WO2010002571A1 - Halitosis treatment - Google Patents
Halitosis treatment Download PDFInfo
- Publication number
- WO2010002571A1 WO2010002571A1 PCT/US2009/047272 US2009047272W WO2010002571A1 WO 2010002571 A1 WO2010002571 A1 WO 2010002571A1 US 2009047272 W US2009047272 W US 2009047272W WO 2010002571 A1 WO2010002571 A1 WO 2010002571A1
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- WO
- WIPO (PCT)
- Prior art keywords
- composition
- compositions
- applying
- zinc
- treatment
- Prior art date
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- 238000011282 treatment Methods 0.000 title claims abstract description 30
- 206010006326 Breath odour Diseases 0.000 title claims abstract description 20
- 208000032139 Halitosis Diseases 0.000 title claims abstract description 20
- 239000000203 mixture Substances 0.000 claims abstract description 93
- 238000000034 method Methods 0.000 claims abstract description 43
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000000341 volatile oil Substances 0.000 claims abstract description 16
- 239000003899 bactericide agent Substances 0.000 claims abstract description 9
- 210000000214 mouth Anatomy 0.000 claims description 20
- 239000002184 metal Substances 0.000 claims description 15
- 229910052751 metal Inorganic materials 0.000 claims description 15
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 14
- 239000011701 zinc Substances 0.000 claims description 14
- 229910052725 zinc Inorganic materials 0.000 claims description 14
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 9
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims description 9
- 229910052802 copper Inorganic materials 0.000 claims description 9
- 239000010949 copper Substances 0.000 claims description 9
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 6
- 229960003260 chlorhexidine Drugs 0.000 claims description 6
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 3
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 3
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 3
- 229960000306 zinc gluconate Drugs 0.000 claims description 3
- 235000011478 zinc gluconate Nutrition 0.000 claims description 3
- 239000011670 zinc gluconate Substances 0.000 claims description 3
- UKLNMMHNWFDKNT-UHFFFAOYSA-M sodium chlorite Chemical compound [Na+].[O-]Cl=O UKLNMMHNWFDKNT-UHFFFAOYSA-M 0.000 claims description 2
- 229960002218 sodium chlorite Drugs 0.000 claims description 2
- 229940107702 grapefruit seed extract Drugs 0.000 claims 1
- 235000019645 odor Nutrition 0.000 abstract description 11
- 238000011418 maintenance treatment Methods 0.000 abstract description 4
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 description 14
- 239000003795 chemical substances by application Substances 0.000 description 9
- 210000003800 pharynx Anatomy 0.000 description 8
- 240000002234 Allium sativum Species 0.000 description 7
- 235000004611 garlic Nutrition 0.000 description 7
- 230000003385 bacteriostatic effect Effects 0.000 description 6
- 239000000284 extract Substances 0.000 description 6
- 150000002739 metals Chemical class 0.000 description 6
- 238000011269 treatment regimen Methods 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 230000001680 brushing effect Effects 0.000 description 4
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 4
- 239000012876 carrier material Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 230000002503 metabolic effect Effects 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 2
- YYNJYMYRHBOARL-UHFFFAOYSA-N 7-methoxyquinoxalin-5-amine Chemical compound N1=CC=NC2=CC(OC)=CC(N)=C21 YYNJYMYRHBOARL-UHFFFAOYSA-N 0.000 description 2
- 244000080208 Canella winterana Species 0.000 description 2
- 235000008499 Canella winterana Nutrition 0.000 description 2
- 235000009024 Ceanothus sanguineus Nutrition 0.000 description 2
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 2
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 description 2
- 244000004281 Eucalyptus maculata Species 0.000 description 2
- 239000005770 Eugenol Substances 0.000 description 2
- 244000178870 Lavandula angustifolia Species 0.000 description 2
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 2
- 240000003553 Leptospermum scoparium Species 0.000 description 2
- 235000015459 Lycium barbarum Nutrition 0.000 description 2
