WO2009067856A8 - 组蛋白去乙酰化酶抑制剂及其制备和用途 - Google Patents

组蛋白去乙酰化酶抑制剂及其制备和用途 Download PDF

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Publication number
WO2009067856A8
WO2009067856A8 PCT/CN2008/001802 CN2008001802W WO2009067856A8 WO 2009067856 A8 WO2009067856 A8 WO 2009067856A8 CN 2008001802 W CN2008001802 W CN 2008001802W WO 2009067856 A8 WO2009067856 A8 WO 2009067856A8
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Prior art keywords
histone deacetylase
composition
deacetylase inhibitor
inhibitor
medicament
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PCT/CN2008/001802
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English (en)
French (fr)
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WO2009067856A1 (en
Inventor
余聂方
刘晓宇
胡晓东
Original Assignee
浙江海正药业股份有限公司
中南大学
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Application filed by 浙江海正药业股份有限公司, 中南大学 filed Critical 浙江海正药业股份有限公司
Priority to EP08854528.0A priority Critical patent/EP2208721B1/en
Priority to US12/739,635 priority patent/US8921424B2/en
Priority to CN2008801117208A priority patent/CN101827811B/zh
Priority to JP2010530252A priority patent/JP5426560B2/ja
Publication of WO2009067856A1 publication Critical patent/WO2009067856A1/zh
Publication of WO2009067856A8 publication Critical patent/WO2009067856A8/zh

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    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
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PCT/CN2008/001802 2007-10-26 2008-10-27 Histone deacetylase inhibitor, composition and use thereof WO2009067856A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP08854528.0A EP2208721B1 (en) 2007-10-26 2008-10-27 Histone deacetylase inhibitor, composition and use thereof
US12/739,635 US8921424B2 (en) 2007-10-26 2008-10-27 Histone deacetylase inhibitors, process for preparation and uses thereof
CN2008801117208A CN101827811B (zh) 2007-10-26 2008-10-27 组蛋白去乙酰化酶抑制剂及其制备和用途
JP2010530252A JP5426560B2 (ja) 2007-10-26 2008-10-27 新規なヒストンデアセチラーゼインヒビター、その調製方法および使用

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CN200710047464.8 2007-10-26
CNA2007100474648A CN101417967A (zh) 2007-10-26 2007-10-26 组蛋白去乙酰酶抑制剂、其组合物及其应用

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WO2009067856A1 WO2009067856A1 (en) 2009-06-04
WO2009067856A8 true WO2009067856A8 (zh) 2010-06-03

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PCT/CN2008/001802 WO2009067856A1 (en) 2007-10-26 2008-10-27 Histone deacetylase inhibitor, composition and use thereof

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US (1) US8921424B2 (zh)
EP (1) EP2208721B1 (zh)
JP (1) JP5426560B2 (zh)
CN (2) CN101417967A (zh)
WO (1) WO2009067856A1 (zh)

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CN102020607B (zh) * 2009-09-16 2013-01-23 深圳微芯生物科技有限责任公司 具有组蛋白去乙酰化酶抑制活性的6-氨基烟酰胺衍生物、其制备方法及应用
RU2013130253A (ru) 2010-12-03 2015-01-10 Эпизайм, Инк. 7-деазапуриновые регуляторы метилтрансферазы гистонов и способы их применения
BR112013013659B8 (pt) 2010-12-03 2024-02-27 Epizyme Inc Compostos moduladores de enzimas epigenéticas, composição farmacêutica compreendendo ditos compostos e usos da dita composição farmacêutica para tratar câncer, câncer hematológico ou leucemia
CA2819734A1 (en) 2010-12-03 2012-06-07 Epizyme, Inc. Carbocycle-substituted purine and 7-deazapurine compounds
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