WO2009050486A2 - Manipulateurs peptidiques de l'activité des lymphocytes t régulateurs - Google Patents

Manipulateurs peptidiques de l'activité des lymphocytes t régulateurs Download PDF

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Publication number
WO2009050486A2
WO2009050486A2 PCT/GB2008/003533 GB2008003533W WO2009050486A2 WO 2009050486 A2 WO2009050486 A2 WO 2009050486A2 GB 2008003533 W GB2008003533 W GB 2008003533W WO 2009050486 A2 WO2009050486 A2 WO 2009050486A2
Authority
WO
WIPO (PCT)
Prior art keywords
peptide
seq
foxp3
cells
amino acids
Prior art date
Application number
PCT/GB2008/003533
Other languages
English (en)
Other versions
WO2009050486A3 (fr
Inventor
Hardev Pandha
Richard George Leonard Morgan
Original Assignee
The University Of Surrey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0720551.1A external-priority patent/GB0720551D0/en
Priority claimed from GBGB0808199.4A external-priority patent/GB0808199D0/en
Application filed by The University Of Surrey filed Critical The University Of Surrey
Publication of WO2009050486A2 publication Critical patent/WO2009050486A2/fr
Publication of WO2009050486A3 publication Critical patent/WO2009050486A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1761—Apoptosis related proteins, e.g. Apoptotic protease-activating factor-1 (APAF-1), Bax, Bax-inhibitory protein(s)(BI; bax-I), Myeloid cell leukemia associated protein (MCL-1), Inhibitor of apoptosis [IAP] or Bcl-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des inhibiteurs peptidiques des lymphocytes T régulateurs. Les peptides selon l'invention sont dérivés de la protéine FOXP3 et inhibent son interaction avec les NFAT. De tels peptides sont efficaces pour bloquer l'interaction entre FOXP3 et NFAT et provoquer l'apoptose des lymphocytes T régulateurs matures. De tels peptides présentent un potentiel prometteur pour la manipulation des réponses immunitaires chez l'homme.
PCT/GB2008/003533 2007-10-19 2008-10-17 Manipulateurs peptidiques de l'activité des lymphocytes t régulateurs WO2009050486A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB0720551.1A GB0720551D0 (en) 2007-10-19 2007-10-19 Peptide manipulators of regulatory t cell activity
GB0720551.1 2007-10-19
GB0808199.4 2008-05-06
GBGB0808199.4A GB0808199D0 (en) 2008-05-06 2008-05-06 Peptide manipulators of regulatory T cell activity

Publications (2)

Publication Number Publication Date
WO2009050486A2 true WO2009050486A2 (fr) 2009-04-23
WO2009050486A3 WO2009050486A3 (fr) 2010-03-11

Family

ID=40567858

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/003533 WO2009050486A2 (fr) 2007-10-19 2008-10-17 Manipulateurs peptidiques de l'activité des lymphocytes t régulateurs

Country Status (1)

Country Link
WO (1) WO2009050486A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011152566A3 (fr) * 2010-06-04 2012-02-02 The University Of Tokyo Composition pour induire une prolifération ou une accumulation de lymphocytes t régulateurs
US9642881B2 (en) 2011-12-01 2017-05-09 The University Of Tokyo Human-derived bacteria that induce proliferation or accumulation of regulatory T cells

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1681568A1 (fr) * 2003-10-29 2006-07-19 Hidechika Okada Anticorps artificiel contenant un peptide complementaire
WO2008081581A1 (fr) * 2007-01-03 2008-07-10 Oncotherapy Science, Inc. Vaccin à peptide foxp3

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1681568A1 (fr) * 2003-10-29 2006-07-19 Hidechika Okada Anticorps artificiel contenant un peptide complementaire
WO2008081581A1 (fr) * 2007-01-03 2008-07-10 Oncotherapy Science, Inc. Vaccin à peptide foxp3

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
Anonymous: "NCT00128622 on 2007_09_20" ClinicalTrials 20 September 2007 (2007-09-20), pages 1-5, XP002561364 Retrieved from the Internet: URL:http://clinicaltrials.gov/archive/NCT00128622/2007_09_20> [retrieved on 2009-12-18] *
HU ET AL: "Transcriptional partners in regulatory T cells: Foxp3, Runx and NFAT" TRENDS IN IMMUNOLOGY, ELSEVIER, RAHWAY, NJ, US, vol. 28, no. 8, 21 July 2007 (2007-07-21), pages 329-332, XP022162860 ISSN: 1471-4906 *
KO K ET AL: "TREATMENT OF ADVANCED TUMORS WITH AGONISTIC ANTI-GITR MAB AND ITS EFFECTS ON TUMOR-INFILTRATING FOXP3(+)CD25(+)CD4(+) REGULATORY T CELLS" JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, JP, vol. 202, no. 7, 3 October 2005 (2005-10-03), pages 885-891, XP009076415 ISSN: 0022-1007 *
NAIR SMITA ET AL: "Vaccination against the forkhead family transcription factor Foxp3 enhances tumor immunity" CANCER RESEARCH, vol. 67, no. 1, January 2007 (2007-01), pages 371-380, XP002561361 ISSN: 0008-5472 *
WOLF DOMINIK ET AL: "The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer." CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH 1 DEC 2005, vol. 11, no. 23, 1 December 2005 (2005-12-01), pages 8326-8331, XP002561365 ISSN: 1078-0432 *
WU YONGQING ET AL: "FOXP3 controls regulatory T cell function through cooperation with NFAT" CELL, vol. 126, no. 2, July 2006 (2006-07), pages 375-387, XP002561362 ISSN: 0092-8674 *
Wu, Y. et al.: "Supplemental material of FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT" Cellno. 126, 27 June 2007 (2007-06-27), pages 1-20, XP002561363 Retrieved from the Internet: URL:http://www.sciencedirect.com/science/MiamiMultiMediaURL/B6WSN-4KH4DBN-P/B6WSN-4KH4DBN-P-1/7051/html/346de8aba3b1a7a706b4a10047ef7f3f/mmc1.pdf> [retrieved on 2010-01-04] *

