WO2010094307A1 - Treating device for treating a body part of a patient with a non-thermal plasma - Google Patents

Treating device for treating a body part of a patient with a non-thermal plasma Download PDF

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Publication number
WO2010094307A1
WO2010094307A1 PCT/EP2009/007478 EP2009007478W WO2010094307A1 WO 2010094307 A1 WO2010094307 A1 WO 2010094307A1 EP 2009007478 W EP2009007478 W EP 2009007478W WO 2010094307 A1 WO2010094307 A1 WO 2010094307A1
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WO
WIPO (PCT)
Prior art keywords
housing
treating device
plasma
electrodes
treating
Prior art date
Application number
PCT/EP2009/007478
Other languages
French (fr)
Other versions
WO2010094307A8 (en
Inventor
Gregor Morfill
Bernd Steffes
Tetsuji Shimizu
Original Assignee
Max-Planck-Gesellschaft Zur Förderung Der ...
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Filing date
Publication date
Application filed by Max-Planck-Gesellschaft Zur Förderung Der ... filed Critical Max-Planck-Gesellschaft Zur Förderung Der ...
Priority to EP09736863A priority Critical patent/EP2398507A1/en
Priority to JP2011550420A priority patent/JP2012517867A/en
Priority to US13/201,852 priority patent/US20120039747A1/en
Priority to CN2009801569411A priority patent/CN102316905A/en
Publication of WO2010094307A1 publication Critical patent/WO2010094307A1/en
Publication of WO2010094307A8 publication Critical patent/WO2010094307A8/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/14—Plasma, i.e. ionised gases
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • H05H1/2406—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • H05H1/2406—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes
    • H05H1/2431—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes using cylindrical electrodes, e.g. rotary drums
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • H05H1/2406—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes
    • H05H1/2443—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes the plasma fluid flowing through a dielectric tube

Definitions

  • the invention relates to a treating device for treating a body part of a patient with a non-thermal plasma, particularly for sterilizing a hand of a human being.
  • non-thermal plasma for the treatment of wounds and especially for the in-vivo sterilization, decontamination or disinfection of wounds is disclosed, for example, in WO 2007/031250 Al, EP 1 925 190 Al and PCT/EP2008/003568.
  • the known devices for plasma treatment are suitable to only a limited extent for the in-vivo sterilization of a hand of a human being.
  • WO 02/099836 Al describes an apparatus and method using capillary discharge plasma shower for steriliz- ing and disinfecting articles.
  • this apparatus is suitable to only a limited extend for the in-vivo sterilization of a hand, in particular due to the turbulences caused by the shower.
  • the sterilizing and disinfection ability of this device is limited by the copious amounts of reactive gases introduced into the atmosphere - which may lead to health hazards. Summary of the invention
  • the treating device according to the invention comprises a housing for temporarily receiving a body part which is to be sterilized within the housing during the treatment and for applying the non-thermal plasma to the body part within the housing. Therefore, the treating device according to the in- vention is different in nature from conventional treating devices in which the object of the treatment (e.g. a hand) is located outside a plasma applicator so that the plasma applicator must be moved along the surface of the object of treatment so that the non-thermal plasma is applied to the entire surface of the object of treatment.
  • the non-thermal plasma is applied to the object of treatment while the invention provides that the object of treatment (e.g. a hand of a human being) is introduced into the non-thermal plasma so that the object of treatment is completely surrounded by the non-thermal plasma.
  • the housing of the treating device according to the invention comprises an inlet opening for introducing the body part (e.g. a hand of a human being) through the inlet opening into the housing so that the plasma treatment takes place within the housing.
  • body part e.g. a hand of a human being
  • the treating device according to the invention is particularly suitable for the in-vivo sterilization of a hand of a human being.
  • the treating device according to the invention can also be used for the plasma treatment of other body parts of a patient, e.g. a foot or a forearm including a hand and preferably further including an elbow of a human be- ing.
  • the object of treatment can be a non- biological article like a surgical instrument, an implant, for example a heart pacemaker, a stent, an artificial joint, or other devices to be sterilized.
  • the treating device according to the invention preferably comprises an integrated plasma generator for generating the non-thermal plasma within the housing. Therefore, the plasma generator is preferable an integral part of the treating device.
  • the treating device merely comprises an inlet for introducing the plasma into the housing wherein the plasma is generated outside the housing by a separate plasma generator which can be connected with the in- let of the treating device via a hose.
  • the plasma generator comprises at least two electrodes and a barrier between the electrodes, so that the plasma is generated between the electrodes by a dielectric barrier discharge (DBD) , which is per se known in the state of the art. Therefore, the barrier between the electrodes preferably consists of an electrically insulating and/or dielectric material, particularly polytetraflouroethylene .
  • the electrodes can be adhered to the barrier on opposite sides of the barrier.
  • the at least two electrodes can be provided in a plurality of manners.
  • at least one of the electrodes can be provided as a single wire.
  • at least one of the electrodes is provided spirally, or wound, or flat, or like a cooling coil, or in a meandering manner.
  • At least one of the electrodes can comprise several perforations, which are distributed over the electrode. Therefore, the plasma can be produced within the perforations of the electrode.
  • At least one of the first electrode and the second electrode comprises a wire-mesh, wherein the aforementioned perforations are arranged between individual meshes of the wire-mesh.
  • each mesh of the wire-mesh forms one of the afore-mentioned perforations.
  • At least one of the first electrode and the second electrode comprises a perforated plate in which the afore-mentioned perforations are arranged.
  • the plate can be made of copper or aluminium wherein the perforations in the plate are punched out of the plate.
  • both electrodes of the electrode arrangement consist of perforated plates, which are separated by the dielectric barrier.
  • At least one of the first and second electrodes consists of parallel wires or stripes made of an electrically conductive material.
  • the perforations are preferably equally distributed over the electrode surface so that the intensity of the plasma generation is also equally distributed over the surface of the electrode.
  • the first electrode comprises a plate made of an electrically conductive material, wherein the plate is preferably massive and does not comprise any perforations.
  • the dielectric barrier is substantially layer-shaped and formed on a surface of the plate.
  • the dielectric barrier can have a thickness in the range of 0.5-lmm.
  • the second electrode comprises either the afore- mentioned wire-mesh or a perforated plate made of an electrically conductive material.
  • the first electrode formed as a massive plate is preferably energized with an alternating current with a voltage of 10-2OkV and a typical electrical current of 10-3OmA while the second electrode formed as a wire-mesh is preferably electrically grounded.
  • both the first electrode and the second electrode comprise a wire-mesh while the dielectric barrier comprises a cladding made of an electrically insulating and dielectric material surrounding the wires of at least one of the first electrode and the second electrode thereby electrically insulating the first electrode from the second electrode.
  • the electrically insulating and di- electric cladding of the individual wires of the wire-mesh forms the dielectric barrier.
  • the first electrode and the second electrode are attached to each other, preferably by an adhesive bond, so that the wire-meshes of the first and second electrodes are contacting each other physically.
  • both the first electrode and the second electrode comprise a cladding surrounding the individual wires of the wire-mesh thereby forming the dielectric barrier.
  • merely one of the first and second electrodes comprises a cladding surrounding the individual wires of the wire-mesh thereby forming the dielectric barrier.
  • only one of the first and second electrodes is electrically insulated by a cladding while the other one of the first and second electrodes is not insulated by a cladding.
  • the invention is not re- stricted to embodiments comprising just two electrodes.
  • the electrodes are preferably adhered to each other. It is also possible that the dielectric barrier is adhered to at least one of the first and second electrodes.
  • the electrode arrangement is substantially two- dimensional, flat and deformable so that the shape of the entire electrode arrangement can be adapted to the contour of a body part, which is to be treated.
  • the electrode arrangement further comprises a cover which is covering the electrode arrangement.
  • the cover can be adapted to increase the local density of the reactive species of the plasma thereby reducing the time needed for sterilization. Further, the cover can be adapted to filter out unused reactive species. It is further possible to adapt the cover to effect a better control of the plasma. Finally, the cover can be adapted so that the electrode ar- rangement can operate under reduced pressure.
