WO2011046963A1 - Oxygen depletion devices and methods for removing oxygen from red blood cells - Google Patents

Oxygen depletion devices and methods for removing oxygen from red blood cells Download PDF

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Publication number
WO2011046963A1
WO2011046963A1 PCT/US2010/052376 US2010052376W WO2011046963A1 WO 2011046963 A1 WO2011046963 A1 WO 2011046963A1 US 2010052376 W US2010052376 W US 2010052376W WO 2011046963 A1 WO2011046963 A1 WO 2011046963A1
Authority
WO
WIPO (PCT)
Prior art keywords
oxygen
red blood
blood cells
hollow fibers
cartridge
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2010/052376
Other languages
English (en)
French (fr)
Inventor
William J. Federspiel
Tatsuro Yoshida
Paul J. Vernicci
Brian J. Frankowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
Hemanext Inc
Original Assignee
University of Pittsburgh
New Health Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pittsburgh, New Health Sciences Inc filed Critical University of Pittsburgh
Priority to JP2012534293A priority Critical patent/JP2013507447A/ja
Priority to BR112012008682A priority patent/BR112012008682A2/pt
Priority to EP10823965.8A priority patent/EP2389064A4/en
Priority to NZ599890A priority patent/NZ599890A/en
Priority to CA2781874A priority patent/CA2781874A1/en
Priority to CN2010800564451A priority patent/CN102905522A/zh
Priority to AU2010306920A priority patent/AU2010306920A1/en
Publication of WO2011046963A1 publication Critical patent/WO2011046963A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0641—Erythrocytes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0272—Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0208—Oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0429—Red blood cells; Erythrocytes

