200942182 六、發明說明： 【發明所屬之技術領域】 本發明是有關於一種滿腹感誘發劑及含有此滿腹感誘 發劑之飲食品，該滿腹感誘發劑係使滿腹感的感覺提前， 以使能量攝取量（用餐量）減少。 【先前技術】 © 4於飽食環境的現代人，多半由於持續用餐直到感覺 到滿腹感（飽足感），所以能量攝取量（用餐量）動概過剩。 特別是，空腹時再加上用餐時間的縮短（所謂的狼吞虎 嚥）’而會有吃太多的傾向。 能量攝取量（用餐量）的過剩，會導致肥胖的發生、 招致起因於肥胖之疾病，所以目前正進行著以卡路里攝取 之減少或控制為目的而具有良好滿腹效果的食品（參照專 U 利文獻1 )的研究與開發。 又，已有報告指出，相較於事先攝取相同卡路里之長 鏈脂肪酸三酸甘油酯的情形，藉由事先攝取100〜300 kcal 的中鏈脂肪酸三酸甘油酉旨，有▼使用餐量減少的效果（參 照非專利文獻1)。 [專利文獻1]曰本專利特表2〇〇7 533297號公報 [非專利文獻 1] The America Journal of Clinical Nutrition 1988. ’ 48，第 66-71 頁 200942182 【發明内容】 [發明所欲解決之問題] 若依照非專利文獻1之揭示，其須事先攝取1〇〇〜3〇〇 kcal (以較多為佳）的中鏈脂肪酸三酸甘油酯，若包含此 事先攝取量在内，則不太此期待其能量攝取量（用餐量） 的減少效果。 因此，本發明之目的是提供一種滿腹感誘發劑及含有 〇 此滿腹感誘發劑之飲食品，其對於包含事先攝取在内的能 量攝取量（用餐量）之減少效果優良。 [解決問題之技術手段] 本發明為達成上述目的，而提供一種滿腹感誘發劑， 其特徵在於：含有一於結構脂肪酸中包含中鏈脂肪酸之三 酸甘油醋（以下稱為中鏈脂肪酸三酸甘油醋）作為有效成 分。 又，本發明為達成上述目的，而提供一種飲食品，其 ©特徵在於：含有上述本發明之滿腹感誘發劑。 [功效] 右依照本發明’可提供一種滿腹感誘發劑及含有此滿 腹感誘發劑之飲会σ 4+ 货时，其包含事先攝取在内之能量攝取量 (用餐量）的減少效果優良。 【實施方式】 [實施發明的較佳形態 4 200942182 〔有關本發明之實施形態的滿腹感誘發劑〕 有關本發明之實施形態的滿腹感誘發劑’其含有中鏈 脂肪酸三酸甘油酯作為有效成分。 (滿腹感誘發劑） 有關本發明之實施形態的滿腹感誘發劑’是使餐間（用 餐期間）的滿腹感提前之物，亦即，是使滿腹感的感覺提前 之物。在此，所謂使滿腹感的感覺提前，意思是能以較少 Φ 量的能量攝取量（用餐量）便能感覺到滿腹感。因此，有 關本發明之實施形態的滿腹感誘發劑，可以稱為能量攝取 量抑制劑或用餐量抑制劑。 (中鏈脂肪酸三酸甘油酯） 作為含有於有關本發明之實施形態的滿腹感誘發劑中 而作為有效成分的中鏈脂肪酸三酸甘油醋（MCT ( Medium ChainTriglycerides)’亦稱為：中鏈三酸甘油酯），沒有特 別限定’可使用藉由一般方法來將中鍵脂肪酸和甘油加以 G 酯化反應而得的三酸甘油酯。 所謂中鏈脂肪酸’是指碳數6〜12的脂肪酸，特別是 飽和脂肪酸。舉例而言’可以是己酸、辛酸、癸酸、月桂 酸。以碳數6〜1 〇的脂肪酸為佳，較佳為碳數8〜1 〇的脂 肪酸’特佳為使用辛酸及癸酸。 可使用單一酸基三酸甘油酯或混合酸基三酸甘油酯， 作為混合酸基三酸甘油酯，例如可適當地使用辛酸/癸駿 = 60/40〜80/20(質量比），較佳為辛酸/癸酸=60/4〇 〜75/ 25 (質量比）的三酸甘油醋。 200942182 (MCT含量） 有關本發明之實施形態的滿腹感誘發劑，含有0.8 g〜 10 g也就是成人1次份量之有效投予量（有效攝取量）的 、〜8g為佳’較佳為Ig〜6g，更佳為i.25g 〜5g。兒童的情形中，也可適用與成人的情形同等之卜欠 份量的有效投予量。 攝取含有MCT1之滿腹感誘發劑後的用餐是低脂肪餐 ❹（月曰質.小於25E% )時，特佳為使其含有上述較佳範圍的 有效技予篁。又，攝取含有MCT之滿腹感誘發劑後的用餐 是高脂肪餐（脂質·· 2 5 E %以上）時，其效果比低脂肪餐（脂 質.小於25E% )顯著，能夠以較少量的MCT得到很大的 效果。 (滿腹感誘發劑的投予時機） 因為在投予（攝取）滿腹感誘發劑後的第30〜90分鐘 之間（6G分鐘）效果特別高，所以較佳的滿腹感誘發劑的 扠予時機，是使此60分鐘可以碰上用餐時間。一般人的用 餐時間可能是1分鐘〜6〇分鐘，則滿腹感誘發劑的投予時 機以餐前3〇分鐘〜90分鐘為佳。較佳為餐前30〜60分鐘。 在用餐時間耗費較長的情況下，也可以階段性地投 予例如在餐前90分鐘前、60分鐘前、30分鐘前、開始 開始用餐3〇分鐘後等，適#地多次投予。藉此°， 即使假叹耗費2小時的用餐時間，在用餐時間的期間，效 果也可以持續。 200942182 〔有關本發明之實施形態的飲食品〕 有關本發明之實施形態的飲食品，含有上述有關本發 明之實施形態的滿腹感誘發劑。 (MCT含量） 有關本發明之實施形態的飲食品，調配有上述滿腹感 誘發劑，以含有0.8 g〜1〇 g之MCT。以含有〇 9 g〜8 g 之MCT為佳，較佳為含有1 g〜6 g，更佳為含有1.25 g〜 ❹ 5 g之MCT。 (飲食品的種類） 作為有關本發明之實施形態的飲食品，並無特別限定 而可舉出各種飲食品’但以低卡路里（包括MCT在内而小 於1〇〇 kcal)的飲食品為佳。以軟糖（s〇ft candy)或橡皮糖 (gummy candy)等特別適合。200942182 VI. Description of the Invention: [Technical Field] The present invention relates to a full-sensation inducer and a food or drink containing the full-sensation inducer, which causes the feeling of fullness to advance in order to make energy The intake (meal amount) is reduced. [Prior Art] © 4 In modern people who are full of food, most of them continue to eat until they feel full (satisfaction), so the amount of energy intake (meal amount) is excessive. In particular, when the fasting is accompanied by a shortening of the meal time (so-called gorging), there is a tendency to eat too much. Excessive energy intake (meal amount) causes obesity and causes diseases caused by obesity. Therefore, foods that have a good effect on the reduction or control of calorie intake are currently being carried out. 1) Research and development. In addition, it has been reported that compared with the case of ingesting the long-chain fatty acid triglyceride of the same calorie in advance, by using a medium-chain fatty acid triglyceride of 100 to 300 kcal in advance, there is a reduction in the amount of meal used. Effect (refer to