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10092603B2 (en) 2010-06-04 2018-10-09 The University Of Tokyo Composition for inducing proliferation or accumulation of regulatory T cells
US9808519B2 (en) 2010-06-04 2017-11-07 The University Of Tokyo Composition for inducing proliferation or accumulation of regulatory T cells
US9415079B2 (en) 2010-06-04 2016-08-16 The University Of Tokyo Composition for inducing proliferation or accumulation of regulatory T cells
US9421230B2 (en) 2010-06-04 2016-08-23 The University Of Tokyo Composition for inducing proliferation or accumulation of regulatory T cells
WO2011152566A3 (fr) * 2010-06-04 2012-02-02 The University Of Tokyo Composition pour induire une prolifération ou une accumulation de lymphocytes t régulateurs
EP4014982A3 (fr) * 2010-06-04 2022-09-07 The University of Tokyo Composition pour induire la prolifération ou l'accumulation de lymphocytes t régulateurs
US9642882B2 (en) 2010-06-04 2017-05-09 The University Of Tokyo Composition for inducing proliferation or accumulation of regulatory T cells
US11090343B2 (en) 2010-06-04 2021-08-17 The University Of Tokyo Composition for inducing proliferation or accumulation of regulatory T cells
US9662381B2 (en) 2010-06-04 2017-05-30 The University Of Tokyo Composition for inducing proliferation or accumulation of regulatory T cells
JP2013528565A (ja) * 2010-06-04 2013-07-11 国立大学法人 東京大学 制御性ｔ細胞の増殖または集積を誘導する作用を有する組成物
US9801933B2 (en) 2010-06-04 2017-10-31 The University Of Tokyo Composition for inducing proliferation or accumulation of regulatory T cells
US10555978B2 (en) 2010-06-04 2020-02-11 The University Of Tokyo Composition for inducing proliferation or accumulation of regulatory T cells
US9827276B2 (en) 2010-06-04 2017-11-28 The University Of Tokyo Composition for inducing proliferation or accumulation of regulatory T cells
US9833483B2 (en) 2010-06-04 2017-12-05 The University Of Tokyo Composition for inducing proliferation or accumulation of regulatory T cells
EP3750549A3 (fr) * 2010-06-04 2021-03-10 The University of Tokyo Composition pour induire la prolifération ou l'accumulation de lymphocytes t régulateurs
EP3178483B1 (fr) 2010-06-04 2020-04-29 The University of Tokyo Composition destinee a induire la proliferation ou l'accumulation de cellules t regulatrices
US9433652B2 (en) 2010-06-04 2016-09-06 The University Of Tokyo Composition for inducing proliferation or accumulation of regulatory T cells
EP3539548B1 (fr) 2010-06-04 2020-04-29 The University of Tokyo Composition pour induire la prolifération ou l'accumulation de cellules régulatrices
EP3178483A1 (fr) * 2010-06-04 2017-06-14 The University of Tokyo Composition destinee a induire la proliferation ou l'accumulation de cellules t regulatrices
US10322150B2 (en) 2010-06-04 2019-06-18 The University Of Tokyo Composition for inducing proliferation or accumulation of regulatory T cells
US10328108B2 (en) 2010-06-04 2019-06-25 The University Of Tokyo Composition for inducing proliferation or accumulation of regulatory T cells
US10588925B2 (en) 2010-06-04 2020-03-17 The University Of Tokyo Composition for inducing proliferation or accumulation of regulatory T cells
EP3539548A1 (fr) * 2010-06-04 2019-09-18 The University of Tokyo Composition pour induire la prolifération ou l'accumulation de cellules régulatrices
EP3552613A1 (fr) * 2010-06-04 2019-10-16 The University of Tokyo Composition pour induire la prolifération ou l'accumulation de lymphocytes t régulateurs
US10238694B2 (en) 2011-12-01 2019-03-26 The University Of Tokyo Human-derived bacteria that induce proliferation or accumulation of regulatory T cells
US10342832B2 (en) 2011-12-01 2019-07-09 The University Of Tokyo Human-derived bacteria that induce proliferation or accumulation of
US10624933B2 (en) 2011-12-01 2020-04-21 The University Of Tokyo Human-derived bacteria that induce proliferation or accumulation of regulatory T cells
US9649345B2 (en) 2011-12-01 2017-05-16 The University Of Tokyo Human-derived bacteria that induce proliferation or accumulation of regulatory T cells
US10058578B2 (en) 2011-12-01 2018-08-28 The University Of Tokyo Human-derived bacteria that induce proliferation or accumulation of regulatory T cells
US10835559B2 (en) 2011-12-01 2020-11-17 The University Of Tokyo Human-derived bacteria that induce proliferation or accumulation of regulatory T cells
US10052353B2 (en) 2011-12-01 2018-08-21 The University Of Tokyo Human-derived bacteria that induce proliferation or accumulation of regulatory T cells
US10183045B2 (en) 2011-12-01 2019-01-22 The University Of Tokyo Human-derived bacteria that induce proliferation or accumulation of regulatory T cells
US9642881B2 (en) 2011-12-01 2017-05-09 The University Of Tokyo Human-derived bacteria that induce proliferation or accumulation of regulatory T cells
US11547732B2 (en) 2011-12-01 2023-01-10 The University Of Tokyo Human-derived bacteria that induce proliferation or accumulation of regulatory T cells

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Publication number Publication date
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