WO2009154369A3 - 오메가-3계 고도불포화 지방산의 고순도 정제방법 - Google Patents
오메가-3계 고도불포화 지방산의 고순도 정제방법 Download PDFInfo
- Publication number
- WO2009154369A3 WO2009154369A3 PCT/KR2009/002958 KR2009002958W WO2009154369A3 WO 2009154369 A3 WO2009154369 A3 WO 2009154369A3 KR 2009002958 W KR2009002958 W KR 2009002958W WO 2009154369 A3 WO2009154369 A3 WO 2009154369A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- genus
- fatty acid
- omega
- purification method
- highly unsaturated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
본 발명은 오메가-3계 고도불포화 지방산의 고순도 정제방법에 관한 것으로, 구체적으로는 a) 캔디다(Candida) 속, 리조퍼스(Rhizopus) 속, 무코(Mucor) 속, 아스퍼질러스(Aspergillus) 속 및 수도모나스(Pseudomonas) 속으로 이루어진 군에서 선택되는 하나이상의 미생물에서 추출된 효소촉매 존재하에서 천연유지를 에탄올을 이용 에탄올리시스(ethanolysis)하여 지방산 에틸 에스테르(Fatty acid ethyl ester; FAEE)를 제조하는 단계;b) 상기 제조된 지방산 에틸 에스테르를 100 내지 200℃ 및 0.001 내지 10mmHg에서 단증류(Short Path Distillation;SPD) 장치를 이용하여 예비증류하는 단계;c) 상기 예비증류를 거친 에틸 에스테르를 100 내지 200℃ 및 0.001 내지 10mmHg에서 감압분별증류하여 농축지방산이 형성되는 단계; d) 상기 농축지방산을 모사 이동상(Simulated Moving Bed;SMB) 컬럼 크로마토그래피를 통해 정제하는 단계;를 포함하는 오메가-3계 고도불포화 지방산의 고순도 정제방법을 포함하여 환경친화적이면서도 용이하게 이용할 수 있는 오메가-3계 고도불포화 지방산의 고순도 정제방법에 관한 것이다.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/999,177 US20110091947A1 (en) | 2008-06-20 | 2009-06-03 | High-Purity Purification Method for Omega-3 Highly Unsaturated Fatty Acids |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2008-0058114 | 2008-06-20 | ||
KR1020080058114A KR101357298B1 (ko) | 2008-06-20 | 2008-06-20 | 오메가-3계 고도불포화 지방산의 고순도 정제방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009154369A2 WO2009154369A2 (ko) | 2009-12-23 |
WO2009154369A3 true WO2009154369A3 (ko) | 2010-03-11 |
Family
ID=41434532
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2009/002958 WO2009154369A2 (ko) | 2008-06-20 | 2009-06-03 | 오메가-3계 고도불포화 지방산의 고순도 정제방법 |
Country Status (3)
Country | Link |
---|---|
US (1) | US20110091947A1 (ko) |
KR (1) | KR101357298B1 (ko) |
WO (1) | WO2009154369A2 (ko) |
Families Citing this family (33)
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ES2862980T3 (es) | 2009-12-30 | 2021-10-08 | Basf Pharma Callanish Ltd | Composiciones de ácido graso poliinsaturado obtenibles mediante un proceso de separación cromatográfica en lecho móvil simulado |
KR101173289B1 (ko) | 2010-05-04 | 2012-08-10 | (주)산엔들 | 초임계 이산화탄소 추출을 이용하여 식물로부터 오메가 지방산 함유 추출물의 제조방법 |
GB201111595D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | Improved process |
GB201111594D0 (en) * | 2011-07-06 | 2011-08-24 | Equateq Ltd | New improved process |
GB201111601D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | New process |
GB201111589D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | New modified process |
GB201111591D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | Further new process |
