WO2010013312A1 - Dispositif et procédé d'alimentation de liquide, dispositif et procédé d'agitation et microréacteur - Google Patents

Dispositif et procédé d'alimentation de liquide, dispositif et procédé d'agitation et microréacteur Download PDF

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Publication number
WO2010013312A1
WO2010013312A1 PCT/JP2008/063586 JP2008063586W WO2010013312A1 WO 2010013312 A1 WO2010013312 A1 WO 2010013312A1 JP 2008063586 W JP2008063586 W JP 2008063586W WO 2010013312 A1 WO2010013312 A1 WO 2010013312A1
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WIPO (PCT)
Prior art keywords
magnetic field
magnetic body
fluid
microreactor
columnar
Prior art date
Application number
PCT/JP2008/063586
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English (en)
Japanese (ja)
Inventor
アダルシュ サンドゥー
Original Assignee
株式会社フォスメガ
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Publication date
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Priority to PCT/JP2008/063586 priority Critical patent/WO2010013312A1/fr
Publication of WO2010013312A1 publication Critical patent/WO2010013312A1/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/42—Mixers with shaking, oscillating, or vibrating mechanisms with pendulum stirrers, i.e. with stirrers suspended so as to oscillate about fixed points or axes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/453—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04D—NON-POSITIVE-DISPLACEMENT PUMPS
    • F04D33/00—Non-positive-displacement pumps with other than pure rotation, e.g. of oscillating type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00831—Glass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00833—Plastic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00835—Comprising catalytically active material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00925—Irradiation
    • B01J2219/0093—Electric or magnetic energy
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure

Definitions

  • the present invention relates to a liquid feeding device and method, a stirring device and method, and a microreactor using them.
  • the microreactor is a reaction apparatus having a micro flow channel of several to several hundred ⁇ m, and is used for compound synthesis / analysis, drug development, genome / DNA analysis, and the like.
  • the microreactor is 1) heat exchange efficiency is extremely high compared to conventional reactors using flasks, etc., and temperature control can be performed efficiently. 2) The area of the interface per unit volume of the fluid becomes very large. In recent years, research and development has been actively conducted because it has many features such as efficient reaction and 3) easy scale-up by numbering up.
  • a general pump such as a syringe pump or a piston pump is provided outside the microreactor.
  • the present invention has been made in view of such circumstances, and as a new microreactor capable of accurately controlling the liquid feeding at an arbitrary position in an apparatus such as a microreactor and a related technique.
  • An object is to provide a liquid apparatus and method.
  • the microreactor of the present invention includes a columnar magnetic body disposed in a fluid in the microreactor, and an end fixing means for fixing one end of the columnar magnetic body in the microreactor using a DC magnetic field. And end movement means for moving the other end of the columnar magnetic body using an alternating magnetic field.
  • the end motion means applies an alternating magnetic field substantially parallel to the liquid feeding direction, and feeds the other end so that the magnetic body operates like a pendulum with the one end as a fulcrum. It can be reciprocated in the liquid direction and vice versa.
  • the end motion means can reciprocate the other end so that the moving speed differs between the forward motion and the backward motion.
  • the end motion means applies an AC magnetic field so that the direction of the magnetic field rotates 360 ° in a plane including the flow path, and the magnetic body operates like a conical pendulum with the one end as a fulcrum. Thus, the other end can be moved in a substantially circular motion within the plane.
  • the columnar magnetic body may be generated by magnetically coupling a plurality of magnetic particles into a columnar shape by the DC magnetic field.
  • the liquid delivery device of the present invention includes an end fixing means for fixing one end of a columnar magnetic body contained in a fluid in the target device within the target device using a DC magnetic field, and the columnar magnetic body.
  • Liquid feeding means for moving the other end of the fluid so as to feed the fluid using an alternating magnetic field.
  • the stirrer according to the present invention includes an end fixing means for fixing one end of a columnar magnetic body contained in a fluid in the target apparatus in the target apparatus using a DC magnetic field, and the columnar magnetic body. And stirring means for moving the other end so as to stir the fluid using an alternating magnetic field.
  • the liquid feeding method of the present invention includes an end fixing step of fixing one end of a columnar magnetic body disposed in a fluid in the target device in the target device using a DC magnetic field, and the columnar magnetic material. A liquid feeding step of moving the other end of the body to feed the fluid using an alternating magnetic field.
  • the stirring method of the present invention includes an end fixing step of fixing one end of a columnar magnetic body disposed in a fluid in the target device within the target device using a DC magnetic field, and the columnar magnetic body. And a stirring step of moving the other end of the fluid so as to stir the fluid using an alternating magnetic field.
  • the liquid feeding at an arbitrary position in the apparatus is accurately and appropriately controlled by the behavior based on the external magnetic field of the magnetic substance contained in the fluid in the apparatus. can do.
  • the fluid can be agitated by the behavior of the magnetic body based on the external magnetic field, the fluids can be effectively mixed at an arbitrary position in the apparatus.
  • FIG. 1A is a perspective view schematically showing a schematic configuration of a microreactor 1 according to an embodiment of the present invention.
  • FIG. 1B is an enlarged plan view of a part of the channel in a state where a fluid is introduced into the channel of the microreactor 1.
  • the microreactor 1 has a microchannel 10 for performing a chemical reaction or the like on the surface of the substrate, as in the conventional microreactor.
  • a plurality of fluids introduced from the inlets 11 and 12 are mixed in the reaction channel 13 and discharged from the outlet 14. Discharged from.
  • the microreactor 1 of this embodiment is for controlling the behavior of the magnetic body 20 as a liquid feeding / stirring device 30 in that the magnetic body 20 is arranged in the fluid in the microchannel 10. It differs from a conventional microreactor in that it includes an end fixing means 31 and an end movement means 32.
  • the size of the microchannel 10 can be determined according to the design.
  • the structure of the microchannel 10 can take various structures such as a T-shape or a multilayer structure depending on the design.
  • the substrate of the microreactor 1 can be formed using various materials such as glass, silicon, and plastic as in the conventional case.
  • the end fixing means 31 is arranged at the lower part of the microreactor 1 and the end moving means 32 is arranged at the introduction port side of the microreactor 1. If it is a position which can apply the magnetic field 40 and the alternating current magnetic fields 41 and 42, it can arrange
