WO2010059655A1 - Intraocular lens delivery device having a cartridge with an internal coating - Google Patents
Intraocular lens delivery device having a cartridge with an internal coating Download PDFInfo
- Publication number
- WO2010059655A1 WO2010059655A1 PCT/US2009/064882 US2009064882W WO2010059655A1 WO 2010059655 A1 WO2010059655 A1 WO 2010059655A1 US 2009064882 W US2009064882 W US 2009064882W WO 2010059655 A1 WO2010059655 A1 WO 2010059655A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- coating
- cartridge
- internal surface
- polyurethane
- typically
- Prior art date
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1662—Instruments for inserting intraocular lenses into the eye
- A61F2/1678—Instruments for inserting intraocular lenses into the eye with a separate cartridge or other lens setting part for storage of a lens, e.g. preloadable for shipping
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1662—Instruments for inserting intraocular lenses into the eye
- A61F2/1664—Instruments for inserting intraocular lenses into the eye for manual insertion during surgery, e.g. forceps-like instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1662—Instruments for inserting intraocular lenses into the eye
- A61F2/1675—Instruments for inserting intraocular lenses into the eye with a lubricated inner surface, e.g. the lubricant being coated on the inner surface or being injected through a port
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/83—Chemically modified polymers
- C08G18/833—Chemically modified polymers by nitrogen containing compounds
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D175/00—Coating compositions based on polyureas or polyurethanes; Coating compositions based on derivatives of such polymers
- C09D175/04—Polyurethanes
Definitions
- the present invention is related to an intraocular lens cartridge having an internal coating wherein the coating includes a polymeric material that is compatible with a polymeric material of a material that forms the cartridge.
- the human eye functions to provide vision by transmitting and refracting light through a clear outer portion called the cornea, and further focusing the image by way of a lens onto the retina at the back of the eye.
- the quality of the focused image depends on many factors including the size, shape and length of the eye, and the shape and transparency of the cornea and lens.
- IOL intraocular lens
- IOLs While early IOLs were made from hard plastic, such as polymethylmethacrylate (PMMA), soft, foldable IOLs made from silicone, soft acrylics and hydrogels have become increasingly popular because of the ability to fold or roll these soft lenses and insert them through a smaller incision.
- PMMA polymethylmethacrylate
- Several methods of rolling or folding the lenses are used.
- One popular method is an injector cartridge that folds the lenses and provides a relatively small diameter lumen through which the lens may be pushed into the eye, usually by a soft tip plunger.
- One commonly used injector cartridge design is illustrated in U.S. Pat. No. 4,681,102 (Bartell), and includes a split, longitudinally hinged cartridge. Similar designs are illustrated in U.S. Pat. Nos.
- low friction coatings are often applied to the internal surface of the cartridges to allow the IOL to more easily pass through the lumen defined by that internal surface.
- conventional coatings for IOL cartridges can be complex to apply and can involve multiple layers and multiple different materials. In turn, such coatings can be difficult to apply in a consistent manner and can take up space of the lumen through which the IOL would normally pass.
- management of IOL delivery forces can also be accomplished through the use of materials that are capable of handling those forces, particularly materials for the delivery cartridge.
- materials that are capable of handling those forces particularly materials for the delivery cartridge.
- the present invention is directed to an IOL delivery device.
- the device includes a delivery cartridge having a body portion and a nozzle, the body portion and nozzle including an internal surface defining a lumen extending along the body portion and the nozzle.
- the internal surface is formed of polymeric material that is either a polyurethane material or a non-olefinic polymeric material having a heterogeneous backbone.
- a coating is disposed over the internal surface and the coating is formed of a polyurethane material and a hydrophilic material.
- the polyurethane material of the coating forms a cross-linked or linear matrix and the hydrophilic material is dispersed throughout the matrix. It is preferable for the coating to be a single layer disposed directly over the internal surface of the cartridge without any coating layers over the single layer, although other configuration may be possible.
- the cartridge and the internal surface are formed of a singular polymeric material.
