WO2010059280A2 - Matériau d'étanchéité de tissu fibreux et procédé d'utilisation de celui-ci - Google Patents

Matériau d'étanchéité de tissu fibreux et procédé d'utilisation de celui-ci Download PDF

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Publication number
WO2010059280A2
WO2010059280A2 PCT/US2009/055487 US2009055487W WO2010059280A2 WO 2010059280 A2 WO2010059280 A2 WO 2010059280A2 US 2009055487 W US2009055487 W US 2009055487W WO 2010059280 A2 WO2010059280 A2 WO 2010059280A2
Authority
WO
WIPO (PCT)
Prior art keywords
groups
component
fibrous
polymer
acetoacetate
Prior art date
Application number
PCT/US2009/055487
Other languages
English (en)
Other versions
WO2010059280A3 (fr
WO2010059280A4 (fr
Inventor
Arthur Samuel David
Tao Huang
William Gerald Dimaio, Jr.
George K. Kodokian
Original Assignee
E. I. Du Pont De Nemours And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E. I. Du Pont De Nemours And Company filed Critical E. I. Du Pont De Nemours And Company
Priority to CN200980146231.0A priority Critical patent/CN102361655B/zh
Priority to JP2011537445A priority patent/JP5559190B2/ja
Priority to US13/129,658 priority patent/US8545871B2/en
Priority to EP09792097.9A priority patent/EP2346538B1/fr
Publication of WO2010059280A2 publication Critical patent/WO2010059280A2/fr
Publication of WO2010059280A3 publication Critical patent/WO2010059280A3/fr
Publication of WO2010059280A4 publication Critical patent/WO2010059280A4/fr
Priority to US13/968,503 priority patent/US9017703B2/en
Priority to US14/668,234 priority patent/US9452144B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La présente invention concerne un matériau d'étanchéité de tissu fibreux sous la forme d'une feuille fibreuse anhydre comprenant un premier composant qui est un polymère fibreux contenant des groupes électrophiles ou nucléophiles et un deuxième composant capable de réticuler le premier composant lorsque la feuille est exposée à un milieu aqueux, de manière à former un hydrogel réticulé qui adhère au tissu biologique. Le matériau d'étanchéité de tissu fibreux peut être utile en tant qu'adhésif de tissu général pour des applications médicales et vétérinaires telles que la fermeture de plaie, en complément ou en remplacement de sutures ou d'agrafes dans des procédures chirurgicales internes, la réparation tissulaire, et pour prévenir des adhésions post-chirurgicales. Le matériau d'étanchéité de tissu fibreux peut être particulièrement adapté à une utilisation en tant que matériau d'étanchéité hémostatique pour contenir le saignement de plaies chirurgicales ou traumatiques.
PCT/US2009/055487 2008-11-19 2009-08-31 Matériau d'étanchéité de tissu fibreux et procédé d'utilisation de celui-ci WO2010059280A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN200980146231.0A CN102361655B (zh) 2008-11-19 2009-08-31 纤维组织封合剂及其使用方法
JP2011537445A JP5559190B2 (ja) 2008-11-19 2009-08-31 繊維状組織シーラントおよびその使用方法
US13/129,658 US8545871B2 (en) 2008-11-19 2009-08-31 Fibrous tissue sealant and method of using same
EP09792097.9A EP2346538B1 (fr) 2008-11-19 2009-08-31 Matériau d étanchéité de tissu fibreux et procédé d utilisation de celui-ci
US13/968,503 US9017703B2 (en) 2008-11-19 2013-08-16 Method of using fibrous tissue sealant
US14/668,234 US9452144B2 (en) 2008-11-19 2015-03-25 Method of using fibrous tissue sealant

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11596808P 2008-11-19 2008-11-19
US61/115,968 2008-11-19

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US13/129,658 A-371-Of-International US8545871B2 (en) 2008-11-19 2009-08-31 Fibrous tissue sealant and method of using same
US13/129,958 A-371-Of-International US10043930B2 (en) 2008-11-26 2009-11-17 High temperature acrylic sheet
US13/968,503 Continuation US9017703B2 (en) 2008-11-19 2013-08-16 Method of using fibrous tissue sealant

Publications (3)

Publication Number Publication Date
WO2010059280A2 true WO2010059280A2 (fr) 2010-05-27
WO2010059280A3 WO2010059280A3 (fr) 2010-11-18
WO2010059280A4 WO2010059280A4 (fr) 2011-03-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/055487 WO2010059280A2 (fr) 2008-11-19 2009-08-31 Matériau d'étanchéité de tissu fibreux et procédé d'utilisation de celui-ci