- 244000024873 Mentha crispa Species 0.000 description 2
- 235000014749 Mentha crispa Nutrition 0.000 description 2
- 244000246386 Mentha pulegium Species 0.000 description 2
- 235000016257 Mentha pulegium Nutrition 0.000 description 2
- 235000004357 Mentha x piperita Nutrition 0.000 description 2
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 2
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 2
- 244000223014 Syzygium aromaticum Species 0.000 description 2
- 239000005844 Thymol Substances 0.000 description 2
- 235000007303 Thymus vulgaris Nutrition 0.000 description 2
- 240000002657 Thymus vulgaris Species 0.000 description 2
- CKZZREIPBTYJEQ-UHFFFAOYSA-N Totarol Natural products C1CC2C(C)(C)CCCC2(C)C2=C1C(C(C)C)=C(C)C=C2 CKZZREIPBTYJEQ-UHFFFAOYSA-N 0.000 description 2
- NVLPQIPTCCLBEU-UHFFFAOYSA-N allyl methyl sulphide Natural products CSCC=C NVLPQIPTCCLBEU-UHFFFAOYSA-N 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 description 2
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 description 2
- 235000007746 carvacrol Nutrition 0.000 description 2
- 229960005233 cineole Drugs 0.000 description 2
- 229940017545 cinnamon bark Drugs 0.000 description 2
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 2
- 229960002217 eugenol Drugs 0.000 description 2
- 235000001050 hortel pimenta Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 description 2
- 239000001102 lavandula vera Substances 0.000 description 2
- 235000018219 lavender Nutrition 0.000 description 2
- UODXCYZDMHPIJE-UHFFFAOYSA-N menthanol Chemical compound CC1CCC(C(C)(C)O)CC1 UODXCYZDMHPIJE-UHFFFAOYSA-N 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 210000002741 palatine tonsil Anatomy 0.000 description 2
- 229960000790 thymol Drugs 0.000 description 2
- 239000001585 thymus vulgaris Substances 0.000 description 2
- ZRVDANDJSTYELM-FXAWDEMLSA-N totarol Chemical compound CC([C@@H]1CC2)(C)CCC[C@]1(C)C1=C2C(C(C)C)=C(O)C=C1 ZRVDANDJSTYELM-FXAWDEMLSA-N 0.000 description 2
- 229940074347 totarol Drugs 0.000 description 2
- ZRVDANDJSTYELM-UHFFFAOYSA-N trans-totarol Natural products C1CC2C(C)(C)CCCC2(C)C2=C1C(C(C)C)=C(O)C=C2 ZRVDANDJSTYELM-UHFFFAOYSA-N 0.000 description 2
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 1
- 241000234282 Allium Species 0.000 description 1
- 235000002732 Allium cepa var. cepa Nutrition 0.000 description 1
- 239000004155 Chlorine dioxide Substances 0.000 description 1
- 240000000560 Citrus x paradisi Species 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 208000032974 Gagging Diseases 0.000 description 1
- 229920000153 Povidone-iodine Polymers 0.000 description 1
- 206010038776 Retching Diseases 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000002272 anti-calculus Effects 0.000 description 1
- 230000002882 anti-plaque Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 235000021152 breakfast Nutrition 0.000 description 1
- 229940078916 carbamide peroxide Drugs 0.000 description 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- 235000019398 chlorine dioxide Nutrition 0.000 description 1
- 239000003975 dentin desensitizing agent Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 210000003254 palate Anatomy 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 229960001621 povidone-iodine Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003464 sulfur compounds Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
- A61K2800/884—Sequential application
Definitions
- This invention relates generally to a method for oral treatment, particularly to a method for treatment of halitosis and more particularly to a method for treating halitosis with gargling in a predetermined manner.
- Halitosis odor is formed by bacterial byproducts during the metabolism primarily of certain proteins. This results in sulfur compounds, for example, hydrogen sulfide, which has the smell of rotten eggs, which are distinctive and objectionable, as well as other compounds that contribute to the smell.
- the causative bacteria reside mainly on the posterior of the tongue, especially the extreme posterior, which cannot be seen when looking in the mirror with the tongue out as far as possible, and the oral pharynx, particularly when tonsils are present.
- Mechanical cleansing of the back of the tongue by brushing or scraping creates temporary reductions in halitosis.
