MX2009005148A - Aptamero contra midcina, y uso del mismo. - Google Patents
Aptamero contra midcina, y uso del mismo.Info
- Publication number
- MX2009005148A MX2009005148A MX2009005148A MX2009005148A MX2009005148A MX 2009005148 A MX2009005148 A MX 2009005148A MX 2009005148 A MX2009005148 A MX 2009005148A MX 2009005148 A MX2009005148 A MX 2009005148A MX 2009005148 A MX2009005148 A MX 2009005148A
- Authority
- MX
- Mexico
- Prior art keywords
- aptamer
- against midkine
- midkine
- substance
- inhibitory activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
Abstract
Se provee un aptámero de alta calidad contra midcina; un aptámero que posee una actividad inhibidora contra midcina; un complejo que comprende un aptámero que posee una actividad de unión o actividad inhibidora contra midcina, y una sustancia funcional, por ejemplo, sustancias de afinidad, sustancias para marcación, enzimas, vehículos de suministro de fármacos, fármacos, y similares; un fármaco farmacéutico, inhibidor de la migración celular, reactivo de diagnóstico, agente de marcación, y similares, que comprende un aptámero que posee una actividad de unión o actividad inhibidora contra midcina, o un complejo que comprende el aptámero y una sustancia funcional; un inhibidor de la migración celular, un reactivo de diagnóstico, un agente de marcación, y similares.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006308482 | 2006-11-14 | ||
PCT/JP2007/072099 WO2008059877A1 (fr) | 2006-11-14 | 2007-11-14 | Aptamère contre la midkine et son utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009005148A true MX2009005148A (es) | 2009-08-24 |
Family
ID=39401681
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009005148A MX2009005148A (es) | 2006-11-14 | 2007-11-14 | Aptamero contra midcina, y uso del mismo. |
Country Status (27)
Country | Link |
---|---|
US (1) | US8080649B2 (es) |
EP (1) | EP2096167B1 (es) |
JP (1) | JP5190573B2 (es) |
KR (1) | KR101516024B1 (es) |
CN (1) | CN101573446B (es) |
AU (1) | AU2007320401B2 (es) |
BR (1) | BRPI0718913A2 (es) |
CA (1) | CA2669523C (es) |
CO (1) | CO6190535A2 (es) |
CY (1) | CY1113679T1 (es) |
DK (1) | DK2096167T3 (es) |
ES (1) | ES2397715T3 (es) |
HK (1) | HK1135729A1 (es) |
HR (1) | HRP20130012T1 (es) |
IL (1) | IL198705A (es) |
MX (1) | MX2009005148A (es) |
MY (1) | MY147374A (es) |
NO (1) | NO342010B1 (es) |
NZ (1) | NZ577396A (es) |
PL (1) | PL2096167T3 (es) |
PT (1) | PT2096167E (es) |
RU (1) | RU2460794C2 (es) |
SI (1) | SI2096167T1 (es) |
TW (1) | TWI481713B (es) |
UA (1) | UA100847C2 (es) |
WO (1) | WO2008059877A1 (es) |
ZA (1) | ZA200903562B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1964574B1 (en) | 2005-11-14 | 2016-09-07 | Cellmid Limited | Method for treatment or prevention of disease associated with functional disorder of regulatory t cell |
US10260070B2 (en) | 2008-09-24 | 2019-04-16 | Ribomic Inc. | Aptamer for NGF and use thereof |
JP6041373B2 (ja) * | 2010-02-01 | 2016-12-07 | Necソリューションイノベータ株式会社 | TNF−αに結合するアプタマー分子 |
EP2551346B1 (en) | 2010-03-24 | 2016-01-27 | Ribomic Inc. | Aptamer for ngf and use thereof |
JP2013545800A (ja) | 2010-12-20 | 2013-12-26 | コルゲート・パーモリブ・カンパニー | 親水性活性剤、疎水性構造化剤および油担体を含有するゼラチンカプセル化された口腔ケア組成物 |
HUE039439T2 (hu) * | 2011-09-28 | 2018-12-28 | Ribomic Inc | NGF aptamer és alkalmazása |
JP6020888B2 (ja) * | 2012-06-29 | 2016-11-02 | 国立大学法人名古屋大学 | エポキシエイコサトリエン酸関連疾患の予防又は治療 |
WO2014080997A1 (ja) | 2012-11-21 | 2014-05-30 | 株式会社リボミック | ミッドカインに対するアプタマー及びその用途 |
RU2549704C1 (ru) * | 2014-03-26 | 2015-04-27 | Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) | Рнк-аптамер, обладающий способностью узнавать характерные для рассеянного склероза аутоантитела |
KR102501963B1 (ko) | 2016-07-01 | 2023-02-21 | 소마로직 오퍼레이팅 컴퍼니, 인코포레이티드 | 변형된 뉴클레오사이드를 포함하는 올리고뉴클레오타이드 |
KR101985300B1 (ko) * | 2016-07-19 | 2019-06-03 | 삼성전자주식회사 | 미드카인 저해제를 포함하는 뇌종양 치료 또는 예방용 약학 조성물 |
