WO2010048891A1 - Procédé de prévention et de destruction d'ectoparasites d'animaux endothermes par application combinée d'amitraz et de bifenthrine - Google Patents

Procédé de prévention et de destruction d'ectoparasites d'animaux endothermes par application combinée d'amitraz et de bifenthrine Download PDF

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Publication number
WO2010048891A1
WO2010048891A1 PCT/CN2009/074683 CN2009074683W WO2010048891A1 WO 2010048891 A1 WO2010048891 A1 WO 2010048891A1 CN 2009074683 W CN2009074683 W CN 2009074683W WO 2010048891 A1 WO2010048891 A1 WO 2010048891A1
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WO
WIPO (PCT)
Prior art keywords
weight
bifenthrin
composition
biguanide
animal
Prior art date
Application number
PCT/CN2009/074683
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English (en)
Chinese (zh)
Inventor
布里斯托·詹姆斯·T
Original Assignee
龙灯农业化工国际有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 龙灯农业化工国际有限公司 filed Critical 龙灯农业化工国际有限公司
Priority to AP2011005723A priority Critical patent/AP2969A/xx
Priority to UAA201106581A priority patent/UA101073C2/ru
Publication of WO2010048891A1 publication Critical patent/WO2010048891A1/fr
Priority to ZA2011/03843A priority patent/ZA201103843B/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/52—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing groups, e.g. carboxylic acid amidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline

Definitions

  • the present invention relates to a method for controlling parasites (especially mites and tsetse flies) by the combination of Amitraz and bifenthrin.
  • Acarids are important blood-sucking arthropod parasites, both of which belong to the Acarina parasite (parasitic parasite).
  • Tsetse flies are one of the genus of the genus Diptera in the Diptera parasite (double-winged parasite).
  • the veterinary community faces the problem of resistance to sputum, organophosphorous, op and synthetic pyrethroid (sp) insecticides. Now we have found that the blue tick is resistant to the scorpion, and in some parts of the world it is impossible to kill the cockroach. In the case of brown cockroaches, we found that cockroaches could not be killed by sp on the market.
  • Another object of the present invention is to provide a novel method of controlling mites and tsetse flies.
  • Another object of the present invention is to provide acaricidal compositions for controlling mites and tsetse flies (especially blue and brown mites) which are resistant to bismuth, op and sp compounds.
  • the mites show a strong control effect.
  • the present invention relates to a method for controlling parasites (especially mites and tsetse flies) by the use of biguanide and bifenthrin.
  • the present invention provides a method of controlling parasites (especially mites and tsetse flies) of animals, the method comprising
  • the present invention provides a method of controlling parasites (especially mites and tsetse flies) of animals, the method comprising
  • the present invention provides compositions comprising biguanides and bifenthrins which are useful for controlling parasites, particularly mites and tsetse flies.
  • the inventive group The biguanide and bifenthrin are synergistically effective amounts.
  • the amount of biguanide in the composition of the invention is preferably from 0.0001% by weight to 95% by weight, preferably from 0.001% by weight to 90% by weight, more preferably from 0.01% by weight to 85% by weight, still more preferably 0.1% From wt to 80% by weight, particularly preferably from 5% by weight to 60% by weight, most preferably from 7.5% by weight to 50% by weight.
  • the amount of bifenthrin in the composition of the invention is preferably from 0.0001% by weight to 50% by weight, preferably from 0.001% by weight to 40% by weight, more preferably from 0.01% by weight to 30% by weight, still more preferably 0.1% % wt to 20% wt, particularly preferably 0.2% wt to 12.5% wt, most preferably 1% wt to 10% wt.
  • the weight ratio of biguanide to bifenthrin in the composition of the invention is from 1000:1 to 0.001:1, preferably from 200:1 to 0.05:1, more preferably from 50:1 to 0.75:1, Most preferred is 5:1 to 1.5:1.
  • the present invention also provides a composition comprising a synergistically effective amount of biguanide and bifenthrin for controlling parasites which have obtained resistance to biguanides, op compounds and sp compounds ( Especially mites and tsetse flies).
  • the invention also provides a product for controlling mites and tsetse flies comprising separate, sequential or simultaneous administration of biguanide and bifenthrin.
  • the parasite of the animal is an ectoparasite of an animal (especially a warm-blooded animal such as a mammal, such as sheep, cattle, etc.), particularly a mites and a picking rope.
  • the present invention also provides the use of a composition comprising biguanide and bifenthrin for the preparation of a medicament for controlling parasites in animals.
  • the parasite is an ectoparasite.
  • the biguanide and bifenthrin in the compositions of the invention are synergistically effective amounts.
  • the amount of biguanide in the composition of the invention is preferably from 0.0001% by weight to 95% by weight, preferably from 0.001% by weight to 90% by weight, more preferably from 0.01% by weight to 85% by weight, still more preferably 0.1% From wt to 80% by weight, particularly preferably from 5% by weight to 60% by weight, most preferably from 7.5% by weight to 50% by weight.
  • the amount of bifenthrin in the composition of the invention is preferably from 0.0001% by weight to 50% by weight, preferably from 0.001% by weight to 40% by weight, more preferably from 0.01% by weight to 30% by weight, still more preferably 0.1% % wt to 20% wt, particularly preferably 0.2% wt to 12.5% wt, most preferably 1% wt to 10% wt.
  • the weight ratio of biguanide to bifenthrin in the composition of the invention is from 1000:1 to 0.001:1, preferably from 200:1 to 0.05:1, more preferably from 50:1 to 0.75:1, Optimal [14]
  • the term "synergistic" as used herein means that the combined effect of two or more substances is significantly greater than the sum of the two.
  • Biguanide is the common name for N,N-bis(2,4-diphenylphenyliminoindenyl)guanamine. Double mites are used for pests in anti-mammal domesticated pets, where they are used to control mites and mites. Also, it is used to control lice on cattle and pigs.
  • These insecticidal formulations contain, as an essential component, biguanide and at least one specific insecticidal active pyrethroid compound. It has been found that these ⁇ -cyanobenzylphenyl acetate pyrethroids and biguanides have synergistic activity against mites (i.e., the combination exhibits activity compared to the two insecticide components). Higher insecticidal activity is expected).
  • the pyrethroids expected to contain a halogen atom (preferably a chlorine atom) having an atomic number of 9 to 35 inclusive, or an alkoxy group having 1 to 4 carbon atoms.
  • a halogen atom preferably a chlorine atom
  • An example is bifenthrin or (2-mercapto[1,1-biphenyl]-3-yl)-indolyl-3-(2-chloro-3,3,3-trifluoro-1-propene -2,2-Dimercaptocyclopropanecarboxylate.
  • Bifenthrin is a synthetic pyrethroid with insecticidal and acaricidal activity.
  • the chemical name is (2-mercapto[1,1-biphenyl]-3-yl)-indolyl-3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2.
  • 2-Dimercaptocyclopropanecarboxylate acts through contact and stomach toxicity, which paralyzes the nervous system of insects and ticks.
  • the composition is formulated into a wettable powder, an aqueous concentrate, an emulsifiable concentrate (EC), a liquid concentrate, etc. by a conventional method.
  • the conventional methods are, for example, admixing the active compound with suitable carriers and adjuvants such as emulsifying agents, dispersing agents, stabilizing agents, suspending agents, penetrating agents and the like.
  • the invention is preferably formulated as an emulsifiable concentrate.
  • composition according to the invention is especially suitable for controlling ectoparasites (preferably mites) of animals, especially warm-blooded animals such as mammals.
  • the composition according to the invention is preferably used in pets.
  • pets should be understood to include especially sheep, cattle and other temperatures. Blood animals.