- the material of the internal surface typically exhibits a flexural modulus that is at least 200 MPa, more typically at least 1200 MPa and even more typically at least 2000 MPa. Further, the material of the internal surface typically exhibits a hardness of at least 50D, more typically at least 75D and even possibly at least 9OD.
- Fig. 1 is a drawing of an exemplary IOL delivery device in accordance with an aspect of the present invention.
- Fig. 2 is a sectional view of a portion of the IOL delivery device of Fig. 1. Detailed Description of the Invention
- the present invention is predicated upon the provision of an IOL delivery device that includes a delivery cartridge formed of a material and a coating that is compatible with that material.
- the material of the delivery cartridge preferably exhibits physical properties that are desirable for accommodating forces that occur during the delivery an IOL through the cartridge. Moreover, the compatibility between the material of the cartridge and the coating may allow for ease of coating application.
- the material of the cartridge is a polymeric material that is from the same family as a polymeric material of the coating or otherwise exhibits an affinity for the material of the polymeric material.
- the cartridge and the coating are both formed of a polyurethane material.
- an exemplary IOL delivery device 10 that includes a cartridge 12 having a body portion 14 and a nozzle 16.
- the cartridge 12, particularly the body portion 14 and the nozzle 16, define an internal surface 18 that defines a lumen 20 extending along a length (L) of the cartridge 12, the body portion 14 and the nozzle 16.
- the internal surface 18 is covered by a coating 22 according to the present invention.
- the nozzle 16 is typically configured to be insertable into an incision in an eye to aid in the delivery an IOL through the nozzle 16 into the eye.
- the nozzle 16 has an inner diameter (ID) and an outer diameter (OD) taken perpendicular to an axis 24 extending along a length of the nozzle such axis being the same as the length (L) shown in Figs. 1-3. It is preferable, although not required unless otherwise stated, that inner diameter, the outer diameter or both of the nozzle 16 be less than 6 millimeter (mm), more typically less than 3 mm, still more typically less than 2.5 mm and even possibly less than 1.9 mm.
- the cartridge can generally be formed of a variety of polymeric materials and may be formed of a singular polymeric material or multiple polymeric materials. When multiple polymeric materials are employed, they may be in layers or intermixed.
- potential polymeric materials include, without limitation, polyurethanes, polycarbonates, polysulphones, polyetherimides, polyether block amides, polypropylenes, polyacrylates and polymethacrylates, polyethylene or polypropylene copolymers, polyvinyl chloride, epoxides, polyamides, polyesters or copolymers with rubbers, siloxanes or other polymers, combinations thereof or the like.
- the material forming the cartridge and/or the internal surface of the lumen be relatively hydrophilic and exhibits a desired water contact angle for making the material more compatible with a matching polymeric material of the coating, which is preferably a polyurethane material.
- a desired water contact angle for making the material more compatible with a matching polymeric material of the coating, which is preferably a polyurethane material.
- Such contact angle is typically at least 50°, more typically at least 70° and even more typically at least 75°.
- Such contact angle is also typically less than 85° and more typically less than 80°.
- Contact angle can be measured for the present invention using Sessile drop contact angle measurement techniques.
- the material of the cartridge that receives the coating is preferably substantially or entirely non-polyolefinic.
- the material forming the cartridge and/or forming the internal surface of the lumen of the cartridge includes less than 50%, more typically less than 30%, even more typically less than 20% and even possibly less than 5% by weight of any poly olefin, particularly polypropylene and polyethylene and, in one preferred embodiment is entirely without any polyolefin.
- the material forming the cartridge and/or forming the internal surface of the lumen of the cartridge be a polyurethane material (i.e., a material that includes a substantial portion of polyurethane).
- the inclusion of a substantial portion of polyurethane means the inclusion of at least 20% more typically at least 40% and possibly at least 70% by weight polyurethane.
- the polyurethane material of the cartridge and/or the internal surface of the lumen can be formed entirely or substantially entirely of polyurethane without any other polymer type blended or copolymerized therewith.
- the polyurethane material can be a blend a polyurethane and one or more other polymers or a copolymer of polyurethane and one or more other polymers.
