WO2009157377A1 - Anesthésique oral - Google Patents

Anesthésique oral Download PDF

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Publication number
WO2009157377A1
WO2009157377A1 PCT/JP2009/061177 JP2009061177W WO2009157377A1 WO 2009157377 A1 WO2009157377 A1 WO 2009157377A1 JP 2009061177 W JP2009061177 W JP 2009061177W WO 2009157377 A1 WO2009157377 A1 WO 2009157377A1
Authority
WO
WIPO (PCT)
Prior art keywords
anesthetic
oral
container
dental
patient
Prior art date
Application number
PCT/JP2009/061177
Other languages
English (en)
Japanese (ja)
Inventor
一也 中嶋
慶太 楠本
Original Assignee
田中 和美
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 田中 和美 filed Critical 田中 和美
Priority to JP2010517971A priority Critical patent/JPWO2009157377A1/ja
Publication of WO2009157377A1 publication Critical patent/WO2009157377A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015—Devices specially adapted for taking medicines
    • A61J7/0046—Cups, bottles or bags

Definitions

  • the present invention relates to an intraoral anesthetic used for professional tooth cleaning, calculus removal, dental examination, dental treatment, oral surgery, or otolaryngology treatment.
  • Tooth surface cleaning by professionals professional mechanical tooth cleaning, hereinafter referred to as “PMTC”), dental removal (hereinafter referred to as “scaling”).
  • PMTC professional mechanical tooth cleaning
  • scaling periodontal disease examination, minor cutting, plaque removal and other dental examinations or treatments do not cause severe pain such as tooth extraction or large-scale cutting, but patients feel uncomfortable Pain occurs.
  • T.A It is often the subject of C, scaling, dental examination, dental treatment or oral surgery. Furthermore, these application-type anesthetics, spray-type anesthetics, and jelly-like anesthetics require a time of about 5 minutes from the time they are administered to a patient until the anesthetic effect is exerted, which impedes rapid treatment. Yes.
  • An object of the present invention is to provide an oral anesthetic agent that enables treatment.
  • P. M, T.M. C Scaling, Periodontal disease examination, Minor cutting, Dental removal such as plaque removal, Dental treatment, Oral surgery, Oral anaesthesia that can safely remove the discomfort experienced by patients I came up with a mouthwash as a dosage form of the agent. If it is the said dosage form, it will osmose
  • the present inventor further tackled the contradictory problem of effectiveness and safety of anesthesia, and examined a strict quantitative administration method of an anesthetic agent. Then, the present invention has been completed by conceiving a configuration in which a predetermined container is filled with only an amount of the oral anesthetic used in one dental treatment or the like.
  • the first invention for solving the above-described problem is A liquid oral anesthetic used during professional tooth cleaning, tartar removal, dental examination, dental treatment, oral surgery, or otolaryngology procedures, Contains anesthetics approved by the Pharmaceutical Affairs Law, The amount of the liquid oral anesthetic used in the single dental examination or dental treatment is filled in a predetermined container in a state of being blocked from the outside air, When performing oral anesthesia, the container is opened and the liquid oral anesthetic agent is administered to a patient, and then the oral anesthetic agent is treated in the form of gargle. Anesthetic.
  • the second invention is In addition to the anesthetic that has been approved by the Pharmaceutical Affairs Law, a bactericide that has been approved by the Pharmaceutical Affairs Law is contained.
  • the third invention is The intraoral anesthetic according to the first or second invention, wherein lidocaine hydrochloride is contained as an anesthetic that has been approved by the Pharmaceutical Affairs Law.
  • the fourth invention is: The oral anesthetic agent according to the second or third invention, characterized in that it contains chlorohexidine as a fungicide that has been approved by the Pharmaceutical Affairs Law.
  • the fifth invention is: The oral anesthetic according to any one of the first to fourth inventions, wherein a plastic portion container is used as the container.
  • P. M.M. T.A. C scaling, dental examination, dental treatment, oral surgery, or otolaryngology treatment is performed by a patient who gargles with the oral anesthetic according to the present invention, so that the patient's oral cavity is sufficient, and Since it is safely and rapidly anesthetized, P.P. M.M. T.A. C, scaling, dental examination, dental treatment, oral surgery, or otolaryngology procedures can be performed.
  • the anesthetics used for the oral anesthetic according to the present invention may be those that have already been approved by the pharmaceutical law (the Pharmaceutical Affairs Law in Japan) in the country where the oral anesthetic is used.
  • Examples thereof include lidocaine, epinephrine, mepivacaine hydrochloride, ethyl paraaminobenzoate, oxybuprocaine, tetracaine, procaine, diethylaminoethyl parabutylaminobenzoate, or a pharmaceutically acceptable salt thereof, or a mixture thereof.
  • lidocaine hydrochloride epinephrine, and mepivacaine hydrochloride are used.
