WO2010032113A3 - Composición y uso de un gel oral endoparasiticida bioadhesivo de larga acción a base de doramectina - Google Patents

Composición y uso de un gel oral endoparasiticida bioadhesivo de larga acción a base de doramectina Download PDF

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Publication number
WO2010032113A3
WO2010032113A3 PCT/IB2009/006867 IB2009006867W WO2010032113A3 WO 2010032113 A3 WO2010032113 A3 WO 2010032113A3 IB 2009006867 W IB2009006867 W IB 2009006867W WO 2010032113 A3 WO2010032113 A3 WO 2010032113A3
Authority
WO
WIPO (PCT)
Prior art keywords
present
doramectin
oral
endoparasiticide
compositions known
Prior art date
Application number
PCT/IB2009/006867
Other languages
English (en)
French (fr)
Other versions
WO2010032113A2 (es
Inventor
Edgar Régulo VEGA CARRASCO
José Fernando TANG PLOOG
Jorge Fabián RUIZ HERRERA
Umberto Calderon Ojeda
Original Assignee
Agrovet Market S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agrovet Market S.A. filed Critical Agrovet Market S.A.
Priority to US13/062,419 priority Critical patent/US8455452B2/en
Priority to CA2737671A priority patent/CA2737671A1/en
Priority to EA201170470A priority patent/EA022209B1/ru
Priority to BRPI0913753A priority patent/BRPI0913753B1/pt
Priority to AU2009294293A priority patent/AU2009294293A1/en
Priority to CN2009801368925A priority patent/CN102202671A/zh
Priority to EP09814154.2A priority patent/EP2345413A4/en
Publication of WO2010032113A2 publication Critical patent/WO2010032113A2/es
Publication of WO2010032113A3 publication Critical patent/WO2010032113A3/es
Priority to ZA2011/02793A priority patent/ZA201102793B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Abstract

La presente invenciόn se refiere a Ia composiciόn de un gel bioadhesivo endoparasiticida a base de doramectina, con un alto nivel de adhesion a Ia mucosa oral equina y con un sabor dulce que facilita enormemente su dosificaciόn, a procedimientos para su preparaciόn y a su utilizaciόn. La helmintosis gastrointestinal es una afecciόn parasitaria causada por nematodos de diversas familias que ocasionan importantes trastornos gastrointestinales en el ganado equino. El control de esta enfermedad es de gran importancia y favorablemente alcanzable mediante el empleo de agentes antihelminticos adecuados tales como Ia doramectina, que es un compuesto quimico administrado ampliamente por Ia via parenteral y poco frecuentemente por Ia via oral en forma liquida debido a las caracteristicas organolepticas y fisicoquimicas de las composiciones conocidas hasta Ia fecha. La presente invenciόn demuestra que es posible administrar doramectina bajo Ia forma farmaceutica de gel oral, a concentraciones de hasta 5,0% peso/volumen, superando las limitantes organolepticas y fisicoquimicas de las composiciones conocidas hasta Ia fecha. Factores, nunca antes incluidos en composiciones endoparasiticidas orales a base de doramectina, que presentan una amplia ventaja diferencial frente a las composiciones conocidas a Ia fecha. Estas y otras caracteristicas, objetivos y ventajas de Ia presente invenciόn seran apreciadas por los expertos en Ia materia a partir de Ia descripciόn detallada expuesta mas adelante en el presente documento, asi como en las reivindicaciones adjuntas.
PCT/IB2009/006867 2008-09-19 2009-08-28 Composición y uso de un gel oral endoparasiticida bioadhesivo de larga acción a base de doramectina WO2010032113A2 (es)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US13/062,419 US8455452B2 (en) 2008-09-19 2009-08-28 Composition and use of a long-acting oral bioadhesive endoparasiticide gel based on doramectin
CA2737671A CA2737671A1 (en) 2008-09-19 2009-08-28 Composition and use of a long-acting oral bioadhesive endoparasiticide gel based on doramectin
EA201170470A EA022209B1 (ru) 2008-09-19 2009-08-28 Биоадгезивная эндопаразитицидная гелевая композиция для лошадей и ее применение
BRPI0913753A BRPI0913753B1 (pt) 2008-09-19 2009-08-28 composição e uso de um gel bioadesivo endoparasiticida oral de ação prolongada a base de doramectina
AU2009294293A AU2009294293A1 (en) 2008-09-19 2009-08-28 Composition and use of a long-acting oral bioadhesive endoparasiticide gel based on doramectin
CN2009801368925A CN102202671A (zh) 2008-09-19 2009-08-28 基于多拉克汀的长效口服生物粘附的杀体内寄生虫药凝胶组合物和用途
EP09814154.2A EP2345413A4 (en) 2008-09-19 2009-08-28 COMPOSITION AND USE OF LONG-DERMAL BIOADHESIVE ENDOPARASITICIDE ORAL GEL BASED ON DORAMECTIN
ZA2011/02793A ZA201102793B (en) 2008-09-19 2011-04-14 Composition and use of a long-acting oral bioadhesive endoparasiticide gel based on doramectin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PE001551-2008 2008-09-19
PE0015512008 2008-09-19