Definitions

  • the present invention relates to devices for depleting oxygen from red blood cells to enhance storage life.
  • the present invention relates to methods for depleting oxygen from red blood cells.
  • Adequate blood supply and the storage thereof is a problem facing every major hospital and health organization around the world. Often, the amount of blood supply in storage is considerably smaller than the need therefor. This is especially true during crisis periods such as natural catastrophes, war and the like, when the blood supply is often perilously close to running out. It is at critical times such as these that the cry for more donations of fresh blood is often heard. However, unfortunately, even when there is no crisis period, the blood supply and that kept in storage must be constantly monitored and replenished, because stored blood does not maintain its viability for long.
  • Hb hemoglobin
  • RBCs red blood cells
  • the present disclosure provides for a disposable device that is able to remove oxygen from red blood cells.
  • the present disclosure provides for an oxygen depletion device.
  • the device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed within the cartridge and contiguous to and in between the plurality of hollow fibers.
  • the hollow fibers are adapted to receiving and conveying red blood cells.
  • the present disclosure provides for an oxygen depletion device.
  • the device has a receptacle of a solid material having an inlet and an outlet adapted to receiving and expelling a flushing gas and a plurality of hollow fibers extending within the receptacle from an entrance to an exit thereof.
  • the hollow fibers are adapted to receiving and conveying red blood cells.
  • the present disclosure provides for a method for removing oxygen from red blood cells.
  • the method has the step of passing the red blood cells through an oxygen device.
  • the device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; and an amount of an oxygen scavenger packed within the cartridge and contiguous to and in between the plurality of hollow fibers.
  • the hollow fibers are adapted to receiving and conveying red blood cells
  • the present disclosure provides for a method for removing oxygen from red blood cells.
  • the method has the step of passing the red blood cells through an oxygen device.
  • the device has a receptacle of a solid material having an inlet and an outlet adapted to receiving and expelling a flushing gas; and a plurality of hollow fibers films extending within the receptacle from an entrance to an exit thereof.
  • the hollow fibers are adapted to receiving and conveying red blood cells.
  • Fig. 1 illustrates a pre-storage oxygen depletion device of the present invention.
  • Figs. 2a through 2c illustrate an embodiment of a depletion device that depletes oxygen from red blood cells prior to storage by a flushing inert gas around a hollow fiber inside the assembly.
  • Figs. 3a through 3c illustrate another embodiment of a depletion device that depletes oxygen from red blood cell prior to storage. 6
  • Figs. 4a through 4c illustrate another embodiment of a depletion
  • oxygen is scavenged by scavenger materials in the core of the cylinder
  • Figs. 5a through 5c illustrate another embodiment of a depletion
  • Fig. 6 illustrates a plot of flow rate of RBC suspension per minute
  • an oxygen depletion device (ODD) 101 contains
  • ODD 101 is a disposable cartridge 105 containing
  • Oxygen sorbent 110 is a mixture of non-toxic inorganic and/or organic salts and ferrous iron or other materials with high reactivity toward oxygen. Oxygen sorbent 110 is made from particles that have significant absorbing capacity for 0 2 (more
  • ODD oxygen permeable envelope
  • 101 of the present disclosure can deplete approximately 100 mL of oxygen from a unit of blood.
  • RBCs pass through hollow porous fibers 115.
  • Porous fibers are
  • ODD fibers include polyolefins, Teflon, polyesters, PVDF, polysulfone, and other hydrophobic polymers as well as inorganic materials (ceramics).
  • Oxygen depletion takes place as RBCs pass through membrane 115.
  • ODD provides a simple structure having a large surface area to remove oxygen and maintain constant flow of blood therethrough. The oxygen depletion or removal is accomplished by irreversible reaction of ferrous ion in oxygen sorbent 110 with ambient oxygen to form ferric oxide.
  • ODD 101 does not need agitation for oxygen removal and can be manufactured easily to withstand centrifugation as part of a blood collection system as necessary.
  • the depletion devices function to deplete 0 2 by supplying appropriate composition of flushing gas.
  • Gases appropriate for depletion devices include, for example, Ar, He, C0 2 ,N 2 .
  • Figs. 4a through 4c and 5a through 5c also disclose scavenging depletion devices. Depletion takes place with the use of scavengers or sorbents and without the use of external gases. In both types of depletion devices however, oxygen depletion is effective to enhance DPG and ATP, respectively, prior to storage in blood storage bags. Referring to Figs. 2a through 2c, a depletion device 20 is shown.
  • Depletion device 20 includes a plurality of fibers 25, approximately 5000 in number, through which red blood cells flow. Plurality of fibers 25 are surrounded by a plastic cylinder 30. Plastic cylinder 30 contains a gas inlet 35 and a gas outlet 40 through which a flushing gas or a combination of flushing gases, such as those mentioned above, are supplied to remove oxygen from blood. Specifications for depletion device 20 are shown in Table 1 below. Table 1
  • a depletion device 45 like device 20 of Figs. 2a to 2c, includes a plurality of fibers 50, approximately 5000 in number, through which red blood cells flow. Plurality of fibers 50 are surrounded by a plastic cylinder 55. Plastic cylinder 55 contains a gas inlet 60 and a gas outlet 65 through which a gas or a combination of gases, such as those mentioned above are supplied to remove oxygen from blood. Specifications for depletion device 45 are shown in Table 2 below. The active surface area of depletion of device 45 is twice that of device 20 because device 45 is twice as long as device 20.
  • Figs. 4a through 4c disclose a depletion device 70 having a core 75 containing scavenging materials for 0 2 .
  • Core 75 is packed by a gas permeable film with very low liquid permeability.
  • Hollow fibers 80 are wound around core 75, and a plastic cylinder 82 contains and envelopes hollow fibers 80.
  • the active surface area for depletion is approximately 0.8796m 2 as shown in Table 3 below.
  • Figs. 5a through 5c disclose a depletion device 85 containing fiber bundles 87 enclosed in gas permeable film with very low liquid permeability. Fiber bundles 87 are surrounded by scavenger materials 89 for 0 2 . Fiber bundles 87 and scavenger materials 89 are contained within a plastic cylinder 90. The active surface area for depletion is
  • Fiber OD (microns): 200 200
  • Fig. 6 is a plot of the performance of flushing depletion devices 20
  • Fig. 6 The data of Fig. 6 was plotted using the following conditions: Hematocrit, 62% (pooled 3 units of pRBC), and 21°C at various head heights to produce different flow rates.
  • Oxygen scavenger Multisorb Technologies, Buffalo, NY
  • the hollow fibers In the oxygen depletion devices disclosed herein, the hollow fibers
  • Fig. 6 shows that lowest oxygen saturation is achieved using
  • Device 45 exhibits a larger active surface area exposed
  • Device 85 also has a long surface area
  • Device 85 has bundles 87
  • a further use of the depletion devices is to add back oxygen prior
  • reoxygenate transfused blood is not adequate, or sickle cell anemia.
  • depletion devices can be used to obtain intermediate
  • oxygen scavenger is a material that irreversibly binds to or combines with oxygen under the conditions of use.
  • oxygen can chemically react with some component of the material and be converted into another compound. Any material where the off-rate of bound oxygen is zero can serve as an oxygen scavenger.
  • oxygen scavengers include iron powders and organic compounds.
  • oxygen sorbent may be used interchangeably herein with oxygen scavenger.
  • oxygen scavengers are provided by Multisorb Technologies (Buffalo, NY). Such materials can be blended to a desired ratio to achieve desired results. It will be appreciated that scavengers can be incorporated into storage receptacles and bags in any known form, such as in sachets, patches, coatings, pockets, and packets.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • External Artificial Organs (AREA)
  • Packages (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Mechanical Engineering (AREA)
  • Gas Separation By Absorption (AREA)
PCT/US2010/052376 2009-10-12 2010-10-12 Oxygen depletion devices and methods for removing oxygen from red blood cells Ceased WO2011046963A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2012534293A JP2013507447A (ja) 2009-10-12 2010-10-12 酸素減損装置及び赤血球から酸素を除去する方法
BR112012008682A BR112012008682A2 (pt) 2009-10-12 2010-10-12 "dispositivo de depleção de oxigênio, e, método para remover oxigênio de células vermelhas do sangue."
EP10823965.8A EP2389064A4 (en) 2009-10-12 2010-10-12 OXYGEN DETECTION DEVICES AND METHOD FOR REMOVING OXYGEN FROM RED BLOOD CELLS
NZ599890A NZ599890A (en) 2009-10-12 2010-10-12 Oxygen depletion devices and methods for removing oxygen from red blood cells
CA2781874A CA2781874A1 (en) 2009-10-12 2010-10-12 Oxygen depletion devices and methods for removing oxygen from red blood cells
CN2010800564451A CN102905522A (zh) 2009-10-12 2010-10-12 用于从红细胞中除去氧的氧消耗装置和方法
AU2010306920A AU2010306920A1 (en) 2009-10-12 2010-10-12 Oxygen depletion devices and methods for removing oxygen from red blood cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25066109P 2009-10-12 2009-10-12
US61/250,661 2009-10-12