Non-Patent Document 1). [Patent Document 1] Japanese Patent Publication No. 2 533 297 [Non-Patent Document 1] The America Journal of Clinical Nutrition 1988. '48, pp. 66-71 200942182 [Summary of the Invention] [Problem] If it is disclosed in Non-Patent Document 1, it is necessary to take 1 〇〇 to 3 〇〇 kcal (more preferably) medium-chain fatty acid triglyceride in advance, and if it contains this prior intake, it does not. The effect of reducing the amount of energy intake (meal amount) is expected from this. In view of the above, it is an object of the present invention to provide a full-sensation-inducing agent and a food or drink containing the sensation-inducing agent, which is excellent in the effect of reducing the amount of energy intake (meal amount) including the ingestion. [Means for Solving the Problems] In order to achieve the above object, the present invention provides a full-sensation inducer comprising a triglyceride vinegar containing a medium-chain fatty acid in a structural fatty acid (hereinafter referred to as a medium-chain fatty acid triacid) Glycerin vinegar) as an active ingredient. Moreover, in order to achieve the above object, the present invention provides a food or drink comprising the above-described fullness-inducing agent of the present invention. [Efficacy] According to the present invention, it is possible to provide a full-sensation inducer and a drink-containing σ 4+ product containing the full-sensitivity inducer, and the effect of reducing the amount of energy intake (meal amount) included in advance is excellent. [Embodiment of the Invention] [Prepared Embodiment 4 of the Invention] 200942182 [A full-sensitivity inducer according to an embodiment of the present invention] The full-sensation inducer of the embodiment of the present invention contains a medium-chain fatty acid triglyceride as an active ingredient . (Allergic sensitizing agent) The sensation of the fullness of the sensation according to the embodiment of the present invention is a thing that advances the feeling of fullness during a meal (during a meal), that is, a thing that advances the feeling of fullness. Here, the feeling of the feeling of fullness is advanced, which means that the feeling of fullness can be felt with an energy intake amount (meal amount) of a small amount of Φ. Therefore, the fullness-inducing agent according to the embodiment of the present invention may be referred to as an energy intake inhibitor or a meal amount inhibitor. (Medium Chain Fatty Acid Triglyceride) The medium chain fatty acid glycerol (MCT (Medium Chain Triglycerides)' is also known as the medium chain three as an active ingredient contained in the fullness induction inducer according to the embodiment of the present invention. The acid glyceride is not particularly limited. A triglyceride obtained by G-esterifying a middle bond fatty acid and glycerin by a general method can be used. The medium-chain fatty acid 'is a fatty acid having 6 to 12 carbon atoms, particularly a saturated fatty acid. For example, it may be hexanoic acid, octanoic acid, citric acid, lauric acid. Preferably, the fatty acid having a carbon number of 6 to 1 Torr is preferably a fatty acid having a carbon number of 8 to 1 Å. Preferably, octanoic acid and citric acid are used. A single acid triglyceride or a mixed acid triglyceride may be used as the mixed acid triglyceride, and for example, octanoic acid/60/40 to 80/20 (mass ratio) may be suitably used. Good for octanoic acid / citric acid = 60 / 4 〇 ~ 75 / 25 (mass ratio) of triglyceride vinegar. 