  • the dielectric barrier may consist of an electrically insulating and dielectric material.
  • the dielectric barrier preferably consists of ceramics if high performance is desired.
  • the dielectric barrier can be made of poly- tetrafluoroethylene if a lower performance of the electrode arrangement is sufficient.
  • the dielectric barrier can be made of polyethylene terephtalate (PET), flexible or rigid glass-ceramic, glas, Mylar®, casting ceramic or ox- ides.
  • PET polyethylene terephtalate
  • the melting point of the dielectric material should preferably be over +100 0 C.
  • the invention is not restricted to an electrode arrangement as a single component.
  • the invention rather comprises a complete apparatus for plasma treatment comprising the afore-mentioned electrode arrangement for generating the non-thermal plasma.
  • the electrode (s) is/are preferably connected with a high voltage generator, which can be arranged separate from the treating device.
  • the housing of the treating device according to the invention is preferably box-shaped, whereas there are two of the afore mentioned sandwich-like DBD arrangements within the housing above and below the area of treatment.
  • the DBD arrangements can be mounted on opposing sides of the housing so that one DBD arrangement is mounted on the left side of the housing, whereas the other DBD arrangement is mounted on the right side of the housing.
  • the afore-mentioned sandwich-like DBD arrangement preferably comprises an outer electric insulation, which is electrically insulating the outer electrode of the plasma generator .
  • the gap there is preferably a gap between the outer elec- trie insulation of the sandwich-like DBD arrangement and the housing, wherein said gap allows a gas flow through the gap.
  • This is advantageous since the plasma generated in the DBD arrangement must reach the area of treatment in the centre of the housing so that there must be a gas flow within the hous- ing.
  • the gas flow within the housing can be generated by natural convection due to the different temperatures within the gas volume.
  • the gas circulation within the housing of the treating device is at least partially caused by a pump, which is preferably ar- ranged separate from the treating device.
  • the treating device includes a waste gas filter.
  • the waste gas filter is arranged and configured to filter waste gas from within the housing.
  • a ventilator or another suitable means can be provided in order to urge (pull/push) the waste gas from within the housing to the waste gas filter.
  • the plasma generator is preferably arranged within the housing so that the plasma is generated within the housing. Therefore, the treating device according to the invention is different in nature from conventional therapeutic concepts in which the area of treatment and the area of plasma generation are separated from each other. On the contrary, the invention provides that the area of treatment and the area of plasma generation are at least overlapping or even identical.
  • the treat- ing device preferably comprises a radiation shielding being arranged between the plasma generator and the area of treatment within the housing thereby shielding the treated body part against the UV radiation generated by the plasma generator.
  • the afore-mentioned radiation shielding is preferably gas permeable so that the plasma can flow through the radiation shielding and reach the body part which is to be treated. This is important since the plasma treatment re- quires a physical contact between the non-thermal plasma and the body part which is to be treated.
  • the radiation shielding comprises several spaced apart UV blocking shielding elements which are preferably curved or angled in such a way that there is no intervisibility between the opposing sides of the radiation shielding while the gas flow between the opposing sides of the radiation shielding is not substantially constricted.
  • the shielding elements are preferably lamellas which are arranged in at least two adjacent layers wherein the lamellas in the adjacent layers are oppositely angled.
  • the radiation shielding and/or the shielding elements e.g. lamellas
  • the radiation shielding and/or the shielding elements preferably consist of or a coated with an electrically conductive material so that there is not charge build-up on the surface of the shielding elements.
  • the electrically conductive material of the radiation shielding is preferably metal, particularly copper or tin. It should further be mentioned that the radiation shielding and/or the shielding elements are preferably electrically grounded.
  • the electrodes, the barrier and the outer insulation of the afore mentioned DBD arrangement are preferably flat or layer-shaped. Further, the electrodes can comprise a wire mesh.
  • the treating device preferably comprises a spacer which is arranged between the area of treatment on the one hand and the plasma generator on the other hand thereby preventing a physical contact between the plasma generator and the body part during treatment.
  • the spacer is preferably sub- stantially flat and/or comprises a wire mesh.
  • the spacer is configured and arranged to support the object to be treated within the housing.
  • the housing of the novel treating device preferably comprises an outer wall consisting of an electrically conductive material which is preferably electrically grounded.
  • the dimensions of the housing are preferably adapted to the size of a hand of a human being so that a patient can introduce his hand through the inlet opening into the housing for sterilizing his hand. Therefore, the inlet opening of the housing preferably comprises a height in the range of 2cm- 20cm and a width in the range of 5cm-30cm. It is preferred that the inlet opening of the housing comprises a width of 10cm and a height of 4cm.
  • the housing is preferably sufficiently large for introducing a hand of a human being into the housing so that the entire hand can be sterilized within the housing. Therefore, the housing preferably comprises an inner length in the range of 5cm-30cm with a preferred value of the inner length of about ll-12cm. Further, the housing preferably comprises an inner width in the range of 5cm-30cm with a preferred value of the width of about ll-12cm. Finally, the housing preferably comprises an inner height in the range of 4cm-20cm with a preferred value of the inner height of about 7cm.
  • the dimensions of the housing are preferably adapted to the size of a forearm including a hand and preferably further including an elbow of a human being so that a patient can introduce his forearm including his hand and preferably further including his elbow through the inlet opening into the housing for sterilizing his forearm including his hand and preferably including his elbow.
  • the housing is preferably sufficiently large for introducing a forearm including a hand and preferably further including an elbow of a human being into the housing so that the entire forearm including the hand and preferably further including the elbow can be sterilized within the housing.
  • the dimensions of the housing are preferably adapted to the size of a foot of a human being.
  • the non-thermal plasma according to the invention preferably comprises a gas temperature (i.e. the temperature of the atoms and molecules) below +40 0 C, when measured on the treated surface.
  • the treating device can include an on/off-switch for switching the integrated plasma generator on and off.
  • a light barrier which detects whether an object of treatment (e.g. a hand) is inserted through the inlet opening into the housing.
  • the light barrier can be coupled with the plasma generator so that the plasma generator is switched off if no object is introduced through the inlet opening, whereas the plasma generator is switched on if an object of treatment is present within the housing.
  • the treating device is configured to provide an after glow within the housing for treating the object with the non-thermal plasma, particularly for the in- vivo sterilization of a hand or a forearm including a hand and preferably including an elbow of a human being.
  • the plasma generator does not produce plasma.
  • plasma within the housing is effective for treating an object, particularly for the in-vivo sterili- zation.
  • the use of the after glow can decrease the energy consumption of the treating device.
  • the use of the after glow can increase the usage safety of the treating device since no object, in particular no part of a human being or other sensible objects/devices, is introduced within the housing when the plasma is generated (power on) .
  • the plasma generator can be switched on and af- ter, for example, 2 sec. switched off.
  • the plasma generated within the 2 sec. remains effective within the housing for a certain time span after switching off for treating an object, particularly for the in-vivo sterilization.
  • the treating device includes indicating means for indicating the beginning and the end of the after glow.
  • the treating device can include an opening/closing means for closing the inlet opening during plasma generating and opening the inlet opening after plasma generating.
  • the opening/closing means is closed and locked during plasma generating and opens only when the plasma generator does not generates plasma.
  • the plasma generator, the indicating means and/or the opening/closing means are controlled based on one or more predetermined time spans.
  • Figure 1 shows a perspective view of a preferred embodiment of a treating device according to the invention.
  • Figure 2 shows another perspective view of the treating device according to Figure 1.
  • Figure 3 shows a cross sectional view of the treating device shown in Figures 1 and 2.
  • Figure 4 shows a schematic view of a plasma generator using dielectric barrier discharge.
  • Figure 5 shows a cross sectional view of the radiation shielding shown in Figure 4.
  • Figure 6 shows a cross sectional view similar to Figure 3 but also showing the design of the radiation shielding.
  • Figure 7A shows a perspective view of a side plate of the housing of the treating device.