Publications (1)

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WO2011046963A1 true WO2011046963A1 (en) 2011-04-21

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PCT/US2010/052376 Ceased WO2011046963A1 (en) 2009-10-12 2010-10-12 Oxygen depletion devices and methods for removing oxygen from red blood cells

Country Status (9)

Country Link
US (2) US8569052B2 (enExample)
EP (1) EP2389064A4 (enExample)
JP (1) JP2013507447A (enExample)
CN (1) CN102905522A (enExample)
AU (1) AU2010306920A1 (enExample)
BR (1) BR112012008682A2 (enExample)
CA (1) CA2781874A1 (enExample)
NZ (1) NZ599890A (enExample)
WO (1) WO2011046963A1 (enExample)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9315775B2 (en) 2011-03-16 2016-04-19 Mayo Foundation For Medical Education And Research Methods and materials for prolonging useful storage of red blood cell preparations and platelet preparations
WO2016145210A1 (en) * 2015-03-10 2016-09-15 New Health Sciences, Inc. Oxygen reduction disposable kits, devices and methods of use thereof
WO2016187353A1 (en) * 2015-05-18 2016-11-24 New Health Sciences, Inc. Methods for the storage of whole blood, and compositions thereof
US9539375B2 (en) 2010-05-05 2017-01-10 New Health Sciences, Inc. Integrated leukocyte, oxygen and/or CO2 depletion, and plasma separation filter device
US9801784B2 (en) 2015-04-23 2017-10-31 New Health Sciences, Inc. Anaerobic blood storage containers
US9844615B2 (en) 2009-10-12 2017-12-19 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
US9877476B2 (en) 2013-02-28 2018-01-30 New Health Sciences, Inc. Gas depletion and gas addition devices for blood treatment
US9968718B2 (en) 2011-03-28 2018-05-15 New Health Sciences, Inc. Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
US10136635B2 (en) 2010-05-05 2018-11-27 New Health Sciences, Inc. Irradiation of red blood cells and anaerobic storage
US10251387B2 (en) 2010-08-25 2019-04-09 New Health Sciences, Inc. Method for enhancing red blood cell quality and survival during storage
US10583192B2 (en) 2016-05-27 2020-03-10 New Health Sciences, Inc. Anaerobic blood storage and pathogen inactivation method
US11284616B2 (en) 2010-05-05 2022-03-29 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US11662353B2 (en) 2020-09-10 2023-05-30 Functional Fluidics Inc. Method for assessing the effects of hypoxia on tissues
US12089589B2 (en) 2009-10-12 2024-09-17 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US12502462B2 (en) 2022-07-25 2025-12-23 Hemanext Inc. System for extended storage of red blood cells and methods of use

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2861272B1 (en) * 2012-06-15 2017-08-09 University of Pittsburgh - Of the Commonwealth System of Higher Education Systems for reducing the concentration of carbon dioxide in blood
WO2015054378A1 (en) * 2013-10-08 2015-04-16 Drexel University Novel microfluidic devices for diagnosing red blood cells abnormalities, and methods using same
KR102405257B1 (ko) * 2015-01-28 2022-06-03 삼성디스플레이 주식회사 표시 장치
ES2983933T3 (es) 2017-12-28 2024-10-28 I Sep Sistema y procedimiento de tratamiento del líquido hemorrágico para autotransfusión
FR3097770B1 (fr) 2019-06-27 2024-03-01 I Sep Système et procédé de traitement de liquide hémorragique pour de l’autotransfusion

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5624794A (en) * 1995-06-05 1997-04-29 The Regents Of The University Of California Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas
EP0890368A1 (en) * 1997-07-09 1999-01-13 SIS-TER S.p.A. Blood treatment apparatus
US20050230856A1 (en) * 2002-03-19 2005-10-20 Parekh Bipin S Hollow fiber membrane contact apparatus and process
US20080243045A1 (en) * 2003-10-03 2008-10-02 Medical Service S.R.L Apparatus and method for the treatment of blood

