WO2007135293A3 - 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur préparation, compositions les contenant et utilisation - Google Patents
2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur préparation, compositions les contenant et utilisation Download PDFInfo
- Publication number
- WO2007135293A3 WO2007135293A3 PCT/FR2007/000866 FR2007000866W WO2007135293A3 WO 2007135293 A3 WO2007135293 A3 WO 2007135293A3 FR 2007000866 W FR2007000866 W FR 2007000866W WO 2007135293 A3 WO2007135293 A3 WO 2007135293A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- benzazepines
- alkylamide
- trihydroxy
- alkoxy
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Abstract
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2007253196A AU2007253196A1 (en) | 2006-05-24 | 2007-05-23 | 2-alkoxy-3,4,5-trihydroxy-alkylamide-benzazepines, the preparation and use thereof, and compositions containing the same |
CA002649336A CA2649336A1 (fr) | 2006-05-24 | 2007-05-23 | 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur preparation, compositions les contenant et utilisation |
EA200870565A EA200870565A1 (ru) | 2006-05-24 | 2007-05-23 | 2-алкокси-3,4,5-тригидроксиалкиламидобензазепины, их получение, содержащие их композиции и применение |
MX2008014844A MX2008014844A (es) | 2006-05-24 | 2007-05-23 | 2-alcoxi-3,4,5-trihidroxi-alquilamida-benzazepina, su preparacion, composiciones que las contienen y utilizacion. |
JP2009511545A JP2009537614A (ja) | 2006-05-24 | 2007-05-23 | 2−アルコキシ−3,4,5−トリヒドロキシ−アルキルアミド−ベンズアゼピン、これの調製およびこれの使用ならびにこれを含有する組成物 |
EP07765942A EP2035387A2 (fr) | 2006-05-24 | 2007-05-23 | 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur préparation, compositions les contenant et utilisation |
BRPI0712925-4A BRPI0712925A2 (pt) | 2006-05-24 | 2007-05-23 | 2-alcàxi-3,4,5-triidràxi-alquilamida-benzazepina, sua preparaÇço, composiÇÕes que as contÊm, e utilizaÇço |
TNP2008000402A TNSN08402A1 (en) | 2006-05-24 | 2008-10-15 | Modular system for realising furnishing elements |
IL195148A IL195148A0 (en) | 2006-05-24 | 2008-11-06 | 2-alkoxy-3,4,5-trihydroxy-alkylamide-benzazepines, the preparation and use thereof and compositions containing the same |
US12/267,689 US7994162B2 (en) | 2006-05-24 | 2008-11-10 | 2-alkoxy-3,4,5-trihydroxy-alkylamide-benzazepines, the preparation and use thereof, and compositions containing the same |
EC2008008893A ECSP088893A (es) | 2006-05-24 | 2008-11-17 | 2-alcoxi-3, 4,5-trihidroxi-alquilamida-benzazepinas, su preparación, composiciones que las contienen y utilización |
NO20085285A NO20085285L (no) | 2006-05-24 | 2008-12-17 | 2-alkosy-3,4,5-tnhydroksyalkylamidbenzazepiner, deres fremstilling og bruk samt preparater inneholdende disse |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0604733A FR2901554B1 (fr) | 2006-05-24 | 2006-05-24 | 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur preparation, compositions les contenant et utilisation |
FR0604733 | 2006-05-24 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/267,689 Continuation US7994162B2 (en) | 2006-05-24 | 2008-11-10 | 2-alkoxy-3,4,5-trihydroxy-alkylamide-benzazepines, the preparation and use thereof, and compositions containing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007135293A2 WO2007135293A2 (fr) | 2007-11-29 |
WO2007135293A3 true WO2007135293A3 (fr) | 2008-05-02 |
Family
ID=37487536
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2007/000866 WO2007135293A2 (fr) | 2006-05-24 | 2007-05-23 | 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur préparation, compositions les contenant et utilisation |
Country Status (24)
Country | Link |
---|---|
US (1) | US7994162B2 (fr) |
EP (1) | EP2035387A2 (fr) |
JP (1) | JP2009537614A (fr) |
KR (1) | KR20090010071A (fr) |
CN (1) | CN101454290A (fr) |
AR (1) | AR061103A1 (fr) |
AU (1) | AU2007253196A1 (fr) |
BR (1) | BRPI0712925A2 (fr) |
CA (1) | CA2649336A1 (fr) |
CR (1) | CR10382A (fr) |
DO (1) | DOP2007000104A (fr) |
EA (1) | EA200870565A1 (fr) |
EC (1) | ECSP088893A (fr) |
FR (1) | FR2901554B1 (fr) |
GT (1) | GT200800249A (fr) |
IL (2) | IL194972A0 (fr) |
MA (1) | MA30561B1 (fr) |
MX (1) | MX2008014844A (fr) |
NO (1) | NO20085285L (fr) |
PE (1) | PE20080705A1 (fr) |
TN (1) | TNSN08402A1 (fr) |
TW (1) | TW200812971A (fr) |
UY (1) | UY30368A1 (fr) |
WO (1) | WO2007135293A2 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2878528B1 (fr) | 2004-11-29 | 2008-05-16 | Aventis Pharma Sa | 2-alcoxy-3,4,5-trihydroxy-alkylamides, leur preparation, compositions les contenant et utilisation |
CN102924462B (zh) * | 2012-10-24 | 2015-01-14 | 华东师范大学 | 1,2,3,4,5,9-取代苯并吖庚因类化合物的合成方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4692522A (en) * | 1985-04-01 | 1987-09-08 | Merck & Co., Inc. | Benzofused lactams useful as cholecystokinin antagonists |
WO2001085697A1 (fr) * | 2000-05-11 | 2001-11-15 | Novartis Ag | Carbonates et ethers de caprolactame substitues et utilisation de ceux-ci comme agents anti tumoraux |
WO2005014574A1 (fr) * | 2003-07-25 | 2005-02-17 | Novartis Ag | Lactames substitues et utilisation de ceux-ci en tant qu'agents anti-cancereux |
WO2006056696A2 (fr) * | 2004-11-29 | 2006-06-01 | Aventis Pharma S.A. | 2-alcoxy-3,4,5-trihydroxy-alkylamides, leur preparation, compositions les contenant et utilisation |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4831135A (en) | 1986-06-18 | 1989-05-16 | The Regents Of The University Of California | Bengamide anthelmintics |
US5283241A (en) | 1992-08-28 | 1994-02-01 | Merck & Co., Inc. | Benzo-fused lactams promote release of growth hormone |
GB9411841D0 (en) | 1994-06-14 | 1994-08-03 | Pharma Mar Sa | New antitumoral compounds from jaspis sponge |
JP2002241368A (ja) | 1997-02-18 | 2002-08-28 | Shionogi & Co Ltd | 新規ベンゾラクタム誘導体およびそれを含有する医薬組成物 |
US6239127B1 (en) | 1999-11-17 | 2001-05-29 | Novartis Ag | Certain substituted caprolactams, pharmaceutical compositions containing them and a process for their preparation |
CO5140099A1 (es) | 1998-11-17 | 2002-03-22 | Novartis Ag | Ciertas caprolactamas sustituidas, composiciones farmaceuticas que las contienen, y su uso en el tratamiento de tumores |
JP2004514122A (ja) | 2000-11-14 | 2004-05-13 | ノバルティス アクチエンゲゼルシャフト | 抗増殖性化合物をスクリーニングしかつ腫瘍増殖を阻害する方法 |
US6545148B2 (en) | 2001-03-12 | 2003-04-08 | Novartis Ag | Process for preparing certain substituted caprolactams |
JP2004262793A (ja) | 2003-02-28 | 2004-09-24 | Noyaku Bio Technology Kaihatsu Gijutsu Kenkyu Kumiai | 化合物n−9011、その製造法及び用途 |
US7153846B2 (en) | 2003-10-24 | 2006-12-26 | Sanofi-Aventis Deutschland Gmbh | Bengamide derivatives, process for preparing them, and their use |
DE10349669B3 (de) | 2003-10-24 | 2005-05-25 | Aventis Pharma Deutschland Gmbh | Bengamide-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
FR2878525B1 (fr) | 2004-11-29 | 2007-02-23 | Aventis Pharma Sa | Bengamides possedant un cycle caprolactame substitue, procede de preparation, compositions les contenant et utilisation |
-
2006
- 2006-05-24 FR FR0604733A patent/FR2901554B1/fr not_active Expired - Fee Related
-
2007
- 2007-05-17 TW TW096117596A patent/TW200812971A/zh unknown
- 2007-05-21 PE PE2007000622A patent/PE20080705A1/es not_active Application Discontinuation
- 2007-05-23 AR ARP070102222A patent/AR061103A1/es unknown
- 2007-05-23 AU AU2007253196A patent/AU2007253196A1/en not_active Abandoned
- 2007-05-23 WO PCT/FR2007/000866 patent/WO2007135293A2/fr active Application Filing
- 2007-05-23 JP JP2009511545A patent/JP2009537614A/ja not_active Withdrawn
- 2007-05-23 KR KR1020087028521A patent/KR20090010071A/ko not_active Application Discontinuation
- 2007-05-23 MX MX2008014844A patent/MX2008014844A/es not_active Application Discontinuation
- 2007-05-23 BR BRPI0712925-4A patent/BRPI0712925A2/pt not_active Application Discontinuation
- 2007-05-23 EP EP07765942A patent/EP2035387A2/fr not_active Withdrawn
