WO2011019393A3 - Inhibiteurs de hdac classe- et isoforme-spécifiques et utilisations de ceux-ci - Google Patents

Inhibiteurs de hdac classe- et isoforme-spécifiques et utilisations de ceux-ci Download PDF

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Publication number
WO2011019393A3
WO2011019393A3 PCT/US2010/002220 US2010002220W WO2011019393A3 WO 2011019393 A3 WO2011019393 A3 WO 2011019393A3 US 2010002220 W US2010002220 W US 2010002220W WO 2011019393 A3 WO2011019393 A3 WO 2011019393A3
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hdac
isoform
class
inhibitors
hdac inhibitors
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PCT/US2010/002220
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WO2011019393A2 (fr
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Ralph Mazitschek
James Elliot Bradner
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President And Fellows Of Harvard College
Dana-Farber Cancer Institute, Inc.
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Application filed by President And Fellows Of Harvard College, Dana-Farber Cancer Institute, Inc. filed Critical President And Fellows Of Harvard College
Priority to US13/389,814 priority Critical patent/US8716344B2/en
Publication of WO2011019393A2 publication Critical patent/WO2011019393A2/fr
Publication of WO2011019393A3 publication Critical patent/WO2011019393A3/fr
Priority to US14/271,170 priority patent/US9540317B2/en
Priority to US15/399,550 priority patent/US10059657B2/en

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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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Abstract

La présente invention concerne des inhibiteurs de HDAC de formule générale (I) et (II) et des sels pharmaceutiquement acceptables de ceux-ci qui sont utiles en tant qu'inhibiteurs de désacétylases d'histone ou d'autres désacétylases, et par conséquent sont utiles pour le traitement de différents troubles et maladies associés à l'activité acétylase/désacétylase (par exemple, le cancer). Dans certains modes de réalisation, les composés de l'invention ciblent sélectivement une classe ou un isoforme de la famille HDAC. Un autre aspect de l'invention concerne un essai pour déterminer l'effet inhibiteur d'un composé d'essai sur une protéine HDAC comprenant : l'incubation de la protéine HDAC avec un substrat de formule générale (IIIc) en présence d'un composé d'essai ; et la détermination de l'activité de la protéine HDAC.
PCT/US2010/002220 2009-08-11 2010-08-11 Inhibiteurs de hdac classe- et isoforme-spécifiques et utilisations de ceux-ci WO2011019393A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US13/389,814 US8716344B2 (en) 2009-08-11 2010-08-11 Class- and isoform-specific HDAC inhibitors and uses thereof
US14/271,170 US9540317B2 (en) 2009-08-11 2014-05-06 Class- and isoform-specific HDAC inhibitors and uses thereof
US15/399,550 US10059657B2 (en) 2009-08-11 2017-01-05 Class-and isoform-specific HDAC inhibitors and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23303509P 2009-08-11 2009-08-11
US61/233,035 2009-08-11

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US13/389,814 A-371-Of-International US8716344B2 (en) 2009-08-11 2010-08-11 Class- and isoform-specific HDAC inhibitors and uses thereof
US201213389814A A-371-Of-International 2009-08-11 2012-04-24
US14/271,170 Continuation US9540317B2 (en) 2009-08-11 2014-05-06 Class- and isoform-specific HDAC inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
WO2011019393A2 WO2011019393A2 (fr) 2011-02-17
WO2011019393A3 true WO2011019393A3 (fr) 2011-06-16

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PCT/US2010/002220 WO2011019393A2 (fr) 2009-08-11 2010-08-11 Inhibiteurs de hdac classe- et isoforme-spécifiques et utilisations de ceux-ci

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US (3) US8716344B2 (fr)
WO (1) WO2011019393A2 (fr)

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WO2011019393A2 (fr) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Inhibiteurs de hdac classe- et isoforme-spécifiques et utilisations de ceux-ci
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JP2019515909A (ja) 2016-04-19 2019-06-13 アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 慢性リンパ性白血病の治療を目的とするｈｄａｃ阻害剤単独またはｂｔｋ阻害剤との配合物
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CN113754625B (zh) * 2020-06-01 2023-04-18 沈阳药科大学 倍半萜香豆素类化合物及其制备方法和应用
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