  • FIG. 2 schematically shows the structure of the magnetic body 20.
  • the magnetic body 20 is formed by magnetically coupling a plurality of magnetic particles 21 in a columnar shape, and includes two end portions 22 and 23 corresponding to both ends of the column.
  • One end 22 of the magnetic body 20 is fixed in contact with the microchannel 10 by an end fixing means 31 as described later.
  • the other end 23 of the magnetic body 20 is not fixed, and is controlled so as to reciprocate by the end motion means 32 as will be described later.
  • the magnetic particles 21 can be manufactured using conventional techniques, and may be particles of a composition containing a magnetic material in addition to particles of the magnetic material itself.
  • the magnetic particles 21 can take various shapes such as granular, plate-like, box-like, and needle-like (for example, magnetic carbon nanotube (CNT)).
  • the size is the size of the microchannel 10 and the type of fluid. It can be determined according to the required liquid feeding ability and stirring ability.
  • the end fixing means 31 is a device that applies a DC magnetic field 40 in a direction substantially orthogonal to the microchannel 10 (for example, a direction orthogonal to a plane including the microchannel 10) (FIG. 3A). reference).
  • a DC magnetic field 40 in a direction substantially orthogonal to the microchannel 10 (for example, a direction orthogonal to a plane including the microchannel 10) (FIG. 3A). reference).
  • Such an apparatus can be realized by using a permanent magnet, an electromagnet, or the like, as in the prior art.
  • the magnetic body 20 of the present embodiment is formed using the above phenomenon. That is, after introducing and dispersing the magnetic particles 21 in the fluid, a DC magnetic field 40 is applied in a direction substantially orthogonal to the microchannel 10 by the end fixing means 31, so that the magnetic field incident side of the microchannel 10 The magnetic particles 21 are magnetically coupled in a columnar shape with the bottom (fixed end portion 22) as a magnetic body 20.
  • magnetic particles or a magnetic thin film may be provided in advance on the magnetic field incident side of the microchannel 10.
  • the attaching method can use a conventional technique such as adhesion.
  • the magnetic particles 21 are magnetically coupled so that the magnetic particles attached in advance are at the bottom of the column, the formation position of the magnetic body 20 can be designated in advance.
  • the end motion means 32 applies an alternating magnetic field 41 substantially parallel to the flow path direction (liquid feeding direction) of the micro flow path 10, and the direction of the magnetic field is 360 ° in a plane including the micro flow path 10.
  • This is a device that applies an alternating magnetic field 42 so as to rotate (see FIGS. 3B and 3C).
  • Such a device can be realized by using a magnetic field generated by an alternating current, as in the prior art.
  • the end portion 23 of the magnetic body 20 is not fixed to the microchannel 10, and therefore moves under the influence of the alternating magnetic field 41 applied by the end motion means 32.
  • the end portion 22 of the magnetic body 20 is also affected by the alternating magnetic field 41 applied by the end portion moving means 32, so that the end portion moving means 32 can be fixed to the microchannel 10 under the influence.
  • the strength of the DC magnetic field 40 applied by the end fixing means 31 is set to be sufficiently larger than the strength of the AC magnetic field 41 applied by.
  • magnetic particles 21 are mixed and dispersed in each fluid to be reacted using the microreactor 1 (step 1).
  • each fluid in which the magnetic particles 21 are dispersed is introduced into the microchannel 10 from the inlets 11 and 12 (step 2).
  • a DC magnetic field 40 is applied to the microchannel 10 by the end fixing means 31 in a substantially orthogonal direction (step 3).
  • the DC magnetic field 40 is applied in a direction from the lower side to the upper side of the plane including the microchannel 10.
  • the magnetic particles 21 dispersed in the fluid are magnetically coupled in a columnar shape with the lower side (fixed end 22) of the microchannel 10 on the side on which the DC magnetic field is incident as the bottom. Then, the magnetic body 20 is formed.
  • the interval (interval between the end portions 22) and the height (number of bonds of the magnetic particles 21) between the magnetic bodies 20 formed on the lower side of the microchannel 10 are the diameter, magnetic moment, and type (Fe, Co, Ni, etc.).
  • the specific spacing and height can be determined according to the size of the microchannel 10, the type of fluid, and the required liquid feeding ability and stirring ability.
  • an alternating magnetic field 41 is applied by the end motion means 32 in the liquid feeding operation mode (step 4).
  • an alternating magnetic field 41 is applied substantially parallel to the flow path direction (liquid feeding direction) of the micro flow path 10 (the reaction flow path 13 in the present embodiment).
  • the end portion 23 of the magnetic body 20 reciprocates in the direction of the AC magnetic field 41 (that is, the liquid feeding direction and the opposite direction).
  • the reciprocating motion of the end portion 23 can be controlled by the waveform of the alternating magnetic field 41 to be applied.
  • the moving speed of the end portion 23 during the forward movement is higher than the moving speed during the backward movement.