- the thermoplastic material be entirely or substantially entirely thermoplastic, although not necessarily required unless otherwise stated.
- Exemplary copolymers can include, without limitation, polyurethane/polyether copolymers, polyester/polyurethane copolymers, combinations thereof or the like.
- Exemplary suitable polyurethane materials include rigid thermoplastic urethanes sold under the tradenames ISOPLAST ® 2531 and ISOPLAST ® 2530, which are commercially available from The Dow Chemical Company, Midland, Michigan.
- Another exemplary suitable polyurethane material is a thermoplastic polyurethane elastomer, which may be a copolymer.
- Examples of such polyurethane material are polyether based polyurethane materials, which are often aliphatic and which are sold under the tradenames PELLETHANE ® 2362 75D and PELLETHANE ® 2363 65D, which are also commercially available from The Dow Chemical Company, Midland, Michigan.
- thermoplastic polyurethane copolymers include, without limitation, aromatic polyether/polyurethane copolymers, polycaprolactam copolyester/polyurethane copolymers or the like. It is also contemplates that combinations of any of the aforementioned polymeric materials may also be employed as the material for the cartridge.
- the material of the cartridge and the surface defining the lumen is preferably a polyurethane material
- other materials may be used where those materials have properties similar to polyurethanes and therefore exhibit a similar affinity for the coating.
- Such materials will typically have water contact angles as described herein.
- such material will typically be polymers with heterogeneous backbones and those backbones will typically include both carbon and oxygen atoms in their monomers, oligomers or both. Polycarbonates are good examples of these alternative materials.
- polyether amide copolymer such as those sold under the tradname PEBAX ® , which are commercially available from Arkema having an address at 420, rue d'Estienne d'Orves, F-92705 Colombes Cedex France.
- the material of the cartridge For use as an IOL delivery cartridge, it is desirable for the material of the cartridge to have a desired flexural modulus and desired hardness.
- the flexural modulus will be at least 200 MPa, more typically at least 1200 MPa and even more typically at least 2000 MPa.
- the flexural modulus will typically be less than 5000 MPa, more typically less than 3000 MPa and even more typically less than 2600 MPa.
- the flexural modulus can be measured in accordance with ASTM D790.
- the hardness will be at least 50D, more typically at least 75D and even possibly at least 9OD.
- the hardness will typically be less than 120D, more typically less than IOOD and even possibly less than 95D.
- the hardness can be measured in accordance with ASTM D2240 Standard Test Method for Rubber Property-Durometer Hardness.
- the material of the coating 22 include a substantial portion of a polymeric material that matches (i.e., is from that same family of) the polymeric material that forms the internal surface 18 of the cartridge 12.
- the matching materials i.e., the polymeric material of the coating and the polymeric material that forms the internal surface 18 of the cartridge 12
- the matching materials can be composed of at least 70%, more preferably at least 90% urethane structures.
- the polymeric material of the coating that matches the polymeric material of the internal surface of the cartridge is preferably at least 30%, more typically at least 40% and even more typically at least 45% by weight of the coating material once the coating material has been applied and dried.
- the polymeric material is also typically no greater than about 90%, more typically no greater than about 80% and even more typically no greater than about 60% by weight of the coating material once the coating material has been applied and dried. It is possible that this matching polymeric material can be from any of the families discussed in relation to the material of the cartridge.
- the matching polymer material is a polyurethane material.
- the polyurethane when used, will typically have particular properties prior to incorporation into the coating.
- the polyurethane will typically have a viscosity at 23 0 C of at least about 50 centipoise (cps), more particularly at least 100 cps.
- the viscosity of the polyurethane at 23 0 C is typically no greater than about 390 cps and more typically no greater than about 250 cps.
- the polyurethane will also typically have a solids content between about 30 and 50 and more particularly between about 35 and 41.
- the polyurethane will also typically have a pH that is between about 6.0 and about 10 and more preferably between about 7.5 and about 9.0.
- the coating includes the polymeric matching material, a hydrophilic material and, optionally, a cross-linking agent or cross-linker.