- 2007-05-23 CN CNA2007800189967A patent/CN101454290A/zh active Pending
- 2007-05-23 CA CA002649336A patent/CA2649336A1/fr not_active Abandoned
- 2007-05-23 EA EA200870565A patent/EA200870565A1/ru unknown
- 2007-05-24 DO DO2007000104A patent/DOP2007000104A/es unknown
- 2007-05-24 UY UY30368A patent/UY30368A1/es not_active Application Discontinuation
-
2008
- 2008-10-15 TN TNP2008000402A patent/TNSN08402A1/en unknown
- 2008-10-20 CR CR10382A patent/CR10382A/es unknown
- 2008-10-28 IL IL194972A patent/IL194972A0/en unknown
- 2008-11-06 IL IL195148A patent/IL195148A0/en unknown
- 2008-11-10 US US12/267,689 patent/US7994162B2/en not_active Expired - Fee Related
- 2008-11-17 EC EC2008008893A patent/ECSP088893A/es unknown
- 2008-11-19 GT GT200800249A patent/GT200800249A/es unknown
- 2008-12-05 MA MA31458A patent/MA30561B1/fr unknown
- 2008-12-17 NO NO20085285A patent/NO20085285L/no not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4692522A (en) * | 1985-04-01 | 1987-09-08 | Merck & Co., Inc. | Benzofused lactams useful as cholecystokinin antagonists |
WO2001085697A1 (fr) * | 2000-05-11 | 2001-11-15 | Novartis Ag | Carbonates et ethers de caprolactame substitues et utilisation de ceux-ci comme agents anti tumoraux |
WO2005014574A1 (fr) * | 2003-07-25 | 2005-02-17 | Novartis Ag | Lactames substitues et utilisation de ceux-ci en tant qu'agents anti-cancereux |
WO2006056696A2 (fr) * | 2004-11-29 | 2006-06-01 | Aventis Pharma S.A. | 2-alcoxy-3,4,5-trihydroxy-alkylamides, leur preparation, compositions les contenant et utilisation |
Non-Patent Citations (6)
Title |
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ADAMCZESKI M ET AL: "Novel Sponge-Derived Amino Acids. 5. Structures, Stereochemistry, and Synthesis of Several New Heterocycles", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 111, no. 2, 1989, pages 647 - 654, XP002171012, ISSN: 0002-7863 * |
CHANG C-Y ET AL: "Synthesis of optically active alpha-aminobenzolactam via an oxidative-cyclization reaction", TETRAHEDRON: ASYMMETRY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 14, no. 14, 18 July 2003 (2003-07-18), pages 2081 - 2085, XP004435224, ISSN: 0957-4166 * |
KINDER F R ET AL: "Synthesis and antitumour activity of ester modified analogues of bengamide B", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 44, 2001, pages 3692 - 3699, XP002311636, ISSN: 0022-2623 * |
PARSONS ET AL.: "Cholecystokinin Antagonists. Synthesis and Biological Evaluation of 3-Substituted Benzolactams", J. MED. CHEM., vol. 32, no. 8, 1989, pages 1681 - 1685, XP002457489 * |
RAMANA ET AL.: "A Carbohydrate-Based Approach for the Total Synthesis of 1,3-Polyol/alpha-Pyrone Antifungal Natural Products", J. ORG. CHEM., vol. 70, 2005, pages 8216 - 8219, XP002411409 * |
THALE Z ET AL: "BENGAMIDES REVISITED: NEW STRUCTURES AND ANTITUMOR STUDIES", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 66, 2001, pages 1733 - 1741, XP002310387, ISSN: 0022-3263 * |
Also Published As
Publication number | Publication date |
---|---|
NO20085285L (no) | 2008-12-17 |
EA200870565A1 (ru) | 2009-06-30 |
US7994162B2 (en) | 2011-08-09 |
MA30561B1 (fr) | 2009-07-01 |
CA2649336A1 (fr) | 2007-11-29 |
JP2009537614A (ja) | 2009-10-29 |
IL195148A0 (en) | 2009-09-22 |
EP2035387A2 (fr) | 2009-03-18 |
US20090099152A1 (en) | 2009-04-16 |
MX2008014844A (es) | 2009-02-17 |
FR2901554B1 (fr) | 2011-04-01 |
ECSP088893A (es) | 2008-12-30 |
UY30368A1 (es) | 2008-01-02 |
IL194972A0 (en) | 2009-08-03 |
GT200800249A (es) | 2009-05-15 |
BRPI0712925A2 (pt) | 2013-01-08 |
WO2007135293A2 (fr) | 2007-11-29 |
DOP2007000104A (es) | 2007-11-15 |
FR2901554A1 (fr) | 2007-11-30 |
TNSN08402A1 (en) | 2010-04-14 |
TW200812971A (en) | 2008-03-16 |
AU2007253196A1 (en) | 2007-11-29 |
PE20080705A1 (es) | 2008-07-30 |
CR10382A (es) | 2009-02-26 |
CN101454290A (zh) | 2009-06-10 |
KR20090010071A (ko) | 2009-01-28 |
AR061103A1 (es) | 2008-08-06 |
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