WO2009057281A1 - 骨芽細胞分化促進及び破骨細胞分化抑制用食品素材 - Google Patents

骨芽細胞分化促進及び破骨細胞分化抑制用食品素材 Download PDF

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Publication number
WO2009057281A1
WO2009057281A1 PCT/JP2008/003065 JP2008003065W WO2009057281A1 WO 2009057281 A1 WO2009057281 A1 WO 2009057281A1 JP 2008003065 W JP2008003065 W JP 2008003065W WO 2009057281 A1 WO2009057281 A1 WO 2009057281A1
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WIPO (PCT)
Prior art keywords
differentiation
amino acid
osteoclast
osteoblast
inhibiting
Prior art date
Application number
PCT/JP2008/003065
Other languages
English (en)
French (fr)
Inventor
Atsushi Serizawa
Yoshikazu Morita
Daisuke Uetsuji
Aiko Ono
Hiroaki Matsuyama
Satoshi Higurashi
Original Assignee
Snow Brand Milk Products Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Snow Brand Milk Products Co., Ltd. filed Critical Snow Brand Milk Products Co., Ltd.
Priority to DK08846202.3T priority Critical patent/DK2208735T3/da
Priority to EP08846202A priority patent/EP2208735B1/en
Priority to US12/740,752 priority patent/US20100298204A1/en
Priority to JP2009538920A priority patent/JPWO2009057281A1/ja
Priority to CN200880113714.6A priority patent/CN101861332B/zh
Priority to CA2704144A priority patent/CA2704144C/en
Priority to AT08846202T priority patent/ATE526344T1/de
Priority to AU2008320271A priority patent/AU2008320271B2/en
Priority to NZ584887A priority patent/NZ584887A/xx
Publication of WO2009057281A1 publication Critical patent/WO2009057281A1/ja

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • A—HUMAN NECESSITIES
    • A21—BAKING; EDIBLE DOUGHS
    • A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
    • A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
    • A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
    • A21D2/24—Organic nitrogen compounds
    • A21D2/26—Proteins
    • A21D2/261—Animal proteins
    • A21D2/263—Animal proteins from dairy products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C19/00—Cheese; Cheese preparations; Making thereof
    • A23C19/06—Treating cheese curd after whey separation; Products obtained thereby
    • A23C19/068—Particular types of cheese
    • A23C19/08—Process cheese preparations; Making thereof, e.g. melting, emulsifying, sterilizing
    • A23C19/082—Adding substances to the curd before or during melting; Melting salts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/04—Animal proteins
    • A23J3/08—Dairy proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A23L2/66—Proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20—Milk; Whey; Colostrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
    • A61K38/018—Hydrolysed proteins; Derivatives thereof from animals from milk
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nutrition Science (AREA)
  • Public Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Husbandry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Birds (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

次の(1)～(4)の特性を有する乳タンパク質画分からなる骨芽細胞分化促進及び破骨細胞分化抑制剤。 　(1) 乳由来であること。 　 (2)分子量75,000～80,000ダルトンの範囲のタンパク質成分を含有する画分であること。 　(3) 構成アミノ酸組成中に塩基性アミノ酸を13～15重量％含有しかつ、塩基性アミノ酸／酸性アミノ酸比が0.5～0.7の範囲であること。 　(4) 骨芽細胞分化促進及び破骨細胞分化抑制作用を有すること。
PCT/JP2008/003065 2007-11-01 2008-10-28 骨芽細胞分化促進及び破骨細胞分化抑制用食品素材 WO2009057281A1 (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
DK08846202.3T DK2208735T3 (da) 2007-11-01 2008-10-28 Næringsmiddel til fremme af differentiering af osteoblast og inhibering af differentiering af osteoklast
EP08846202A EP2208735B1 (en) 2007-11-01 2008-10-28 Food material for promoting the differentiation of osteoblast and inhibiting the differentiation of osteoclast
US12/740,752 US20100298204A1 (en) 2007-11-01 2008-10-28 Food material for promoting the differentiation of osteoblast and inhibiting the differentiation of osteoclast
JP2009538920A JPWO2009057281A1 (ja) 2007-11-01 2008-10-28 骨芽細胞分化促進及び破骨細胞分化抑制用食品素材
CN200880113714.6A CN101861332B (zh) 2007-11-01 2008-10-28 用于促进成骨细胞分化和抑制破骨细胞分化的食品原材料
CA2704144A CA2704144C (en) 2007-11-01 2008-10-28 Food material for promoting the differentiation of osteoblast and inhibiting the differentiation of osteoclast
AT08846202T ATE526344T1 (de) 2007-11-01 2008-10-28 Nahrungsmittel zur förderung der differenzierung von osteoblasten und zur inhibierung der differenzierung von osteoclasten
AU2008320271A AU2008320271B2 (en) 2007-11-01 2008-10-28 Food material for promoting the differentiation of osteoblast and inhibiting the differentiation of osteoclast
NZ584887A NZ584887A (en) 2007-11-01 2008-10-28 Food material for promoting the differentiation of osteoblast and inhibiting the differentiation of osteoclast

