WO2009118968A1 - Agent induisant une sensation de satiété et aliment ou boisson le contenant - Google Patents

Agent induisant une sensation de satiété et aliment ou boisson le contenant Download PDF

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Publication number
WO2009118968A1
WO2009118968A1 PCT/JP2008/073480 JP2008073480W WO2009118968A1 WO 2009118968 A1 WO2009118968 A1 WO 2009118968A1 JP 2008073480 W JP2008073480 W JP 2008073480W WO 2009118968 A1 WO2009118968 A1 WO 2009118968A1
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WO
WIPO (PCT)
Prior art keywords
satiety
food
intake
fatty acid
chain fatty
Prior art date
Application number
PCT/JP2008/073480
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English (en)
Japanese (ja)
Inventor
勝彦 大山
圭一 小島
弘幸 竹内
Original Assignee
日清オイリオグループ株式会社
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Filing date
Publication date
Application filed by 日清オイリオグループ株式会社 filed Critical 日清オイリオグループ株式会社
Publication of WO2009118968A1 publication Critical patent/WO2009118968A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Definitions

  • the present invention relates to a satiety-inducing agent that accelerates the sense of satiety in order to reduce energy intake (meal amount) and food and drink containing the same.
  • Non-Patent Document 1 it is necessary to take in advance 100 to 300 kcal (higher is better) medium chain fatty acid triglyceride, and if this pre-intake is included, the effect of reducing energy intake (meal amount) is I can't hope much.
  • an object of the present invention is to provide a satiety-inducing agent excellent in the effect of reducing energy intake (meal amount) including pre-intake and food and drink containing the same.
  • the present invention provides a satiety inducer characterized by containing a triglyceride containing a medium chain fatty acid in a constituent fatty acid (hereinafter referred to as a medium chain fatty acid triglyceride) as an active ingredient.
  • the present invention also provides a food or drink characterized by containing the satiety-inducing agent of the present invention to achieve the above object.
  • the satiety inducer according to an embodiment of the present invention contains medium chain fatty acid triglyceride as an active ingredient.
  • the satiety inducer according to the embodiment of the present invention induces a feeling of satiety during meals at an early stage, that is, accelerates the sense of satiety.
  • early detection of fullness means that fullness can be detected with a smaller amount of energy intake (meal amount). Therefore, the satiety-inducing agent according to the embodiment of the present invention can also be referred to as an energy intake inhibitor or a meal intake inhibitor.
  • the medium chain triglycerides (MCT) to be contained as an active ingredient in the satiety inducer according to the embodiment of the present invention is not particularly limited, but medium chain fatty acids and glycerin are usually used. Triglycerides obtained by subjecting to an esterification reaction by the method can be used.
  • the medium chain fatty acid is a fatty acid having 6 to 12 carbon atoms, particularly a saturated fatty acid.
  • Examples include hexanoic acid, octanoic acid, decanoic acid, lauric acid.
  • Fatty acids having 6 to 10 carbon atoms are preferred, saturated fatty acids having 8 to 10 carbon atoms are more preferred, and octanoic acid and decanoic acid are particularly preferred.
  • a monoacid group triglyceride or a mixed acid group triglyceride can be used.
  • the satiety inducer according to the embodiment of the present invention contains 0.8 to 10 g of MCT, which is an effective dose (effective intake) for one adult. Preferably, it is 0.9 g to 8 g, more preferably 1 g to 6 g, and still more preferably 1.25 g to 5 g. The same effective dose for children can be applied as for adults.