Family Cites Families (151)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4086924A (en) 1976-10-06 1978-05-02 Haemonetics Corporation Plasmapheresis apparatus
US4370160A (en) 1978-06-27 1983-01-25 Dow Corning Corporation Process for preparing silicone microparticles
US6150085A (en) 1998-09-16 2000-11-21 The United States Of America As Represented By The Secretary Of The Army Prolonged storage of red blood cells and composition
US6447987B1 (en) 1978-09-09 2002-09-10 The United States Of America As Represented By The Secretary Of The Army Prolonged storage of red blood cells
GB2035093B (en) 1978-10-26 1983-01-12 Baxter Travenol Lab Medical articles made of blood compatible polymers
US4228032A (en) 1978-11-06 1980-10-14 Dow Corning Corporation Method of storing blood and a blood storage bag therefore
US4381775A (en) 1980-02-05 1983-05-03 Takeda Chemical Industries, Ltd. Method for low pressure filtration of plasma from blood
US4267269A (en) 1980-02-05 1981-05-12 Baxter Travenol Laboratories, Inc. Red cell storage solution
DE3364674D1 (en) 1982-04-27 1986-08-28 Wellcome Found Tricyclic compounds, preparation, use and intermediates
US5310674A (en) 1982-05-10 1994-05-10 Bar-Ilan University Apertured cell carrier
JPS58194879U (ja) 1982-06-17 1983-12-24 三菱電機株式会社 電子ビ−ム溶接機
DE3225408A1 (de) 1982-07-07 1984-01-12 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Waessrige loesung zum suspendieren und lagern von zellen, insbesondere erythrozyten
US4670013A (en) 1982-12-27 1987-06-02 Miles Laboratories, Inc. Container for blood and blood components
US4540416A (en) 1983-08-18 1985-09-10 El Paso Polyolefins Company Heat-sterilizable polyolefin compositions and articles manufactured therefrom
US4701267B1 (en) 1984-03-15 1996-03-12 Asahi Medical Co Method for removing leukocytes
US5417986A (en) 1984-03-16 1995-05-23 The United States Of America As Represented By The Secretary Of The Army Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
EP0168755B1 (en) 1984-07-16 1991-04-17 Sumitomo Bakelite Company Limited Container and method for storing blood
US4585735A (en) 1984-07-19 1986-04-29 American National Red Cross Prolonged storage of red blood cells
US4654053A (en) 1984-07-27 1987-03-31 University Patents, Inc. Oxygen sorbent
US4748121A (en) 1984-11-30 1988-05-31 Ppg Industries, Inc. Porous glass fibers with immobilized biochemically active material
US4713176A (en) 1985-04-12 1987-12-15 Hemascience Laboratories, Inc. Plasmapheresis system and method
FR2581289A1 (fr) 1985-05-06 1986-11-07 Rgl Transfusion Sanguine Centr Solution synthetique pour la conservation prolongee de concentres erythrocytaires
KR890002855B1 (ko) 1985-06-26 1989-08-05 미쯔비시 가스 가가구 가부시기가이샤 시이트상 탈산소제 및 그 제조방법
IT1218450B (it) 1985-09-24 1990-04-19 Teresa Borgione Perfezionamenti agli ossigenatori per il sangue, a fibre cave
US4961928A (en) 1986-03-19 1990-10-09 American Red Cross Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets
US4769318A (en) 1986-06-03 1988-09-06 Ube Industries, Ltd. Additive solution for blood preservation and activation
JPS6363616A (ja) 1986-09-04 1988-03-22 Showa Denko Kk 赤血球濃厚液の保存剤及び保存方法
US4880786A (en) 1987-01-14 1989-11-14 Ube Industries, Ltd. Additive solution for blood preservation and activation
US5000848A (en) 1987-01-28 1991-03-19 Membrex, Inc. Rotary filtration device with hyperphilic membrane
CA1323271C (en) 1987-07-11 1993-10-19 Takanori Anazawa Membrane-type artificial lung and method of using it
US5192320A (en) 1987-07-11 1993-03-09 Dainippon Ink And Chemicals Inc. Artificial lung and method of using it
JPH07121340B2 (ja) 1987-07-11 1995-12-25 大日本インキ化学工業株式会社 中空繊維膜
DE3722984A1 (de) 1987-07-11 1989-01-19 Biotest Pharma Gmbh Waessrige loesung zum suspendieren und lagern von zellen, insbesondere erythrozyten
JP2700170B2 (ja) 1987-07-11 1998-01-19 大日本インキ化学工業株式会社 膜型人工肺
US4925572A (en) 1987-10-20 1990-05-15 Pall Corporation Device and method for depletion of the leukocyte content of blood and blood components
US4880548A (en) 1988-02-17 1989-11-14 Pall Corporation Device and method for separating leucocytes from platelet concentrate
JP2685544B2 (ja) 1988-11-11 1997-12-03 株式会社日立製作所 血液フィルタおよび血液検査方法並びに血液検査装置
US5229012A (en) 1989-05-09 1993-07-20 Pall Corporation Method for depletion of the leucocyte content of blood and blood components
DK0413378T3 (da) 1989-08-18 1995-05-15 Akzo Nobel Nv Escherichia coli vaccine
US5152905A (en) 1989-09-12 1992-10-06 Pall Corporation Method for processing blood for human transfusion
US5037419A (en) 1989-09-21 1991-08-06 Eastman Kodak Company Blood bag system containing vitamin E