CN109536505B (zh) * | 2018-12-07 | 2021-11-09 | 暨南大学 | 鬼臼毒素的核酸适配体及其应用 |
WO2020124095A1 (en) * | 2018-12-14 | 2020-06-18 | Board Of Regents, The University Of Texas System Aka | Dna aptamers and use thereof for the treatment of cancer |
WO2020241493A1 (ja) * | 2019-05-24 | 2020-12-03 | 株式会社リボミック | 骨形成や骨代謝の異常に関連する疾患の治療薬 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5660985A (en) | 1990-06-11 | 1997-08-26 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands containing modified nucleotides |
JP3842304B2 (ja) | 1992-10-08 | 2006-11-08 | 喬 村松 | 癌の診断、治療薬 |
ATE330620T1 (de) | 1997-07-14 | 2006-07-15 | Takashi Muramatsu | Verwendung von midkin oder von anti-midkin antikörper |
DE69941263D1 (de) | 1998-08-24 | 2009-09-24 | Medical Therapies Ltd | Zusammensetzungen zur vorbeugung und behandlung der artheriosklerose und der restenose nach ptca |
US6858390B2 (en) * | 1998-12-31 | 2005-02-22 | Ingeneus Corporation | Aptamers containing sequences of nucleic acid or nucleic acid analogues bound homologously, or in novel complexes |
JP2000354487A (ja) * | 1999-06-15 | 2000-12-26 | Takashi Muramatsu | ミッドカイン受容体 |
EP1607102B1 (en) | 2003-03-06 | 2017-01-18 | Medical Therapies Limited | Preventive for adhesion following abdominal surgery |
JP4646070B2 (ja) | 2003-03-27 | 2011-03-09 | メディカル セラピーズ リミテッド | 関節炎関連遺伝子及びこれの関節炎検査等への利用 |
JP3940097B2 (ja) * | 2003-05-20 | 2007-07-04 | 株式会社リボミック | 翻訳開始因子eIF4Eに結合するリガンド |
JP2007297282A (ja) | 2004-08-13 | 2007-11-15 | Cell Signals Inc | 子宮内膜症の発生の際にミッドカインによって起こる影響 |
JP2006141305A (ja) * | 2004-11-22 | 2006-06-08 | Univ Of Tokyo | 翻訳開始因子eIF4Gに結合するリボ核酸 |
JP2006211905A (ja) * | 2005-02-01 | 2006-08-17 | Univ Of Tokyo | 腫瘍壊死因子受容体ファミリータンパク質に結合する核酸リガンド |
JP2006308482A (ja) | 2005-04-28 | 2006-11-09 | Sanyo Electric Co Ltd | 検出装置 |
-
2007
- 2007-11-14 CN CN2007800424280A patent/CN101573446B/zh not_active Expired - Fee Related
- 2007-11-14 SI SI200731120T patent/SI2096167T1/sl unknown
- 2007-11-14 US US12/312,519 patent/US8080649B2/en not_active Expired - Fee Related
- 2007-11-14 DK DK07831829.2T patent/DK2096167T3/da active
- 2007-11-14 MX MX2009005148A patent/MX2009005148A/es active IP Right Grant
- 2007-11-14 NZ NZ577396A patent/NZ577396A/en not_active IP Right Cessation
- 2007-11-14 BR BRPI0718913-3A patent/BRPI0718913A2/pt not_active IP Right Cessation
- 2007-11-14 ZA ZA200903562A patent/ZA200903562B/xx unknown
- 2007-11-14 KR KR1020097012216A patent/KR101516024B1/ko not_active IP Right Cessation
- 2007-11-14 JP JP2008544174A patent/JP5190573B2/ja not_active Expired - Fee Related
- 2007-11-14 MY MYPI20091947A patent/MY147374A/en unknown
- 2007-11-14 CA CA2669523A patent/CA2669523C/en not_active Expired - Fee Related
- 2007-11-14 PL PL07831829T patent/PL2096167T3/pl unknown
- 2007-11-14 UA UAA200906094A patent/UA100847C2/uk unknown
- 2007-11-14 PT PT78318292T patent/PT2096167E/pt unknown
- 2007-11-14 ES ES07831829T patent/ES2397715T3/es active Active
- 2007-11-14 EP EP07831829A patent/EP2096167B1/en active Active
- 2007-11-14 RU RU2009122476/10A patent/RU2460794C2/ru not_active IP Right Cessation
- 2007-11-14 TW TW096142969A patent/TWI481713B/zh not_active IP Right Cessation
- 2007-11-14 WO PCT/JP2007/072099 patent/WO2008059877A1/ja active Application Filing
- 2007-11-14 AU AU2007320401A patent/AU2007320401B2/en not_active Ceased
-
2009
- 2009-05-12 IL IL198705A patent/IL198705A/en active IP Right Grant
- 2009-05-27 CO CO09054211A patent/CO6190535A2/es active IP Right Grant
- 2009-06-12 NO NO20092280A patent/NO342010B1/no not_active IP Right Cessation
-
2010
- 2010-03-02 HK HK10102240.2A patent/HK1135729A1/xx not_active IP Right Cessation
-
2013
- 2013-01-07 HR HRP20130012TT patent/HRP20130012T1/hr unknown
- 2013-01-17 CY CY20131100031T patent/CY1113679T1/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |