WO2009060608A1 - Sdf-1を含有してなる徐放性組成物 - Google Patents
Sdf-1を含有してなる徐放性組成物 Download PDFInfo
- Publication number
- WO2009060608A1 WO2009060608A1 PCT/JP2008/003204 JP2008003204W WO2009060608A1 WO 2009060608 A1 WO2009060608 A1 WO 2009060608A1 JP 2008003204 W JP2008003204 W JP 2008003204W WO 2009060608 A1 WO2009060608 A1 WO 2009060608A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sdf
- sustained release
- composition
- release composition
- composition containing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/195—Chemokines, e.g. RANTES
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
本発明の課題は、SDF-1含有徐放性組成物の提供にある。本発明は、(1)SDF-1と、(2)カルボキシル基および/またはスルホ基を有する修飾ゼラチンからなるハイドロゲルとを含有してなる徐放性組成物を提供する。該組成物は、生体内にて血管前駆細胞の集積を促すケモカインであるSDF-1を持続的に放出することができるので、種々の剤形の医薬組成物として、例えば、虚血性疾患や骨疾患の治療および/または症状進展抑制剤として使用可能である。
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT08847868T ATE543507T1 (de) | 2007-11-07 | 2008-11-06 | Sdf-1 enthaltende zusammensetzung mit anhaltender freisetzung |
US12/741,694 US8435953B2 (en) | 2007-11-07 | 2008-11-06 | Sustained release composition containing SDF-1 |
EP08847868A EP2218459B1 (en) | 2007-11-07 | 2008-11-06 | Sustained release composition containing sdf-1 |
JP2009539954A JP5248519B2 (ja) | 2007-11-07 | 2008-11-06 | Sdf−1を含有してなる徐放性組成物 |
ES08847868T ES2378918T3 (es) | 2007-11-07 | 2008-11-06 | Composición de liberación sostenida que contiene SDF-1 |
US13/771,511 US9107953B2 (en) | 2007-11-07 | 2013-02-20 | Sustained release composition containing SDF-1 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-289598 | 2007-11-07 | ||
JP2007289598 | 2007-11-07 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/741,694 A-371-Of-International US8435953B2 (en) | 2007-11-07 | 2008-11-06 | Sustained release composition containing SDF-1 |
US13/771,511 Division US9107953B2 (en) | 2007-11-07 | 2013-02-20 | Sustained release composition containing SDF-1 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009060608A1 true WO2009060608A1 (ja) | 2009-05-14 |
Family
ID=40625516
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/003204 WO2009060608A1 (ja) | 2007-11-07 | 2008-11-06 | Sdf-1を含有してなる徐放性組成物 |
Country Status (6)
Country | Link |
---|---|
US (2) | US8435953B2 (ja) |
EP (1) | EP2218459B1 (ja) |
JP (1) | JP5248519B2 (ja) |
AT (1) | ATE543507T1 (ja) |
ES (1) | ES2378918T3 (ja) |
WO (1) | WO2009060608A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9821027B2 (en) | 2011-08-23 | 2017-11-21 | Mochida Pharmaceutical Co., Ltd. | Method for regenerating cartilage comprising applying a monovalent metal salt of alginic acid and SDF-1 |
JP2020512338A (ja) * | 2017-03-30 | 2020-04-23 | ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ | 腎臓疾患の治療方法 |
CN113144283A (zh) * | 2021-04-26 | 2021-07-23 | 广东海洋大学 | 一种促进创伤愈合的TSCP-GelMA水凝胶及其制备和应用 |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9308277B2 (en) | 2010-02-25 | 2016-04-12 | Mesoblast International Sàrl | Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage |
AU2012268078B2 (en) * | 2011-06-07 | 2017-06-01 | Mesoblast International Sarl | Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived Factor-1 |
BR112016008267A2 (pt) | 2013-10-22 | 2017-10-03 | Viromed Co Ltd | Composição para prevenir ou tratar esclerose lateral amiotrófica usando duas ou mais isoformas de fator de crescimento de hepatócito |
EP3139945A4 (en) * | 2014-05-08 | 2017-11-29 | Wake Forest University Health Sciences | Methods of treating incontinence and other sphincter deficiency disorders |
WO2016048105A1 (ko) * | 2014-09-26 | 2016-03-31 | 주식회사 바이로메드 | 간세포 성장인자 및 기질세포 유발인자1알파를 이용한 말초동맥질환의 예방 또는 치료용 조성물 |
CN113403244B (zh) | 2014-12-23 | 2022-08-19 | 伊利亚制药公司 | 伤口愈合的方法 |
WO2019032930A1 (en) * | 2017-08-11 | 2019-02-14 | Wake Forest University Health Sciences | USE OF CXCL12 FOR THERAPY AFTER SURGERY OF THE PROSTATE |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994027630A1 (fr) | 1993-05-31 | 1994-12-08 | Kaken Pharmaceutical Co., Ltd. | Preparation de gel a base de gelatine reticulee contenant un facteur de croissance de fibroblaste de base |