  • Figure 7B shows a perspective view of the isolator of the DBD arrangement.
  • Figure 7C shows a perspective view of the front plate of the treating device with an inlet opening.
  • Figure 7D shows a perspective view of an intermediate plate of the treating device.
  • Figure 7E shows a perspective view of a rear plate of the treating device comprising an opening for cables.
  • Figure 7F shows a perspective view of an upper and lower plate of the housing.
  • Figure 7G shows an exemplary embodiment of the electrodes of the afore mentioned DBD arrangement.
  • FIG 8 shows another embodiment of an electrode arrangement which can be used for plasma generation instead of the DBD arrangement.
  • Figure 9A shows a perspective view of a preferred embodiment of a DBD electrode arrangement comprising a plate as a first electrode and a wire-mesh as a second electrode.
  • Figure 9B shows a sectional view of the electrode arrangement according to Figure 9A.
  • Figure 10 shows a perspective view of an electrode arrangement comprising two wire-meshs.
  • Figure 11 shows a perspective view of a junction of the wires of several wire-meshs.
  • Figure 12 shows a perspective view of a junction of two insulated wires.
  • Figure 13 shows a modification of the electrode arrangement according to Figure 10 additionally comprising a cover.
  • Figure 14 shows a cross-sectional view of a sandwich-like DBD electrode arrangement comprising three electrodes.
  • Figure 15 shows a sectional view of a modification of the embodiment according to Figures 9A and 9B, wherein a wire-mesh is embedded into the dielectric barrier.
  • Figures 16A and 16B are schematic views illustrating different uses of an after glow.
  • FIG. 1 illustrates a preferred embodiment of a treating device 1 for the in-vivo sterilization of a hand or a forearm including a hand and preferably further including an elbow of a human being by means of a non-thermal plasma.
  • the treating device 1 comprises a box-shaped housing 2 with an inlet opening 3 at the front side of the housing 2 wherein the dimensions of the inlet opening 3 are adapted to the size of a hand of a human being so that a patient can introduce his hand through the inlet opening 3 into the housing 2 of the treating device 1. Further, the dimensions of the entire housing 2 are adapted to the size of a hand of a human being so that the entire hand can be placed within the housing 2 for a plasma treatment.
  • the housing 2 comprises a length of 11,5cm, a width of 11,4cm and a height of 7cm.
  • the inlet opening 3 comprises a width of 10cm and a height of 4cm.
  • the treating device 1 comprises an opening 4 at its rear surface opposite the inlet opening 3 while the opening 4 serves for accommodating cables or the like.
  • the rear opening 4 is covered by an insulator 5 consisting of polytetraflouroethylene .
  • the treating device 1 comprises an integrated plasma generator which generates a non-thermal plasma for the in- vivo sterilization.
  • the plasma generator comprises two substantially flat dielec- trie barrier discharge (DBD) arrangements 6, 7.
  • the DBD arrangement 6 is arranged within the housing 2 above the area of treatment as shown in Figure 3, while the DBD arrangement 7 is arranged within the housing 2 below the area of treatment .
  • Each of the DBD arrangements 6, 7 comprises a barrier 8 sandwiched between two electrodes 9, 10 which are adhered to the top and bottom sides of the bar- rier 8 which consists of polytetraflouroethylene.
  • the DBD arrangement 6 comprises an outer insulator 11 and a radiation shielding 12 facing to the area of treatment within the housing 2 so that the radiation shield- ing 12 prevents that the hand of the patient within the housing 2 is affected by any ultraviolet radiation generated by the DBD arrangements 6, 7.
  • Figure 5 shows a cross sectional view of the radiation shielding 12 along line A-A in Figure 4.
  • the radiation shielding 12 comprises two adjacent layers 13, 14 of parallel metallic lamellas 15, 16.
  • the lamellas 15 in the upper layer 13 of the radiation shielding 12 are oppositionally angled with regard to the lamellas 16 in the lower layer 14 of the radiation shielding 12. Therefore, there is no intervisibil- ity between the opposing sides of the radiation shielding 12 so that no ultraviolet radiation is transmitted through the radiation shielding 12.
  • the radiation shielding 12 blocks any ultraviolet radiation generated by the DBD arrangements 6, 7.
  • the treating device 1 comprises two spacers 17, 18 for the DBD arrangements 6, 7, wherein the spacers 17, 18 avoid a physical contact between the hand and the DBD arrangements 6, 8.
  • the spacers 17, 18 each consist of a wire mesh.
  • Figures 7A-7G show different views of the parts of the afore mentioned treating device while the views are self explanatory so that no further explanation is necessary.
  • Figure 8 shows another embodiment of an electrode arrangement which can be used instead of the afore-mentioned DBD arrangements 6, 7.
  • the electrode arrangement comprises a copper plate 19, a teflon plate 20 and a wire mesh 21 made of an electrically on- cudctive material.
  • the copper plate 19 and the wire-mesh 21 are adhered to opposing sides of the teflon plate 20.
  • FIGS 9A and 9B show another preferred embodiment of a DBD electrode arrangement IA for generating a non-thermal plasma.
  • the electrode arrangement IA comprises a plate-shaped electrode 2A made of an electrically conductive material, e.g. copper or aluminium.
  • the plate-shaped electrode 2A has a thickness in the range of 0.5-lmm.
  • the electrode arrangement IA comprises a dielectric barrier 3A made of polytetrafluoroethylene, wherein the material of the dielectric barrier 3A is applied to the lower surface of the plate-shaped electrode 2A.
  • the electrode arrangement IA comprises a further electrode 4A formed by a wire-mesh which is adhered to the dielectric barrier 3A on the side opposite the electrode 2A.
  • Figure 10 shows another embodiment of a two-dimensional electrode arrangement HA similar to the electrode arrangement IA shown in Figures 9A and 9B.
  • the electrode arrangement HA comprises two mesh- shaped electrodes 12A, 13A, wherein the individual wires of at least one of the electrodes 12A, 13A are surrounded by a cladding made of an electrically insulating and dielectric material forming a dielectric barrier between the electrodes HA, 12A.
  • the electrode 13A is electrically grounded while the other electrode 12A is connected to a high-voltage generator 14A triggering a dielectric barrier discharge in the electrode arrangement HA wherein the plasma is generated in the meshes of the electrodes 12A, 13A.
  • the electrode arrangement HA is flexible so that the shape of the electrode arrangement HA can be adapted to any desired shape.
  • Figure H shows a junction between individual wires 15A, 16A, 17A of adjacent mesh-shaped electrodes.
  • the wire 16A is surrounded by a cladding 18A made of an electrically insulating and dielectric material thereby forming the dielectric barrier.
  • the other wires 15A, 17A are not in- sulated.
  • Figure 12 shows another embodiment of a junction of wires 19A, 2OA of adjacent mesh-shaped electrodes.
  • both the wire 19A and the wire 2OA is surrounded by a cladding 21A, 22A made of an electrically insulating and dielectric material.
  • Figure 13 shows a modification of the electrode arrangement shown in Figure 10 so that reference is made to the above de- scription relating to Figure 10.
  • the electrode arrangement HA additionally comprises a cover 23A.
  • the cover can have different purposes, e.g. increasing the local density of reactive species, reducing the time for sterilization, filtering out unused reactive species, effecting a better control over the plasma or operating under reduced pressure.
  • FIG 14 shows another embodiment of an electrode arrangement 28A suitable for generating a non-thermal plasma.
  • the electrode arrangement 28A comprises a centre electrode 29A formed by a massive plate made of copper.
  • the electrode arrangement 28A comprises two flat dielectric barriers 3OA, 31A each consisting of a flat plate made of polytetrafluoroethylene, wherein the dielectric barriers 3OA, 31A are attached to opposing sides of the centre electrode 29A.
  • the electrode arrangement 28A comprises two mesh- shaped outer electrodes 32A, 33A which are attached to the outer sides of the dielectric barriers 3OA, 31A.
  • Figure 15 shows a modification of the electrode arrangement shown in Figures 9A and 9B so that reference is made to the above description relating to Figures 9A and 9B. Further, the same reference numerals are used for corresponding parts and details.