200942182 (MCT content) The full-sensation inducer according to the embodiment of the present invention contains 0.8 g to 10 g, which is an effective dose (effective intake) of an adult one-time, and preferably ~8 g is preferably 'Ig. ~6g, more preferably i.25g ~ 5g. In the case of a child, an effective amount of the same amount as that of the adult can also be applied. When the meal after ingesting the fullness-inducing agent containing MCT1 is a low-fat meal (monthly tannin. less than 25E%), it is particularly preferable to have an effective technique of containing the above preferred range. Moreover, when the meal after the ingestion of the fullness-inducing agent containing MCT is a high-fat meal (lipid··25 E% or more), the effect is remarkable compared with the low-fat meal (the lipid is less than 25E%), and the amount can be reduced by a small amount. MCT has a great effect. (The timing of administration of the full-sensation inducer) Since the effect is particularly high between the 30th and 90th minutes (6G minutes) after administration (intake) of the full-sensation inducer, the preferred timing of the full-sensation inducer It is to make this 60 minutes to meet the meal time. The average meal time of the person may be from 1 minute to 6 minutes, and the timing of the administration of the fullness-inducing agent is preferably from 3 minutes to 90 minutes before the meal. It is preferably 30 to 60 minutes before the meal. In the case where the meal time is long, it may be administered in stages, for example, 90 minutes before the meal, 60 minutes ago, 30 minutes ago, 3 minutes after the start of the meal, and the like. By this, even if the sigh consumes 2 hours of meal time, the effect can be continued during the meal time. (Food and beverage according to the embodiment of the present invention) The food or drink according to the embodiment of the present invention contains the above-mentioned fullness-inducing agent according to the embodiment of the present invention. (MCT content) The food or drink according to the embodiment of the present invention is formulated with the above-mentioned fullness sensation inducing agent, and contains MCT of 0.8 g to 1 g. MCT containing 〇 9 g to 8 g is preferred, preferably 1 g to 6 g, more preferably 1.25 g to ❹ 5 g of MCT. (Types of Foods and Drinks) The foods and drinks according to the embodiments of the present invention are not particularly limited, and various food and beverage products are mentioned, but foods and drinks having low calories (including MCT and less than 1 〇〇 kcal) are preferred. . It is especially suitable for soft candy (s〇ft candy) or gummy candy.
又’作成軟膠囊等形態亦佳。亦可是2種形態以上（例 如’2個膠囊），只要2種形態合計含有〇.8§〜1〇§之MCT 〇 即可（例如’攝取2個膠囊，其每1膠囊中含有〇 4 g〜5 g 之 MCT) 〇 作成軟糖或橡皮糖的情況下，以製造成含有丨質量〇/〇 〜20質量％之MCT為佳。 〔有關本發明之實施形態的滿腹感誘發方法〕. 第1圖是表示有關本發明之實施形態的滿腹感绣發方 法的流程圖。 有關本發明之實施形態的滿腹感誘發方法，是藉由在 200942182 餐前或餐間投^ (攝取）上述有關本發明之實施形態的滿 腹感誘發劑（MCT含量〇·8 g〜10 g)，而可使餐間之滿腹 感的感覺提前，使能量攝取量（用餐量）減少。 MCT可使用如同前述者。作為投予（攝取）方法，可 列舉軟膠囊之形態或是軟糖或橡皮糖等形態。 MCT之投予（攝取）量，是〇 8g〜i〇g。以〇9g g為佳，較佳為1 g〜6 g，更佳為i 25 g〜5 g。