- the polymeric matching material is typically cross-linkable to form a matrix suitable for assisting in retaining the hydrophilic material. Examples of such coatings are provided in U.S. Patent No. 6,238,799, which is incorporated herein by reference for all purposes. Another example of a suitable coating is sold under the tradename LUBRILAST ® and is commercially available from Advanced Surface Technologies, 9 Linnell Circle, Billerica, MA 01821.
- the hydrophilic material is typically a polymer which swells in the presence of water to provide a "slippery" or lubricous surface.
- exemplary hydrophilic polymers include, but are not limited to, poly(N-vinyl lactams, such as poly(vinylpyrrolidone) (PVP) and the like, poly(ethylene oxide) (PEO), poly(propylene oxide) (PPO), polyacrylamides, cellulosics, such as methyl cellulose and the like, polyacrylic acids, such as acrylic and methacrylic acids and the like, polyvinyl alcohols, and polyvinyl ethers and the like.
- the ratio of polymeric matching material (e.g., polyurethane) to hydrophilic polymer in the coating, by weight, is typically between about 10: 1 and about 1 : 10, more typically between about 5: 1 and about 1 :5, still more typically between about 2:1 and about 1 :2 and even still more typically between about 1.3:1 and about 1 :1.3.
- the hydrophilic material is or includes PVP.
- the PVP may have one or a mixture of K values from Kl 5 or possibly lower to K90 or possibly higher.
- Preferred PVPs have a K value between about 80 and 110.
- the PVP typically has an average molecular weight that is at least about 500,000 Daltons, more typically at least 800,000 Daltons and even more typically at least 1.0M Daltons.
- the molecular weight of the PVP is also typically less than about 3.0M Daltons, more typically less than about 1.8M Daltons and even more typically less than about 1.4M Daltons.
- the crosslink reaction of the matching polymeric material of the coating may be self-initiating so that functional groups of the polymer themselves form the crosslink.
- Suitable functional groups capable of self-crosslinking include, but are not limited to, alkyd oxidatively drying resins, formaldehyde condensates, methyol aery 1 amides and ally lie groups.
- Such crosslinking may be initiated by application of heat or UV energy, for example. Heating up to 150 0 C or more may be used.
- the crosslink reaction may be initiated by addition of a crosslink agent to the coating composition.
- a crosslink agent may be added to the coating composition immediately prior to the coating operation.
- the coated article may be exposed to the crosslinking agent after coating, such as, by way of example, swelling of a dry coating in an aqueous solution containing the crosslinking agent.
- Suitable crosslinking agent include, but are not limited to, polyfunctional aziridines, polyfunctional carbodiimides and polyfunctional epoxides.
- the crosslinking agent is a di- or tri- functional compound; however, it is contemplated as being within the scope of the invention to use polyfunctional crosslink agents having any number of functional groups.
- the crosslinking agent may form one or more crosslinks with the supporting polymer and/or crosslinking with adjacent crosslink agent.
- the crosslink agent may additionally react with active substrate moieties on the IOL cartridge surface, especially if the functional groups are generated on the surface by pretreatment of the surface to expose functional groups. This results in a higher crosslink density for the hydrophilic polymer, which may be desirable in some instances, for example, where the hydrophilic polymer is of lower molecular weight, has a poorer affinity for the supporting polymer than desired or where the supporting polymer possesses a low level of functional moieties.
- the IOL cartridge can be formed using various polymer molding or shaping techniques. Examples include, without limitation, compression molding or injection molding (e.g., thermoplastic injection molding or reaction injection molding).
- the surface of the cartridge to be coated with the coating may be treated (e.g., plasma treated) to provide that surface with reactive groups, which are discussed above.
- the cartridge, including the internal surface defining the lumen is injection molded of a singular continuous material.
- the coating is typically formed by combining the matching polymeric material with the hydrophilic material and, optionally the cross-linking agent, in an aqueous or other medium.
- the matching polymeric material and the hydrophilic material are both separately provide in aqueous mediums and are mixed together in a container (e.g., a flask or beaker) with a mixing bar to form an admixture.
- the cross-linking agent is then mixed into this admixture shortly before application of the coating to the IOL cartridge.