  • the waveform of the AC magnetic field 41 can be set. Specifically, during the forward movement, the waveform of the AC magnetic field 41 is set so that a relatively steep magnetic field gradient (change in magnetic flux density) is generated, and the end 23 is controlled to move at a relatively high speed. To do. Further, during the backward movement, the waveform of the AC magnetic field 41 is set so that a relatively gentle magnetic field gradient is generated, and the end portion 23 is controlled to move at a relatively slow speed.
  • the magnetic body 20 is like a pendulum with the fixed end portion 22 as a fulcrum. It works to feed fluid (functions as a nanopump).
  • FIG. 4 schematically shows how the magnetic substance 20 in the fluid functions as a nanopump.
  • 4A is a view of the columnar magnetic body 20 viewed from the side
  • FIG. 4B is a view of the columnar magnetic body 20 viewed from above.
  • the magnetic body 20 in each drawing is schematically shown, and the dimensional ratio is not limited to the illustrated ratio.
  • the moving speed difference of the reciprocating motion in the liquid feeding operation mode can be determined according to the type of fluid and the required liquid feeding capacity. Moreover, what is necessary is just to stop the application of the alternating current magnetic field 41, when a liquid feeding effect becomes unnecessary.
  • an alternating magnetic field 42 is applied by the end motion means 32 in the stirring operation mode (step 5).
  • the application direction and strength of the alternating magnetic field 42 in the stirring operation mode can be determined according to the type of fluid and the required stirring ability.
  • the waveform of the alternating magnetic field 42 can be set so that the end portion 23 rotates 360 degrees in the direction of the magnetic field in the plane including the microchannel 10.
  • the end portion 23 of the magnetic body 20 moves in a substantially circular motion within the plane.
  • the magnetic body 20 operates like a conical pendulum with the fixed end 22 as a fulcrum, and acts to stir the fluid (functions as a nanostirrer).
  • FIG. 5 schematically shows how the magnetic substance 20 in the fluid functions as a nanostirrer.
  • 5A is a view of the columnar magnetic body 20 viewed from the side
  • FIG. 5B is a view of the columnar magnetic body 20 viewed from above.
  • the magnetic body 20 in each drawing is schematically shown, and the dimensional ratio is not limited to the illustrated ratio.
  • the rotation speed of the magnetic field in the stirring operation mode can be determined according to the type of fluid and the required stirring ability. Further, when the stirring action becomes unnecessary, the application of the alternating magnetic field 42 may be stopped.
  • the microreactor 1 of this embodiment can send a fluid by the behavior of the magnetic body 20 in the fluid, a conventional pump device is unnecessary. As a result, the amount of fluid required to pass through the piping in the pump device, which has been necessary in the past, is no longer necessary, so that a necessary amount of a necessary amount can be produced as necessary. Further, since the mechanical part called the pump device can be eliminated, it is possible to avoid shortening the apparatus life due to a failure of the mechanical part.
  • the magnetic body 20 that functions as a nanopump can be selected by locally applying an alternating magnetic field 41 to the microchannel 10, and the nanopump liquid feed can be controlled by controlling the waveform of the alternating magnetic field 41 to be applied. Since the ability can be controlled, fluid feeding can be accurately controlled at an arbitrary position of the micro flow path 10.
  • the magnetic body 20 can function as a nanostirrer, so that mixing of fluids can be effectively performed at an arbitrary position in the reaction channel 13. It can be carried out.
  • the present invention is not limited to the above embodiment and can be applied in various modifications.
  • the AC magnetic fields 41 and 42 are uniformly applied to the entire micro flow path 10, but are locally applied to the reaction flow path 13 and the flow path portions on the side of the introduction ports 11 and 12.
  • an AC magnetic field may be applied.
  • the AC magnetic field 41 is locally applied to each of the flow passage portions on the inlets 11 and 12 side to enter the liquid feeding operation mode, and the AC magnetic field 42 is locally applied to the reaction flow channel 13. It is good also as a structure set as stirring operation mode.
  • the liquid feeding / stirring device 30 is operated in both the liquid feeding operation mode and the stirring operation mode, but only one of the operation modes (that is, only as the liquid feeding device or the stirring device). As well). Alternatively, the liquid feeding operation mode and the stirring operation mode may be switched so that the liquid feeding operation and the stirring operation are alternately performed.
  • liquid feeding device and method, the stirring device and the method of the present invention are not limited to the application to the microreactor, and can be applied to other devices such as an artificial heart device.
  • the liquid feeding function and the stirring function can be realized by controlling the behavior of the magnetic body 20 in the fluid.
  • the present invention can be widely used for apparatuses for feeding and stirring liquids in fine channels, including various microreactors, and their production.
  • FIG. 6 is a diagram for explaining a magnetic body 20. It is a figure for demonstrating the DC magnetic field 40 and the AC magnetic fields 41 and 42 which are applied by the edge part fixing means 31 and the edge movement means 32. FIG. It is a figure for demonstrating the magnetic body 20 which functions as a nanopump. It is a figure for demonstrating the magnetic body 20 which functions as a nanostirrer.