Also, it is also preferable to form a soft capsule. It is also possible to use two or more types (for example, '2 capsules), as long as the two forms together contain MCT 〇 of 〇.8§~1〇§ (for example, 'take 2 capsules, which contain 〇4 g per capsule) When the MCT of ~5 g is made into a soft candy or a gummy candy, it is preferable to manufacture MCT containing 丨 mass 〇 / 〇 ~ 20% by mass. [Method for inducing fullness of the sensation according to the embodiment of the present invention] Fig. 1 is a flowchart showing a method of embroidering the full-feeling according to the embodiment of the present invention. In the method for inducing the feeling of fullness according to the embodiment of the present invention, the above-mentioned full-sensitivity inducer (MCT content 〇·8 g to 10 g) according to the embodiment of the present invention is administered (ingested) before or during the meal at 200942182. In addition, the feeling of fullness of the meal can be advanced, and the amount of energy intake (the amount of meal) can be reduced. MCT can be used as described above. The method of administration (ingestion) may be in the form of a soft capsule or a form such as a soft candy or a gummy candy. The amount of (intake) administered by MCT is 〇 8g~i〇g. Preferably, 〇9 g g is used, preferably 1 g to 6 g, more preferably i 25 g to 5 g.
MCT是在餐前或餐間投予（攝取）。以餐前3〇分鐘〜 90分鐘為佳’較佳為餐前3〇〜6〇分鐘。 〔本發明之實施形態的功效〕 若依照本發明之實施形態，因為藉由事先攝取少量的 MCT而可使餐間之滿腹感的感覺提前，所以可使包括事先 攝取在内之能量攝取量（用餐量）減少。藉此，可防止肥 胖。 接著，藉由實施例來說明本發明，但本發明並不受這 些實施例所限定。 [實施例] 〔藉由大鼠來驗證效果之預備試驗〕 藉由以下的試驗條件與方法’來進行用以驗證能量攝 取之抑制效果的預備試驗’該能量攝取之抑制效果係基於 MCT攝取所致之使滿腹感的感覺提前（使滿腹感提前被誘 發）的效果。 200942182 〈試驗條件> 群8隻 《動物》WistarRat (雄），6週齡， 《預備飼養用飼料》 、實施例群：SAIN93G標準飼料中添加Μ 日清奥利友集團株式會社製的mct(辛酸/癸酸= 广W〇)及2質量%之曰清奥利友集 )MCT is administered (ingested) before or during meals. It is better to take 3 minutes to 90 minutes before meals. It is better to 3 minutes to 6 minutes before meals. [Effect of the embodiment of the present invention] According to the embodiment of the present invention, since the feeling of the feeling of fullness between meals can be advanced by ingesting a small amount of MCT in advance, the amount of energy intake including the intake in advance can be obtained ( The amount of meal is reduced. In this way, fatness can be prevented. Next, the invention is illustrated by the examples, but the invention is not limited by the examples. [Examples] [Preliminary test for verifying effect by rat] A preliminary test for verifying the effect of suppressing energy intake was performed by the following test conditions and methods'. The effect of suppressing energy intake was based on MCT ingestion. The result is that the feeling of fullness is advanced (the feeling of fullness is induced in advance). 200942182 <Test conditions> Group 8 "Animals" WistarRat (male), 6 weeks old, "Prepared feed", Example group: Addition to SAIN93G standard feed m mct (made by Nisshin Olympus Group Co., Ltd.) Caprylic/Citrate = Wide W〇) and 2% by mass of 曰清奥利友集)
製的菜籽油（商品名：菜籽油）而成I ❹ 比較料：於細93G標準飼料中添加12質量％之日 者奥利友集團株式會社製的菜籽油（商品名：菜籽油）而 成者 《試驗用乳劑》 實施例群110質量％之曰清奥利友集圏 的⑽（辛酸/癸酸=75/25)(商品名：〇D〇)、^ 量/。之松谷化學工業株式會社製的麥芽糊精（商品名： τκ·16)、K5 f量％之日本pr〇tein株式會社製的絡蛋白Rapeseed oil (trade name: rapeseed oil) is used as a product I. ❹Comparatively: 12% by mass of the finest 93G standard feed is added to the rapeseed oil made by Oriyou Group Co., Ltd. (trade name: rapeseed Oil) "Testing Emulsion" Example 110% by mass of 曰清奥利友集(10) (octanoic acid / decanoic acid = 75/25) (trade name: 〇D〇), ^ quantity /. Maltodextrin (trade name: τκ·16) manufactured by Matsutani Chemical Industry Co., Ltd., and complex protein produced by Japan pr〇tein Co., Ltd.
(商品名：ALANATE180)、及63 5質量％之蒸館水予心 合而作成乳劑者；8.31 kJ/mI 比較例群·'將i 0質量％之曰清奥利友集團株式會社製 的菜籽油（商品名：菜籽油）、25質量％之松谷化學工業株 式會社製的麥芽糊精（商品名：τκ·16)、i 5 f量％之曰本 pR〇tEIN株式會社製的路蛋白（商品f alanate⑽）、 及63.5質量％之蒸館水予以混合而作成乳劑者；79ι ml <試驗方法> 200942182 將上述預備飼養用飼料，餵飼予各 柄赖，腺甘# a 群之大鼠並飼養4(product name: ALANATE 180), and 63% by mass of steamed water to make a mixture into the emulsion; 8.31 kJ/mI Comparative example group - 'I will be 0% by mass of 曰清奥利友集团公司籽 p 商品 商品 商品 p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p p Road protein (commodity f alanate (10)), and 63.5 mass% of steamed water are mixed to form an emulsion; 79 ι ml <test method> 200942182 The above-mentioned feed for feeding is fed to each of the stalks, gland Group of rats and rearing 4
週t其禁食18小時。之後，對各群之大鼠投予W 之试驗用礼齊卜投予試驗用乳劑後，使其安靜3〇分鐘，之 後使其自由攝食各群之㈣3G分鐘及6g分鐘，測定攝食 量，算出每H)〇g體重之能量攝取量。結果顯示於第2圖。 由第2圖可知，相較於比較例群之大鼠，實施例群之 大鼠在30分鐘及6〇分鐘均為顯著較低之攝食量 ❹ 0.05)。此可能是因為在實施例群事先投予的mct迅速地 在肝臟被轉為能量之故。 〔用以進行效果驗證、有效量探討之比較試驗〕 (實施例1〜7、比較例丨〜2、參考例丨〜3 ) 藉由以下的試驗條件與方法，來進行用以驗證在人類 中能量攝取之抑制效果及探討其有效量的比較試驗，該能 量攝取之抑制效果係基於MCT攝取所致之使滿腹感提前 Ο 被誘發的效果。 <試驗條件> 《受試者》健康者7名：成年男性5名（體重65〜 72 kg)、成年女性2名（體重49〜60 kg) 《試驗餐》分別製備5〇g之含有0g、0.625 g、1.25g、 2·5 g、5 g、1〇 g之mct (商品名：〇 D 〇，曰清奥利友集 團株式會社製）的凝膠（jelly)(凝膠之商品名：吞食幫手， 龍角散株式會社製 MCT 0 g (凝膠 50 g) : 8.5 kcal 200942182 MCT 1.25 g (凝膠 48.75 g) : 18.3 kcal MCT 2.5 g (凝膠 47.5 g) : 28.1 kcal MCT 5 g (凝膠 45 g) : 47.7 kcal MCT 10 g (凝膠 40 g) : 86.8 kcal <試驗方法> 1. 受試者於試驗前一日的19點至21點之間，攝取配 發作為晚餐的便當（海苔便當：816 kcal、蛋白質26.9 g、 φ 脂質22_7 g、碳水化合物125.9 g、日本7-11公司製），於 試驗當曰的6點30分至7點30分之間，則攝取配發作為 早餐的2個飯糰（373 kcal、蛋白質10.3 g、脂質1.7 g、 碳水化合物79.1 g、日本7-11公司製）。 2. 使各群之受試者於11點30分在3分鐘之内攝取上 述試驗餐50g，12點開始使低脂肪餐群（實施例1〜3、比 較例1、參考例1〜2 )攝取和風義大利麵（spaghetti)(曰清 食品株式會社製，351 kcal/ 275 g、蛋白質12.9 g(14.7 Ο Ε%)、脂質 7.2 g(18.5 Ε%)、碳水化合物 58.6 g(66.8 Ε%))、 使高脂肪餐群（實施例4〜7、比較例2、參考例3 )攝取 培根蛋麵（carbonara)(日清食品株式會社製，468 kcal/ 300 g、蛋白質 14.7 g(12.6 E%)、脂質 20.9 g(40.2 E%)、碳水化 合物55.2 g(47.2 E%))直到飽足以作為午餐，測定其攝取 量’計算攝取能量。另外，攝取能量係在丨1點30分攝取 之試驗餐能量之量與在午餐攝取能量之量的合計。 滿腹感之確認’是依據滿腹感評分法（由本人將自「相 當餓」至「相當飽」為止的感覺於100mm之視覺類比量表 200942182 (visual analog scales)[VAS s]中記入x記號的「森谷等人之 方法」’日本營養食糧學會諸第6〇卷5號第257頁，2007 年）。顯著檢定是依據受試者内因子之多重比較（丹内特測 驗法（Dunnett’stest))來進行。 結果表示於表1、第3圖及第4圖。將試驗餐（MCT0 g )之群作為對照來進行比較。 [表1] 表1 華得滿腹感為止的能量攝取量之測定 試驗餐中之 MCT含量 〇g(對照組） 0.625 g [25 g 2-5 g 5g l〇g 比較例1 參考例1 p實施例1 實施例2 實施例3 參考例2 能量攝取量 (kcal) (低脂肪餐） 637.8±31.6 628.7 ±26_9 本 596.8±30.7 氺氺 5 86.4 ±22.0 氺氺 568.1 ±24.4 600.9±20.2 比較例2 參考例3 實施例4 實施例 實施例6 實施例7 能量攝取量 (kcal) (高脂肪餐） 795.5 ±35.7 746.5 ±34.1 氺氺 703.9土32.0 氺氺 673_2±45.2 木氺 692.3 ±30.7 氺氺 711.4±31.1 ΟWeek t was fasted for 18 hours. Then, the test emulsion was administered to the rats of each group, and then the test emulsion was administered, and then allowed to stand for 3 minutes, and then allowed to freely ingest (4) 3G minutes and 6 g minutes of each group, and the food intake was measured. The energy intake per 〇g body weight was calculated. The results are shown in Figure 2. As can be seen from Fig. 2, the rats of the example group showed significantly lower food intake ❹ 0.05) at 30 minutes and 6 minutes compared to the rats of the comparative group. This may be because the mct administered in advance in the embodiment group is rapidly converted into energy in the liver. [Comparative test for effect verification and effective amount investigation] (Examples 1 to 7, Comparative Example 2、2, Reference Example 丨3) were carried out by using the following test conditions and methods for verification in humans. The effect of suppressing energy intake and a comparative test for investigating the effective amount thereof, the effect of suppressing the energy intake is based on the effect of premature sensation caused by MCT uptake. <Test conditions> "Subject" 7 healthy persons: 5 adult males (body weight 65 to 72 kg), 2 adult females (body weight 49 to 60 kg), "Test meal" prepared separately for 5 〇g Gel of the 0g, 0.625 g, 1.25 g, 2·5 g, 5 g, 1 〇g of mct (trade name: 〇D 〇, 曰清奥利友集团株式会社) (product of gel) Name: Swallowing Helper, MCT 0 g (gel 50 g) manufactured by Longjiao Powder Co., Ltd.: 8.5 kcal 200942182 MCT 1.25 g (gel 48.75 g): 18.3 kcal MCT 2.5 g (gel 47.5 g): 28.1 kcal MCT 5 g (gel 45 g): 47.7 kcal MCT 10 g (gel 40 g): 86.8 kcal <test method> 1. Subjects were ingested between 19:00 and 21:00 on the day before the test. As a lunch lunch (seaweed lunch: 816 kcal, protein 26.9 g, φ lipid 22_7 g, carbohydrate 125.9 g, Japan 7-11 company), between 6:30 and 7:30 in the test, Then, two rice balls (373 kcal, protein 10.3 g, lipid 1.7 g, carbohydrate 79.1 g, and Japanese 7-11 company) were distributed as breakfast. 2. Subjects of each group were 11 At 30 minutes, 50 g of the above test meal was taken within 3 minutes, and at 12 o'clock, the low-fat meal group (Examples 1 to 3, Comparative Example 1, Reference Example 1 to 2) was ingested and the spaghetti (spaghetti) was obtained. Manufactured by Foods Co., Ltd., 351 kcal/275 g, protein 12.9 g (14.7 Ο Ε%), lipid 7.2 g (18.5 Ε%), carbohydrate 58.6 g (66.8 Ε%), high fat meal group (Example 4) ～7, Comparative Example 2, Reference Example 3) Intake of Bacon (carbonara) (made by Nissin Foods Co., Ltd., 468 kcal/300 g, protein 14.7 g (12.6 E%), lipid 20.9 g (40.2 E%), Carbohydrate 55.2 g (47.2 E%)) until sufficient for lunch, measure the amount of intake 'calculate the energy intake. In addition, the energy intake is the amount of test meal energy taken at 1:30 and the amount of energy taken at lunch. The total sensation of the sensation is based on the full sensation score (from the visual analog scales 200942182 (VAS s) that I feel from "very hungry" to "very full". "The method of Morigu et al." by the x mark, the 6th volume of the Japanese Nutrition and Food Research Society 5 Page 257, 2007). Significant assays were performed based on multiple comparisons of factors within the subject (Dunnett’s test). The results are shown in Table 1, Figure 3 and Figure 4. A group of test meals (MCT0 g ) was compared as a control. [Table 1] Table 1 Measurement of Energy Intake of Huade Fullness Sense MCT Content in Test Meal 对照组g (Control Group) 0.625 g [25 g 2-5 g 5g l〇g Comparative Example 1 Reference Example 1 p Implementation Example 1 Example 2 Example 3 Reference Example 2 Energy intake (kcal) (low fat meal) 637.8 ± 31.6 628.7 ± 26_9 596.8 ± 30.7 氺氺 5 86.4 ± 22.0 氺氺 568.1 ± 24.4 600.9 ± 20.2 Comparative Example 2 Reference Example 3 Example 4 Example Example 6 Example 7 Energy intake (kcal) (high fat meal) 795.5 ±35.7 746.5 ±34.1 氺氺703.9 soil 32.0 氺氺673_2±45.2 hibiscus 692.3 ±30.7 氺氺711.4±31.1 Ο