- brushing and flossing do not relieve morning breath as well as eating breakfast. It is believed that eating affects the rear of the tongue and throat, while brushing and flossing do not.
- the vast majority of halitosis is caused by odors released from bacteria on the back of the tongue.
- the present invention relates to an oral treatment method comprising applying at least two, particularly at least three oral treatment compositions.
- the oral treatment method includes a treatment regimen in a predetermined order.
- An aspect of the present invention includes a method for providing oral treatment comprising the steps of applying at least two compositions to a human oral cavity selected from the group consisting of a first composition comprising hydrogen peroxide; a second composition comprising a metal selected from the group consisting of copper, tin and/or zinc; a third composition comprising a bactericidal agent; and/or a fourth composition comprising essential oils.
- Another aspect of the present invention includes a method for providing oral treatment comprising the steps of applying a first composition comprising hydrogen peroxide to a human oral cavity; applying a second composition comprising a metal selected from the group consisting of copper, tin and/or zinc after said first composition; applying a third composition comprising chlorhexidine after said second composition; and applying a fourth composition comprising essential oils after said third composition.
- Other aspects of the present invention may include a method for providing oral treatment comprising the steps of applying a first composition comprising hydrogen peroxide to a human oral cavity; applying a second composition comprising a metal selected from the group consisting of copper, tin and/or zinc after said first composition; applying a third composition comprising chlorhexidine after said second composition; and applying a fourth composition comprising essential oils after said third composition, wherein each composition is applied two times per day for a period of time of about four days.
- Still other aspects of the present invention may include applying a fifth composition after the fourth day, said fifth composition comprising a metal selected from the group consisting of copper, tin and/or zinc; and applying a sixth composition comprising essential oils, after said fifth composition.
- halitosis treatment regimen comprising gargling.
- embodiments of the present invention relate to a method of oral treatment.
- the method of oral treatment includes a method of oral treatment of halitosis.
- the methods and compositions useful in the present invention are described below.
- the teeth, gums, cheek, palate and the tongue may be brushed. It is preferred to brush as far back in the oral cavity as possible, which may result in gagging, for a period of time of at least about two minutes Toothpaste may be used.
- the method of oral treatment to eliminate halitosis and/or other odors comprises the use of compositions which chemically neutralize the odiferous molecules.
- the method of oral treatment of the present invention further comprises the use of compositions which mechanically remove the causative bacteria and their food sources.
- the method of oral treatment of the present invention still further comprises compositions which chemically deactivate the metabolic mechanism of the causative bacteria.
- the method of oral treatment of the present invention comprises compositions which inhibit the bacteria from reproducing, i.e. compositions having a bacteristatic effect and compositions which chemically kill the causative bacteria, i.e. compositions which have a bactericidal effect.
- compositions particularly at least three compositions are applied to the human oral cavity.
- the treatment regimen of the present invention follows a predetermined and/or sequential order.
- the present invention relates to applying the compositions to the oral cavity by gargling.
- gargling is a physical act wherein a person tilts the head back allowing a mouthful of liquid to sit in the upper throat. Air is then expelled from the lungs, causing the liquid to bubble and undulate throughout the throat and mouth region.
- gargling comprises getting a liquid onto the furthest back portion of the tongue and deep into the throat.
- the rear of the tongue is targeted by sticking it out and making an "aaahhh” sound.
- the back of the throat is reached by relaxing the tongue, letting it fall back, loosely, and making the "oooooo" sound.
- the two sounds may be alternated with occasional/intermittent mouth swishing when a break is needed.
- Gargling is not merely swishing liquid around your mouth, teeth and gums. It is believed that gargling, as described above, increases the effectiveness of the oral treatment method of the present invention.
- the first composition comprises an effective amount of an agent that chemically neutralizes the odiferous molecules; mechanically removes the causative bacteria and their food sources; and has both a bacteristatic and bactericidal effect.
- Suitable agents include, but are not limited to, hydrogen peroxide and/or carbamide peroxide and/or chlorine dioxide. Hydrogen peroxide is preferred.
- the term "effective amount" as used herein means an amount of an agent sufficient to significantly induce a positive effect in the oral treatment method of the present invention.
- hydrogen peroxide may be used in an amount in the range of from about 0.5% to about 3.0% by weight, particularly in an amount of about 3.0% by weight. It is believed that hydrogen peroxide breaks up microorganism biofilm structure in the oral cavity so the causative bacteria are more susceptible to treatment.
- the second composition of the present invention comprises an effective amount of an agent that chemically deactivates the metabolic mechanism of the causative bacteria.
- Metals are useful in the second composition of the present invention. Suitable metals include, but are not limited to, metals selected from the group consisting of copper, tin and/or zinc. Metal salts are preferred, particularly zinc gluconate. For example, zinc gluconate may be used in an amount in the range of from about 0.001% to about 1.5% by weight, particularly in an amount in the range of from about 0.05% to about 1.0% by weight. Seed or pulp extracts may also be included such as grapefruit seed.
- the third composition comprises an effective amount of a bactericidal agent.
- Suitable bactericidal agents include, but are not limited to, chlorhexidine and/or cetylpyridinium chloride and/or povidone-iodine.
- Chlorhexidine is preferred.
- chlorhexidine gluconate may be used in an amount in the range of from about 0.025% to about 0.2% by weight, particularly in an amount of about 0.12% by weight.
- Cetylpyridinium chloride may be used in an amount in the range of from about 0.025% to about 0.10% by weight, particularly in an amount of about 0.07% by weight. It is believed that chlorhexidine exhibits excellent causative bacteria attachment capability.
- the fourth composition comprises an effective amount of a bacteristatic and bactericidal agent.
- Suitable bactericidal and bacteristatic agents include, but are not limited to, essential oils and extracts.
- Essential oils which may be used include essential oils of peppermint, red thyme, cinnamon bark, eucalyptus globules, lavender, tea tree, spearmint, and clove and/or mixtures thereof. Extracts which may be used include eugenol, thymol, carvacrol, menthanol, eucalyptol, and totarol and/or mixtures thereof. It is believed that the essential oils penetrate the microorganism biofilm structure found in the oral cavity and kill or retard the growth of the causative bacteria.
- the fifth composition includes an agent which chemically neutralizes the odorous molecules and chemically deactivates the metabolic mechanism of the causative bacteria.
- Metals are useful in the fifth composition of the present invention. Suitable metals include, but are not limited to, metals selected from the group consisting of copper, tin and/or zinc. Zinc is preferred. It is believed that zinc, for example, binds to the protein receptor sites on the bacteria, suppressing the metabolic process that creates the odor causing compounds. Sodium chlorite may also be included.
- the sixth composition comprises an effective amount of a bacteristatic and bactericidal agent.
- Suitable bactericidal and bacteristatic agents include, but are not limited to, essential oils and extracts.
- Essential oils which may be used include essential oils of peppermint, red thyme, cinnamon bark, eucalyptus globules, lavender, tea tree, spearmint, and clove and/or mixtures thereof. Extracts which may be used include eugenol, thymol, carvacrol, menthanol, eucalyptol, and totarol. It is believed that the essential oils and extracts penetrate the microorganism biofilm structure found in the oral cavity and kill or retard the growth of the causative bacteria.
- compositions of the present invention may comprise a carrier material into which other ingredients are solubilised, dispersed or otherwise mixed.
- the carrier material can differ.
- mouth wash compositions commonly have a carrier material which comprises from about 20:1 to about 2:1 aqueous alcoholic matrix.
- compositions of the present invention are prepared by standard techniques well known to those skilled in the art.
- Other ingredients useful in the compositions herein include, but are not limited to, anti-plaque agents, desensitizing agents, anti- calculus agents, surfactants, nutrients, sweeteners and/or flavoring agents.
- Typical amounts of each of the six compositions of the present invention are in the range of from 1/8 ounce to about 1 ounce. Generally about 1 A ounce of each composition is used per application.
- the four steps as discussed above should be performed twice a day for a period of four days.
- a maintenance treatment may be performed using the fifth and sixth compositions.
- the maintenance treatment should be carried out twice daily after brushing. It is believed that the compositions of the present invention must reach the target area, the rear of the tongue and deep into the throat to be effective in the treatment of halitosis.
- compositions of the present invention must remain in contact with the oral cavity for an adequate amount of time to be effective.
- the amount of time for the initial treatment regimen of the present invention is in the range of about to about 30 seconds to 120 seconds.
- the amount of contact time is about 60 seconds.
- the amount of time for the maintenance treatment of the present invention is in the range of from about 15 seconds to 120 seconds.
- the amount of contact time is about 30 seconds.
- compositions exert a synergistic effect and operate by different mechanisms. It is also believed that the specified application order has an effect on the halitosis treatment of the present invention.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A method of oral treatment to eliminate odors, particularly halitosis, using two or more oral treatment compositions. A four step method in a sequential order may be followed using compositions including hydrogen peroxide, metal ions, bactericidal agents and essential oils. Gargling increases the effectiveness of the treatment. Good breath is maintained with a two step maintenance treatment.
Description
HALITOSIS TREATMENT
BACKGROUND OF THE INVENTION
Technical Field
[0001] This invention relates generally to a method for oral treatment, particularly to a method for treatment of halitosis and more particularly to a method for treating halitosis with gargling in a predetermined manner.
State of the Art
[0002] Contrary to popular thought, halitosis does not come from the stomach. There is a physical closure between the esophagus and stomach. Nothing is transmitted through this closure from the stomach to the mouth unless you burp or regurgitate.
[0003] Food breath is not halitosis. Garlic, onions, spices and alcohol create characteristic odors, but if these substances are avoided the odor is not present. This is easily controlled and is not considered halitosis. Garlic breath, for instance, remains long after garlic residues have been cleared from the mouth, for several hours, because the odor comes from the lungs. As garlic is digested several byproducts are formed. Only one, however, is not quickly further metabolized by the gut and liver into non-odiferous compounds. Allyl methyl sulfide (AMS) has the familiar odor of garlic breath and is eliminated from the body by the excretory functions of the lungs, skin and kidneys. Studies that compare fresh garlic with various garlic preparations are commonly done at 30 hours after ingestion and are
measured in mouth air. There is presently no well accepted or proven remedy for this type of breath.
[0004] Eighty-five to ninety percent of halitosis originates in the mouth. Numerous studies support this assertion. Of the remaining sites of origin, the nose and sinuses contribute five to ten percent, the tonsils three percent and all other sources account for one percent.
[0005] Halitosis odor is formed by bacterial byproducts during the metabolism primarily of certain proteins. This results in sulfur compounds, for example, hydrogen sulfide, which has the smell of rotten eggs, which are distinctive and objectionable, as well as other compounds that contribute to the smell.
[0006] The causative bacteria reside mainly on the posterior of the tongue, especially the extreme posterior, which cannot be seen when looking in the mirror with the tongue out as far as possible, and the oral pharynx, particularly when tonsils are present. Mechanical cleansing of the back of the tongue by brushing or scraping creates temporary reductions in halitosis. However, brushing and flossing do not relieve morning breath as well as eating breakfast. It is believed that eating affects the rear of the tongue and throat, while brushing and flossing do not. The vast majority of halitosis is caused by odors released from bacteria on the back of the tongue.
[0007] Accordingly, there is a need in the field of oral treatment for a treatment regimen to eliminate halitosis odor. Furthermore, there is a need for the treatment regimen to eliminate halitosis odor to reach the back of the tongue.
DISCLOSURE OF THE INVENTION
[0008] The present invention relates to an oral treatment method comprising applying at least two, particularly at least three oral treatment compositions. The oral treatment method includes a treatment regimen in a predetermined order.
[0009] An aspect of the present invention includes a method for providing oral treatment comprising the steps of applying at least two compositions to a human oral cavity selected from the group consisting of a first composition comprising hydrogen peroxide; a second composition comprising a metal selected from the group consisting of copper, tin and/or zinc; a third composition comprising a bactericidal agent; and/or a fourth composition comprising essential oils.
[0010] Another aspect of the present invention includes a method for providing oral treatment comprising the steps of applying a first composition comprising hydrogen peroxide to a human oral cavity; applying a second composition comprising a metal selected from the group consisting of copper, tin and/or zinc after said first composition; applying a third composition comprising chlorhexidine after said second composition; and applying a fourth composition comprising essential oils after said third composition.
[0011] Other aspects of the present invention may include a method for providing oral treatment comprising the steps of applying a first composition comprising hydrogen peroxide to a human oral cavity; applying a second composition comprising a metal selected from the group consisting of copper, tin and/or zinc after said first composition; applying a third composition comprising chlorhexidine after said second
composition; and applying a fourth composition comprising essential oils after said third composition, wherein each composition is applied two times per day for a period of time of about four days.
[0012] Still other aspects of the present invention may include applying a fifth composition after the fourth day, said fifth composition comprising a metal selected from the group consisting of copper, tin and/or zinc; and applying a sixth composition comprising essential oils, after said fifth composition.
[0013] Further still other aspects of the present invention may include a halitosis treatment regimen comprising gargling.
[0014] The foregoing and other features and advantages of the present invention will be apparent from the following more detailed description of the particular embodiments of the invention.
DETAILED DESCRIPTION OF EMBODIMENTS OF THE INVENTION
[0015] As discussed above, embodiments of the present invention relate to a method of oral treatment. The method of oral treatment includes a method of oral treatment of halitosis. The methods and compositions useful in the present invention are described below.
[0016] Prior to the treatment method of the present invention, the teeth, gums, cheek, palate and the tongue may be brushed. It is preferred to brush as far back in the oral cavity as possible, which may result in gagging, for a period of time of at least about two minutes Toothpaste may be used.
[0017] The method of oral treatment to eliminate halitosis and/or other odors comprises the use of compositions which chemically neutralize the odiferous molecules. The method of oral treatment of the present invention further comprises the use of compositions which mechanically remove the causative bacteria and their food sources. The method of oral treatment of the present invention still further comprises compositions which chemically deactivate the metabolic mechanism of the causative bacteria. Additionally, the method of oral treatment of the present invention
comprises compositions which inhibit the bacteria from reproducing, i.e. compositions having a bacteristatic effect and compositions which chemically kill the causative bacteria, i.e. compositions which have a bactericidal effect.
[0018] In the present invention at least two compositions, particularly at least three compositions are applied to the human oral cavity. The treatment regimen of the present invention follows a predetermined and/or sequential order.
[0019] In one embodiment, the present invention relates to applying the compositions to the oral cavity by gargling. Generally, gargling is a physical act wherein a person tilts the head back allowing a mouthful of liquid to sit in the upper throat. Air is then expelled from the lungs, causing the liquid to bubble and undulate throughout the throat and mouth region.
[0020] In the method of the present invention, gargling comprises getting a liquid onto the furthest back portion of the tongue and deep into the throat. The rear of the tongue is targeted by sticking it out and making an "aaahhh" sound. The back of the throat is reached by relaxing the tongue, letting it fall back, loosely, and making the "oooooo" sound. The two sounds may be alternated with occasional/intermittent mouth swishing when a break is needed. Gargling is not merely swishing liquid around your mouth, teeth and gums. It is believed that gargling, as described above, increases the effectiveness of the oral treatment method of the present invention.
[0021] The first composition comprises an effective amount of an agent that chemically neutralizes the odiferous molecules; mechanically removes the causative bacteria and their food sources; and has both a bacteristatic and bactericidal effect.
Suitable agents include, but are not limited to, hydrogen peroxide and/or carbamide peroxide and/or chlorine dioxide. Hydrogen peroxide is preferred. The term "effective amount" as used herein means an amount of an agent sufficient to significantly induce a positive effect in the oral treatment method of the present invention. For example, hydrogen peroxide may be used in an amount in the range of from about 0.5% to about 3.0% by weight, particularly in an amount of about 3.0% by weight. It is believed that hydrogen peroxide breaks up microorganism biofilm structure in the oral cavity so the causative bacteria are more susceptible to treatment.
[0022] The second composition of the present invention comprises an effective amount of an agent that chemically deactivates the metabolic mechanism of the causative bacteria. Metals are useful in the second composition of the present invention. Suitable metals include, but are not limited to, metals selected from the group consisting of copper, tin and/or zinc. Metal salts are preferred, particularly zinc gluconate. For example, zinc gluconate may be used in an amount in the range of from about 0.001% to about 1.5% by weight, particularly in an amount in the range of from about 0.05% to about 1.0% by weight. Seed or pulp extracts may also be included such as grapefruit seed.
[0023] The third composition comprises an effective amount of a bactericidal agent. Suitable bactericidal agents include, but are not limited to, chlorhexidine and/or cetylpyridinium chloride and/or povidone-iodine. Chlorhexidine is preferred. For example, chlorhexidine gluconate may be used in an amount in the range of from about 0.025% to about 0.2% by weight, particularly in an amount of about 0.12% by weight. Cetylpyridinium chloride may be used in an amount in the range of from
about 0.025% to about 0.10% by weight, particularly in an amount of about 0.07% by weight. It is believed that chlorhexidine exhibits excellent causative bacteria attachment capability.
[0024] The fourth composition comprises an effective amount of a bacteristatic and bactericidal agent. Suitable bactericidal and bacteristatic agents include, but are not limited to, essential oils and extracts. Essential oils which may be used include essential oils of peppermint, red thyme, cinnamon bark, eucalyptus globules, lavender, tea tree, spearmint, and clove and/or mixtures thereof. Extracts which may be used include eugenol, thymol, carvacrol, menthanol, eucalyptol, and totarol and/or mixtures thereof. It is believed that the essential oils penetrate the microorganism biofilm structure found in the oral cavity and kill or retard the growth of the causative bacteria.
[0025] The fifth composition, similar to the second composition, includes an agent which chemically neutralizes the odorous molecules and chemically deactivates the metabolic mechanism of the causative bacteria. Metals are useful in the fifth composition of the present invention. Suitable metals include, but are not limited to, metals selected from the group consisting of copper, tin and/or zinc. Zinc is preferred. It is believed that zinc, for example, binds to the protein receptor sites on the bacteria, suppressing the metabolic process that creates the odor causing compounds. Sodium chlorite may also be included.
[0026] Similar to the fourth composition, the sixth composition comprises an effective amount of a bacteristatic and bactericidal agent. Suitable bactericidal and
bacteristatic agents include, but are not limited to, essential oils and extracts. Essential oils which may be used include essential oils of peppermint, red thyme, cinnamon bark, eucalyptus globules, lavender, tea tree, spearmint, and clove and/or mixtures thereof. Extracts which may be used include eugenol, thymol, carvacrol, menthanol, eucalyptol, and totarol. It is believed that the essential oils and extracts penetrate the microorganism biofilm structure found in the oral cavity and kill or retard the growth of the causative bacteria.
[0027] Compositions of the present invention may comprise a carrier material into which other ingredients are solubilised, dispersed or otherwise mixed. Depending upon the type of composition in question the carrier material can differ. For example, mouth wash compositions commonly have a carrier material which comprises from about 20:1 to about 2:1 aqueous alcoholic matrix.
[0028] The compositions of the present invention are prepared by standard techniques well known to those skilled in the art. Other ingredients useful in the compositions herein include, but are not limited to, anti-plaque agents, desensitizing agents, anti- calculus agents, surfactants, nutrients, sweeteners and/or flavoring agents. Typical amounts of each of the six compositions of the present invention are in the range of from 1/8 ounce to about 1 ounce. Generally about 1A ounce of each composition is used per application.
[0029] The four steps as discussed above should be performed twice a day for a period of four days. After four days, a maintenance treatment may be performed using the fifth and sixth compositions. The maintenance treatment should be carried
out twice daily after brushing. It is believed that the compositions of the present invention must reach the target area, the rear of the tongue and deep into the throat to be effective in the treatment of halitosis.
[0030] The compositions of the present invention must remain in contact with the oral cavity for an adequate amount of time to be effective. Generally, the amount of time for the initial treatment regimen of the present invention is in the range of about to about 30 seconds to 120 seconds. Preferably, the amount of contact time is about 60 seconds. Generally, the amount of time for the maintenance treatment of the present invention is in the range of from about 15 seconds to 120 seconds. Preferably, the amount of contact time is about 30 seconds. In each step of the present invention, it is preferred to reach the target area, i.e. the rear of the tongue and deep into the throat for the entire contact time.