  • the meal after ingestion of the satiety inducer containing MCT is a low-fat diet (lipid: less than 25E%), it is particularly preferable to contain an effective dose in the above preferred range.
  • the meal after ingestion of the satiety inducer containing MCT is a high fat diet (lipid: 25 E% or more), the effect is remarkable as compared with the case of a low fat diet (lipid: less than 25 E%). Thus, a large effect can be obtained with a smaller amount of MCT.
  • the administration timing of the satiety inducer is preferably 30 minutes to 90 minutes before meals. More preferably, it is 30 minutes to 60 minutes before a meal.
  • the food and drink according to the embodiment of the present invention contains the satiety inducer so as to contain 0.8 to 10 g of MCT.
  • the MCT is 0.9 g to 8 g, more preferably 1 g to 6 g, and still more preferably MCT 1.25 g to 5 g.
  • Type of food and drink Although it does not specifically limit as food / beverage products which concern on embodiment of this invention, although various food / beverage products are mentioned, It is preferable that it is a food / beverage product of a low calorie (less than 100 kcal including MCT). Soft candy, gummi and the like are particularly suitable.
  • a form such as a soft capsule. It may be in two or more forms (for example, 2 capsules) and may contain 0.8 g to 10 g of MCT in total in two or more forms (for example, 2 capsules containing 0.4 g to 5 g of MCT in one capsule) Capsule intake).
  • FIG. 1 is a diagram showing a flow of a satiety inducing method according to an embodiment of the present invention.
  • the satiety inducing method according to the embodiment of the present invention comprises administering (ingesting) the satiety inducing agent (MCT content 0.8 g to 10 g) according to the above-described embodiment of the present invention before or during a meal. Sensation of satiety during meals can be accelerated and energy intake (meal amount) can be reduced.
  • MCT content 0.8 g to 10 g
  • MCT can be the same as described above.
  • Examples of the administration (intake) method include a soft capsule form, a soft candy form, a gummy form, and the like.
  • the administration (intake) amount of MCT is 0.8 to 10 g. Preferably, it is 0.9 g to 8 g, more preferably 1 g to 6 g, and still more preferably 1.25 g to 5 g.
  • MCT is administered (ingested) before or during a meal.
  • it is 30 minutes to 90 minutes before meal, and more preferably 30 minutes to 60 minutes before meal.
  • ⁇ Test conditions> [Animal] Wistar Rat (male), 6 weeks old, 8 per group [feed for pre-breeding] -Example group: Nisshin Oillio Group Co., Ltd. MCT (octanoic acid / decanoic acid 75/25) (trade name: OD) 11.25 mass% and Nisshin Oillio Group A rapeseed oil (trade name: rapeseed oil) 2% by mass manufactured by Co., Ltd./Comparative Example Group: AIN93G standard feed with a rapeseed oil (trade name: rapeseed oil) 12% by mass made by Nissin Oilio Group Co., Ltd.
  • maltodextrin (trade name: TK-16) manufactured by Matsutani Chemical Co., Ltd., manufactured by Nippon Protein Co., Ltd.
  • Casein (trade name: ALANATE 180) 1.5% by mass and 63.5% by mass of distilled water were mixed into an emulsion; 7.91 kJ / ml
  • ⁇ Test method> Each group of rats was fed with the above-mentioned feed for pre-breeding, reared for 4 weeks, and then fasted for 18 hours. Thereafter, 1 ml of the test emulsion was administered to each group of rats. After the test emulsion was administered, it was allowed to rest for 30 minutes, and then allowed to freely feed each group for 30 minutes and 60 minutes. The amount of food intake was measured, and the amount of energy intake per 100 g body weight was calculated. The results are shown in FIG.
  • the rats in the Example group had significantly lower food consumption (p ⁇ 0.05) in both 30 minutes and 60 minutes compared to the rats in the Comparative group. This is considered to be due to the fact that the MCT administered in advance in the Example group was rapidly energized by the liver.