- the coating may be applied to the internal surface of the lumen of the cartridge using various techniques.
- the coating may be dip coated, swabbed, brushed or otherwise applied.
- injection devices such as needles are used to fill the internal lumen of the cartridge with the coating material at areas such as the nozzle and areas adjacent the nozzle along which an IOL will travel during delivery.
- the coating is allowed to associated with (i.e., adhere and/or react with) the internal surface of the lumen.
- the extra coating is then purged (i.e., drained) from the cartridge. Thereafter, the coating is allowed to dry through heating and/or water evaporation.
- the coating typically provides a surface that can receive and retain water and, in turn, provide a lubricious surface.
- An IOL can then relatively easily slide across the coated surface during delivery thereof. This is particularly advantageous for delivery of softer IOLs that are being delivered through a relatively narrow lumen.
- the delivery system is quite desirable for delivery of hydrophobic acrylic foldable IOLs into the eye of an individual.
- those materials can provide properties that are highly desirable for an IOL cartridge, particularly the nozzle of the cartridge. Moreover, those materials are also quite desirable for use with a polyurethane matching polymer material of the coating since such a coating is able to directly adhere and/or bond with the surface of IOL cartridge.
- This allows for the coating to be applied as a single layer and one or more layers and/or one or more application steps of conventional IOL coatings can be avoided. For example, at least one conventional IOL coating required that the internal surface of the cartridge be plasma treated and that a base coat be applied to the internal surface before application of the desired coating. Using the preferred single layer coating the base coat and, even possibly the plasma treatment, become superfluous.
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- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
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- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
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- Surgery (AREA)
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Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2011004941A MX2011004941A (es) | 2008-11-20 | 2009-11-18 | Dispositivo de suministro de lente intraocular que tiene un cartucho con un revestimiento interno. |
JP2011537558A JP5481490B2 (ja) | 2008-11-20 | 2009-11-18 | 内部塗膜を備えるカートリッジを有する眼内レンズ送達デバイス |
DK09759847.8T DK2349091T3 (da) | 2008-11-20 | 2009-11-18 | Indretning til afgivelse af intraokulære linser omfattende en kassette med en indvendig coating |
CA2743169A CA2743169C (en) | 2008-11-20 | 2009-11-18 | Intraocular lens delivery device having a cartridge with an internal coating |
RU2011124872/14A RU2519746C2 (ru) | 2008-11-20 | 2009-11-18 | Устройство для введения интраокулярной линзы, содержащее картридж с внутренним покрытием |
CN200980154354.9A CN102271622B (zh) | 2008-11-20 | 2009-11-18 | 带有具备内部包被的套筒的眼内晶状体递送装置 |
BRPI0921945A BRPI0921945B1 (pt) | 2008-11-20 | 2009-11-18 | dispositivo de entrega de lente intraocular |
AU2009316743A AU2009316743B2 (en) | 2008-11-20 | 2009-11-18 | Intraocular lens delivery device having a cartridge with an internal coating |
ES09759847T ES2394905T3 (es) | 2008-11-20 | 2009-11-18 | Dispositivo de administración de una lentilla intraocular dotado de un cartucho con un revestimiento interno |
SG2011036407A SG171767A1 (en) | 2008-11-20 | 2009-11-18 | Intraocular lens delivery device having a cartridge with an internal coating |
SI200930397T SI2349091T1 (sl) | 2008-11-20 | 2009-11-18 | Naprava za oddajanje intraokularnih leč s kartušo z notranjo prevleko |
EP09759847A EP2349091B1 (en) | 2008-11-20 | 2009-11-18 | Intraocular lens delivery device having a cartridge with an internal coating |
PL09759847T PL2349091T3 (pl) | 2008-11-20 | 2009-11-18 | Urządzenie wprowadzające soczewkę wewnątrzgałkową posiadające kartridż z wewnętrzną powłoką |
NZ593055A NZ593055A (en) | 2008-11-20 | 2009-11-18 | Intraocular lens delivery syringe device having a cartridge with an single internal coating of polyurethane and an hydrophilic material |
IL212500A IL212500A0 (en) | 2008-11-20 | 2011-04-26 | Intraocular lens delivery device having a cartridge with an internal coating |
ZA2011/03084A ZA201103084B (en) | 2008-11-20 | 2011-04-26 | Intraocular lens delivery device having a cartridge with an internal coating |
HK11108531.6A HK1154340A1 (en) | 2008-11-20 | 2011-08-15 | Intraocular lens delivery device having a cartridge with an internal coating |
HRP20120871AT HRP20120871T1 (hr) | 2008-11-20 | 2012-10-29 | Uređaj za polaganje intraokularnih leća, koji uređaj ima patronu s unutarnjim slojem za oblaganje |
SM201200052T SMT201200052B (it) | 2008-11-20 | 2012-11-27 | Dispositivo per l'erogazione di lenti intraocularidotato di una cartuccia con un rivestimento inter no |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11644308P | 2008-11-20 | 2008-11-20 | |
US61/116,443 | 2008-11-20 |
Publications (1)
Publication Number | Publication Date |
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WO2010059655A1 true WO2010059655A1 (en) | 2010-05-27 |
Family
ID=41620450
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2009/064882 WO2010059655A1 (en) | 2008-11-20 | 2009-11-18 | Intraocular lens delivery device having a cartridge with an internal coating |
Country Status (26)
Country | Link |
---|---|
US (1) | US8821572B2 (ja) |
EP (1) | EP2349091B1 (ja) |
JP (1) | JP5481490B2 (ja) |
KR (1) | KR101654100B1 (ja) |
CN (2) | CN102271622B (ja) |
AR (1) | AR076741A1 (ja) |
AU (1) | AU2009316743B2 (ja) |
BR (1) | BRPI0921945B1 (ja) |
CA (1) | CA2743169C (ja) |
CY (1) | CY1113613T1 (ja) |
DK (1) | DK2349091T3 (ja) |
ES (1) | ES2394905T3 (ja) |
HK (1) | HK1154340A1 (ja) |
HR (1) | HRP20120871T1 (ja) |
IL (1) | IL212500A0 (ja) |
MX (1) | MX2011004941A (ja) |
NZ (1) | NZ593055A (ja) |
PL (1) | PL2349091T3 (ja) |
PT (1) | PT2349091E (ja) |
RU (1) | RU2519746C2 (ja) |
SG (1) | SG171767A1 (ja) |
SI (1) | SI2349091T1 (ja) |
SM (1) | SMT201200052B (ja) |
TW (1) | TWI455734B (ja) |
WO (1) | WO2010059655A1 (ja) |
ZA (1) | ZA201103084B (ja) |
Cited By (3)
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WO2011123315A3 (en) * | 2010-04-02 | 2011-11-24 | Abbott Medical Optics Inc. | Intraocular lens insertion device |
WO2013117863A1 (fr) | 2012-02-07 | 2013-08-15 | Polymerexpert Sa | Composition polymeres metastables pour dispositifs d'injection d'implants ophtalmiques |
WO2022112730A1 (fr) | 2020-11-30 | 2022-06-02 | Polymerexpert Sa | Polymère apte à former un revêtement glissant pour injecteur ophtalmique |
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US8968396B2 (en) | 2007-07-23 | 2015-03-03 | Powervision, Inc. | Intraocular lens delivery systems and methods of use |
US10299913B2 (en) | 2009-01-09 | 2019-05-28 | Powervision, Inc. | Accommodating intraocular lenses and methods of use |
JP2013520291A (ja) | 2010-02-23 | 2013-06-06 | パワーヴィジョン・インコーポレーテッド | 遠近調節型眼内レンズのための液体 |
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US10433949B2 (en) | 2011-11-08 | 2019-10-08 | Powervision, Inc. | Accommodating intraocular lenses |