  • the amount of active ingredient in the compositions of the present invention may vary widely, but will generally be from about 0.1% to about 95% of the active ingredient (the percentages in the specification and claims of the present application are usually by weight unless otherwise indicated) .
  • the ratio of the amount of bifenthrin to the amount of bismuth is from about 1:5 to about 4:6.
  • the amount of biguanide in the composition according to the invention may vary widely from 0.1% to about 80%. Amounts of from 5 to 60% are preferred, and more preferably, the composition according to the invention comprises biguanides in the range of from 7.5 to 50%.
  • the amount of bifenthrin can vary widely from 0.2% to 12.5%. An amount of from 1 to 10% is preferred, and more preferably, the amount of bifenthrin used in the composition according to the present invention is from 2 to 8%.
  • Residues that bring the composition to 100% include a carrier and various additives.
  • Carrier as used herein, means an organic substance which may be natural or synthetic and which is associated with the active ingredient and which facilitates its administration to an animal. Thus, the carrier is generally inert and should be achievable by an animal Acceptable (especially for cattle or sheep).
  • the carrier can be solid (eg clay, silicate, silica, resin, wax, fertilizer, etc.) or liquid (eg water, alcohols, ketones, oil solvents, saturated) Or unsaturated hydrocarbons, chlorinated hydrocarbons, liquefied petroleum gas, etc.).
  • compositions of the present invention may comprise surfactants as well as other ingredients such as dispersants, stickers, antifoaming agents, antifreeze agents, dyes, thickeners, binders, protections. Colloids, penetrants, stabilizers, chelating agents, anti-flocculants, corrosion inhibitors, pigments and polymers.
  • compositions of the present invention may comprise all types of solid or liquid additives well known in the art of insecticides and insecticidal treatments.
  • Surfactants may be emulsified or wetted, ionic or nonionic.
  • Nonionic surfactants such as: polyethoxylated castor oil, polysorbated sorbitan monooleate, sorbitan monostearate, glyceryl monostearate, polyoxyethylene Stearic acid ester, alkylphenol polyglycol ether.
  • Anionic surfactants such as sodium lauryl sulfate, fatty alcohol ether sulfates, mono/dialkyl polyethylene glycol ether orthophosphate monoethanolamine salts.
  • the composition according to the present invention can be prepared by a conventional method of mixing the active compound and preparing a solution, for example, by stirring with other ingredients.
  • the formulation according to the invention is characterized in that it has a good storage stability of at least 3 years in all climatic zones. Due to its high potency, the application volume can be small.
  • the preferred administration volume is 0.075-0.25 ml/kg [weight of the pet to be treated], preferably 0.1-0.15 ml/1.0 kg [weight of the pet to be treated].
  • composition according to the present invention is non-irritating to the skin and low in toxicity to animals.
  • Example 2 lOO composition
  • Solvesso 150 72.9g Butylhydroxyindole Benzene O.lg Polyethoxylated Sorbitan Monooleate ll.OOg Sodium Lauryl Sulfate 3.50g
  • N-methylpyrrolidone 68.9g water 4.0g butylhydroxytoluene O.lg polyethoxylated sorbitan monooleate ll ll.OOg sodium lauryl sulfate 3.50g
  • Solvesso 150 67.9g Butylhydroxyindole Benzene .ig Ethoxylated Soybean Oil ll.OOg Calcium Benzosulfonate 3.50g
  • Solvesso 150 67.9g butyl hydroxy benzene o.ig polyoxyethyl stearate ll.OOg sodium lauryl sulfate 3.50g
  • composition A According to Example 1 containing 12.5% biguanide + 5% bifenthrin 6 The composition was prepared to provide 250 ppm of biguanide and 100 ppm of bifenthrin.
  • Composition B This composition was prepared according to Examples 7-12 containing 10.0% biguanide + 2.5% bifenthrin to provide 250 ppm biguanide and 62.25 ppm bifenthrin.
  • Composition C The composition was prepared according to a registered hydrazine based on biguanide to provide 250 ppm biguanide.
  • the sheep are appropriately imprisoned to count the face (including the ears) and the mites on the perineum. Identify, count, and record all adult monuments that are parasitic on the animal in each region.
  • Effectiveness % [1- (Process / Control) ] ⁇ 100%
  • compositions of the invention were evaluated by comparing the counts of treated mites on treated sheep to the counts of untreated sheep.
  • composition A reached 98.91%, 97.73%, and 96.67% on days 3, 5, and 7, and Composition B reached 98.91%, 97.73%, and 95.56% on days 3, 5, and 7.
  • Composition C reached 97.82%, 95.45%, and 93.33% on days 3, 5, and 7.
  • the results also show the sheep body treated by Composition A and Composition B after 2 weeks (14 days).
  • the mites on the count were 0, while the mites were present on the sheep treated with Composition C. Therefore, composition C was used to cause resistance to blue sputum based on the efficacy data on day 7 and the sputum count data after 2 weeks (14 days). This phenomenon corresponds to the practical application of a three-week rotation spray method applied by farmers to remove mites (especially blue sputum and brown sputum).
  • Composition A and Composition B according to the present invention showed no resistance.
  • the combination of bismuth-bifenthrin forms a stable emulsion which can be effectively used as an acaricide. This combination is also safe for livestock. No adverse effects associated with the use of the formulation were observed on the test sheep.
  • the biguanide-bifenthrin combination of the present invention is better against flies which cause sleep disorders which cannot be killed by the biguanide.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Emergency Medicine (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un procédé de prévention et de destruction de parasites (en particulier les tiques et la mouche tsé-tsé) par application combinée d'amitraz et de bifenthrine. Le procédé utilise une composition comprenant de l'amitraz et de la bifenthrine, et l'application de la composition médicinale pour prévenir et détruire les parasites chez les animaux facilement lésés par les parasites.
PCT/CN2009/074683 2008-10-30 2009-10-29 Procédé de prévention et de destruction d'ectoparasites d'animaux endothermes par application combinée d'amitraz et de bifenthrine WO2010048891A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AP2011005723A AP2969A (en) 2008-10-30 2009-10-29 Method of preventing and killing ectoparasites of endotherm by combined application of amitraz and bifenthrin
UAA201106581A UA101073C2 (ru) 2008-10-30 2009-10-29 Применение композиции для борьбы с клещами у животных
ZA2011/03843A ZA201103843B (en) 2008-10-30 2011-05-25 Method of preventing and killing ectoparasites of endotherm by combined application of amitraz and bifenthrin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN200810168392.7 2008-10-30
CN2008101683927A CN101380017B (zh) 2008-10-30 2008-10-30 通过双甲脒和联苯菊酯联用来防治恒温动物的外寄生虫的方法