  • ⁇ Test method> 1 The test subject had a lunch box (nori lunch box: 816 kcal, protein 26.9 g, lipid 22.7 g, carbohydrates 125.9 g, manufactured by Seven-Eleven Japan Co., Ltd.) served as dinner between 19:00 and 21:00 the day before the test. 2 rice balls served as breakfast between 3:1 and 7:30 on the day of the test (373 kcal, protein 10.3 g, lipid 1.7 g, carbohydrates 79.1 g, manufactured by Seven Eleven Japan Co., Ltd.) ).
  • the prepared gelatin solution (gelatin 4.4% by mass) was added to 72% by mass of the prepared varicella dough, stirred thoroughly, and 20% by mass of MCT (trade name: OD, manufactured by Nisshin Oillio Group, Inc.). % And an emulsifier (trade name: Sugar Ester s-770: manufactured by Mitsubishi Chemical Foods Co., Ltd.) 0.3% by mass was added and stirred well on a hot plate.
  • MCT trade name: OD, manufactured by Nisshin Oillio Group, Inc.
  • % And an emulsifier (trade name: Sugar Ester s-770: manufactured by Mitsubishi Chemical Foods Co., Ltd.) 0.3% by mass was added and stirred well on a hot plate.
  • the administration (intake) timing was examined for the effect of suppressing energy intake based on the effect of accelerating the perception of satiety due to MCT intake (inducing satiety early) under the following test conditions and methods.
  • ⁇ Test conditions> [Animal] Wistar Rat (male), 6 weeks old, 8 per group [feed for pre-breeding] -Example group: Nisshin Oillio Group Co., Ltd. MCT (octanoic acid / decanoic acid 75/25) (trade name: OD) 11.25 mass% and Nisshin Oillio Group A rapeseed oil (trade name: rapeseed oil) 2% by mass manufactured by Co., Ltd./Comparative Example Group: AIN93G standard feed with a rapeseed oil (trade name: rapeseed oil) 12% by mass made by Nissin Oilio Group Co., Ltd.
  • Example group (MCT): MCT (octanoic acid / decanoic acid 75/25) manufactured by Nisshin Oillio Group Co., Ltd. (trade name: OD) 10% by mass, malt manufactured by Matsutani Chemical Industry Co., Ltd. Dextrin (trade name: TK-16) 25% by mass, Nippon Protein Co., Ltd.
  • casein (trade name: ALANATE 180) 1.5% by mass, and distilled water 63.5% by mass to make an emulsion; 8 .31kJ / ml ⁇ Comparative example group (LCT): 10% by mass of rapeseed oil (trade name: rapeseed oil) manufactured by Nissin Oilio Group, Ltd. 25% by mass of maltodextrin (trade name: TK-16) manufactured by Matsutani Chemical Co., Ltd., Nippon Protein Casein (trade name: ALANATE180) 1.5% by mass and 63.5% by mass of distilled water mixed to form an emulsion; 7.91 kJ / ml
  • ⁇ Test method> Each group of rats was fed with the above-mentioned feed for pre-breeding, reared for 4 weeks, and then fasted for 18 hours. Thereafter, 1 ml of the test emulsion was administered to each group of rats (the reference example group was not administered). After administration of the test emulsion, rest for 30 minutes, then 60 minutes (30 to 90 minutes after administration), 120 minutes (30 to 150 minutes after administration) and 180 minutes (30 to 210 minutes after administration). The food was ad libitum, the food intake was measured, and the energy intake per 100 g body weight was calculated. The results are shown in Table 2.
  • the rats in the Example group were significantly 30 to 90 minutes after administration compared to the rats in the Comparative Example group (LCT administration group) and the Reference Example group (Non-administration group).
  • the food intake was low (p ⁇ 0.05, relative to the comparative group or reference group).
  • since there was no significant difference between 30 to 150 minutes after administration and 30 to 210 minutes after administration it can be seen that the satiety-inducing effect cannot be expected much after 90 minutes after administration.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nutrition Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Mycology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Child & Adolescent Psychology (AREA)