[0031] It is believed that the compositions exert a synergistic effect and operate by different mechanisms. It is also believed that the specified application order has an effect on the halitosis treatment of the present invention.
[0032] The embodiments and examples set forth herein were presented in order to best explain the present invention and its practical applications and to thereby enable those of ordinary skill in the art to make and use the invention. However, those of ordinary skill in the art will recognize that the foregoing description and examples have been presented for the purposes of illustration and example only. The description as set forth is not intended to be exhaustive or to limit the invention to the precise form disclosed. Many modifications and variations are possible in light of the
teachings above without departing from the spirit and scope of the forthcoming claims. Accordingly, any components of the present invention indicated in the drawings or herein are given as an example of possible components and not as a limitation.
Claims
1. A method for providing oral treatment comprising the steps of applying at least two compositions to a human oral cavity selected from the group consisting of a first composition comprising hydrogen peroxide; a second composition comprising a metal selected from the group consisting of copper, tin and/or zinc; a third composition comprising a bactericidal agent; and/or a fourth composition comprising essential oils.
2. The method of claim 1 wherein at least three compositions are applied to the human oral cavity.
3. The method of claim 1 wherein said first composition, second composition, third composition and fourth composition are applied in sequential order.
4. A method for providing oral treatment comprising the steps of applying a first composition comprising hydrogen peroxide to a human oral cavity; applying a second composition comprising a metal selected from the group consisting of copper, tin and/or zinc after said first composition; applying a third composition comprising a bactericidal agent after said second composition; and applying a fourth composition comprising essential oils after said third composition.
5. The method of claim 4 wherein the oral treatment is for halitosis.
6. The method of claim 4 wherein the bactericidal agent is selected from the group consisting of chlorhexidine and/or cetylpyridinium chloride.
7. The method of claim 4 wherein each composition is applied by gargling
8. The method of claim 7 wherein said gargling reaches the rear of the tongue and the throat.
9. The method of claim 8 wherein an aaahhh sound is made during said gargling
10. The method of claim 7 wherein each composition is gargled for a period of time of about 60 seconds.
11. The method of claim 4 wherein each composition is in an amount of about .25 ounces.
12. The method of claim 4 wherein said second composition further comprises grapefruit seed extract.
13. The method of claim 4 wherein the second composition comprises zinc.
14. The method of claim 13 wherein the zinc is in the form of zinc gluconate
15. The method of claim 4 wherein each composition is applied two times per day for a period of time of about four days.
16. The method of claim 15 further comprising applying a fifth composition after the fourth day, said fifth composition comprising a metal selected from the group consisting of copper, tin and/or zinc; and applying a sixth composition comprising essential oils, after said fifth composition.
17. The method of claim 16 wherein the fifth and sixth compositions are applied daily.
18. The method of claim 16 wherein the fifth and sixth compositions are applied by gargling
19. The method of claim 16 wherein the fifth and sixth compositions are applied for 30 seconds.
20. The method of claim 16 wherein the metal is zinc.
21. The method of claim 16 wherein the fifth composition further comprises sodium chlorite.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/165,316 | 2008-06-30 | ||
| US12/165,316 US20090324517A1 (en) | 2008-06-30 | 2008-06-30 | Halitosis treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2010002571A1 true WO2010002571A1 (en) | 2010-01-07 |
| WO2010002571A8 WO2010002571A8 (en) | 2010-02-11 |
Family
ID=41447716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2009/047272 WO2010002571A1 (en) | 2008-06-30 | 2009-06-12 | Halitosis treatment |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US20090324517A1 (en) |
| WO (1) | WO2010002571A1 (en) |
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| MX2014007496A (en) | 2011-12-21 | 2015-02-17 | Univ Brigham Young | Oral care compositions. |
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Also Published As
| Publication number | Publication date |
|---|---|
| US20090324517A1 (en) | 2009-12-31 |
| WO2010002571A8 (en) | 2010-02-11 |
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