WO2011071520A1 - Procédés de préparation d'acide (s)-3-(aminométhyl)-5-méthylhexanoïque - Google Patents

Procédés de préparation d'acide (s)-3-(aminométhyl)-5-méthylhexanoïque Download PDF

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Publication number
WO2011071520A1
WO2011071520A1 PCT/US2010/003102 US2010003102W WO2011071520A1 WO 2011071520 A1 WO2011071520 A1 WO 2011071520A1 US 2010003102 W US2010003102 W US 2010003102W WO 2011071520 A1 WO2011071520 A1 WO 2011071520A1
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WO
WIPO (PCT)
Prior art keywords
occurs
formula
reaction step
isomer
compound
Prior art date
Application number
PCT/US2010/003102
Other languages
English (en)
Inventor
Satyanarayana Janagani
Venogopala Roa Bandi
Venkata Rao Thanneru
Venkateswara Rao Kadali
Original Assignee
Dissymmetrix (Pvt) Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dissymmetrix (Pvt) Ltd. filed Critical Dissymmetrix (Pvt) Ltd.
Publication of WO2011071520A1 publication Critical patent/WO2011071520A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C243/34—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a carbon skeleton further substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention concerne de nouveaux composés d'acide hexanoïque et de tétrahydrooxazindione comme intermédiaires pour la préparation de (S)-prégabaline de formule (I). L'invention concerne également un nouveau procédé de synthèse pour préparer de la (S)-prégabaline à l'aide desdits intermédiaires.
PCT/US2010/003102 2009-12-07 2010-12-07 Procédés de préparation d'acide (s)-3-(aminométhyl)-5-méthylhexanoïque WO2011071520A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26742409P 2009-12-07 2009-12-07
US61/267,424 2009-12-07

Publications (1)

Publication Number Publication Date
WO2011071520A1 true WO2011071520A1 (fr) 2011-06-16

Family

ID=44145832

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/003102 WO2011071520A1 (fr) 2009-12-07 2010-12-07 Procédés de préparation d'acide (s)-3-(aminométhyl)-5-méthylhexanoïque

Country Status (1)

Country Link
WO (1) WO2011071520A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108358799A (zh) * 2018-04-24 2018-08-03 贵州师范大学 一种普瑞巴林的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009001372A2 (fr) * 2007-06-25 2008-12-31 Manne Satyanarayana Reddy Nouveau procédé pour la préparation de la prégabaline
US20090143615A1 (en) * 2007-12-03 2009-06-04 Dipharma Francis S.R.L. Process for the Preparation of (S)(+)-3-(Aminomethyl)-5-Methylhexanoic Acid

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009001372A2 (fr) * 2007-06-25 2008-12-31 Manne Satyanarayana Reddy Nouveau procédé pour la préparation de la prégabaline
US20090143615A1 (en) * 2007-12-03 2009-06-04 Dipharma Francis S.R.L. Process for the Preparation of (S)(+)-3-(Aminomethyl)-5-Methylhexanoic Acid

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SECHI ET AL.: "Design and Synthesis of Bis-amide and Hydrazide-containing Derivatives of Malonic Acid as Potential HIV-1 Integrase Inhibitors.", MOLECULES, vol. 13, 2008, pages 2442 - 2461 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108358799A (zh) * 2018-04-24 2018-08-03 贵州师范大学 一种普瑞巴林的制备方法

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