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Abstract

L'invention porte sur un nouveau microréacteur, par lequel l'alimentation d'un liquide situé à une position arbitraire dans un dispositif peut être commandée avec une grande précision et des liquides peuvent être efficacement mélangés ensemble, et sur des techniques correspondantes. A savoir, l'invention porte sur un microréacteur qui comprend un corps magnétique en forme de barre disposé dans un liquide dans le microréacteur, une unité de fixation d'extrémité pour fixer une extrémité du corps magnétique en forme de barre tel que décrit ci-dessus dans le microréacteur par l'utilisation d'un champ magnétique de courant direct, et une unité de déplacement d'extrémité pour déplacer l'autre extrémité du corps magnétique en forme de barre tel que décrit ci-dessus par l'utilisation d'un champ magnétique de courant alternatif.
PCT/JP2008/063586 2008-07-29 2008-07-29 Dispositif et procédé d'alimentation de liquide, dispositif et procédé d'agitation et microréacteur WO2010013312A1 (fr)

Priority Applications (1)

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PCT/JP2008/063586 WO2010013312A1 (fr) 2008-07-29 2008-07-29 Dispositif et procédé d'alimentation de liquide, dispositif et procédé d'agitation et microréacteur

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Application Number Priority Date Filing Date Title
PCT/JP2008/063586 WO2010013312A1 (fr) 2008-07-29 2008-07-29 Dispositif et procédé d'alimentation de liquide, dispositif et procédé d'agitation et microréacteur

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Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52100657A (en) * 1976-02-20 1977-08-23 Gorou Yabe Mixing method and apparatus therefor
JPS58210863A (ja) * 1982-06-03 1983-12-08 株式会社富士電機総合研究所 移動磁界式処理装置のワ−キングピ−ス
JPS601793Y2 (ja) * 1980-08-25 1985-01-18 日本電気ホームエレクトロニクス株式会社 液体の撹拌装置
JPS62247382A (ja) * 1986-04-19 1987-10-28 Konika Corp 二成分現像剤を用いた現像装置
JP2003504195A (ja) * 1999-07-19 2003-02-04 オルガノン・テクニカ・ベー・ヴエー 磁性粒子を流体と混合するための装置および方法
JP2003248008A (ja) * 2001-12-18 2003-09-05 Inst Of Physical & Chemical Res 反応液の攪拌方法
JP2004534243A (ja) * 2001-07-09 2004-11-11 ビオムリュー、エス．エー 磁性粒子の処理方法及び磁石を用いた生物学的分析装置
WO2006079998A1 (fr) * 2005-01-31 2006-08-03 Koninklijke Philips Electronics N.V. Biodetection rapide et sensible
JP2007319735A (ja) * 2006-05-30 2007-12-13 Fuji Xerox Co Ltd マイクロリアクター装置及び微小流路の洗浄方法
JP2008012490A (ja) * 2006-07-07 2008-01-24 Shimadzu Corp 微量化学反応方法及び装置

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52100657A (en) * 1976-02-20 1977-08-23 Gorou Yabe Mixing method and apparatus therefor
JPS601793Y2 (ja) * 1980-08-25 1985-01-18 日本電気ホームエレクトロニクス株式会社 液体の撹拌装置
JPS58210863A (ja) * 1982-06-03 1983-12-08 株式会社富士電機総合研究所 移動磁界式処理装置のワ−キングピ−ス
JPS62247382A (ja) * 1986-04-19 1987-10-28 Konika Corp 二成分現像剤を用いた現像装置
JP2003504195A (ja) * 1999-07-19 2003-02-04 オルガノン・テクニカ・ベー・ヴエー 磁性粒子を流体と混合するための装置および方法
JP2004534243A (ja) * 2001-07-09 2004-11-11 ビオムリュー、エス．エー 磁性粒子の処理方法及び磁石を用いた生物学的分析装置
JP2003248008A (ja) * 2001-12-18 2003-09-05 Inst Of Physical & Chemical Res 反応液の攪拌方法
WO2006079998A1 (fr) * 2005-01-31 2006-08-03 Koninklijke Philips Electronics N.V. Biodetection rapide et sensible
JP2007319735A (ja) * 2006-05-30 2007-12-13 Fuji Xerox Co Ltd マイクロリアクター装置及び微小流路の洗浄方法
JP2008012490A (ja) * 2006-07-07 2008-01-24 Shimadzu Corp 微量化学反応方法及び装置

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