extract is in the range from 1: 1 to 30: 1 (mm), preferably in the range from 4: 1 to 20: 1 (m / m), particularly preferred at 6.5: 1 to 10.5: 1 (m / m).
  • the weight ratio of macerated or percolored plant parts of Passiflora incarnata L. to the extract is in the range from 1: 1 to 30: 1 (m / m), preferably in the range from 3: 1 to 19.5: 1 (mm), more preferably at 4: 1 to 8: 1 (mm).
  • the weight ratio is preferably macerated or percolored plant parts of Valeriana officinalis agg.
  • extracts and tinctures can be prepared by means of alcoholic, aqueous or aqueous-alcoholic extractants. Extracts and tinctures according to pharmacopoeia are preferably preparable by means of ethanol-water mixtures.
  • the extractant used is an ethanol-water mixture, the concentration of ethanol preferably being in the range from 30% (m / m) to 75% (mm), particularly preferably in the range from 43% (m / m) to 62%. (m / m) is.
  • the concentration of ethanol of the aqueous-ethanolic tinctures of Lavandula angustifolia Mill. And Valeriana officinalis agg. at 62% (m / m).
  • the concentration of ethanol of the aqueous-ethanolic tinctures of Humulus lupulus L., Melissa officinalis L. and Passiflora incarnata L. is 43% (m / m).
  • the composition in preferred embodiments is a pharmaceutical, pharmaceutical preparation, medical device, nutritional supplement, dietetic food and / or a supplemental balanced diet.
  • the composition is in the form of a drug or a pharmaceutical preparation.
  • the composition is useful as a drug, most preferably the composition is a herbal drug.
  • the composition may further be in the form of a dietetic food.
  • the composition may be solid, liquid, and / or gel.
  • the composition is in a solid dosage form, preferably selected from the group comprising tablets, dragees, capsules, powders and / or granules, particularly preferably in the form of a tablet.
  • the composition is a solid dosage form.
  • the solid composition is formulated for oral administration.
  • the solid dosage form is selected from the group comprising tablets, dragees, capsules, powders and / or granules. These contain extracts, tinctures and / or extracts of plants or parts thereof from Lavandula angustifolia Mill., Humulus lupulus L., Melissa officinalis L., Passiflora incarnata L. and / or Valeriana officinalis agg. preferably in dried form. Tablets can be made with excipients to a size that is easy to handle.
  • Dragees are provided with a coating that facilitates swallowing and / or protects the active ingredient against decomposition. Further, tablets and capsules can be made to produce sustained release of the agent (s). A powder or granules can be used in particular for the preparation of a tea or other drinks, which allows a pleasant absorption of the active ingredients.
  • the composition is in the form of a gel-like dosage form, preferably in the form of a so-called power gel.
  • a gel may be in a gel form for direct administration or particularly preferably be useful for the preparation of a beverage.
  • the advantage of a gel-like administration form lies in the easy swallowability of the gel and in particular in a comparatively small volume, which can facilitate the administration.
  • the composition may be a liquid dosage form.
  • the liquid composition is formulated for oral administration.
  • the advantage of liquids is their quick onset of action and easy intake.
  • liquid administration forms in the form of drops or small volumes in the range of several milliliters can be administered several times a day.
  • liquid dosage forms are easily and reliably dosed by volume.
  • Liquid dosage forms are also advantageous if the swallowing of solid dosage forms is perceived as unpleasant.
  • Preferred dosages of a solid composition according to the invention are for oral administration to humans in the range of> 200 mg / day to ⁇ 1700 mg / day. preferably in the range of> 400 mg / day to ⁇ 1200 mg / day, more preferably in the range of> 750 mg / day to ⁇ 850 mg / day.
  • the dosages per day are administered in the form of a single dose, preferably the dosages in the form of multiple doses are administrable, for example, 392.5 mg composition twice a day.
  • the dosages are administrable in the form of several doses, for example 262 mg each time three times a day.
  • weight contents of the respective components are chosen so that the total weight of the components does not exceed 100% by weight.
  • Solid dosage forms in the form of a powder or granules and gelatinous administration forms are preferably in the form of sachets which preferably contain a single dose.
  • the composition consists of extracts, tinctures and / or extracts of plants and / or plant parts of Lavandula angustifolia MilL, Humulus lupulus L., Melissa officinalis L., Passiflora incarnata L. and / or Valeriana officinalis agg., As effective ingredients and conventional excipients of the formulation.
  • Another aspect of the present invention relates to the use of a herbal composition of the invention for the manufacture of a pharmaceutical, pharmaceutical, medical device, nutritional supplement, dietetic food and / or supplemental balanced diet.
  • the herbal composition is useful for the treatment of nervous disorders and sleep disorders.
  • the herbal composition may be used to prepare an agent for prophylactic and / or therapeutic treatment of nervous disorders and sleep disorders.
  • the herbal composition is particularly suitable for the manufacture of a medicament, pharmaceutical preparation, medical device, dietary supplement, dietetic food and / or a supplemented balanced diet for the prophylactic and / or therapeutic treatment of nervous disorders, especially selected from the group comprising inner restlessness Excitability, irritability, insomnia, insomnia, depression, resignation, depressive mood, aversion, listlessness, melancholy, exhaustion, anxiety, agitation, nervousness, dizziness, menopausal symptoms, shallow breathing, shortness of breath, headache, migraine, muscle tension and cramping of the muscles (toe cramps , Calf cramps and muscle tremors), heart complaints (heartache, tachycardia, irregular heartbeat, tightness in the chest), spasms in the stomach, in the intestine and in the bladder, diffuse discomfort in the neck area (Feeling choking, dysphagia), constipation, flat
  • Formulation for a herbal composition for oral administration in case of nervous disorders and sleep disorders is intended to be asymmetrical disorder.
  • the formulation included ethanolic tinctures of Lavandula angustifolia Mill., Humulus lupulus L., Melissa officinalis L., Passiflora incarnata L. and Valeriana officinalis agg.
  • Table I shows a comparison of the improvement by administration of the composition of the invention according to Example 1 and a comparable preparation.