  • both electrodes 2A, 4A are made of a flexible wire-mesh or parallel wires having a distance of approximately lcm, wherein the dielectric barrier 3A can be made of a flexible material, e.g. silicone rubber.
  • the outer electrodes 32A, 33A are electrically grounded while the centre electrode 29A is electrically connected to a high- voltage generator.
  • Figures 16A and 16B are schematic views describing different uses of an after glow.
  • the plasma generator is switched on at time tl and preferably automatically switched off after a predeter- mined time at time t2.
  • the plasma generator generates plasma within time tl and time t2.
  • the plasma generator is switched off between time t2 (beginning of the after glow) and time t3 (end of after glow)
  • the plasma generated between time tl and time t2 and contained within the housing 2 is effective for treating an object, particularly for the in-vivo sterilization for a hand and/or a forearm of a human being.
  • the time span between time t2 and time t3 can thus be referred to as after glow.
  • the treating device can include an indicating means, for example acoustic and/or visual means, for example one or more lamps for indicating particularly times tl, t2 and t3.
  • an indicating means for example acoustic and/or visual means, for example one or more lamps for indicating particularly times tl, t2 and t3.
  • one lamp can light yellow between time tl and time t2 indicating that an object should or must not be introduced into the housing.
  • Another lamp can light green between time t2 and time t3 indicating that the treating device is ready for treating/sterilizing.
  • Still another lamp can light red after time t3 indicating that the plasma within the housing is no longer effective for treating/sterilizing.
  • the treating device can further include an opening/closing means arranged and configured to close the inlet opening 3 when the plasma generator generates plasma (e.g. between time tl and time t2) for preventing an object, for example a hand, to be introduced into the housing and to open the inlet opening 3 when the plasma generator does not produce plasma (e.g. during time t2 and time t3) .
  • an opening/closing means arranged and configured to close the inlet opening 3 when the plasma generator generates plasma (e.g. between time tl and time t2) for preventing an object, for example a hand, to be introduced into the housing and to open the inlet opening 3 when the plasma generator does not produce plasma (e.g. during time t2 and time t3) .
  • the use of the after glow may further increase usage safety.
  • the use of the after glow can have advantages in particular with regard to wet objects and metallic objects (e.g. rings, watches, bracelets) .
  • a plasma ionization degree sensor for detecting the plasma effectiveness/ionization degree within the housing 2 and to control the plasma generator, the opening/closing means and/or the indicating means in response to the values detected by the plasma ionization de- gree sensor.
  • control the plasma generator, the indicating means and/or the opening/closing means by one or more predetermined time spans.
  • the one or more time spans can be preset by the manufacturer of the treating device and/or individually definable by a user, for example a physician or a nurse.
  • the plasma generator is initially switched on at time t.
  • the plasma generator is automatically switched off at time t'', automatically switched on at time t', automatically switched off at time t' ' and so on.
  • the plasma effec- tiveness/ionization degree within the housing 2 is kept at a sufficient (predetermined) degree for treating/sterilizing.
  • the treating device is after switching on permanently effective for treating an object, particularly for the in-vivo sterilization.
  • the embodiment shown in Figure 16B can be used with the indicating means, the opening/closing means and/or the plasma ionization degree sensor according to Figure 16A.

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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Fluid Mechanics (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Plasma Technology (AREA)
  • Electrotherapy Devices (AREA)
  • Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Accommodation For Nursing Or Treatment Tables (AREA)

Abstract

The invention relates to a treating device (1) for treating a body part of a patient with a non-thermal plasma, particularly for sterilizing a hand of a human being, said treating device (1) comprising a housing (2) for temporarily receiving the body part within the housing (2) during the treatment and for applying the plasma to the body part within the housing (2), and an inlet opening (3) being arranged in the housing (2) for introducing the body part through the inlet opening (3) into the housing (2).

Description

DESCRIPTION
Treating device for treating a body part of a patient with a non-thermal plasma
Field of the invention
The invention relates to a treating device for treating a body part of a patient with a non-thermal plasma, particularly for sterilizing a hand of a human being.
Background of the invention
The use of non-thermal plasma for the treatment of wounds and especially for the in-vivo sterilization, decontamination or disinfection of wounds is disclosed, for example, in WO 2007/031250 Al, EP 1 925 190 Al and PCT/EP2008/003568. However, the known devices for plasma treatment are suitable to only a limited extent for the in-vivo sterilization of a hand of a human being. WO 02/099836 Al describes an apparatus and method using capillary discharge plasma shower for steriliz- ing and disinfecting articles. However, also this apparatus is suitable to only a limited extend for the in-vivo sterilization of a hand, in particular due to the turbulences caused by the shower. Also, the sterilizing and disinfection ability of this device is limited by the copious amounts of reactive gases introduced into the atmosphere - which may lead to health hazards. Summary of the invention
Therefore, it is a general object of the invention to provide a treating device which is suitable for the in-vivo sterili- zation of a hand of a human being.
This object is achieved by a novel treating device according to the main claim.
The treating device according to the invention comprises a housing for temporarily receiving a body part which is to be sterilized within the housing during the treatment and for applying the non-thermal plasma to the body part within the housing. Therefore, the treating device according to the in- vention is different in nature from conventional treating devices in which the object of the treatment (e.g. a hand) is located outside a plasma applicator so that the plasma applicator must be moved along the surface of the object of treatment so that the non-thermal plasma is applied to the entire surface of the object of treatment. In other words, in conventional treating devices the non-thermal plasma is applied to the object of treatment while the invention provides that the object of treatment (e.g. a hand of a human being) is introduced into the non-thermal plasma so that the object of treatment is completely surrounded by the non-thermal plasma.
The housing of the treating device according to the invention comprises an inlet opening for introducing the body part (e.g. a hand of a human being) through the inlet opening into the housing so that the plasma treatment takes place within the housing.
The treating device according to the invention is particularly suitable for the in-vivo sterilization of a hand of a human being. However, the treating device according to the invention can also be used for the plasma treatment of other body parts of a patient, e.g. a foot or a forearm including a hand and preferably further including an elbow of a human be- ing. Furthermore, the object of treatment can be a non- biological article like a surgical instrument, an implant, for example a heart pacemaker, a stent, an artificial joint, or other devices to be sterilized.
Further, the treating device according to the invention preferably comprises an integrated plasma generator for generating the non-thermal plasma within the housing. Therefore, the plasma generator is preferable an integral part of the treating device.
Alternatively, it is possible that the treating device merely comprises an inlet for introducing the plasma into the housing wherein the plasma is generated outside the housing by a separate plasma generator which can be connected with the in- let of the treating device via a hose.
In a preferred embodiment of the invention, the plasma generator comprises at least two electrodes and a barrier between the electrodes, so that the plasma is generated between the electrodes by a dielectric barrier discharge (DBD) , which is per se known in the state of the art. Therefore, the barrier between the electrodes preferably consists of an electrically insulating and/or dielectric material, particularly polytetraflouroethylene .
Further, the electrodes can be adhered to the barrier on opposite sides of the barrier. The at least two electrodes can be provided in a plurality of manners. For example, at least one of the electrodes can be provided as a single wire. Preferably, at least one of the electrodes is provided spirally, or wound, or flat, or like a cooling coil, or in a meandering manner.
At least one of the electrodes can comprise several perforations, which are distributed over the electrode. Therefore, the plasma can be produced within the perforations of the electrode.
Preferably, at least one of the first electrode and the second electrode comprises a wire-mesh, wherein the aforementioned perforations are arranged between individual meshes of the wire-mesh. In other words, each mesh of the wire-mesh forms one of the afore-mentioned perforations. One advantage of such an arrangement is that it is scalable, adaptive and can be customized to any form and shape thereby allowing new applications, e.g. as a wound dressing. Further, such an electrode arrangement is easy to manufacture and very cost- effective. Unlike conventional dielectric barrier devices proposed for plasma medicine, it does not pass a current through human tissue. Moreover, a double mesh system can be gas permeable so that a gas flow can transversely penetrate the electrode arrangement so that it is useful for air purification, sterilization and pollution (exhaust) control.