KR102117725B1 (ko) | 2012-05-14 | 2020-06-01 | 닛폰 스이산 가부시키가이샤 | 환경 오염 물질을 저감시킨 고도 불포화 지방산 또는 고도 불포화 지방산 에틸에스테르 및 그 제조 방법 |
CN104411296A (zh) * | 2012-05-16 | 2015-03-11 | 考希德芭以奧帕有限公司 | 含有鱼类眼球的粉碎物或提取物的化妆料、药学及食品组合物 |
FR2991337B1 (fr) * | 2012-05-29 | 2016-09-02 | Roquette Freres | Procede continu d'enrichissement en esters ethyliques de dha d'une huile produite par des microalgues |
GB201300354D0 (en) * | 2013-01-09 | 2013-02-20 | Basf Pharma Callanish Ltd | Multi-step separation process |
EP2801604B1 (en) | 2013-05-07 | 2017-04-12 | Groupe Novasep | Chromatographic process for the production of highly purified polyunsaturated fatty acids |
US9428711B2 (en) | 2013-05-07 | 2016-08-30 | Groupe Novasep | Chromatographic process for the production of highly purified polyunsaturated fatty acids |
US8802880B1 (en) | 2013-05-07 | 2014-08-12 | Group Novasep | Chromatographic process for the production of highly purified polyunsaturated fatty acids |
JP6546911B2 (ja) | 2013-05-07 | 2019-07-17 | グループ ノヴァセップGroupe Novasep | 高度に精製したポリ不飽和脂肪酸を生成するクロマトグラフプロセス |
JP2015030685A (ja) * | 2013-07-31 | 2015-02-16 | 備前化成株式会社 | 逆相カラムを用いる擬似移動層クロマトグラフィーによる脂溶性物質の分離法およびそのための装置 |
JP2015031538A (ja) * | 2013-07-31 | 2015-02-16 | 備前化成株式会社 | 順相カラムを用いる擬似移動層クロマトグラフィーによる脂溶性物質の分離法およびそのための装置 |
WO2015015716A1 (ja) * | 2013-07-31 | 2015-02-05 | 備前化成株式会社 | 疑似移動床クロマトグラフィーによる脂溶性物質の分離法およびそのための装置 |
EP3118186B1 (fr) * | 2013-12-11 | 2022-02-09 | Novasep Process | Installation chromatographique de production d acides gras polyinsatures |
FR3014435B1 (fr) | 2013-12-11 | 2016-10-21 | Novasep Process | Purification d'acides gras par un procede chromatographique |
FR3014436B1 (fr) | 2013-12-11 | 2016-10-21 | Novasep Process | Procede de purification chromatographique d'un acide gras |
US10975031B2 (en) | 2014-01-07 | 2021-04-13 | Novasep Process | Method for purifying aromatic amino acids |
CN103805338B (zh) * | 2014-01-10 | 2016-12-07 | 陈汉卿 | 一种提高植物油中不饱和脂肪酸含量的短程蒸馏生产方法及短程蒸馏器 |
WO2016043251A1 (ja) | 2014-09-17 | 2016-03-24 | 日本水産株式会社 | エイコサペンタエン酸アルキルエステルを含有する組成物及びその製造方法 |
US10273431B2 (en) | 2015-07-06 | 2019-04-30 | K.D. Pharma Bexbach Gmbh | Process for obtaining free fatty acid and/or fatty acid ester |
JP6998935B2 (ja) | 2016-07-13 | 2022-01-18 | エボニック オペレーションズ ゲーエムベーハー | 溶解された脂質含有バイオマスから脂質を分離する方法 |
DK3562925T3 (da) | 2016-12-27 | 2021-05-25 | Evonik Operations Gmbh | Fremgangsmåde til isolering af lipider fra en lipidholdig biomasse |
EP3470502A1 (en) | 2017-10-13 | 2019-04-17 | Evonik Degussa GmbH | Method of separating lipids from a lysed lipids containing biomass |
EP3527664A1 (en) | 2018-02-15 | 2019-08-21 | Evonik Degussa GmbH | Method of isolating lipids from a lipids containing biomass |
WO2019219443A1 (en) | 2018-05-15 | 2019-11-21 | Evonik Operations Gmbh | Method of isolating lipids from a lipids containing biomass with aid of hydrophobic silica |
BR112020023222A2 (pt) | 2018-05-15 | 2021-03-23 | Evonik Operations Gmbh | método de isolamento de lipídios a partir de uma biomassa contendo lipídios lisados por inversão por emulsão |
CN110790337B (zh) * | 2019-09-26 | 2020-09-08 | 江苏爱佳福如土壤修复有限公司 | 一种去除水体中重金属Cd的组合物及其制备方法与应用 |
KR20240035176A (ko) | 2022-09-08 | 2024-03-15 | 한국과학기술원 | 미세조류 내 epa의 고순도 연속 흡착분리 장치 및 이를 이용한 미세조류 내 epa의 고순도 연속 흡착분리 방법 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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JPH0633088A (ja) * | 1992-07-21 | 1994-02-08 | Nippon Suisan Kaisha Ltd | 高純度ドコサヘキサエン酸またはそのエステルの 製造方法 |
JPH10152693A (ja) * | 1996-11-22 | 1998-06-09 | Osaka City | ω−3系高度不飽和脂肪酸エステルの精製方法 |
JPH10310556A (ja) * | 1997-05-12 | 1998-11-24 | Y M Shii:Kk | 微生物由来の多価不飽和脂肪酸エステルの分離精製方法 |
WO2000073254A1 (en) * | 1999-05-31 | 2000-12-07 | Jfs Envirohealth Ltd. | Concentration and purification of polyunsaturated fatty acid esters by distillation-enzymatic transesterification coupling |
Family Cites Families (4)
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JP3400466B2 (ja) * | 1991-10-28 | 2003-04-28 | 日本水産株式会社 | 高純度エイコサペンタエン酸またはそのエステルの製造方法 |
AU676910B2 (en) * | 1993-04-29 | 1997-03-27 | Norsk Hydro A.S | Processes for chromatographic fractionation of fatty acids and their derivatives |
NO312973B1 (no) * | 1999-02-17 | 2002-07-22 | Norsk Hydro As | Lipase-katalysert forestring av marine oljer |
NO319194B1 (no) * | 2002-11-14 | 2005-06-27 | Pronova Biocare As | Lipase-katalysert forestringsfremgangsmate av marine oljer |
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2008
- 2008-06-20 KR KR1020080058114A patent/KR101357298B1/ko active IP Right Grant
-
2009
- 2009-06-03 WO PCT/KR2009/002958 patent/WO2009154369A2/ko active Application Filing
- 2009-06-03 US US12/999,177 patent/US20110091947A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0633088A (ja) * | 1992-07-21 | 1994-02-08 | Nippon Suisan Kaisha Ltd | 高純度ドコサヘキサエン酸またはそのエステルの 製造方法 |
JPH10152693A (ja) * | 1996-11-22 | 1998-06-09 | Osaka City | ω−3系高度不飽和脂肪酸エステルの精製方法 |
JPH10310556A (ja) * | 1997-05-12 | 1998-11-24 | Y M Shii:Kk | 微生物由来の多価不飽和脂肪酸エステルの分離精製方法 |
WO2000073254A1 (en) * | 1999-05-31 | 2000-12-07 | Jfs Envirohealth Ltd. | Concentration and purification of polyunsaturated fatty acid esters by distillation-enzymatic transesterification coupling |
Also Published As
Publication number | Publication date |
---|---|
KR101357298B1 (ko) | 2014-01-28 |
US20110091947A1 (en) | 2011-04-21 |
KR20090132048A (ko) | 2009-12-30 |
WO2009154369A2 (ko) | 2009-12-23 |
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