WO2003007982A1 (fr) | 2001-07-18 | 2003-01-30 | Yasuhiko Tabata | Preparations d'hydrogel hgf a liberation prolongee |
WO2004030691A1 (ja) * | 2002-10-04 | 2004-04-15 | Medgel Corporation | Nk4を含有する徐放性製剤 |
WO2005120549A2 (en) * | 2004-06-07 | 2005-12-22 | Conor Medsystems, Inc. | Local delivery of growth factors for stem cell transplantation |
WO2006030887A1 (ja) * | 2004-09-17 | 2006-03-23 | Cellgentech, Inc. | 外用皮膚潰瘍治療剤 |
WO2007080898A1 (ja) * | 2006-01-10 | 2007-07-19 | Medgel Corporation | 徐放性ハイドロゲル製剤 |
JP2007289598A (ja) | 2006-04-24 | 2007-11-08 | Sanada Seiko Kk | 食器収納器具 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2566798B1 (fr) * | 1984-06-27 | 1986-12-12 | Centre Nat Rech Scient | Membrane porteuse de la luciferase pour le dosage de l'atp et son procede de production |
US6297337B1 (en) * | 1999-05-19 | 2001-10-02 | Pmd Holdings Corp. | Bioadhesive polymer compositions |
GB0201674D0 (en) * | 2002-01-25 | 2002-03-13 | Lorantis Ltd | Medical treatment |
DE10228103A1 (de) | 2002-06-24 | 2004-01-15 | Bayer Cropscience Ag | Fungizide Wirkstoffkombinationen |
US7563748B2 (en) | 2003-06-23 | 2009-07-21 | Cognis Ip Management Gmbh | Alcohol alkoxylate carriers for pesticide active ingredients |
WO2006000020A1 (en) | 2004-06-29 | 2006-01-05 | European Nickel Plc | Improved leaching of base metals |
BRPI0611707A2 (pt) | 2005-06-29 | 2012-04-24 | Compumedics Ltd | conjunto de sensor com ponte condutiva |
-
2008
- 2008-11-06 ES ES08847868T patent/ES2378918T3/es active Active
- 2008-11-06 JP JP2009539954A patent/JP5248519B2/ja not_active Expired - Fee Related
- 2008-11-06 US US12/741,694 patent/US8435953B2/en not_active Expired - Fee Related
- 2008-11-06 AT AT08847868T patent/ATE543507T1/de active
- 2008-11-06 EP EP08847868A patent/EP2218459B1/en not_active Not-in-force
- 2008-11-06 WO PCT/JP2008/003204 patent/WO2009060608A1/ja active Application Filing
-
2013
- 2013-02-20 US US13/771,511 patent/US9107953B2/en not_active Expired - Fee Related
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994027630A1 (fr) | 1993-05-31 | 1994-12-08 | Kaken Pharmaceutical Co., Ltd. | Preparation de gel a base de gelatine reticulee contenant un facteur de croissance de fibroblaste de base |
WO2003007982A1 (fr) | 2001-07-18 | 2003-01-30 | Yasuhiko Tabata | Preparations d'hydrogel hgf a liberation prolongee |
WO2004030691A1 (ja) * | 2002-10-04 | 2004-04-15 | Medgel Corporation | Nk4を含有する徐放性製剤 |
WO2005120549A2 (en) * | 2004-06-07 | 2005-12-22 | Conor Medsystems, Inc. | Local delivery of growth factors for stem cell transplantation |
WO2006030887A1 (ja) * | 2004-09-17 | 2006-03-23 | Cellgentech, Inc. | 外用皮膚潰瘍治療剤 |
WO2007080898A1 (ja) * | 2006-01-10 | 2007-07-19 | Medgel Corporation | 徐放性ハイドロゲル製剤 |
JP2007289598A (ja) | 2006-04-24 | 2007-11-08 | Sanada Seiko Kk | 食器収納器具 |
Non-Patent Citations (5)
Title |
---|
BIOMATERIALS, vol. 19, 1998, pages 1781 - 9 |
CIRCULATION, vol. 109, 2004, pages 2454 - 2461 |
KOHEI MIYAO: "Practical Drug Delivery Systems", MEDICINE AND DRUG JOURNAL, 1986 |
LANCET, vol. 362, 2003, pages 697 - 703 |
NATURE MEDICINE, vol. 10, no. 8, 2004, pages 858 - 864 |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9821027B2 (en) | 2011-08-23 | 2017-11-21 | Mochida Pharmaceutical Co., Ltd. | Method for regenerating cartilage comprising applying a monovalent metal salt of alginic acid and SDF-1 |
JP2020512338A (ja) * | 2017-03-30 | 2020-04-23 | ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ | 腎臓疾患の治療方法 |
CN113144283A (zh) * | 2021-04-26 | 2021-07-23 | 广东海洋大学 | 一种促进创伤愈合的TSCP-GelMA水凝胶及其制备和应用 |
CN113144283B (zh) * | 2021-04-26 | 2022-06-28 | 广东海洋大学 | 一种促进创伤愈合的TSCP-GelMA水凝胶及其制备和应用 |
Also Published As
Publication number | Publication date |
---|---|
JP5248519B2 (ja) | 2013-07-31 |
EP2218459A4 (en) | 2011-06-01 |
US8435953B2 (en) | 2013-05-07 |
US20130243824A1 (en) | 2013-09-19 |
US9107953B2 (en) | 2015-08-18 |
ATE543507T1 (de) | 2012-02-15 |
US20100267612A1 (en) | 2010-10-21 |
ES2378918T3 (es) | 2012-04-19 |
JPWO2009060608A1 (ja) | 2011-03-17 |
EP2218459B1 (en) | 2012-02-01 |
EP2218459A1 (en) | 2010-08-18 |
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