Country Status (5)

Country Link
US (3) US8545871B2 (fr)
EP (1) EP2346538B1 (fr)
JP (1) JP5559190B2 (fr)
CN (2) CN102361655B (fr)
WO (1) WO2010059280A2 (fr)

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WO2010146582A2 (fr) 2009-06-15 2010-12-23 Technion- Research And Development Foundation Ltd. Adhésifs chirurgicaux renforcés et colles et leur application in situ
EP2346538A2 (fr) * 2008-11-19 2011-07-27 Actamax Surgical Materials LLC Matériau d étanchéité de tissu fibreux et procédé d utilisation de celui-ci
US8282959B2 (en) 2006-11-27 2012-10-09 Actamax Surgical Materials, Llc Branched end reactants and polymeric hydrogel tissue adhesives therefrom
US8426492B2 (en) 2007-11-14 2013-04-23 Actamax Surgical Materials, Llc Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use
US8431114B2 (en) 2004-10-07 2013-04-30 Actamax Surgical Materials, Llc Polysaccharide-based polymer tissue adhesive for medical use
WO2013137736A1 (fr) 2012-03-16 2013-09-19 Bender Analytical Holding B.V. Polymères réticulés et produits médicaux dérivés de polyoxazoline activée au plan nucléophile
US8551136B2 (en) 2008-07-17 2013-10-08 Actamax Surgical Materials, Llc High swell, long-lived hydrogel sealant
US8778326B2 (en) 2009-07-02 2014-07-15 Actamax Surgical Materials, Llc Hydrogel tissue adhesive for medical use
US8796242B2 (en) 2009-07-02 2014-08-05 Actamax Surgical Materials, Llc Hydrogel tissue adhesive for medical use
US9044529B2 (en) 2008-11-19 2015-06-02 Actamax Surgical Materials, Llc Hydrogel tissue adhesive formed from aminated polysaccharide and aldehyde-functionalized multi-arm polyether
US9770527B2 (en) 2011-01-04 2017-09-26 Bender Analytical Holding B.V. Cross-linked polymers and implants derived from electrophilically activated polyoxazoline
CN108992701A (zh) * 2018-08-17 2018-12-14 佛山市森昂生物科技有限公司 一种鼻腔填塞止血材料的制备方法
US10207021B2 (en) 2013-07-29 2019-02-19 Actamax Surgical Materials, Llc Low sweel tissue adhesive and sealant formulations
US10293289B2 (en) 2013-02-14 2019-05-21 Nanopareil, Llc Hybrid felts of electrospun nanofibers
US10751441B2 (en) 2014-10-06 2020-08-25 Gatt Technologies B.V. Tissue-adhesive porous haemostatic product
WO2021009015A1 (fr) 2019-07-12 2021-01-21 Gatt Technologies B.V Feuille hémostatique flexible biocompatible
WO2021009014A1 (fr) 2019-07-12 2021-01-21 Gatt Technologies B.V. Poudre hémostatique
WO2021009013A1 (fr) 2019-07-12 2021-01-21 Gatt Technologies B.V. Feuille hémostatique flexible biocompatible
WO2022018611A1 (fr) * 2020-07-21 2022-01-27 Ethicon, Inc. Pansement étanche à couche de séparation intermédiaire amovible
WO2022023375A1 (fr) 2020-07-28 2022-02-03 Gatt Technologies B.V. Feuille adhésive osseuse
CN115989046A (zh) * 2020-08-31 2023-04-18 爱惜康股份有限公司 具有受保护的反应性组分的密封剂敷料

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MX338212B (es) 2008-04-11 2016-04-07 Univ Virginia Commonwealth Fibras de dextran electrohiladas y dispositivos formados de las mismas.
US10046081B2 (en) 2008-04-11 2018-08-14 The Henry M Jackson Foundation For The Advancement Of Military Medicine, Inc. Electrospun dextran fibers and devices formed therefrom
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EP2416811B1 (fr) 2009-04-09 2015-09-09 Actamax Surgical Materials LLC Adhésif de type hydrogel pour tissus, ayant un temps de dégradation réduit
US8580951B2 (en) 2009-07-02 2013-11-12 Actamax Surgical Materials, Llc Aldehyde-functionalized polysaccharides
US8580950B2 (en) 2009-07-02 2013-11-12 Actamax Surgical Materials, Llc Aldehyde-functionalized polysaccharides
SA111320355B1 (ar) 2010-04-07 2015-01-08 Baxter Heathcare S A إسفنجة لايقاف النزف
ES2548406T3 (es) 2011-04-13 2015-10-16 Massachusetts Institute Of Technology Materiales adhesivos biocompatibles y métodos
CA2854294C (fr) * 2011-10-18 2018-11-20 St. Teresa Medical, Inc. Procede de formation de feuilles de dextran et de thrombine
US9597425B2 (en) * 2011-10-18 2017-03-21 St. Teresa Medical, Inc. Method of forming a hemostatic product
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US8859705B2 (en) * 2012-11-19 2014-10-14 Actamax Surgical Materials Llc Hydrogel tissue adhesive having decreased gelation time and decreased degradation time
DE102013211316A1 (de) * 2013-06-17 2014-12-18 Aesculap Ag Hämostyptikum
KR20160085267A (ko) 2013-11-12 2016-07-15 세인트 테레사 메디컬, 아이엔씨. 지혈 제품
US9775929B2 (en) 2014-04-14 2017-10-03 University Of Maryland College Park Solution blow spun polymer fibers, polymer blends therefor and methods and use thereof
EP3152118B2 (fr) * 2014-06-06 2022-02-16 The Procter & Gamble Company Récipient à facettes
US10828387B2 (en) 2015-11-12 2020-11-10 St. Teresa Medical, Inc. Method of sealing a durotomy
USD865526S1 (en) 2015-12-04 2019-11-05 The Procter & Gamble Company Bottle
CN105496566B (zh) * 2015-12-14 2018-07-13 清华大学 一种医用多层复合防粘连膜及其制备方法
USD931107S1 (en) 2017-09-08 2021-09-21 The Procter & Gamble Company Bottle
WO2019089717A1 (fr) 2017-11-02 2019-05-09 St. Teresa Medical, Inc. Produits de scellement à base de fibrine
CN109646708B (zh) * 2018-12-25 2021-07-02 宁波六麦新材料科技有限公司 一种医用胶粘带的制备方法
CN109646723B (zh) * 2019-02-02 2020-05-22 上海瑞凝生物科技有限公司 具有辐射防护作用的医用水凝胶
EP3996760B1 (fr) 2019-07-12 2023-08-09 Cilag GmbH International Procédé de préparation d'une feuille adhérant aux tissus
US20220273842A1 (en) * 2019-07-22 2022-09-01 Nurami Medical Ltd. A tissue-adhesive matrix and uses thereof
CN110975002A (zh) * 2019-12-24 2020-04-10 中国人民解放军陆军军医大学第二附属医院 一种用于战创伤的止血材料及其制备方法和应用
CN111803454B (zh) * 2020-07-01 2022-05-06 中国科学院长春应用化学研究所 一种支架材料、其制备方法及应用
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
JP1688407S (fr) 2020-08-14 2021-06-28
CN112169012B (zh) * 2020-09-29 2021-09-07 江南大学 一种可自修复的热熔型生物医用粘合剂及其制备方法
CN113181416B (zh) * 2021-04-26 2022-04-05 苏州和塑美科技有限公司 一种易转移的自粘性纳米纤维抗菌敷料及其制备方法
CN113521376B (zh) * 2021-07-22 2022-08-30 赛克赛斯生物科技股份有限公司 一种外科密封剂试剂盒及其在脑、脊柱外科手术中的应用
CN115245709A (zh) * 2022-07-28 2022-10-28 中国医学科学院输血研究所 一种选择性去除白细胞同时保留血小板的滤材及其制备方法