G 12 200942182 係位於攝取量5 g左右，相對於此在高脂肪餐的條件下 則係位於攝取量2.5 g左右’在高脂肪餐的條件下能夠以較 少的量獲得較大效果。另—方面，在〇 625 g以下之攝取量 則未確認到顯著的效果差異。 〔添加MCT之軟糖的製造〕 (實施例8 ) φ 用以下的配方來製造添加MCT之軟糖。 澱粉糖漿原料 72質量％ 明膠 7.7質量％ MCT 20質量％ 乳化劑 0.3質量％ 風味劑 適量 首先’添加28.8質量％之晶粒砂糖（granulated sugar) Ο ( Pearl Ace株式會社製）於43.2質量°/。之澱粉糖漿（永旺 株式會社製）中’在熱板上溶解，以製作72質量％之澱粉 糠漿原料°又’將明膠（商品名：AP-250，新田明膠株式 會社製）和水以「明膠：水=1 : 2」之比例混合，用熱板 使其完全溶解’以製作明膠溶解液（7.7質量％之明膠）。 於所製作之72質量％之澱粉糖漿原料中，加入所製作 之明膠溶解液（4.4質量％之明膠），完全地攪拌，加入20 質量。/。之MCT (商品名：〇 D 〇，曰清奥利友集團株式會社 製）和0.3質量。/。之乳化劑（商品名：糖酯s_77〇，三菱化 13 200942182 學食品株式會社製），然後在熱板上充分攪拌。 自熱板上取下，冷卻後適量地加入風味劑，每6 以分取’藉此獲得添加MCT之軟糖。 〔投予時機之探討〕 藉由以下的試驗條件與方法，來對於能量攝取之抑制 效果進行投予（攝取）時機之探討，該能量攝取之抑制欵 ❹果係基於MCT攝取所致之使滿腹感的感覺提前（使滿腹感 提前被誘發）的效果。 <試驗條件> 《動物》Wistar Rat (雄），6週齡，1群8隻 《預備飼養用飼料》 實施例群：於AIN93G標準飼料中添加1125質量％之 日清奥利友集團株式會社製的MCT(辛酸/癸酸 (商品名：O.D_〇)及2質量％之曰清奥利友集團株式會社 〇 製的菜籽油（商品名：菜籽油）而成者 比較例群：於AIN93G標準飼料中添加12質量％之曰 清奥利友集團株式會社製的菜籽油（商品名：菜籽油）而 成者 《試驗用乳劑》 實施例群（MCT):將10質量％之曰清奥利友集團株 式會社製的MCT (辛酸/癸酸=75 / 25)(商品名： )25質量％之松谷化學工業株式會社製的麥芽糊精 (商。口名.Τκ_16)、15質量％之曰本pr〇tein株式會社 14 200942182 製的路蛋白（商品名：ALANATE180)、及63.5質量％之蒸 餾水予以混合而作成乳劑者；8.31 kj/ml 比較例群（1^(：丁）：將10質量％之日清奥利友集團株式 會社製的菜籽油（商品名：菜籽油）、25質量％之松谷化學 工業株式會社製的麥芽糊精（商品名：TK-16)、1.5質量％ 之曰本PROTEIN株式會社製的酪蛋白（商品名： ALANATE180)、及63.5質量％之蒸餾水予以混合而作成乳 ❹ 劑者；7.91 kJ/ml <試驗方法> 將上述預備飼養用飼料餵飼予各群之大鼠並飼養4週 後’將其禁食1 8小時。之後，對各群之大鼠投予1 m丨之 試驗用乳劑（參考例群則未投予）。投予試驗用乳劑後，使 其安靜30分鐘，之後使其自由攝食各群之餌料6〇分鐘（投 予後第30〜90分鐘）、12〇分鐘（投予後第30〜150分鐘）、 及180分鐘（投予後第30〜210分鐘），測定攝食量，算出 © 每l〇〇g體重之能量攝取量。結果顯示於表2。 [表2] 投予物質 攝食量（g/l〇〇gBW) 第30〜90分鐘 第30〜150分鐘 第30〜210分鐘 MCT 1.72±0.25 1，2 2.78 ±0.26 3.45 ±0.25 LCT 2.46 ±0.17 3.35±0.31 3.80 ±0.29 未投予 2.58 ±0.22 未測定 未測定 15 1 : p< 0.05 (相較於 LCT 投予群），1 1 : p< 〇.〇1 (相 2 較於未投予群） 200942182 由表2可知’相較於比較例群（LCT投予群）或參考 例群（未投予群）之大鼠，實施例群（MCT投予群）之大 鼠在投予後第30〜90分為顯著較低之攝食量（p<0.05, 相對於比較例群或參考例群）。另一方面，在投予後第3〇 〜150分鐘及第30〜210分鐘方面則無顯著差異，所以可 知投予後若超過90分鐘’則不太能期待其滿腹感誘發效 果0 【圖式簡單說明】 第1圖是表示有關本發明之實施形態的滿腹感誘發方 法的流程圖。 第2圖是顯示大鼠中的實施例及比較例的測定結果的 圖表。 第3圖是表示人類（低脂肪餐）中的實施例、參考例 及比較例的測定結果的圖表。 第4圖是表示人類（高脂肪餐）中的實施例、參考例 及比較例的測定結果的圖表。 【主要元件符號說明】 無 16G 12 200942182 is located at an intake of about 5 g, and in the case of a high-fat meal, it is located at an intake of about 2.5 g. Under a high-fat meal, a large effect can be obtained in a small amount. On the other hand, no significant difference in effect was observed in the intake below 625 625 g. [Production of MTC-added Fudge] (Example 8) φ The MTC-added soft candy was produced by the following formulation. Starch syrup raw material 72% by mass of gelatin 7.7 mass% MCT 20% by mass Emulsifier 0.3% by mass Flavoring agent First amount First, 28.8 mass% of granulated sugar Ο (manufactured by Pearl Ace Co., Ltd.) was added at 43.2 mass%. In the starch syrup (made by AEON Co., Ltd.), it was dissolved on a hot plate to prepare a 72% by mass of starch mash raw material, and 'gelatin (trade name: AP-250, manufactured by Nitta Gelatin Co., Ltd.) and water. Mix in a ratio of "gelatin: water = 1:2" and completely dissolve it with a hot plate to prepare a gelatin solution (7.7 mass% gelatin). To the produced 72% by mass of the starch syrup raw material, the produced gelatin solution (4.4% by mass of gelatin) was added, and the mixture was thoroughly stirred, and 20 mass was added. /. MCT (trade name: 〇 D 〇, 曰清奥利友集团株式会社) and 0.3 quality. /. The emulsifier (trade name: sugar ester s_77〇, Mitsubishi 13 200942182), and then thoroughly stirred on a hot plate. It was taken out from the hot plate, and after cooling, the flavor was added in an appropriate amount, and the gel was added every 6 minutes to obtain a soft candy to which MCT was added. [Exploration of timing of administration] The timing of administration (intake) of the effect of suppressing energy intake is examined by the following test conditions and methods, and the inhibition effect of this energy intake is based on MCT intake. The feeling of feeling is advanced (the feeling