WO2009090989A1 - Récipient à réactif - Google Patents

Récipient à réactif Download PDF

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Publication number
WO2009090989A1
WO2009090989A1 PCT/JP2009/050450 JP2009050450W WO2009090989A1 WO 2009090989 A1 WO2009090989 A1 WO 2009090989A1 JP 2009050450 W JP2009050450 W JP 2009050450W WO 2009090989 A1 WO2009090989 A1 WO 2009090989A1
Authority
WO
WIPO (PCT)
Prior art keywords
reagent
container
reagent container
reagents
view
Prior art date
Application number
PCT/JP2009/050450
Other languages
English (en)
Japanese (ja)
Inventor
Noriyuki Suzuki
Original Assignee
Kyowa Medex Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Medex Co., Ltd. filed Critical Kyowa Medex Co., Ltd.
Priority to JP2009550037A priority Critical patent/JP5069755B2/ja
Publication of WO2009090989A1 publication Critical patent/WO2009090989A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/22—Mixing the contents of independent containers, e.g. test tubes with supporting means moving in a horizontal plane, e.g. describing an orbital path for moving the containers about an axis which intersects the receptacle axis at an angle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50—Mixing receptacles
    • B01F35/53—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components
    • B01F35/531—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components with baffles, plates or bars on the wall or the bottom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0858—Side walls
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00524—Mixing by agitating sample carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00534—Mixing by a special element, e.g. stirrer

Definitions

  • the present invention relates to a reagent container used in an automatic analyzer, and more particularly, to a reagent container capable of uniformly mixing two or more types of reagents, particularly two or more types of reagents having different specific gravities within a container body.
  • a plurality of reagent containers as shown in Patent Document 1 are placed on a turntable provided in a case, -An automatic analyzer that rotates the table so that the reagent container is positioned above the probe provided outside the case, and the probe is lowered to suck the reagent in the container. More known.
  • the reagent in the container is kept at a temperature of 5 to 10 ° C in order to prevent qualitative deterioration of the reagent. It is necessary to save the range.
  • the reagent in the container is stored at a low temperature of 5 to 10 ° C., the air in the case becomes low in humidity, so that the reagent in the container evaporates and its concentration changes. there were.
  • the reagents In order to obtain a uniform concentration of two or more types of reagents having different specific gravities, the reagents must be mixed. For this reason, conventionally, a stirring bar is inserted into the reagent, and the stirring bar is rotated. Since the mixing and moving device must be mixed, a moving device for moving up and down the stirring bar, a control device, and a cleaning device for the stirring rod are indispensable. This increases the complexity and size of the device and increases the cost. There was a problem that carryover could not be prevented unless it was done.
  • the present invention was devised in view of the current situation, and the object of the present invention is that a stirring bar is not required, and as a result, a cleaning device is not required, and the reagent in the reagent container is reliably mixed.
  • An object of the present invention is to provide a reagent container suitable for an automatic analyzer capable of making the reagent concentration uniform.
  • the reagent container according to the present invention has a cylindrical container main body that stores two or more types of reagents, and an uneven portion that protrudes inwardly on the outer peripheral surface of the container main body. It is characterized by.
  • the two or more types of reagents are two or more types of reagents having different specific gravities.
  • the uneven portion is formed to be inclined on the outer peripheral surface of the container body.
  • the reagent container according to the present invention does not require a stirrer and, as a result, does not require a cleaning device, and can reliably mix the reagents in the reagent container and make the reagent concentration uniform. Therefore, the automatic analyzer can be simplified and downsized.
  • FIG. 1 is a perspective view of a reagent container according to an embodiment of the present invention with a lid attached
  • FIG. 2 is an explanatory diagram showing an example of a state in which the reagent container is set in an automatic analyzer
  • FIG. 4 is a front view of the reagent container
  • FIG. 4 is a rear view of the reagent container
  • FIG. 5 is a right side view of the reagent container
  • FIG. 6 is a left side view of the reagent container
  • FIG. FIG. 8 is a plan view
  • FIG. 8 is a bottom view of the reagent container
  • FIG. 9 is a sectional view taken along the line AA in FIG. 3
  • FIG. 10 is a sectional view taken along the line BB in FIG.
  • a reagent container 1 is a reagent mixing container used in a biochemical analyzer or the like, and the entire container body 2 formed in a substantially U-shaped section having a height of 50 mm and a diameter of 10 mm is transparent. Alternatively, it is formed in a cylindrical shape with a semitransparent synthetic resin. Of course, the size can be appropriately changed according to the amount of the mixed reagent.
  • an uneven portion 3 protruding inward is formed on the outer peripheral surface of the container main body 2 in a state of being inclined with a downward slope toward the bottom of the container main body 2.
  • the reagent in the container main body 2 is also turbulent by the concavo-convex portion 3 while rotating and mixed and stirred to a uniform concentration.
  • grooved part 3 is not limited to this embodiment example, For example, if it is a shape mixed efficiently according to the specific gravity of the reagent accommodated, it will be scattered and protrude inward. It may be a plurality of irregularities.
  • a lid 4 such as a rubber stopper is attached to the upper opening of the container body 2 in a watertight manner and closed. That is, after filling the target mixing reagent, the opening is closed with the lid 4 and placed at a predetermined position of the automatic analyzer A. Subsequently, the automatic analyzer A is activated, and the reagent inside is mixed by rotating the reagent container 1 in the horizontal direction by a motor (not shown).
  • the concentration of the whole reagent can be made uniform by the action of the uneven portion 3.
  • the mixed reagent present in the center of the bottom of the reagent container 1 is also kept at a uniform concentration.
  • the two or more kinds of reagents having different specific gravities include a combination of solutions having different specific gravities, a combination of a solid and a solution, and the like, and a combination of a solid and a solution is preferable.
  • the solid in the combination of the solid and the solution include insoluble carrier particles such as magnetic particles and latex particles.
  • the solution include an aqueous medium such as a buffer solution.
  • the combination of the solid and the solution is preferably a combination of magnetic particles and a buffer solution. Since the magnetic particles have a large specific gravity, they settle on the bottom of the reagent container 1 in a stationary state. However, when the container body 2 rotates, it is uniformly mixed and stirred, unlike a container in which the uneven part 3 does not exist.
  • the stirring device and the cleaning device are not required, and the automatic analyzer can be simplified and the cost can be reduced. It has excellent effects such as no worries.
  • FIG. 3 is a sectional view taken along line AA in FIG.
  • FIG. 3B is a sectional view taken along line BB.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne un récipient à réactif destiné à un dispositif d'analyse automatique. Ledit récipient à réactif ne nécessite pas d'agitateur, ce qui permet d'éliminer le recours à un dispositif de nettoyage, et permet d'agiter un réactif de manière fiable dans le récipient à réactif afin d'obtenir une concentration du réactif uniforme. Le récipient à réactif comprend un corps circulaire tubulaire destiné à contenir au moins deux sortes de réactifs différents, en particulier, au moins deux sortes de réactifs présentant des poids spécifiques différents et ainsi qu'une partie évidée formée dans la surface périphérique extérieure du récipient à réactif afin de former une saillie vers l'intérieur. La partie évidée et saillante est formée en oblique dans la surface périphérique extérieure du corps du récipient.
PCT/JP2009/050450 2008-01-15 2009-01-15 Récipient à réactif WO2009090989A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009550037A JP5069755B2 (ja) 2008-01-15 2009-01-15 試薬容器

