WO2010082787A2 - 연골줄기세포를 유효성분으로 포함하는 골질환 치료용 또는 항염증용 약제학적 조성물 - Google Patents

연골줄기세포를 유효성분으로 포함하는 골질환 치료용 또는 항염증용 약제학적 조성물 Download PDF

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Publication number
WO2010082787A2
WO2010082787A2 PCT/KR2010/000270 KR2010000270W WO2010082787A2 WO 2010082787 A2 WO2010082787 A2 WO 2010082787A2 KR 2010000270 W KR2010000270 W KR 2010000270W WO 2010082787 A2 WO2010082787 A2 WO 2010082787A2
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WO
WIPO (PCT)
Prior art keywords
stem cells
bone
cartilage stem
cartilage
active principle
Prior art date
Application number
PCT/KR2010/000270
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English (en)
French (fr)
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WO2010082787A3 (ko
Inventor
김경숙
정재준
윤현수
이준호
구세광
Original Assignee
코아스템(주)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 코아스템(주) filed Critical 코아스템(주)
Priority to EP10731402A priority Critical patent/EP2377542A4/en
Priority to US13/144,506 priority patent/US20120121545A1/en
Publication of WO2010082787A2 publication Critical patent/WO2010082787A2/ko
Publication of WO2010082787A3 publication Critical patent/WO2010082787A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Abstract

본 발명은 연골줄기세포를 유효성분으로 포함하는 골질환 치료용 또는 항염증용 약제학적 조성물에 관한 것이다. 본 발명은 연골줄기세포를 유효성분으로 이용하여 골질환 및 염증질환의 새로운 세포치료 영역(regimen)을 제공한다. 본 발명의 연골줄기세포를 관절낭 내에 투여하는 경우, 투여된 연골줄기세포는 투여된 부위에서 연골세포로 증식 또는 분화되고, 항염증 활성을 나타냄으로써 골질환 및 골염증질환을 치료하는 데 매우 유효하다. 본 발명의 연골줄기세포는 조직이나 장기 이식에서 거부반응을 일으키는 조직적합항원을 발현하지 않으며, 골질환 및 항염증 치료를 위한 세포이식(transplantation) 시 자가세포 또는 타가세포를 이용할 수 있는 장점이 있다.
PCT/KR2010/000270 2009-01-15 2010-01-15 연골줄기세포를 유효성분으로 포함하는 골질환 치료용 또는 항염증용 약제학적 조성물 WO2010082787A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP10731402A EP2377542A4 (en) 2009-01-15 2010-01-15 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF BONE DISEASE OR TO PREVENT INFLAMMATION, COMPRISING CARTILAGE STEM CELLS AS AN ACTIVE PRINCIPLE
US13/144,506 US20120121545A1 (en) 2009-01-15 2010-01-15 Pharmaceutical Composition For Bone Disease Treatment Or Countering Inflammation, Comprising Cartilage Stem Cells As An Active Principle

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2009-0003228 2009-01-15
KR20090003228 2009-01-15

Publications (2)

Publication Number Publication Date
WO2010082787A2 true WO2010082787A2 (ko) 2010-07-22
WO2010082787A3 WO2010082787A3 (ko) 2010-11-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/000270 WO2010082787A2 (ko) 2009-01-15 2010-01-15 연골줄기세포를 유효성분으로 포함하는 골질환 치료용 또는 항염증용 약제학적 조성물

Country Status (4)

Country Link
US (1) US20120121545A1 (ko)
EP (1) EP2377542A4 (ko)
KR (1) KR101158473B1 (ko)
WO (1) WO2010082787A2 (ko)

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US8147824B2 (en) 1999-08-05 2012-04-03 Athersys, Inc. Immunomodulatory properties of multipotent adult progenitor cells and uses thereof
EP2392339A1 (en) 2006-01-23 2011-12-07 Athersys, Inc. MAPC Therapeutics without adjunctive immunosuppressive treatment
US9901625B2 (en) 2011-10-15 2018-02-27 University Of Maryland, College Park Methods of regulating uptake and transcellular transport of leukocytes and therapeutics
CN102399745A (zh) * 2011-11-22 2012-04-04 浙江大学 一种软骨干细胞分离培养方法
KR101536815B1 (ko) * 2012-09-05 2015-07-15 아주대학교산학협력단 태아연골유래 세포를 이용한 면역질환의 예방 및 치료용 조성물
WO2014038864A1 (ko) * 2012-09-05 2014-03-13 아주대학교산학협력단 태아연골유래 세포를 이용한 면역질환의 예방 및 치료용 조성물
AU2014250761B2 (en) * 2013-04-12 2019-02-28 Robert J. Deans Improving organs for transplantation
KR101444883B1 (ko) 2014-01-27 2014-09-26 주식회사 기가코리아 숫자 ｕｒｌ 서비스 제공 방법
KR102061740B1 (ko) 2017-01-25 2020-01-02 (주)세포바이오 골재생용 세포 치료제 및 이것의 제조 방법
WO2019080942A1 (en) * 2017-10-27 2019-05-02 Alis Pharma Ltd. EXTRACT OF FETAL TISSUES, METHODS OF PRODUCTION OF THE EXTRACT AND USE THEREOF
KR102508357B1 (ko) 2018-10-23 2023-03-09 (주)세포바이오 갈색지방 유래 간엽줄기세포의 골 분화를 이용한 개과 동물의 골 조직 재생용 세포치료제 및 이것의 제조 방법
JP2022528378A (ja) * 2019-03-28 2022-06-10 アジュ ユニバーシティー インダストリー－アカデミック コーオペレイション ファウンデーション 組織接着及び分化特性を有する組織癒合用組成物及びその製造方法
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KR20230060131A (ko) 2021-10-27 2023-05-04 재단법인 아산사회복지재단 Ｆｇｆ２－ｒｇｄ 융합 단백질을 포함하는 줄기세포의 연골세포로의 분화용 조성물

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Also Published As

Publication number Publication date
KR101158473B1 (ko) 2012-06-20
EP2377542A4 (en) 2013-04-03
WO2010082787A3 (ko) 2010-11-25
KR20100084142A (ko) 2010-07-23
EP2377542A2 (en) 2011-10-19
US20120121545A1 (en) 2012-05-17

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