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-285394 2007-11-01
JP2007285394 2007-11-01

Publications (1)

Publication Number Publication Date
WO2009057281A1 true WO2009057281A1 (ja) 2009-05-07

Family

ID=40590688

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/003065 WO2009057281A1 (ja) 2007-11-01 2008-10-28 骨芽細胞分化促進及び破骨細胞分化抑制用食品素材

Country Status (13)

Country Link
US (1) US20100298204A1 (ja)
EP (1) EP2208735B1 (ja)
JP (1) JPWO2009057281A1 (ja)
KR (1) KR20100100831A (ja)
CN (1) CN101861332B (ja)
AT (1) ATE526344T1 (ja)
AU (1) AU2008320271B2 (ja)
CA (1) CA2704144C (ja)
DK (1) DK2208735T3 (ja)
ES (1) ES2370122T3 (ja)
NZ (1) NZ584887A (ja)
PT (1) PT2208735E (ja)
WO (1) WO2009057281A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012043713A1 (ja) * 2010-09-30 2012-04-05 雪印メグミルク株式会社 皮膚コラーゲン産生促進剤

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ584888A (en) * 2007-11-01 2012-08-31 Megmilk Snow Brand Co Ltd Bone-strengthening food material
US20120040908A1 (en) * 2008-11-18 2012-02-16 Megmilk Snow Brand Co., Ltd. Fracture repair promoter
FR2988566B1 (fr) * 2012-03-28 2014-08-08 Yoplait France Compositions alimentaires pour stimuler la formation de tissu osseux
JP6309202B2 (ja) 2013-03-28 2018-04-11 雪印メグミルク株式会社 タンパク質組成物およびその製造方法

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61246198A (ja) 1985-02-07 1986-11-01 オレオフイナ・ソシエテ・アノニム 蛋白の精製法
JPS63255300A (ja) 1987-04-10 1988-10-21 Snow Brand Milk Prod Co Ltd 硫酸エステル化物を用いて乳からラクトフエリンを分離、精製する方法
JPS6486839A (en) 1987-06-19 1989-03-31 Entamonto Sa Method for selectively extracting metal protein from whey
JPH05202098A (ja) 1992-01-29 1993-08-10 Snow Brand Milk Prod Co Ltd 乳質原料から生理活性物質の製造法
JPH05320066A (ja) 1992-05-07 1993-12-03 Snow Brand Milk Prod Co Ltd 乳清由来の骨芽細胞増殖促進及び骨強化因子ならびに該因子を含有せしめた骨強化食品、医薬および飼料
JPH08151331A (ja) * 1994-09-30 1996-06-11 Snow Brand Milk Prod Co Ltd 骨強化剤
JPH107585A (ja) * 1996-06-20 1998-01-13 Snow Brand Milk Prod Co Ltd 骨形成促進及び骨吸収防止剤
JP3092874B2 (ja) 1991-12-26 2000-09-25 雪印乳業株式会社 乳清由来の骨芽細胞増殖・骨強化画分及び該画分を含有する骨強化食品、飼料、薬品類
JP3160862B2 (ja) 1990-11-15 2001-04-25 雪印乳業株式会社 骨強化食品、飼料及び医薬
JP2001346519A (ja) * 2000-06-09 2001-12-18 Snow Brand Milk Prod Co Ltd 乳塩基性シスタチン高含有画分及びその分解物の製造方法
JP2004115509A (ja) * 2002-09-05 2004-04-15 Snow Brand Milk Prod Co Ltd 破骨細胞分化抑制因子産生促進剤
JP2005060321A (ja) * 2003-08-15 2005-03-10 Snow Brand Milk Prod Co Ltd 骨形成促進剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
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SE458818B (sv) * 1987-11-27 1989-05-16 Svenska Mejeriernas Riksforeni Foerfarande foer utvinning av rena fraktioner av laktoperoxidas och laktoferrin ur mjoelkserum
AU3110500A (en) * 1998-12-04 2000-06-19 Barnes-Jewish Hospital Cell matrix plaques of initial bone formation
US6649590B2 (en) * 2000-06-09 2003-11-18 Snow Brand Milk Products Co., Ltd. Method of producing fractions containing a high concentration of milk basic cystatin and decomposition products thereof
JP2004238320A (ja) * 2003-02-05 2004-08-26 Snow Brand Milk Prod Co Ltd 骨吸収抑制剤
CA2539445A1 (en) * 2003-09-30 2005-04-07 Snow Brand Milk Products Co., Ltd. Agent for promoting osteogenesis and/or inhibiting bone resorption
WO2009057287A1 (ja) * 2007-11-01 2009-05-07 Snow Brand Milk Products Co., Ltd. 破骨細胞形成抑制用食品素材