Further, it is possible to arrange several of the aforementioned double-mesh electrode systems at distances of a few centimeters, wherein the double-mesh systems are preferably aligned parallel to each other.
In another embodiment, at least one of the first electrode and the second electrode comprises a perforated plate in which the afore-mentioned perforations are arranged. For example, the plate can be made of copper or aluminium wherein the perforations in the plate are punched out of the plate. Further, it is possible that both electrodes of the electrode arrangement consist of perforated plates, which are separated by the dielectric barrier.
In yet another embodiment, at least one of the first and second electrodes consists of parallel wires or stripes made of an electrically conductive material.
It should further be noted that in the afore-mentioned embodiments, the perforations are preferably equally distributed over the electrode surface so that the intensity of the plasma generation is also equally distributed over the surface of the electrode.
In one embodiment, the first electrode comprises a plate made of an electrically conductive material, wherein the plate is preferably massive and does not comprise any perforations. The dielectric barrier is substantially layer-shaped and formed on a surface of the plate. For example, the dielectric barrier can have a thickness in the range of 0.5-lmm. In this embodiment, the second electrode comprises either the afore- mentioned wire-mesh or a perforated plate made of an electrically conductive material. The first electrode formed as a massive plate is preferably energized with an alternating current with a voltage of 10-2OkV and a typical electrical current of 10-3OmA while the second electrode formed as a wire-mesh is preferably electrically grounded.
In another embodiment, both the first electrode and the second electrode comprise a wire-mesh while the dielectric barrier comprises a cladding made of an electrically insulating and dielectric material surrounding the wires of at least one of the first electrode and the second electrode thereby electrically insulating the first electrode from the second electrode. In other words, the electrically insulating and di- electric cladding of the individual wires of the wire-mesh forms the dielectric barrier. The first electrode and the second electrode are attached to each other, preferably by an adhesive bond, so that the wire-meshes of the first and second electrodes are contacting each other physically.
In one variant of this embodiment, both the first electrode and the second electrode comprise a cladding surrounding the individual wires of the wire-mesh thereby forming the dielectric barrier.
In another variant of this embodiment, merely one of the first and second electrodes comprises a cladding surrounding the individual wires of the wire-mesh thereby forming the dielectric barrier. In other words, only one of the first and second electrodes is electrically insulated by a cladding while the other one of the first and second electrodes is not insulated by a cladding.
It should further be noted that the invention is not re- stricted to embodiments comprising just two electrodes. For example, it is possible to provide a third electrode and a further dielectric barrier so that there are two dielectric barrier discharge arrangements on both sides of a centre electrode thereby forming a sandwich-like arrangement.
It has already been mentioned that the electrodes are preferably adhered to each other. It is also possible that the dielectric barrier is adhered to at least one of the first and second electrodes. Preferably, the electrode arrangement is substantially two- dimensional, flat and deformable so that the shape of the entire electrode arrangement can be adapted to the contour of a body part, which is to be treated.
In another embodiment, the electrode arrangement further comprises a cover which is covering the electrode arrangement. The cover can be adapted to increase the local density of the reactive species of the plasma thereby reducing the time needed for sterilization. Further, the cover can be adapted to filter out unused reactive species. It is further possible to adapt the cover to effect a better control of the plasma. Finally, the cover can be adapted so that the electrode ar- rangement can operate under reduced pressure.
The dielectric barrier may consist of an electrically insulating and dielectric material. The dielectric barrier preferably consists of ceramics if high performance is desired. Alternatively, the dielectric barrier can be made of poly- tetrafluoroethylene if a lower performance of the electrode arrangement is sufficient. Further, the dielectric barrier can be made of polyethylene terephtalate (PET), flexible or rigid glass-ceramic, glas, Mylar®, casting ceramic or ox- ides. However, the melting point of the dielectric material should preferably be over +1000C.
It should further be noted that the invention is not restricted to an electrode arrangement as a single component. The invention rather comprises a complete apparatus for plasma treatment comprising the afore-mentioned electrode arrangement for generating the non-thermal plasma. Moreover, the electrode (s) is/are preferably connected with a high voltage generator, which can be arranged separate from the treating device.
The housing of the treating device according to the invention is preferably box-shaped, whereas there are two of the afore mentioned sandwich-like DBD arrangements within the housing above and below the area of treatment. Alternatively, the DBD arrangements can be mounted on opposing sides of the housing so that one DBD arrangement is mounted on the left side of the housing, whereas the other DBD arrangement is mounted on the right side of the housing.
Further, the afore-mentioned sandwich-like DBD arrangement preferably comprises an outer electric insulation, which is electrically insulating the outer electrode of the plasma generator .
Moreover, there is preferably a gap between the outer elec- trie insulation of the sandwich-like DBD arrangement and the housing, wherein said gap allows a gas flow through the gap. This is advantageous since the plasma generated in the DBD arrangement must reach the area of treatment in the centre of the housing so that there must be a gas flow within the hous- ing. The gas flow within the housing can be generated by natural convection due to the different temperatures within the gas volume. However, it is also possible that the gas circulation within the housing of the treating device is at least partially caused by a pump, which is preferably ar- ranged separate from the treating device.
Preferably, the treating device includes a waste gas filter. The waste gas filter is arranged and configured to filter waste gas from within the housing. For example, a ventilator or another suitable means can be provided in order to urge (pull/push) the waste gas from within the housing to the waste gas filter.
It should further be mentioned that the plasma generator is preferably arranged within the housing so that the plasma is generated within the housing. Therefore, the treating device according to the invention is different in nature from conventional therapeutic concepts in which the area of treatment and the area of plasma generation are separated from each other. On the contrary, the invention provides that the area of treatment and the area of plasma generation are at least overlapping or even identical.
It is well known in the state of the art that plasma generators generally produce ultraviolet (UV) radiation. In some applications this UV radiation contributes to the therapeutic effect of the plasma treatment. However, in other applications, the UV radiation is undesirable. Therefore, the treat- ing device according to the invention preferably comprises a radiation shielding being arranged between the plasma generator and the area of treatment within the housing thereby shielding the treated body part against the UV radiation generated by the plasma generator.
However, the afore-mentioned radiation shielding is preferably gas permeable so that the plasma can flow through the radiation shielding and reach the body part which is to be treated. This is important since the plasma treatment re- quires a physical contact between the non-thermal plasma and the body part which is to be treated.
In a preferred embodiment, the radiation shielding comprises several spaced apart UV blocking shielding elements which are preferably curved or angled in such a way that there is no intervisibility between the opposing sides of the radiation shielding while the gas flow between the opposing sides of the radiation shielding is not substantially constricted.
The shielding elements are preferably lamellas which are arranged in at least two adjacent layers wherein the lamellas in the adjacent layers are oppositely angled.
It should further be mentioned that the radiation shielding and/or the shielding elements (e.g. lamellas) preferably consist of or a coated with an electrically conductive material so that there is not charge build-up on the surface of the shielding elements. The electrically conductive material of the radiation shielding is preferably metal, particularly copper or tin. It should further be mentioned that the radiation shielding and/or the shielding elements are preferably electrically grounded.
In the preferred embodiment of the invention, the electrodes, the barrier and the outer insulation of the afore mentioned DBD arrangement are preferably flat or layer-shaped. Further, the electrodes can comprise a wire mesh.
Further, the treating device preferably comprises a spacer which is arranged between the area of treatment on the one hand and the plasma generator on the other hand thereby preventing a physical contact between the plasma generator and the body part during treatment. The spacer is preferably sub- stantially flat and/or comprises a wire mesh. In a preferred embodiment, the spacer is configured and arranged to support the object to be treated within the housing. Moreover, it should be noted that the housing of the novel treating device preferably comprises an outer wall consisting of an electrically conductive material which is preferably electrically grounded.
The dimensions of the housing are preferably adapted to the size of a hand of a human being so that a patient can introduce his hand through the inlet opening into the housing for sterilizing his hand. Therefore, the inlet opening of the housing preferably comprises a height in the range of 2cm- 20cm and a width in the range of 5cm-30cm. It is preferred that the inlet opening of the housing comprises a width of 10cm and a height of 4cm.
Further, the housing is preferably sufficiently large for introducing a hand of a human being into the housing so that the entire hand can be sterilized within the housing. Therefore, the housing preferably comprises an inner length in the range of 5cm-30cm with a preferred value of the inner length of about ll-12cm. Further, the housing preferably comprises an inner width in the range of 5cm-30cm with a preferred value of the width of about ll-12cm. Finally, the housing preferably comprises an inner height in the range of 4cm-20cm with a preferred value of the inner height of about 7cm.
In another preferred embodiment, the dimensions of the housing are preferably adapted to the size of a forearm including a hand and preferably further including an elbow of a human being so that a patient can introduce his forearm including his hand and preferably further including his elbow through the inlet opening into the housing for sterilizing his forearm including his hand and preferably including his elbow. Further, the housing is preferably sufficiently large for introducing a forearm including a hand and preferably further including an elbow of a human being into the housing so that the entire forearm including the hand and preferably further including the elbow can be sterilized within the housing.
In another preferred embodiment, the dimensions of the housing are preferably adapted to the size of a foot of a human being.
It should further be noted that the non-thermal plasma according to the invention preferably comprises a gas temperature (i.e. the temperature of the atoms and molecules) below +400C, when measured on the treated surface.
Further, the treating device can include an on/off-switch for switching the integrated plasma generator on and off.
Moreover, there can be a light barrier which detects whether an object of treatment (e.g. a hand) is inserted through the inlet opening into the housing. The light barrier can be coupled with the plasma generator so that the plasma generator is switched off if no object is introduced through the inlet opening, whereas the plasma generator is switched on if an object of treatment is present within the housing.
In a preferred embodiment, the treating device is configured to provide an after glow within the housing for treating the object with the non-thermal plasma, particularly for the in- vivo sterilization of a hand or a forearm including a hand and preferably including an elbow of a human being. Within the phase of after glow, the plasma generator does not produce plasma. However, plasma within the housing is effective for treating an object, particularly for the in-vivo sterili- zation. On the one hand, the use of the after glow can decrease the energy consumption of the treating device. On the other hand, the use of the after glow can increase the usage safety of the treating device since no object, in particular no part of a human being or other sensible objects/devices, is introduced within the housing when the plasma is generated (power on) .
For example, the plasma generator can be switched on and af- ter, for example, 2 sec. switched off. The plasma generated within the 2 sec. remains effective within the housing for a certain time span after switching off for treating an object, particularly for the in-vivo sterilization.
Preferably, the treating device includes indicating means for indicating the beginning and the end of the after glow.
Preferably, the treating device can include an opening/closing means for closing the inlet opening during plasma generating and opening the inlet opening after plasma generating. In one embodiment, the opening/closing means is closed and locked during plasma generating and opens only when the plasma generator does not generates plasma.
Further, it is possible to provide a plasma ionization degree sensor for detecting the ionization degree of the plasma within the housing.
Preferably, the plasma generator, the indicating means and/or the opening/closing means are controlled based on one or more predetermined time spans.
However, it is also possible to control the plasma generator, the indicating means and/or the opening/closing means based on the ionization degree of the plasma within the housing detected by the plasma ionization degree sensor.
The invention and its particular features and advantages will become apparent from the following detailed description considered with reference to the accompanying drawings.
Brief description of the drawings
Figure 1 shows a perspective view of a preferred embodiment of a treating device according to the invention.
Figure 2 shows another perspective view of the treating device according to Figure 1.
Figure 3 shows a cross sectional view of the treating device shown in Figures 1 and 2.
Figure 4 shows a schematic view of a plasma generator using dielectric barrier discharge.
Figure 5 shows a cross sectional view of the radiation shielding shown in Figure 4.
Figure 6 shows a cross sectional view similar to Figure 3 but also showing the design of the radiation shielding.
Figure 7A shows a perspective view of a side plate of the housing of the treating device.
Figure 7B shows a perspective view of the isolator of the DBD arrangement. Figure 7C shows a perspective view of the front plate of the treating device with an inlet opening.
Figure 7D shows a perspective view of an intermediate plate of the treating device.
Figure 7E shows a perspective view of a rear plate of the treating device comprising an opening for cables.
Figure 7F shows a perspective view of an upper and lower plate of the housing.
Figure 7G shows an exemplary embodiment of the electrodes of the afore mentioned DBD arrangement.
Figure 8 shows another embodiment of an electrode arrangement which can be used for plasma generation instead of the DBD arrangement.
Figure 9A shows a perspective view of a preferred embodiment of a DBD electrode arrangement comprising a plate as a first electrode and a wire-mesh as a second electrode.
Figure 9B shows a sectional view of the electrode arrangement according to Figure 9A.
Figure 10 shows a perspective view of an electrode arrangement comprising two wire-meshs.
Figure 11 shows a perspective view of a junction of the wires of several wire-meshs. Figure 12 shows a perspective view of a junction of two insulated wires.
Figure 13 shows a modification of the electrode arrangement according to Figure 10 additionally comprising a cover.
Figure 14 shows a cross-sectional view of a sandwich-like DBD electrode arrangement comprising three electrodes.
Figure 15 shows a sectional view of a modification of the embodiment according to Figures 9A and 9B, wherein a wire-mesh is embedded into the dielectric barrier.
Figures 16A and 16B are schematic views illustrating different uses of an after glow.
Detailed description of the drawings
The drawings illustrate a preferred embodiment of a treating device 1 for the in-vivo sterilization of a hand or a forearm including a hand and preferably further including an elbow of a human being by means of a non-thermal plasma.
The treating device 1 comprises a box-shaped housing 2 with an inlet opening 3 at the front side of the housing 2 wherein the dimensions of the inlet opening 3 are adapted to the size of a hand of a human being so that a patient can introduce his hand through the inlet opening 3 into the housing 2 of the treating device 1. Further, the dimensions of the entire housing 2 are adapted to the size of a hand of a human being so that the entire hand can be placed within the housing 2 for a plasma treatment. In this embodiment, the housing 2 comprises a length of 11,5cm, a width of 11,4cm and a height of 7cm. Further, the inlet opening 3 comprises a width of 10cm and a height of 4cm.
Further, the treating device 1 comprises an opening 4 at its rear surface opposite the inlet opening 3 while the opening 4 serves for accommodating cables or the like. However, the rear opening 4 is covered by an insulator 5 consisting of polytetraflouroethylene .
Further, the treating device 1 comprises an integrated plasma generator which generates a non-thermal plasma for the in- vivo sterilization.
The plasma generator comprises two substantially flat dielec- trie barrier discharge (DBD) arrangements 6, 7. The DBD arrangement 6 is arranged within the housing 2 above the area of treatment as shown in Figure 3, while the DBD arrangement 7 is arranged within the housing 2 below the area of treatment .
The design of the DBD arrangements 6, 7 is schematically shown in Figure 4. Each of the DBD arrangements 6, 7 comprises a barrier 8 sandwiched between two electrodes 9, 10 which are adhered to the top and bottom sides of the bar- rier 8 which consists of polytetraflouroethylene.
Further, the DBD arrangement 6 comprises an outer insulator 11 and a radiation shielding 12 facing to the area of treatment within the housing 2 so that the radiation shield- ing 12 prevents that the hand of the patient within the housing 2 is affected by any ultraviolet radiation generated by the DBD arrangements 6, 7. Figure 5 shows a cross sectional view of the radiation shielding 12 along line A-A in Figure 4. The radiation shielding 12 comprises two adjacent layers 13, 14 of parallel metallic lamellas 15, 16. The lamellas 15 in the upper layer 13 of the radiation shielding 12 are oppositionally angled with regard to the lamellas 16 in the lower layer 14 of the radiation shielding 12. Therefore, there is no intervisibil- ity between the opposing sides of the radiation shielding 12 so that no ultraviolet radiation is transmitted through the radiation shielding 12. In other words, the radiation shielding 12 blocks any ultraviolet radiation generated by the DBD arrangements 6, 7.
Further, the treating device 1 comprises two spacers 17, 18 for the DBD arrangements 6, 7, wherein the spacers 17, 18 avoid a physical contact between the hand and the DBD arrangements 6, 8. In this embodiment, the spacers 17, 18 each consist of a wire mesh.
Figures 7A-7G show different views of the parts of the afore mentioned treating device while the views are self explanatory so that no further explanation is necessary.
Figure 8 shows another embodiment of an electrode arrangement which can be used instead of the afore-mentioned DBD arrangements 6, 7.
The electrode arrangement comprises a copper plate 19, a teflon plate 20 and a wire mesh 21 made of an electrically on- cudctive material. The copper plate 19 and the wire-mesh 21 are adhered to opposing sides of the teflon plate 20.
Further, the wire mesh 21 is electrically grounded, whereas the copper plate 19 is connected with a high voltage source generating a high-voltage of U=18kVPP and a frequency of f=12,5kHz.
Figures 9A and 9B show another preferred embodiment of a DBD electrode arrangement IA for generating a non-thermal plasma. The electrode arrangement IA comprises a plate-shaped electrode 2A made of an electrically conductive material, e.g. copper or aluminium. The plate-shaped electrode 2A has a thickness in the range of 0.5-lmm.
Further, the electrode arrangement IA comprises a dielectric barrier 3A made of polytetrafluoroethylene, wherein the material of the dielectric barrier 3A is applied to the lower surface of the plate-shaped electrode 2A.
Moreover, the electrode arrangement IA comprises a further electrode 4A formed by a wire-mesh which is adhered to the dielectric barrier 3A on the side opposite the electrode 2A.
The electrode 4A is electrically grounded while the other electrode 2A is electrically connected to a high voltage generator 5A which is applying an alternating current signal to the electrode 2A with a frequency of f=12,5kHz and a peak-to- peak-voltage of HV=18kVPp. Therefore, the high voltage gen- erator 5A triggers a dielectric discharge wherein the plasma is generated in the meshes of the mesh-shaped electrode 4A.
Figure 10 shows another embodiment of a two-dimensional electrode arrangement HA similar to the electrode arrangement IA shown in Figures 9A and 9B.
However, the electrode arrangement HA comprises two mesh- shaped electrodes 12A, 13A, wherein the individual wires of at least one of the electrodes 12A, 13A are surrounded by a cladding made of an electrically insulating and dielectric material forming a dielectric barrier between the electrodes HA, 12A.
The electrode 13A is electrically grounded while the other electrode 12A is connected to a high-voltage generator 14A triggering a dielectric barrier discharge in the electrode arrangement HA wherein the plasma is generated in the meshes of the electrodes 12A, 13A.
It should further be noted that the electrode arrangement HA is flexible so that the shape of the electrode arrangement HA can be adapted to any desired shape.
Figure H shows a junction between individual wires 15A, 16A, 17A of adjacent mesh-shaped electrodes. In this embodiment, the wire 16A is surrounded by a cladding 18A made of an electrically insulating and dielectric material thereby forming the dielectric barrier. The other wires 15A, 17A are not in- sulated.
Figure 12 shows another embodiment of a junction of wires 19A, 2OA of adjacent mesh-shaped electrodes. In this embodiment both the wire 19A and the wire 2OA is surrounded by a cladding 21A, 22A made of an electrically insulating and dielectric material.
Figure 13 shows a modification of the electrode arrangement shown in Figure 10 so that reference is made to the above de- scription relating to Figure 10.
One characteristic feature of this embodiment is that the electrode arrangement HA additionally comprises a cover 23A. The cover can have different purposes, e.g. increasing the local density of reactive species, reducing the time for sterilization, filtering out unused reactive species, effecting a better control over the plasma or operating under reduced pressure.
Figure 14 shows another embodiment of an electrode arrangement 28A suitable for generating a non-thermal plasma. The electrode arrangement 28A comprises a centre electrode 29A formed by a massive plate made of copper.
Further, the electrode arrangement 28A comprises two flat dielectric barriers 3OA, 31A each consisting of a flat plate made of polytetrafluoroethylene, wherein the dielectric barriers 3OA, 31A are attached to opposing sides of the centre electrode 29A.
Further, the electrode arrangement 28A comprises two mesh- shaped outer electrodes 32A, 33A which are attached to the outer sides of the dielectric barriers 3OA, 31A.
Figure 15 shows a modification of the electrode arrangement shown in Figures 9A and 9B so that reference is made to the above description relating to Figures 9A and 9B. Further, the same reference numerals are used for corresponding parts and details.
One characteristic feature of the electrode arrangement IA according to Figure 15 is that the electrode 4A is embedded into the dielectric barrier 3A. There is a distance dl=lmm between the wire-mesh of the electrode 4A and the lower surface of the electrode 2A. Further, there is a distance d2=0.1mm between the wire-mesh of the electrode 4A and the outer surface of the dielectric barrier 3A. It is essential that the distance dl is greater than the distance d2. How- ever, if it is desired to have a discharge on one side only, the embedded electrode 4A must be embedded more deeply than the distance dl between the electrodes 2A, 4A.
If a flexible electrode arrangement IA is desired, both electrodes 2A, 4A are made of a flexible wire-mesh or parallel wires having a distance of approximately lcm, wherein the dielectric barrier 3A can be made of a flexible material, e.g. silicone rubber.
The outer electrodes 32A, 33A are electrically grounded while the centre electrode 29A is electrically connected to a high- voltage generator.
Figures 16A and 16B are schematic views describing different uses of an after glow.
In Figure 16A, the plasma generator is switched on at time tl and preferably automatically switched off after a predeter- mined time at time t2. Thus, the plasma generator generates plasma within time tl and time t2. Although the plasma generator is switched off between time t2 (beginning of the after glow) and time t3 (end of after glow) , the plasma generated between time tl and time t2 and contained within the housing 2 is effective for treating an object, particularly for the in-vivo sterilization for a hand and/or a forearm of a human being. The time span between time t2 and time t3 can thus be referred to as after glow.
After time t3, the plasma within the housing is no longer effective for treating an object, particularly not effective for the in-vivo sterilization. The treating device can include an indicating means, for example acoustic and/or visual means, for example one or more lamps for indicating particularly times tl, t2 and t3. For example, one lamp can light yellow between time tl and time t2 indicating that an object should or must not be introduced into the housing. Another lamp can light green between time t2 and time t3 indicating that the treating device is ready for treating/sterilizing. Still another lamp can light red after time t3 indicating that the plasma within the housing is no longer effective for treating/sterilizing.
The treating device can further include an opening/closing means arranged and configured to close the inlet opening 3 when the plasma generator generates plasma (e.g. between time tl and time t2) for preventing an object, for example a hand, to be introduced into the housing and to open the inlet opening 3 when the plasma generator does not produce plasma (e.g. during time t2 and time t3) . Although the device is safe even when the plasma is generated (due to the grounded electrode configuration) , the use of the after glow may further increase usage safety. For example, the use of the after glow can have advantages in particular with regard to wet objects and metallic objects (e.g. rings, watches, bracelets) .
It is also possible to provide a plasma ionization degree sensor for detecting the plasma effectiveness/ionization degree within the housing 2 and to control the plasma generator, the opening/closing means and/or the indicating means in response to the values detected by the plasma ionization de- gree sensor. However, it is also possible to control the plasma generator, the indicating means and/or the opening/closing means by one or more predetermined time spans. The one or more time spans can be preset by the manufacturer of the treating device and/or individually definable by a user, for example a physician or a nurse.
It is further possible to maintain the treating device in a "stand by mode" as schematically shown in Figure 16B. In Figure 16B, the plasma generator is initially switched on at time t. The plasma generator is automatically switched off at time t'', automatically switched on at time t', automatically switched off at time t' ' and so on. Thus, after ini- tially switching on the treating device (for example in the morning and switched off in the evening) , the plasma effec- tiveness/ionization degree within the housing 2 is kept at a sufficient (predetermined) degree for treating/sterilizing. With other words, the treating device is after switching on permanently effective for treating an object, particularly for the in-vivo sterilization. The embodiment shown in Figure 16B can be used with the indicating means, the opening/closing means and/or the plasma ionization degree sensor according to Figure 16A.