IL95912A (en) 1989-10-06 1998-08-16 American Nat Red Cross Method for prolonging the shelf life or red blood cells
US5386014A (en) 1989-11-22 1995-01-31 Enzon, Inc. Chemically modified hemoglobin as an effective, stable, non-immunogenic red blood cell substitute
SU1718766A1 (ru) 1990-01-30 1992-03-15 Ленинградский научно-исследовательский институт гематологии и переливания крови Способ консервировани эритроцитов крови
US6187572B1 (en) 1990-04-16 2001-02-13 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants
JP2953753B2 (ja) 1990-06-28 1999-09-27 テルモ株式会社 血漿採取装置
DE69126861T2 (de) 1990-11-07 1998-02-26 Baxter Int Lösung zur aufbewahrung roter blutzellen
US5208335A (en) 1991-03-19 1993-05-04 Air Products And Chemicals, Inc. Reversible oxygen sorbent compositions
US5443743A (en) 1991-09-11 1995-08-22 Pall Corporation Gas plasma treated porous medium and method of separation using same
US5353793A (en) 1991-11-25 1994-10-11 Oishi-Kogyo Company Sensor apparatus
JP3337232B2 (ja) 1991-12-26 2002-10-21 東レ・ダウコーニング・シリコーン株式会社 シリコーン硬化物微粒子と無機質微粒子からなる粉体混合物の製造方法
US5356375A (en) 1992-04-06 1994-10-18 Namic U.S.A. Corporation Positive pressure fluid delivery and waste removal system
JP3177713B2 (ja) 1992-04-30 2001-06-18 科学技術振興事業団 輸血用血液または血液製剤の保存方法
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5529821A (en) 1992-06-29 1996-06-25 Terumo Kabushiki Kaisha Container for storing blood or blood component
US5427663A (en) 1993-06-08 1995-06-27 British Technology Group Usa Inc. Microlithographic array for macromolecule and cell fractionation
US5362442A (en) 1993-07-22 1994-11-08 2920913 Canada Inc. Method for sterilizing products with gamma radiation
US20010037978A1 (en) 1999-04-20 2001-11-08 Daryl R. Calhoun Filter assembly having a flexible housing and method of making same
CA2143365A1 (en) 1994-03-14 1995-09-15 Hugh V. Cottingham Nucleic acid amplification method and apparatus
ES2128055T3 (es) 1994-04-20 1999-05-01 Us Army Vacuna contra infecciones de bacterias gram-negativas.
US5617873A (en) 1994-08-25 1997-04-08 The United States Of America As Represented By The Administrator, Of The National Aeronautics And Space Administration Non-invasive method and apparatus for monitoring intracranial pressure and pressure volume index in humans
US5476764A (en) 1994-09-16 1995-12-19 The Regents Of The University Of California Method using CO for extending the useful shelf-life of refrigerated red blood cells
US6045701A (en) 1994-10-17 2000-04-04 Baxter International Inc. Method of filtering a fluid suspension with a membrane having a particular coating
US5730989A (en) 1995-02-16 1998-03-24 Novavax, Inc. Oral vaccine against gram negative bacterial infection
ATE447324T1 (de) 1995-03-23 2009-11-15 Biopure Corp Stabiles blutersatzmittel mit polymerisiertem hämoglobin
US5605934A (en) 1995-03-23 1997-02-25 Baxter International Inc. Method of manufacturing and storing solutions
US5691452A (en) 1995-03-23 1997-11-25 Biopure Corporation Method for preserving a hemoglobin blood substitute
AU5429396A (en) 1995-03-24 1996-10-16 American National Red Cross, The Rejuvenating outdated red cells
AU5309396A (en) 1995-04-13 1996-10-30 Travenol Laboratories (Israel) Ltd. Leukocyte filtration method and apparatus
US5716852A (en) 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US6527957B1 (en) 1995-08-09 2003-03-04 Baxter International Inc. Methods for separating, collecting and storing red blood cells
US5846427A (en) 1995-10-23 1998-12-08 Hemasure, Inc. Extra-lumenal crossflow plasmapheresis devices and method of use thereof
US5693230A (en) * 1996-01-25 1997-12-02 Gas Research Institute Hollow fiber contactor and process
US5698250A (en) 1996-04-03 1997-12-16 Tenneco Packaging Inc. Modifield atmosphere package for cut of raw meat
SE9601348D0 (sv) 1996-04-10 1996-04-10 Pharmacia Ab Improved containers for parenteral fluids
US6231770B1 (en) 1996-07-09 2001-05-15 Pall Corporation Multiple element filter and method of using therefor
US6254628B1 (en) 1996-12-09 2001-07-03 Micro Therapeutics, Inc. Intracranial stent
US5876604A (en) * 1996-10-24 1999-03-02 Compact Membrane Systems, Inc Method of gasifying or degasifying a liquid
EP2305110B1 (en) 1997-03-17 2018-04-11 Adidas AG Physiologic signs feedback system
US6482585B2 (en) 1997-04-16 2002-11-19 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Storage and maintenance of blood products including red blood cells and platelets
US6403124B1 (en) 1997-04-16 2002-06-11 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Storage and maintenance of blood products including red blood cells and platelets
US6162396A (en) * 1997-04-26 2000-12-19 The Regents Of The University Of California Blood storage device and method for oxygen removal
US5789151A (en) 1997-05-15 1998-08-04 The Regents Of The University Of California Prolonged cold storage of red blood cells by oxygen removal and additive usage
DE69834185T2 (de) 1997-05-20 2007-01-25 Zymequest, Inc., Beverly Optische Sensoren für Zellbehandlungssysteme
US6368871B1 (en) 1997-08-13 2002-04-09 Cepheid Non-planar microstructures for manipulation of fluid samples
EP1066337B1 (en) 1998-03-25 2004-11-03 Chevron Phillips Chemical Company Lp Oxygen scavengers with reduced oxidation products for use in plastic films and beverage and food containers
US6027623A (en) 1998-04-22 2000-02-22 Toyo Technologies, Inc. Device and method for electrophoretic fraction
US6090062A (en) 1998-05-29 2000-07-18 Wayne State University Programmable antisiphon shunt system
US6908553B1 (en) 1998-07-08 2005-06-21 Baxter International Inc. Composite membrane with particulate matter substantially immobilized therein
WO2000023140A1 (en) 1998-10-16 2000-04-27 Mission Medical, Inc. Blood processing system
US6413713B1 (en) 1998-10-30 2002-07-02 Hyperbaric Systems Method for preserving blood platelets
CA2287768C (en) 1998-11-02 2004-01-13 Ahmed Abdoh Method for automated data collection, analysis and reporting
US6475147B1 (en) 1999-01-27 2002-11-05 The United States Of America As Represented By The United States National Aeronautics And Space Administration Ultrasonic apparatus and technique to measure changes in intracranial pressure
US6582496B1 (en) 2000-01-28 2003-06-24 Mykrolis Corporation Hollow fiber membrane contactor
US6337026B1 (en) 1999-03-08 2002-01-08 Whatman Hemasure, Inc. Leukocyte reduction filtration media
US6945411B1 (en) 1999-03-16 2005-09-20 Pall Corporation Biological fluid filter and system
US6210601B1 (en) 1999-04-21 2001-04-03 Larry A. Hottle Method of making an oxygen scavenging sealant composition
US7371400B2 (en) 2001-01-02 2008-05-13 The General Hospital Corporation Multilayer device for tissue engineering
AU772484B2 (en) 1999-04-30 2004-04-29 Massachusetts General Hospital Fabrication of vascularized tissue using microfabricated two-dimensional molds
US6387461B1 (en) 1999-05-06 2002-05-14 Cryovac, Inc. Oxygen scavenger compositions
US6629919B2 (en) 1999-06-03 2003-10-07 Haemonetics Corporation Core for blood processing apparatus
US6610772B1 (en) 1999-08-10 2003-08-26 Eastman Chemical Company Platelet particle polymer composite with oxygen scavenging organic cations
JP2003525736A (ja) * 2000-03-07 2003-09-02 エムアーテー アツォルプツィオーン テヒノロギース ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディートゲゼルシャフト クロスフロー及びデッドエンドの構成の膜エレメントを有するモジュール
US6468732B1 (en) 2000-04-04 2002-10-22 Bayer Corporation Method and long-term stable bicarbonate-containing diluent composition, and storage means therefor, for reducing or reversing aeration induced cell shrinkage and storage induced cell swelling of a whole blood sample
US7904313B2 (en) 2000-08-24 2011-03-08 Quintiles, Inc. Recruiting a patient into a clinical trial
US20030135152A1 (en) 2000-09-27 2003-07-17 Kollar Kevin J. Disposable cartridge for a blood perfusion system
US7208120B2 (en) 2000-09-27 2007-04-24 The Trustees Of Boston University Cellular diagnostic arrays, methods of using and processing for producing same
US7104958B2 (en) 2001-10-01 2006-09-12 New Health Sciences, Inc. Systems and methods for investigating intracranial pressure
US6955648B2 (en) 2000-09-29 2005-10-18 New Health Sciences, Inc. Precision brain blood flow assessment remotely in real time using nanotechnology ultrasound
US7604599B2 (en) 2000-09-29 2009-10-20 New Health Sciences, Inc. Systems and methods for using dynamic vascular assessment to improve vascular stent placement, application, design and marketing
US6699193B2 (en) 2000-09-29 2004-03-02 New Health Sciences, Inc. Decision support systems and methods for assessing vascular health
US6770434B2 (en) 2000-12-29 2004-08-03 The Provost, Fellows And Scholars Of The College Of The Holy & Undivided Trinity Of Queen Elizabeth Near Dublin Biological assay method
JP2002253936A (ja) * 2001-02-28 2002-09-10 Japan Gore Tex Inc 分離膜チューブ及び分離膜モジュール
US6974447B2 (en) 2001-04-17 2005-12-13 Baxter International Inc. High gas barrier receptacle and closure assembly
US6697667B1 (en) 2001-05-31 2004-02-24 Advanced Cardiovascular Systems, Inc. Apparatus and method for locating coronary sinus
ATE425995T1 (de) 2001-07-31 2009-04-15 Asahi Kasei Medical Co Ltd Leukozytenfilter mit polymerbeschichtung
US7909788B2 (en) 2001-08-01 2011-03-22 Battelle Memorial Institute Carbon dioxide removal from whole blood by photolytic activation
US20030124504A1 (en) 2001-11-16 2003-07-03 Bitensky Mark W. Additive solution for blood preservation
US20030153074A1 (en) 2001-11-16 2003-08-14 Bitensky Mark W. Method for extending the useful shelf-life of refrigerated red blood cells by nutrient supplementation
US6761695B2 (en) 2002-03-07 2004-07-13 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Method and apparatus for non-invasive measurement of changes in intracranial pressure
US20030183801A1 (en) 2002-03-28 2003-10-02 Hu Yang Porous oxygen scavenging material
US6773407B2 (en) 2002-04-08 2004-08-10 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Non-invasive method of determining absolute intracranial pressure
US6767466B2 (en) 2002-04-08 2004-07-27 Teva Medical Ltd. Leukocyte filter construction
WO2003089027A2 (en) 2002-04-16 2003-10-30 Gambro, Inc. Blood component processing system, apparatus and method
US6817979B2 (en) 2002-06-28 2004-11-16 Nokia Corporation System and method for interacting with a user's virtual physiological model via a mobile terminal
JP2004089495A (ja) 2002-08-30 2004-03-25 Terumo Corp バッグ連結体
US20080160107A1 (en) 2002-09-10 2008-07-03 Nitric Biotherapeutics, Inc. Use of nitric oxide gas to treat blood and blood products
DE10327988B4 (de) 2002-12-18 2009-05-14 Alpha Plan Gmbh Filtermodul zur Aufbereitung von Flüssigkeiten
ITTO20030039A1 (it) 2003-01-24 2004-07-25 Fresenius Hemocare Italia Srl Filtro per separare leucociti da sangue intero e/o da preparati derivati dal sangue, procedimento per la fabbricazione del filtro, dispositivo e utilizzazione.
US8828226B2 (en) 2003-03-01 2014-09-09 The Trustees Of Boston University System for assessing the efficacy of stored red blood cells using microvascular networks
US7517453B2 (en) 2003-03-01 2009-04-14 The Trustees Of Boston University Microvascular network device
US7754798B2 (en) 2003-08-28 2010-07-13 Cryovac, Inc. Oxygen scavenger block copolymers and compositions
US7078100B2 (en) 2003-08-28 2006-07-18 Cryovac, Inc. Oxygen scavenger compositions derived from isophthalic acid and/or terephthalic acid monomer or derivatives thereof
US20050137517A1 (en) 2003-12-19 2005-06-23 Baxter International Inc. Processing systems and methods for providing leukocyte-reduced blood components conditioned for pathogen inactivation
US7347887B2 (en) 2003-12-22 2008-03-25 The Boc Group, Inc. Oxygen sorbent compositions and methods of using same
WO2005066042A2 (en) 2003-12-24 2005-07-21 Cryovac, Inc. Oxygen scavenger compositions
US9314014B2 (en) 2004-02-18 2016-04-19 University Of Maryland, Baltimore Compositions and methods for the storage of red blood cells
WO2006031385A2 (en) 2004-08-24 2006-03-23 The General Hospital Corporation Particle separating devices, systems and methods
US20060081524A1 (en) 2004-10-15 2006-04-20 Amitava Sengupta Membrane contactor and method of making the same
KR100721054B1 (ko) 2004-11-23 2007-05-25 주식회사 뉴하트바이오 혈액정화 및/또는 혈액산화용 필터모듈, 그를 이용한혈액정화 및 혈액산화 방법 그리고 그를 포함하는혈액정화 장치
US20100221697A1 (en) 2005-01-12 2010-09-02 BioVec Transfusions, LLC Composition for preserving platelets and method of using and storing the same
AU2006236150A1 (en) 2005-04-20 2006-10-26 Fred Hutchinson Cancer Research Center Methods, compositions and articles of manufacture for enhancing survivability of cells, tissues, organs, and organisms
JP4584018B2 (ja) * 2005-05-09 2010-11-17 日東電工株式会社 脱気装置
CN2894710Y (zh) 2006-03-31 2007-05-02 天津市海河医院 医用血气交换器
US8377172B2 (en) 2009-06-11 2013-02-19 Georgia Tech Research Corporation Fiber sorbents
NZ598410A (en) * 2009-07-31 2014-04-30 Univ Pittsburgh Removal of oxygen from biological fluids
JP6199557B2 (ja) 2009-10-12 2017-09-20 ニュー ヘルス サイエンシーズ、インク．Ｎｅｗ Ｈｅａｌｔｈ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． 酸素及び二酸化炭素の減損能力をもつ血液保存袋システム及び減損装置
PT2608816T (pt) 2010-08-25 2023-10-12 Dartmouth College Método para melhorar a qualidade e a sobrevivência dos glóbulos vermelhos durante o armazenamento
JP5859558B2 (ja) 2010-11-05 2016-02-10 ニュー・ヘルス・サイエンシーズ・インコーポレイテッドＮｅｗ Ｈｅａｌｔｈ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． 赤血球の照射及び嫌気性保存
US20120219633A1 (en) 2011-02-28 2012-08-30 Pall Corporation Removal of immunoglobulins and leukocytes from biological fluids
US9174771B2 (en) 2013-03-15 2015-11-03 Sangart, Inc. Packaging system for preserving a nonoxygenated hemoglobin based oxygen therapeutic product

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5624794A (en) * 1995-06-05 1997-04-29 The Regents Of The University Of California Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas
EP0890368A1 (en) * 1997-07-09 1999-01-13 SIS-TER S.p.A. Blood treatment apparatus
US20050230856A1 (en) * 2002-03-19 2005-10-20 Parekh Bipin S Hollow fiber membrane contact apparatus and process
US20080243045A1 (en) * 2003-10-03 2008-10-02 Medical Service S.R.L Apparatus and method for the treatment of blood

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2389064A4 *

Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12089589B2 (en) 2009-10-12 2024-09-17 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US11433164B2 (en) 2009-10-12 2022-09-06 Hemanext Inc. System for extended storage of red blood cells and methods of use
US9844615B2 (en) 2009-10-12 2017-12-19 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
US10603417B2 (en) 2009-10-12 2020-03-31 Hemanext Inc. System for extended storage of red blood cells and methods of use
US10065134B2 (en) 2010-05-05 2018-09-04 New Health Sciences, Inc. Integrated leukocyte, oxygen and/or CO2 depletion, and plasma separation filter device
US9539375B2 (en) 2010-05-05 2017-01-10 New Health Sciences, Inc. Integrated leukocyte, oxygen and/or CO2 depletion, and plasma separation filter device
US11284616B2 (en) 2010-05-05 2022-03-29 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US10136635B2 (en) 2010-05-05 2018-11-27 New Health Sciences, Inc. Irradiation of red blood cells and anaerobic storage
US10251387B2 (en) 2010-08-25 2019-04-09 New Health Sciences, Inc. Method for enhancing red blood cell quality and survival during storage
US9315775B2 (en) 2011-03-16 2016-04-19 Mayo Foundation For Medical Education And Research Methods and materials for prolonging useful storage of red blood cell preparations and platelet preparations
US9968718B2 (en) 2011-03-28 2018-05-15 New Health Sciences, Inc. Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
US9877476B2 (en) 2013-02-28 2018-01-30 New Health Sciences, Inc. Gas depletion and gas addition devices for blood treatment
JP2019065039A (ja) * 2013-02-28 2019-04-25 ニュー・ヘルス・サイエンシーズ・インコーポレイテッドＮｅｗ Ｈｅａｌｔｈ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． 血液処理のためのガス枯渇化およびガス添加デバイス
US10687526B2 (en) 2013-02-28 2020-06-23 Hemanext Inc. Gas depletion and gas addition devices for blood treatment
US10058091B2 (en) 2015-03-10 2018-08-28 New Health Sciences, Inc. Oxygen reduction disposable kits, devices and methods of use thereof
WO2016145210A1 (en) * 2015-03-10 2016-09-15 New Health Sciences, Inc. Oxygen reduction disposable kits, devices and methods of use thereof
CN107530377A (zh) * 2015-03-10 2018-01-02 新健康科学股份有限公司 氧减少一次性套件、装置及其使用方法
US11638421B2 (en) 2015-03-10 2023-05-02 Hemanext Inc. Oxygen reduction disposable kits, devices and methods of use thereof
US11375709B2 (en) 2015-03-10 2022-07-05 Hemanext Inc. Oxygen reduction disposable kits, devices and methods of use thereof
CN107530377B (zh) * 2015-03-10 2021-09-03 新健康科学股份有限公司 氧减少一次性套件、装置及其使用方法
US11350626B2 (en) 2015-03-10 2022-06-07 Hemanext Inc. Oxygen reduction disposable kits, devices and methods of use thereof (ORDKit)
US9801784B2 (en) 2015-04-23 2017-10-31 New Health Sciences, Inc. Anaerobic blood storage containers
US10849824B2 (en) 2015-04-23 2020-12-01 Hemanext Inc. Anaerobic blood storage containers
US12201584B2 (en) 2015-04-23 2025-01-21 Hemanext Inc. Anaerobic blood storage containers
US11013771B2 (en) 2015-05-18 2021-05-25 Hemanext Inc. Methods for the storage of whole blood, and compositions thereof
WO2016187353A1 (en) * 2015-05-18 2016-11-24 New Health Sciences, Inc. Methods for the storage of whole blood, and compositions thereof
US11147876B2 (en) 2016-05-27 2021-10-19 Hemanext Inc. Anaerobic blood storage and pathogen inactivation method
US11911471B2 (en) 2016-05-27 2024-02-27 Hemanext Inc. Anaerobic blood storage and pathogen inactivation method
US10583192B2 (en) 2016-05-27 2020-03-10 New Health Sciences, Inc. Anaerobic blood storage and pathogen inactivation method
US12364760B2 (en) 2016-05-27 2025-07-22 Hemanext Inc. Anaerobic blood storage and pathogen inactivation method
US11662353B2 (en) 2020-09-10 2023-05-30 Functional Fluidics Inc. Method for assessing the effects of hypoxia on tissues
US12502462B2 (en) 2022-07-25 2025-12-23 Hemanext Inc. System for extended storage of red blood cells and methods of use

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US8569052B2 (en) 2013-10-29
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