Abstract

La présente invention concerne un agent induisant une sensation de satiété qui a un excellent effet de réduction de prise d’énergie (absorption de nourriture) comprenant la prise précédente, et un aliment ou une boisson le contenant. En prenant un aliment ou une boisson contenant un agent induisant une sensation de satiété, lequel comprend un triglycéride à chaîne moyenne comme principe actif en quantité allant de 0,8 g à 10 g correspondant à sa dose (prise) unique efficace, avant (par exemple, 30 minutes avant) un repas, la sensation de satiété peut être ressentie plus tôt pendant le repas et la prise d’énergie (absorption de nourriture) peut ainsi être réduite.
PCT/JP2008/073480 2008-03-26 2008-12-24 Agent induisant une sensation de satiété et aliment ou boisson le contenant WO2009118968A1 (fr)

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JP2008-081722 2008-03-26

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3135119A1 (fr) * 2015-08-31 2017-03-01 Miyagi Health Innovation, Ltd. Composition de boisson pour suppression de gain de poids
WO2020193291A1 (fr) * 2019-03-22 2020-10-01 Société des Produits Nestlé S.A. Méthodes utilisant l'administration de triglycérides à chaîne moyenne (tcm) avant un repas pour augmenter la production de cétones à partir des tcm
WO2020193385A1 (fr) * 2019-03-22 2020-10-01 Société des Produits Nestlé S.A. Procédés utilisant des triglycérides à chaîne moyenne administrés avant un repas pour réduire le glucose postprandial à la suite du repas
US10993455B2 (en) * 2014-11-13 2021-05-04 The Nisshin Oillio Group, Ltd. Powdered oil and/or fat, food and drink containing powdered oil and/or fat, and method for manufacturing powdered oil and/or fat
JP7498723B2 (ja) 2019-03-22 2024-06-12 ソシエテ・デ・プロデュイ・ネスレ・エス・アー 中鎖トリグリセリドの食前投与により食事に由来する食後血糖を低減する組成物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001120227A (ja) * 1999-10-29 2001-05-08 We'll Corporation:Kk ダイエット食品
WO2003007932A1 (fr) * 2001-07-16 2003-01-30 The Nisshin Oillio, Ltd. Substances pour le controle du degre d'adiposite
JP2006213711A (ja) * 2005-01-31 2006-08-17 Loders Croklaan Bv ピノレン酸の使用
JP2007503835A (ja) * 2003-09-05 2007-03-01 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド 動物摂取用組成物。

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001120227A (ja) * 1999-10-29 2001-05-08 We'll Corporation:Kk ダイエット食品
WO2003007932A1 (fr) * 2001-07-16 2003-01-30 The Nisshin Oillio, Ltd. Substances pour le controle du degre d'adiposite
JP2007503835A (ja) * 2003-09-05 2007-03-01 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド 動物摂取用組成物。
JP2006213711A (ja) * 2005-01-31 2006-08-17 Loders Croklaan Bv ピノレン酸の使用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MARIE-PIERRE ST-ONGE: "Physiological Effects of Medium-Chain Triglycerides: Potential Agents in the Prevention of Obesity", J. NUTR., vol. 132, 2002, pages 329 - 332 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10993455B2 (en) * 2014-11-13 2021-05-04 The Nisshin Oillio Group, Ltd. Powdered oil and/or fat, food and drink containing powdered oil and/or fat, and method for manufacturing powdered oil and/or fat
EP3135119A1 (fr) * 2015-08-31 2017-03-01 Miyagi Health Innovation, Ltd. Composition de boisson pour suppression de gain de poids
WO2020193291A1 (fr) * 2019-03-22 2020-10-01 Société des Produits Nestlé S.A. Méthodes utilisant l'administration de triglycérides à chaîne moyenne (tcm) avant un repas pour augmenter la production de cétones à partir des tcm
WO2020193385A1 (fr) * 2019-03-22 2020-10-01 Société des Produits Nestlé S.A. Procédés utilisant des triglycérides à chaîne moyenne administrés avant un repas pour réduire le glucose postprandial à la suite du repas
CN113518617A (zh) * 2019-03-22 2021-10-19 雀巢产品有限公司 采用在膳食之前施用中链甘油三酯(mct)以增加来自mct的酮产量的方法
CN113543780A (zh) * 2019-03-22 2021-10-22 雀巢产品有限公司 使用在餐前施用的中链甘油三酯来降低来自餐食的餐后葡萄糖的方法
JP7498723B2 (ja) 2019-03-22 2024-06-12 ソシエテ・デ・プロデュイ・ネスレ・エス・アー 中鎖トリグリセリドの食前投与により食事に由来する食後血糖を低減する組成物

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