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Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8431114B2 (en) 2004-10-07 2013-04-30 Actamax Surgical Materials, Llc Polysaccharide-based polymer tissue adhesive for medical use
US8715636B2 (en) 2004-10-07 2014-05-06 Actamax Surgical Materials, Llc Polysaccharide-based polymer tissue adhesive for medical use
US8771738B2 (en) 2004-10-07 2014-07-08 Actamax Surgical Materials, Llc Polysaccharide-based polymer tissue adhesive for medical use
US8282959B2 (en) 2006-11-27 2012-10-09 Actamax Surgical Materials, Llc Branched end reactants and polymeric hydrogel tissue adhesives therefrom
US8426492B2 (en) 2007-11-14 2013-04-23 Actamax Surgical Materials, Llc Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use
US8551136B2 (en) 2008-07-17 2013-10-08 Actamax Surgical Materials, Llc High swell, long-lived hydrogel sealant
EP2346538B1 (fr) * 2008-11-19 2018-06-27 Actamax Surgical Materials LLC Matériau d étanchéité de tissu fibreux et procédé d utilisation de celui-ci
EP2346538A2 (fr) * 2008-11-19 2011-07-27 Actamax Surgical Materials LLC Matériau d étanchéité de tissu fibreux et procédé d utilisation de celui-ci
US9044529B2 (en) 2008-11-19 2015-06-02 Actamax Surgical Materials, Llc Hydrogel tissue adhesive formed from aminated polysaccharide and aldehyde-functionalized multi-arm polyether
WO2010146582A2 (fr) 2009-06-15 2010-12-23 Technion- Research And Development Foundation Ltd. Adhésifs chirurgicaux renforcés et colles et leur application in situ
US8778326B2 (en) 2009-07-02 2014-07-15 Actamax Surgical Materials, Llc Hydrogel tissue adhesive for medical use
US8796242B2 (en) 2009-07-02 2014-08-05 Actamax Surgical Materials, Llc Hydrogel tissue adhesive for medical use
US10925996B2 (en) 2011-01-04 2021-02-23 Gatt Technologies Bv Cross-linked polymers and implants derived from electrophilically activated polyoxazoline
US9770527B2 (en) 2011-01-04 2017-09-26 Bender Analytical Holding B.V. Cross-linked polymers and implants derived from electrophilically activated polyoxazoline
US10314936B2 (en) 2011-01-04 2019-06-11 Gatt Technologies Bv Cross-linked polymers and implants derived from electrophilically activated polyoxazoline
US9868822B2 (en) 2012-03-16 2018-01-16 Gatt Technologies B.V. Cross-linked polymers and medical products derived from nucleophilically activated polyoxazoline
US9416228B2 (en) 2012-03-16 2016-08-16 Bender Analytical Holding B.V. Cross-linked polymers and medical products derived from nucleophilically activated polyoxazoline
WO2013137736A1 (fr) 2012-03-16 2013-09-19 Bender Analytical Holding B.V. Polymères réticulés et produits médicaux dérivés de polyoxazoline activée au plan nucléophile
US10293289B2 (en) 2013-02-14 2019-05-21 Nanopareil, Llc Hybrid felts of electrospun nanofibers
USRE49773E1 (en) 2013-02-14 2024-01-02 Nanopareil, Llc Hybrid felts of electrospun nanofibers
US10207021B2 (en) 2013-07-29 2019-02-19 Actamax Surgical Materials, Llc Low sweel tissue adhesive and sealant formulations
US10751441B2 (en) 2014-10-06 2020-08-25 Gatt Technologies B.V. Tissue-adhesive porous haemostatic product
CN108992701A (zh) * 2018-08-17 2018-12-14 佛山市森昂生物科技有限公司 一种鼻腔填塞止血材料的制备方法
WO2021009013A1 (fr) 2019-07-12 2021-01-21 Gatt Technologies B.V. Feuille hémostatique flexible biocompatible
WO2021009014A1 (fr) 2019-07-12 2021-01-21 Gatt Technologies B.V. Poudre hémostatique
CN114126672A (zh) * 2019-07-12 2022-03-01 加特技术公司 止血粉末
EP4215221A1 (fr) 2019-07-12 2023-07-26 GATT Technologies B.V. Feuille hémostatique biocompatible et flexible
EP4218839A1 (fr) 2019-07-12 2023-08-02 GATT Technologies B.V. Feuille hémostatique
EP4238590A1 (fr) 2019-07-12 2023-09-06 Ethicon, Inc. Feuille hémostatique biocompatible et flexible
WO2021009015A1 (fr) 2019-07-12 2021-01-21 Gatt Technologies B.V Feuille hémostatique flexible biocompatible
WO2022018611A1 (fr) * 2020-07-21 2022-01-27 Ethicon, Inc. Pansement étanche à couche de séparation intermédiaire amovible
WO2022023375A1 (fr) 2020-07-28 2022-02-03 Gatt Technologies B.V. Feuille adhésive osseuse
CN115989046A (zh) * 2020-08-31 2023-04-18 爱惜康股份有限公司 具有受保护的反应性组分的密封剂敷料

Also Published As

Publication number Publication date
CN102361655B (zh) 2016-08-03
EP2346538A2 (fr) 2011-07-27
EP2346538B1 (fr) 2018-06-27
WO2010059280A3 (fr) 2010-11-18
US20110250257A1 (en) 2011-10-13
US9017703B2 (en) 2015-04-28
US8545871B2 (en) 2013-10-01
US20150196496A1 (en) 2015-07-16
CN105833337A (zh) 2016-08-10
US9452144B2 (en) 2016-09-27
WO2010059280A4 (fr) 2011-03-10
JP5559190B2 (ja) 2014-07-23
CN105833337B (zh) 2020-01-21
US20130337036A1 (en) 2013-12-19
CN102361655A (zh) 2012-02-22
JP2012509139A (ja) 2012-04-19

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