Publications (1)

Publication Number Publication Date
WO2010048891A1 true WO2010048891A1 (fr) 2010-05-06

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PCT/CN2009/074683 WO2010048891A1 (fr) 2008-10-30 2009-10-29 Procédé de prévention et de destruction d'ectoparasites d'animaux endothermes par application combinée d'amitraz et de bifenthrine

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CN (1) CN101380017B (fr)
AP (1) AP2969A (fr)
UA (1) UA101073C2 (fr)
WO (1) WO2010048891A1 (fr)
ZA (1) ZA201103843B (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101380017B (zh) * 2008-10-30 2012-07-25 龙灯农业化工国际有限公司 通过双甲脒和联苯菊酯联用来防治恒温动物的外寄生虫的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1092248A (zh) * 1994-02-05 1994-09-21 化学工业部沈阳化工研究院 含双甲脒的广谱增效杀虫剂
CN101380017A (zh) * 2008-10-30 2009-03-11 龙灯农化国际有限公司 通过双甲脒和联苯菊酯联用来防治恒温动物的外寄生虫的方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1092248A (zh) * 1994-02-05 1994-09-21 化学工业部沈阳化工研究院 含双甲脒的广谱增效杀虫剂
CN101380017A (zh) * 2008-10-30 2009-03-11 龙灯农化国际有限公司 通过双甲脒和联苯菊酯联用来防治恒温动物的外寄生虫的方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JESUS LOERA-GALLARDO ET AL: "Insecticidal Mixture Interactions Against B-strain Sweetpotato Whitefly (Homoptera:Aleyrodidae)", JOURNAL OF ENTOMOLOGICAL SCIENCE, vol. 33, no. 4, October 1998 (1998-10-01), pages 407 - 411 *
MITREA I.L. ET AL: "The efficacy of a compound product with formamidine and a synthetic pyrethroid against some ectoparasitoses of chickens and cattle", LUCRAI STIINIFICE -MEDICINA VTERINARA,UNIVERSITATEA DE STIINTE AGRICOLE SI MEDICINA VTERINARA,''LON LONESCU DE LA BRAD'' LASI, vol. 47, no. 6, 2004, pages 699 - 703 *

Also Published As

Publication number Publication date
AP2969A (en) 2014-09-30
AP2011005723A0 (en) 2011-06-30
UA101073C2 (ru) 2013-02-25
CN101380017B (zh) 2012-07-25
CN101380017A (zh) 2009-03-11
ZA201103843B (en) 2012-08-29

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