WO2009050486A3 - Manipulateurs peptidiques de l'activité des lymphocytes t régulateurs - Google Patents

Manipulateurs peptidiques de l'activité des lymphocytes t régulateurs Download PDF

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Publication number
WO2009050486A3
WO2009050486A3 PCT/GB2008/003533 GB2008003533W WO2009050486A3 WO 2009050486 A3 WO2009050486 A3 WO 2009050486A3 GB 2008003533 W GB2008003533 W GB 2008003533W WO 2009050486 A3 WO2009050486 A3 WO 2009050486A3
Authority
WO
WIPO (PCT)
Prior art keywords
f0xp3
cancer
treatment
nfat
peptides
Prior art date
Application number
PCT/GB2008/003533
Other languages
English (en)
Other versions
WO2009050486A2 (fr
Inventor
Hardev Pandha
Richard George Leonard Morgan
Original Assignee
The University Of Surrey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0720551.1A external-priority patent/GB0720551D0/en
Priority claimed from GBGB0808199.4A external-priority patent/GB0808199D0/en
Application filed by The University Of Surrey filed Critical The University Of Surrey
Publication of WO2009050486A2 publication Critical patent/WO2009050486A2/fr
Publication of WO2009050486A3 publication Critical patent/WO2009050486A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1761—Apoptosis related proteins, e.g. Apoptotic protease-activating factor-1 (APAF-1), Bax, Bax-inhibitory protein(s)(BI; bax-I), Myeloid cell leukemia associated protein (MCL-1), Inhibitor of apoptosis [IAP] or Bcl-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des inhibiteurs peptidiques des lymphocytes T régulateurs. Les peptides selon l'invention sont dérivés de la protéine FOXP3 et inhibent son interaction avec les NFAT. De tels peptides sont efficaces pour bloquer l'interaction entre FOXP3 et NFAT et provoquer l'apoptose des lymphocytes T régulateurs matures. De tels peptides présentent un potentiel prometteur pour la manipulation des réponses immunitaires chez l'homme.
PCT/GB2008/003533 2007-10-19 2008-10-17 Manipulateurs peptidiques de l'activité des lymphocytes t régulateurs WO2009050486A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB0720551.1A GB0720551D0 (en) 2007-10-19 2007-10-19 Peptide manipulators of regulatory t cell activity
GB0720551.1 2007-10-19
GB0808199.4 2008-05-06
GBGB0808199.4A GB0808199D0 (en) 2008-05-06 2008-05-06 Peptide manipulators of regulatory T cell activity

Publications (2)

Publication Number Publication Date
WO2009050486A2 WO2009050486A2 (fr) 2009-04-23
WO2009050486A3 true WO2009050486A3 (fr) 2010-03-11

Family

ID=40567858

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/003533 WO2009050486A2 (fr) 2007-10-19 2008-10-17 Manipulateurs peptidiques de l'activité des lymphocytes t régulateurs

Country Status (1)

Country Link
WO (1) WO2009050486A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011151941A1 (fr) 2010-06-04 2011-12-08 国立大学法人東京大学 Composition présentant une activité d'induction de la prolifération ou de l'accumulation de cellule t régulatrice
JP6306507B2 (ja) 2011-12-01 2018-04-18 国立大学法人 東京大学 制御性ｔ細胞の増殖または集積を誘導するヒト由来細菌

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1681568A1 (fr) * 2003-10-29 2006-07-19 Hidechika Okada Anticorps artificiel contenant un peptide complementaire
WO2008081581A1 (fr) * 2007-01-03 2008-07-10 Oncotherapy Science, Inc. Vaccin à peptide foxp3

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1681568A1 (fr) * 2003-10-29 2006-07-19 Hidechika Okada Anticorps artificiel contenant un peptide complementaire
WO2008081581A1 (fr) * 2007-01-03 2008-07-10 Oncotherapy Science, Inc. Vaccin à peptide foxp3

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "NCT00128622 on 2007_09_20", 20 September 2007 (2007-09-20), pages 1 - 5, XP002561364, Retrieved from the Internet <URL:http://clinicaltrials.gov/archive/NCT00128622/2007_09_20> [retrieved on 20091218] *
HU ET AL: "Transcriptional partners in regulatory T cells: Foxp3, Runx and NFAT", TRENDS IN IMMUNOLOGY, ELSEVIER, RAHWAY, NJ, US, vol. 28, no. 8, 21 July 2007 (2007-07-21), pages 329 - 332, XP022162860, ISSN: 1471-4906 *
KO K ET AL: "TREATMENT OF ADVANCED TUMORS WITH AGONISTIC ANTI-GITR MAB AND ITS EFFECTS ON TUMOR-INFILTRATING FOXP3(+)CD25(+)CD4(+) REGULATORY T CELLS", JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, JP, vol. 202, no. 7, 3 October 2005 (2005-10-03), pages 885 - 891, XP009076415, ISSN: 0022-1007 *
NAIR SMITA ET AL: "Vaccination against the forkhead family transcription factor Foxp3 enhances tumor immunity", CANCER RESEARCH, vol. 67, no. 1, January 2007 (2007-01-01), pages 371 - 380, XP002561361, ISSN: 0008-5472 *
WOLF DOMINIK ET AL: "The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH 1 DEC 2005, vol. 11, no. 23, 1 December 2005 (2005-12-01), pages 8326 - 8331, XP002561365, ISSN: 1078-0432 *
WU YONGQING ET AL: "FOXP3 controls regulatory T cell function through cooperation with NFAT", CELL, vol. 126, no. 2, July 2006 (2006-07-01), pages 375 - 387, XP002561362, ISSN: 0092-8674 *
WU, Y. ET AL.: "Supplemental material of FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT", CELL, no. 126, 27 June 2007 (2007-06-27), pages 1 - 20, XP002561363, Retrieved from the Internet <URL:http://www.sciencedirect.com/science/MiamiMultiMediaURL/B6WSN-4KH4DBN-P/B6WSN-4KH4DBN-P-1/7051/html/346de8aba3b1a7a706b4a10047ef7f3f/mmc1.pdf> [retrieved on 20100104] *

Also Published As

Publication number Publication date
WO2009050486A2 (fr) 2009-04-23

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