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61246198A (ja) 1985-02-07 1986-11-01 オレオフイナ・ソシエテ・アノニム 蛋白の精製法
JPS63255300A (ja) 1987-04-10 1988-10-21 Snow Brand Milk Prod Co Ltd 硫酸エステル化物を用いて乳からラクトフエリンを分離、精製する方法
JPS6486839A (en) 1987-06-19 1989-03-31 Entamonto Sa Method for selectively extracting metal protein from whey
JP3160862B2 (ja) 1990-11-15 2001-04-25 雪印乳業株式会社 骨強化食品、飼料及び医薬
JP3092874B2 (ja) 1991-12-26 2000-09-25 雪印乳業株式会社 乳清由来の骨芽細胞増殖・骨強化画分及び該画分を含有する骨強化食品、飼料、薬品類
JPH05202098A (ja) 1992-01-29 1993-08-10 Snow Brand Milk Prod Co Ltd 乳質原料から生理活性物質の製造法
JPH05320066A (ja) 1992-05-07 1993-12-03 Snow Brand Milk Prod Co Ltd 乳清由来の骨芽細胞増殖促進及び骨強化因子ならびに該因子を含有せしめた骨強化食品、医薬および飼料
JPH08151331A (ja) * 1994-09-30 1996-06-11 Snow Brand Milk Prod Co Ltd 骨強化剤
JP3112637B2 (ja) 1994-09-30 2000-11-27 雪印乳業株式会社 骨強化剤
JPH107585A (ja) * 1996-06-20 1998-01-13 Snow Brand Milk Prod Co Ltd 骨形成促進及び骨吸収防止剤
JP2001346519A (ja) * 2000-06-09 2001-12-18 Snow Brand Milk Prod Co Ltd 乳塩基性シスタチン高含有画分及びその分解物の製造方法
JP2004115509A (ja) * 2002-09-05 2004-04-15 Snow Brand Milk Prod Co Ltd 破骨細胞分化抑制因子産生促進剤
JP2005060321A (ja) * 2003-08-15 2005-03-10 Snow Brand Milk Prod Co Ltd 骨形成促進剤

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012043713A1 (ja) * 2010-09-30 2012-04-05 雪印メグミルク株式会社 皮膚コラーゲン産生促進剤
JP2012077017A (ja) * 2010-09-30 2012-04-19 Snow Brand Milk Products Co Ltd 皮膚コラーゲン産生促進剤

Also Published As

Publication number Publication date
US20100298204A1 (en) 2010-11-25
NZ584887A (en) 2012-08-31
ATE526344T1 (de) 2011-10-15
EP2208735A1 (en) 2010-07-21
EP2208735B1 (en) 2011-09-28
AU2008320271B2 (en) 2012-09-13
ES2370122T3 (es) 2011-12-12
CN101861332B (zh) 2014-04-02
CN101861332A (zh) 2010-10-13
JPWO2009057281A1 (ja) 2011-03-10
CA2704144A1 (en) 2009-05-07
DK2208735T3 (da) 2012-01-02
EP2208735A4 (en) 2010-11-10
KR20100100831A (ko) 2010-09-15
PT2208735E (pt) 2012-01-05
CA2704144C (en) 2015-12-29
AU2008320271A1 (en) 2009-05-07

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