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BR112014030246B1 (pt) | 2012-06-04 | 2021-10-19 | Alcon Inc | Introdutor de lente intraocular |
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WO2014052283A1 (en) * | 2012-09-25 | 2014-04-03 | Bausch & Lomb Incorporated | Polyether-polyamide plastics for surgical applications |
JP6717740B2 (ja) | 2013-03-15 | 2020-07-01 | パワーヴィジョン・インコーポレーテッド | 眼内レンズの収容および載置装置ならびにその使用方法 |
US9636216B2 (en) * | 2013-04-19 | 2017-05-02 | Staar Surgical Company | Injector cartridge with improved lubricity |
CA2944513C (en) | 2014-04-04 | 2022-07-05 | Jack R. Auld | Intraocular lens inserter |
US10485655B2 (en) | 2014-09-09 | 2019-11-26 | Staar Surgical Company | Ophthalmic implants with extended depth of field and enhanced distance visual acuity |
CN114452440A (zh) | 2015-06-10 | 2022-05-10 | 爱尔康公司 | 人工晶状体材料和组分 |
CA3005151C (en) * | 2015-09-22 | 2024-05-28 | Novartis Ag | Ocular implant container |
US10172706B2 (en) | 2015-10-31 | 2019-01-08 | Novartis Ag | Intraocular lens inserter |
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US11000367B2 (en) | 2017-01-13 | 2021-05-11 | Alcon Inc. | Intraocular lens injector |
KR20230113645A (ko) | 2018-08-17 | 2023-07-31 | 스타 서지컬 컴퍼니 | 나노 구배의 굴절률을 나타내는 중합체 조성물 |
US11224537B2 (en) | 2018-10-19 | 2022-01-18 | Alcon Inc. | Intraocular gas injector |
TR201916931A2 (tr) * | 2019-11-01 | 2021-05-21 | Vsy Biyoteknoloji Ve Ilac Sanayi Anonim Sirketi | Kendi̇nden vi̇skoelasti̇kli̇ gözi̇çi̇ lens kartuşu ve bunun üreti̇m yöntemi̇ |
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- 2009-11-18 KR KR1020117010198A patent/KR101654100B1/ko active IP Right Grant
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- 2009-11-18 EP EP09759847A patent/EP2349091B1/en not_active Revoked
- 2009-11-18 CN CN201510184556.5A patent/CN104814810B/zh not_active Expired - Fee Related
- 2009-11-18 SI SI200930397T patent/SI2349091T1/sl unknown
- 2009-11-18 BR BRPI0921945A patent/BRPI0921945B1/pt not_active IP Right Cessation
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- 2009-11-18 MX MX2011004941A patent/MX2011004941A/es active IP Right Grant
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- 2009-11-18 PT PT97598478T patent/PT2349091E/pt unknown
- 2009-11-18 SG SG2011036407A patent/SG171767A1/en unknown
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2011123315A3 (en) * | 2010-04-02 | 2011-11-24 | Abbott Medical Optics Inc. | Intraocular lens insertion device |
US8696682B2 (en) | 2010-04-02 | 2014-04-15 | Abbott Medical Optics Inc. | Intraocular lens insertion devices |
AU2011232876B2 (en) * | 2010-04-02 | 2015-04-02 | Johnson & Johnson Surgical Vision, Inc. | Intraocular lens insertion device |
US9198754B2 (en) | 2010-04-02 | 2015-12-01 | Abbott Medical Optics Inc. | Intraocular lens insertion device |
US10022217B2 (en) | 2010-04-02 | 2018-07-17 | Johnson & Johnson Surgical Vision, Inc. | Intraocular lens insertion device |
WO2013117863A1 (fr) | 2012-02-07 | 2013-08-15 | Polymerexpert Sa | Composition polymeres metastables pour dispositifs d'injection d'implants ophtalmiques |
US9708480B2 (en) | 2012-02-07 | 2017-07-18 | Polymerexpert Sa | Metastable polymer compositions for ophthalmic implant injection devices |
WO2022112730A1 (fr) | 2020-11-30 | 2022-06-02 | Polymerexpert Sa | Polymère apte à former un revêtement glissant pour injecteur ophtalmique |
FR3116715A1 (fr) | 2020-11-30 | 2022-06-03 | Polymerexpert Sa | Polymère apte à former un revêtement glissant pour injecteur ophtalmique |
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