Although the invention has been described with reference to the particular arrangement of parts, features and the like, these are not intended to exhaust all possible arrangements of features, and indeed many other modifications and varia- tions will be ascertainable to those of skill in the art.

Claims

Claims
1. Treating device (1) for treating an object with a nonthermal plasma, particularly for the in-vivo sterilization of a hand of a human being, characterized by a) a housing (2) for temporarily receiving the object within the housing (2) during the treatment and for applying the plasma to the object within the housing (2) , and b) an inlet opening (3) being arranged in the housing (2) for introducing the object through the inlet opening (3) into the housing (2) .
2. Treating device (1) according to claim 1, further comprising a) an integrated plasma generator (6, 7) for generating the non-thermal plasma within the housing (2), or b) - an inlet for introducing the plasma into the housing (2) wherein the plasma is generated outside the housing (2) .
3. Treating device (1) according to claim 2, wherein the plasma generator (6, 7) comprises at least two electrodes (9, 10) and a barrier (8) between the electrodes (9, 10), so that the plasma is generated between the electrodes (9, 10) by a dielectric barrier discharge.
4. Treating device (1) according to claim 2 or 3, wherein the barrier (8) between the electrodes consists of an electrically insulating and/or dielectric material, particularly polytetrafluoroethylene .
5. Treating device (1) according to any of claims 2-4, wherein the electrode (9, 10) is adhered to the barrier (8.
6. Treating device (1) according to any of claims 2-5, wherein at least one of the electrodes (9, 10) is connected with a high voltage generator.
7. Treating device (1) according to any of claims 3-6, further comprisingan outer electric insulation (11) which is electrically insulating the outer electrode (9) of the plasma generator (6, 7) .
8. Treating device (1) according to any of claims 3-7, further comprising a gap between the outer electric insulation (11) and the housing (2) for allowing a gas flow through the gap.
9. Treating device (1) according to any of claims 3 to 8, wherein the plasma generator (6, 7) is arranged within the housing (2) .
10. Treating device (1) according to any of claims 2 to 9, further comprising a radiation shielding (12) being arranged between the plasma generator (6, 7) and the object within the housing (2) thereby shielding the object against ultraviolet radiation generated by the plasma generator (6, 7) .
11. Treating device (1) according to claim 10, wherein the radiation shielding (12) is gas permeable so that the plasma can flow through the radiation shielding (12) and reach the object .
12. Treating device (1) according to claim 10 or 11, wherein a) the radiation shielding (12) comprises several spaced apart shielding elements (15, 16), andb) the shielding elements (15, 16) are curved or angled so that there is no intervisibility between the opposing sides of the radiation shielding (12).
13. Treating device (1) according to claim 12, wherein a) the shielding elements (15, 16) are lamellas and b) the lamellas (15, 16) are arranged in at least two adjacent layers (13, 14), and c) the lamellas (15, 16) in the adjacent layers (13, 14) are oppositionally angled.
14. Treating device (1) according to claim 12 or 13, wherein a) the radiation shielding (12) and/or the shielding elements (15, 16) consist of or are coated with an electrically conductive material, and b) the electrically conductive material is metal, particu- larly copper or tin, and c) the radiation shielding (12) and/or the shielding elements (15, 16) are electrically grounded.
15. Treating device (1) according to any of claims 3 to 14, wherein the electrodes (9, 10) and/or the barrier (8) and/or the outer insulation (11) and/or the radiation shielding (12) is substantially flat and/or layer-shaped.
16. Treating device (1) according to any of claims 3-15, wherein the electrodes (9, 10) and/or the barrier (8) and/or the outer insulation (11) comprise a wire mesh.
17. Treating device (1) according to any of the preceding claims, further comprising a spacer for preventing a physical contact between the plasma generator (6, 7) and the object within the housing (2) .
18. Treating device (1) according to claim 17, wherein the spacer is substantially flat.
19. Treating device (1) according to claim 17 or 18, wherein the spacer comprises a wire mesh.
20. Treating device (1) according to any of claims 17-19, wherein the spacer is configured and arranged to support the object within the housing (2).
21. Treating device (1) according to any of the preceding claims, wherein a) the housing (2) comprises an outer wall consisting of an electrically conductive material, or b) the outer wall of the housing (2) is electrically grounded.
22. Treating device (1) according to any of the preceding claims, wherein a) the inlet opening (3) in the housing (2) is suitable for introducing a hand or a forearm including a hand and preferably further including an elbow of a human being through the inlet opening (3) into the housing (2), and b) the inlet opening (3) in the housing (2) comprises a height which is greater than 2cm or 3cm and smaller than 30cm, 20cm, 10cm, 7cm or 5cm, and c) the inlet opening (3) in the housing (2) comprises a width, which is greater than 5cm, 7cm or 9cm and smaller than 65cm, 45cm, 30cm, 20cm, 15cm, 13cm or 11cm, and/or d) the housing (2) is adapted for introducing a hand or a forearm including a hand and preferably further including an elbow of a human being into the housing (2), and e) the housing (2) comprises an inner length, which is greater than 5cm, 7cm or 10cm and smaller than 65cm,
45cm, 30cm, 20cm, 15cm, 13cm or 12cm, and f) the housing (2) comprises an inner width, which is greater than 5cm, 7cm or 10cm and smaller than 65cm, 45cm, 30cm 20cm, 15cm or 12cm, and g) the housing (2) comprises an inner height, which is greater than 4cm, 5cm or 6cm and smaller than 30cm, 20cm, 15cm, 10cm or 8cm.
23. Treating device (1) according to any of claims 1-22, wherein the treating device (1) is configured to provide an after glow within the housing (2).
24. Treating device (1) according to claim 23, further comprising indicating means for indicating the beginning and the end of the after glow.
25. Treating device (1) according to any of the preceding claims, further comprising opening/closing means for closing the inlet opening (3) when the plasma generator generates plasma and opening the inlet opening (3) when the plasma generator does not generate plasma.
26. Treating device (1) according to any of the preceding claims, further comprising a plasma ionization degree sensor for detecting the ionization degree of the plasma within the housing (2) .
27. Treating device (1) according to any of the preceding claims, wherein at least one of the plasma generator, the in- dicating means and the opening/closing means is controlled based on one ore more predetermined and/or individually definable time spans.
28. Treating device (1) according to any of the preceding claims, wherein at least one of the plasma generator, the indicating means and the opening/closing means is controlled based on the ionization degree of the plasma within the housing (2) , preferably detected by the plasma ionization degree sensor.
29. Use of the treating device (1) according to any of the preceding claims for applying a non-thermal plasma to an object of treatment, wherein the object of treatment is se- lected from a group consisting of: a) an extremity of a human being, particularly a hand or a foot, b) a surgical instrument, c) an implant, particularly a heart pacemaker, a stent, an artificial joint, d) other devices to be sterilised.
* * * * *
PCT/EP2009/007478 2009-02-17 2009-10-19 Treating device for treating a body part of a patient with a non-thermal plasma WO2010094307A1 (en)

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US13/201,852 US20120039747A1 (en) 2009-02-17 2009-10-19 Treating device for treating a body part of a patient with a non-thermal plasma
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WO2010094304A1 (en) 2010-08-26
JP2012518256A (en) 2012-08-09
JP5746980B2 (en) 2015-07-08
US9889218B2 (en) 2018-02-13
EP2223704A1 (en) 2010-09-01
EP2399432B1 (en) 2017-10-18
US20120039747A1 (en) 2012-02-16
KR20110120298A (en) 2011-11-03
KR20110115593A (en) 2011-10-21
EP2398507A1 (en) 2011-12-28
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CN102316905A (en) 2012-01-11
JP2012517867A (en) 2012-08-09

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