  • the optimum concentration of the anesthetic varies depending on the drug type, but 2% to 3% is preferable for lidocaine hydrochloride and mepivacaine hydrochloride.
  • These anesthetics act on C-FIBER at the nerve endings and have the effect of instantly relieving pain such as the mild mucous membranes in the oral cavity that many patients feel uncomfortable.
  • the immediate alleviation of pain in the mucous membrane and the like has made it possible to reduce the unpleasant experience that patients feel during dental treatment and the uncomfortable feeling during injection. As a result, dentists can now perform treatment more safely.
  • Bactericidal agent / anti-inflammatory agent It is preferable to add a bactericidal agent or an anti-inflammatory agent to the oral anesthetic agent according to the present invention for the purpose of bactericidal / anti-inflammatory in the oral cavity. It can be expected to have an effect on periodontal disease and its prevention by using in combination with the cleaning aid described later.
  • the disinfectant and anti-inflammatory agent include chlorohexidine, azulene salt, tranexamic acid salt, carnosine salt, cetylpyridinium chloride, triclosan, methylene blue, povidone iodine, benzalkonium chloride, and ethanol.
  • addition of a fluorine mouthwash is also preferable.
  • pH adjuster In order for the anesthetic agent to act effectively, it is preferable to adjust the preparation to a predetermined pH when using the oral anesthetic agent. For example, it is preferable to adjust to pH 4 ⁇ 1 for lidocaine hydrochloride and pH 5.5 ⁇ 1 for mepivacaine hydrochloride. Therefore, it is preferable to add a pH adjuster.
  • Examples of the pH adjuster include acids such as hydrochloric acid, dilute hydrochloric acid, boric acid, phosphoric acid and salts thereof, citric acid, succinic acid, malic acid, tartaric acid, lactic acid, ascorbic acid, fumaric acid, maleic acid, gluconic acid, Examples thereof include organic acids such as glucuronic acid and acetic acid and salts thereof, and bases such as potassium hydroxide, calcium hydroxide, sodium hydroxide, magnesium hydroxide, sodium carbonate and sodium hydrogen carbonate. It may be a mixture of the acid and base.
  • the mixture of the organic acid of a citric acid and malic acid, sodium hydroxide, and sodium hydrogencarbonate is mentioned.
  • Thickener It is also preferable to add a thickener so that the oral anesthetic agent according to the present invention effectively stays in the oral cavity.
  • the thickener include glycerin, propylene glycol, hydroxyethyl cellulose, hydroxyethyl methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, sodium alginate, and gelatin.
  • a bad breath inhibitor such as aspartame, stevia, thaumatin, erythritol, sorbitol, xylitol, and saccharin sodium can be blended.
  • sweeteners such as aspartame, stevia, thaumatin, erythritol, sorbitol, xylitol, and saccharin sodium can be blended.
  • fragrances such as lemon, orange, grapefruit, pine, banana, chocolate, yogurt, vanilla, menthol and the like can be blended.
  • various herbs, cinnamon bark, licorice, clove and other herbal medicines can be blended.
  • various vitamins such as vitamin C and vitamin E can be blended.
  • a solubilizer such as polyoxyethylene hydrogenated castor oil and a cleaning aid such as cocoyl arginine ethyl PCA can be blended.
  • Oral anesthetic agent dosage form according to the present invention is preferably an aqueous solution dosage form. This is because the oral anesthetic agent can be opened at the side of the patient and immediately administered to the patient to gargle. Then, the present inventors can administer the oral anesthetic agent to the patient in the form of gargle, so that the oral anesthetic agent according to the present invention is a conventional application-type anesthetic, spray-type anesthetic, jelly Compared to a state-of-the-art anesthetic, it is considered to exhibit an anesthetic effect quickly.
  • the liquid which is an oral anesthetic according to the present invention becomes a turbulent state in the oral cavity.
  • a sufficient amount of the drug can be quickly applied to a narrow part including a periodontal pocket and a tooth.
  • Rapid penetration of a sufficient amount of drug into the narrow part of the oral cavity and the rapid supply of anesthetic by the constant supply of fresh drug to the oral part other than the narrow part is achieved. It is thought to be a thing.
  • the intraoral anesthetic agent according to the present invention is prepared by sealing and storing an amount of the oral anesthetic agent used once per patient as one pack.
  • the container is preferably a disposable sealed container.
  • a portion type container, a bottle type container, an ampoule, etc. are mentioned.
  • FIG. 1 is a perspective view of an example of a portion type container
  • FIG. 2 is a perspective view of an example of a bottle type container with a lid.
  • the portion type container shown in FIG. 1 has a plastic lid (2) bonded to the upper part of a plastic cup-shaped container (1).
  • the oral anesthetic agent according to the present invention filled in the container part (1) is blocked from the outside air by the lid part (2). What is necessary is just to peel a cover part (2) from a container part (1) at the time of use of the oral cavity anesthetic which concerns on this invention.
  • the interval of the scale (9) is preferably 25%, 50%, 75% of the total content.
  • the upper part of the plastic bottle container (3) and the plastic lid (4) are in close contact with each other by screws.
  • the oral anesthetic agent according to the present invention filled in the container part (3) is blocked from the outside air by the lid part (4).
  • the lid (4) may be removed from the container (3).
  • the interval of the scale (9) is preferably 25%, 50%, 75% of the total content.
  • the ampule type container shown in FIG. 3 is a glass ampule container (5) filled with the oral anesthetic agent according to the present invention.
  • the oral anesthetic according to the present invention filled in the glass ampoule container (5) is blocked from the outside air.
  • the ampoule container head may be cut off and removed.
  • You may give a scale (9) to a container part (5) if desired.
  • the interval of the scale (9) is preferably 25%, 50%, 75% of the total content.
  • the portion type container shown in FIG. 4 has a plastic lid portion (8) bonded to the upper part of two or more plastic cup-shaped container portions (6) and (7).
  • the oral anesthetics according to the present invention filled in two or more container parts (6) and (7) are blocked from the outside air while being separated from each other by the lid part (8).
  • the lid (8) may be peeled off from the container (6) (7).
  • the container is suitable for the case where it is desired to keep each component separated until just before administration to a patient from the viewpoint of mixing stability, compatibility and the like of components contained in the oral anesthetic agent.
  • You may give a scale (9) to a container part (6) (7) if desired.
  • the interval of the scale (9) is preferably 25%, 50%, 75% of the total content.
  • the amount of oral anesthetic agent at one time is preferably 10 to 15 ml, more preferably 12 to 13 ml. It is done. Furthermore, for children, it is convenient to use the same oral anesthetic agent as that for adults, and to reduce the amount of oral anesthetic agent to 1 ⁇ 2 amount for adults, for example. Of course, the amount of the oral anesthetic agent can be the same as that for adults, and the concentration of the oral anesthetic agent can be halved for adults, for example.
  • the concentration of the oral anesthetic agent it is also preferable to pre-scale the container. For example, if a scale is provided at positions corresponding to 25%, 50%, and 75% of the total amount of the oral anesthetic agent, the dose to the patient can be easily adjusted.
  • P. of the present invention M.M. T.A.
  • Application to C scaling, dental treatment, oral surgery, or otolaryngology treatment
  • the present invention does not cause severe pain such as tooth extraction or large-scale cutting, but causes pain that makes the patient feel uncomfortable
  • C Scaling, Periodontal disease examination, Minor cutting, Dental removal or dental treatment such as plaque removal, etc.
  • P.I. M.M. T.A In the case of C, scaling, dental treatment, etc., a unique tingling pain occurs, making the patient feel uncomfortable.
  • the oral anesthetic agent according to the present invention is included in the patient's mouth immediately before the above-described treatment, and the patient side and the dentist / doctor side are comfortable and quick by garbling for about 10 seconds. You can share the treatment time.
  • Example 1 As an intraoral anesthetic according to Example 1, Leptospan S (containing 2% lidocaine hydrochloride and 0.00125% epinephrine) manufactured by Septdon was prepared. The oral anesthetic agent 12 ml shown in FIG. 1 is filled and sealed in a plastic portion type container (internal volume 12 ml), the lid of the portion type container is sealed, and the oral cavity according to Example 1 is sealed. An internal anesthetic was used.
  • M.M. T.A. C Scaling, Periodontal Examination, Dental Examination and Dental Treatment of Plaque Removal. According to interviews with the patient, the effect of anesthesia began immediately after gargle. The intensity of anesthesia was not so strong. M.M. T.A. C, scaling, periodontal disease test, the tingling sensation associated with the removal of plaque and the impression that mild pain was not felt.
  • an oral anesthetic is prepared right next to the patient, and appropriate oral anesthesia is treated for the patient simply by gargleing the oral anesthetic.
  • both the patient and the dentist were relieved and were able to perform dental examination and treatment in a relaxed state.
  • the oral anesthetic agent according to the present invention has been described by taking dental examination or dental treatment with relatively light pain such as C, scaling, periodontal disease examination, minor cutting, and plaque removal as an example.
  • the intraoral anesthetic according to the present invention can also be used as an anesthetic for oral surgery and otolaryngology treatment.
  • it can also be used as a preliminary anesthetic agent that relieves the pain of anesthesia injection performed prior to treatment such as extraction with strong pain.
  • Container part (2) Lid part (3) Container part (4) Lid part (5) Container part (6) Container part (7) Container part (8) Lid part (9) Scale

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Anesthesiology (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
  • Communicable Diseases (AREA)

Abstract

La présente invention concerne un anesthésique oral, qui est un anesthésique oral liquide utilisé pour un examen dentaire ou un traitement dentaire, et qui contient un anesthésique autorisé par la « Pharmaceutical Affairs Law ». Un récipient donné est rempli d’une quantité de l’anesthésique oral liquide susmentionné utilisé pour un traitement dentaire ou un examen dentaire unique, dans un état selon lequel l’air externe est exclu. Lorsque l’anesthésie orale est réalisée, on administre l’anesthésique oral liquide susmentionné au patient en ouvrant le récipient hermétique, après quoi ledit anesthésique oral est utilisé en tant que solution pour gargarisme.
PCT/JP2009/061177 2008-06-24 2009-06-19 Anesthésique oral WO2009157377A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2010517971A JPWO2009157377A1 (ja) 2008-06-24 2009-06-19 口腔内麻酔剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008-164943 2008-06-24
JP2008164943 2008-06-24

Publications (1)

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WO2009157377A1 true WO2009157377A1 (fr) 2009-12-30

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PCT/JP2009/061177 WO2009157377A1 (fr) 2008-06-24 2009-06-19 Anesthésique oral

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016535793A (ja) * 2013-11-11 2016-11-17 ジヴ エム．ディー． ハリシュ 口腔アレルギー症候群の予防および治療のための製剤および方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH101441A (ja) * 1996-06-14 1998-01-06 Tendou Seiyaku Kk 局所麻酔組成物
JP2004113759A (ja) * 2002-09-26 2004-04-15 Takao Kasahara 使い捨て容器にいれられたうがい薬。
JP2005041832A (ja) * 2003-07-24 2005-02-17 Medorekkusu:Kk 局所麻酔薬物含有含嗽剤
JP2007222270A (ja) * 2006-02-22 2007-09-06 Nipro Corp 薬剤包装物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH101441A (ja) * 1996-06-14 1998-01-06 Tendou Seiyaku Kk 局所麻酔組成物
JP2004113759A (ja) * 2002-09-26 2004-04-15 Takao Kasahara 使い捨て容器にいれられたうがい薬。
JP2005041832A (ja) * 2003-07-24 2005-02-17 Medorekkusu:Kk 局所麻酔薬物含有含嗽剤
JP2007222270A (ja) * 2006-02-22 2007-09-06 Nipro Corp 薬剤包装物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016535793A (ja) * 2013-11-11 2016-11-17 ジヴ エム．ディー． ハリシュ 口腔アレルギー症候群の予防および治療のための製剤および方法

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