of fullness is induced in advance). <Test conditions> "Animal" Wistar Rat (male), 6 weeks old, 1 group of 8 "prepared feeds" Example group: 1125 mass% of Nisshin Olympus group was added to AIN93G standard feed Comparison of the MCT (Cinnamon/Citrate (trade name: O.D_〇) and the 2% by mass of the rapeseed oil (trade name: rapeseed oil) prepared by the Ao Liyou Group Co., Ltd. In the AIN93G standard feed, a 12% by mass of rapeseed oil (trade name: rapeseed oil) manufactured by Toray Clear Olivia Group Co., Ltd. was added as a "test emulsion". Example group (MCT): 10% by mass of MCT (octanoic acid / decanoic acid = 75 / 25) (product name: ) 25 mass% of maltodextrin manufactured by Matsutani Chemical Industry Co., Ltd. .Τκ_16), 15% by mass of pr〇tein Co., Ltd. 14 200942182 manufactured road protein (trade name: ALANATE 180), and 63.5 mass% distilled water were mixed to form an emulsion; 8.31 kj/ml comparative group (1) ^(:丁): 10% by mass of Rapeseed Oil made by Nisshin Olympus Group Co., Ltd. : Rapeseed oil (25% by mass), maltodextrin (trade name: TK-16), 1.5% by mass of casein (product name: ALANATE180) manufactured by PROTEIN Co., Ltd. And 63.5% by mass of distilled water is mixed to prepare a chyle; 7.91 kJ/ml <Test Method> The above-mentioned feed for feeding is fed to each group of rats and fed for 4 weeks, 'fasting it 1 After 8 hours, rats of each group were administered with a test emulsion of 1 m (the reference group was not administered). After the test emulsion was administered, it was allowed to stand for 30 minutes, and then allowed to freely ingest each group. The bait is 6 minutes (30th to 90th minutes after administration), 12 minutes (30th to 150th minutes after administration), and 180 minutes (30th to 210th minutes after administration), and the food intake is measured and calculated. The energy intake of 〇g body weight. The results are shown in Table 2. [Table 2] Food intake (g/l〇〇gBW) 30th to 90th minutes 30th to 150th minutes 30th to 210th minutes MCT 1.72±0.25 1,2 2.78 ±0.26 3.45 ±0.25 LCT 2.46 ±0.17 3.35±0.31 3.80 ±0.29 Not administered 2.58 ±0.22 Not determined Not determined 15 1 : p< 0.05 (compared to the LCT administration group), 1 1 : p< 〇.〇1 (phase 2 compared to the uninvested group) 200942182 It can be seen from Table 2 Rats of the comparative group (LCT-administered group) or the reference group (un-administered group), and the rats of the example group (MCT-administered group) were divided into significantly lower food intakes at the 30th to 90th after administration. (p < 0.05, relative to the comparative group or the reference group). On the other hand, there is no significant difference between the third 〇 150 minutes and the 30th to 210th minutes after the administration, so it can be seen that if the application is more than 90 minutes after the administration, the sensation of the full sensation is not expected. Fig. 1 is a flow chart showing a method of inducing a feeling of fullness in accordance with an embodiment of the present invention. Fig. 2 is a graph showing the measurement results of the examples and comparative examples in the rat. Fig. 3 is a graph showing the measurement results of Examples, Reference Examples and Comparative Examples in humans (low fat meals). Fig. 4 is a graph showing the measurement results of Examples, Reference Examples and Comparative Examples in humans (high fat meals). [Main component symbol description] None 16