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008005874 2008-01-15
JP2008-005874 2008-01-15

Publications (1)

Publication Number Publication Date
WO2009090989A1 true WO2009090989A1 (fr) 2009-07-23

Family

ID=40885375

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2009/050450 WO2009090989A1 (fr) 2008-01-15 2009-01-15 Récipient à réactif

Country Status (2)

Country Link
JP (1) JP5069755B2 (fr)
WO (1) WO2009090989A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013509571A (ja) * 2009-10-28 2013-03-14 エフ．ホフマン−ラ ロシュ アーゲー 試料液中のアナライトを検出するための方法、および前記方法を実施するための装置
WO2013172299A1 (fr) * 2012-05-18 2013-11-21 協和メデックス株式会社 Récipient pour réactifs
US20160169779A1 (en) * 2013-07-26 2016-06-16 Sekisui Medical Co., Ltd. Container for specimen preparation
JP2019162586A (ja) * 2018-03-19 2019-09-26 凸版印刷株式会社 試薬カートリッジ

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2585740B2 (ja) * 1987-11-12 1997-02-26 株式会社日立製作所 自動分析装置および反応容器
JP2000137032A (ja) * 1999-08-12 2000-05-16 Olympus Optical Co Ltd 試薬含有容器
WO2004101601A1 (fr) * 2003-05-13 2004-11-25 Universal Bio Research Co., Ltd. Appareil de repliage de proteines et son procede d'utilisation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0538833Y2 (fr) * 1989-04-13 1993-09-30
DE10360526A1 (de) * 2003-12-22 2005-07-14 Roche Diagnostics Gmbh Reagenzkassette mit Reagenzbehälter für partikelhaltiges Reagenz für dessen noninvasive Homogenisierung

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2585740B2 (ja) * 1987-11-12 1997-02-26 株式会社日立製作所 自動分析装置および反応容器
JP2000137032A (ja) * 1999-08-12 2000-05-16 Olympus Optical Co Ltd 試薬含有容器
WO2004101601A1 (fr) * 2003-05-13 2004-11-25 Universal Bio Research Co., Ltd. Appareil de repliage de proteines et son procede d'utilisation

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013509571A (ja) * 2009-10-28 2013-03-14 エフ．ホフマン−ラ ロシュ アーゲー 試料液中のアナライトを検出するための方法、および前記方法を実施するための装置
WO2013172299A1 (fr) * 2012-05-18 2013-11-21 協和メデックス株式会社 Récipient pour réactifs
JPWO2013172299A1 (ja) * 2012-05-18 2016-01-12 協和メデックス株式会社 試薬容器
US20160169779A1 (en) * 2013-07-26 2016-06-16 Sekisui Medical Co., Ltd. Container for specimen preparation
JPWO2015012390A1 (ja) * 2013-07-26 2017-03-02 積水メディカル株式会社 検体調製用容器
EP3026417A4 (fr) * 2013-07-26 2017-07-12 Sekisui Medical Co., Ltd. Récipient pour préparation d'échantillon
US10386277B2 (en) 2013-07-26 2019-08-20 Sekisui Medical Co., Ltd. Container for specimen preparation
JP2019162586A (ja) * 2018-03-19 2019-09-26 凸版印刷株式会社 試薬カートリッジ
JP7003763B2 (ja) 2018-03-19 2022-02-04 凸版印刷株式会社 試薬カートリッジ

Also Published As

Publication number Publication date
JP5069755B2 (ja) 2012-11-07
JPWO2009090989A1 (ja) 2011-05-26

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