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention concerne une composition à base de plantes pour le traitement et/ou la prophylaxie de troubles nerveux et de troubles du sommeil, la composition contenant des extraits et/ou des teintures de plantes et/ou de parties de plantes telles que Lavandula angustifolia MiIl. (lavande), Humulus lupulus L. (houblon), Melissa officinalis L. (mélisse), Passiflora incarnata L. (passiflore) et Valeriana officinalis agg. (valériane).
EP11701692A 2010-02-09 2011-02-03 Composition pour le traitement et la prophylaxie de troubles nerveux et de troubles du sommeil Withdrawn EP2533790A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010007433 2010-02-09
PCT/EP2011/051604 WO2011098394A2 (fr) 2010-02-09 2011-02-03 Composition pour le traitement et la prophylaxie de troubles nerveux et de troubles du sommeil

Publications (1)

Publication Number Publication Date
EP2533790A2 true EP2533790A2 (fr) 2012-12-19

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EP11701692A Withdrawn EP2533790A2 (fr) 2010-02-09 2011-02-03 Composition pour le traitement et la prophylaxie de troubles nerveux et de troubles du sommeil

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EP (1) EP2533790A2 (fr)
WO (1) WO2011098394A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2675297A4 (fr) * 2011-02-16 2014-10-01 Wellbemed Sweden Ab Produit alimentaire contenant un mélange d'extraits
ES2472345B1 (es) * 2013-06-20 2015-04-27 José María NAVA ALEVIA Procedimiento de obtención de un jarabe para el tratamiento de los nervios y otras patologías
ES2706302T3 (es) * 2014-05-05 2019-03-28 Sanofi Aventis Deutschland Granulado de disolución rápida
ES2597784T3 (es) * 2014-07-14 2017-01-23 Dr. Willmar Schwabe Gmbh & Co. Kg Combinación de extracto de raíz de valeriana y aceite de lavanda para utilizar en el tratamiento de trastornos del sueño
CN104383130A (zh) * 2014-11-29 2015-03-04 李洋 一种用于治疗失眠的中药组合物及其制备方法和应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004033785A1 (de) * 2004-07-12 2006-02-16 Finzelberg Gmbh & Co. Kg Beruhigende Pflanzenpräparate-Kombination mit aromatherapeutischen Komponenten, deren Herstellung und Verwendung
WO2007095716A1 (fr) * 2006-02-23 2007-08-30 Iomedix Sleep International Srl Compositions et méthodes pour l'induction et la conservation d'un sommeil de qualité

Non-Patent Citations (1)

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Title
See references of WO2011098394A2 *

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WO2011098394A2 (fr) 2011-08-18

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