Publications (2)

Publication Number Publication Date
WO2010032113A2 WO2010032113A2 (es) 2010-03-25
WO2010032113A3 true WO2010032113A3 (es) 2010-06-17

Family

ID=42039956

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2009/006867 WO2010032113A2 (es) 2008-09-19 2009-08-28 Composición y uso de un gel oral endoparasiticida bioadhesivo de larga acción a base de doramectina

Country Status (12)

Country Link
US (1) US8455452B2 (es)
EP (1) EP2345413A4 (es)
CN (1) CN102202671A (es)
AU (1) AU2009294293A1 (es)
BR (1) BRPI0913753B1 (es)
CA (1) CA2737671A1 (es)
CR (1) CR20110207A (es)
EA (1) EA022209B1 (es)
MX (1) MX2009001235A (es)
PE (1) PE20100713A1 (es)
WO (1) WO2010032113A2 (es)
ZA (1) ZA201102793B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104168886A (zh) * 2012-03-13 2014-11-26 拜耳新西兰有限公司 长效组合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1308163A1 (en) * 2001-08-27 2003-05-07 Wyeth Endoparasiticidal gel composition
ES2221455T3 (es) * 1998-12-16 2004-12-16 Pfizer Inc. Formulaciones de doramectina.
US20050032716A1 (en) * 2001-09-17 2005-02-10 Lowe Lionel Barry Pesticidal formulations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPN933396A0 (en) * 1996-04-17 1996-05-09 Pfizer Pty Limited Non-aqueuos oral-drench compositions containing avermectin compounds
EP0959891A1 (en) 1996-07-30 1999-12-01 Ashmont Holdings Limited Anthelmintic formulations
US7001889B2 (en) * 2002-06-21 2006-02-21 Merial Limited Anthelmintic oral homogeneous veterinary pastes
US20080027011A1 (en) * 2005-12-20 2008-01-31 Hassan Nached Homogeneous paste and gel formulations

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2221455T3 (es) * 1998-12-16 2004-12-16 Pfizer Inc. Formulaciones de doramectina.
EP1308163A1 (en) * 2001-08-27 2003-05-07 Wyeth Endoparasiticidal gel composition
US20050032716A1 (en) * 2001-09-17 2005-02-10 Lowe Lionel Barry Pesticidal formulations

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS DATABASE Database accession no. PREV200510258800 *
KLAVONS, JEROME ET AL.: "Sustained-release, bio- absorbable, injectable gel formulatio n for delivery of doramectin to cattle for control of ticks and biting flies", ABSTRACTS OF PAPERS AMERICAN CHEMICAL SOCIETY, vol. 229, no. PARTE, 13 March 2005 (2005-03-13), pages U75, XP008146689 *

Also Published As

Publication number Publication date
PE20100713A1 (es) 2010-10-13
EP2345413A2 (en) 2011-07-20
WO2010032113A2 (es) 2010-03-25
EP2345413A4 (en) 2013-11-20
BRPI0913753B1 (pt) 2018-07-17
CN102202671A (zh) 2011-09-28
ZA201102793B (en) 2011-12-28
AU2009294293A1 (en) 2010-03-25
CR20110207A (es) 2011-09-06
BRPI0913753A2 (pt) 2015-10-20
EA022209B1 (ru) 2015-11-30
US20110160155A1 (en) 2011-06-30
EA201170470A1 (ru) 2011-10-31
CA2737671A1 (en) 2010-03-25
US8455452B2 (en) 2013-06-04
MX2009001235A (es) 2010-04-29

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